IMP

Process View

Mus musculus

18 genes annotated in mouse

cellular response to decreased oxygen levels

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular response to decreased oxygen levels"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular response to decreased oxygen levels" (in gray)

Name	Description	Probability	Func Analog Organism
Vegfa	vascular endothelial growth factor A	0.885	Human
Pten	phosphatase and tensin homolog	0.867
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.863
Trp53	transformation related protein 53	0.817	Human Zebrafish
Vhl	von Hippel-Lindau tumor suppressor	0.727	Human Fly
Mdm2	transformed mouse 3T3 cell double minute 2	0.723	Human
Bcl2	B-cell leukemia/lymphoma 2	0.653
Nos3	nitric oxide synthase 3, endothelial cell	0.598
Gata4	GATA binding protein 4	0.563
Ldb3	LIM domain binding 3	0.559
Bax	BCL2-associated X protein	0.520	Mouse
Egln1	EGL nine homolog 1 (C. elegans)	0.412	Fly
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.339
Dab1	disabled homolog 1 (Drosophila)	0.311
Notch2	Notch gene homolog 2 (Drosophila)	0.296	Mouse
Hif1a	hypoxia inducible factor 1, alpha subunit	0.263
Rxra	retinoid X receptor alpha	0.220
Pparg	peroxisome proliferator activated receptor gamma	0.219	Mouse
Ahr	aryl-hydrocarbon receptor	0.205
Mmp9	matrix metallopeptidase 9	0.187
Tsc2	tuberous sclerosis 2	0.164	Fly
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.149
Cd44	CD44 antigen	0.136
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.127
Nos1	nitric oxide synthase 1, neuronal	0.115
Csf1	colony stimulating factor 1 (macrophage)	0.110
Wt1	Wilms tumor 1 homolog	0.110	Mouse
Thbs1	thrombospondin 1	0.106
Otp	orthopedia homolog (Drosophila)	0.103
Egln3	EGL nine homolog 3 (C. elegans)	0.103	Fly
Nf2	neurofibromatosis 2	0.102
Lep	leptin	0.100
Rb1	retinoblastoma 1	0.099
Apc	adenomatosis polyposis coli	0.098
Foxo1	forkhead box O1	0.096
Insr	insulin receptor	0.090
Neurl1a	neuralized homolog 1A (Drosophila)	0.078
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.076	Human
Neurod1	neurogenic differentiation 1	0.076	Mouse
Kiss1	KiSS-1 metastasis-suppressor	0.074
Nab2	Ngfi-A binding protein 2	0.072
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.064
Mdm4	transformed mouse 3T3 cell double minute 4	0.063	Human
Tlr4	toll-like receptor 4	0.062
Gdnf	glial cell line derived neurotrophic factor	0.061
Gata6	GATA binding protein 6	0.060	Human
Gata1	GATA binding protein 1	0.059
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.058
Isl1	ISL1 transcription factor, LIM/homeodomain	0.053
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.052
Ptgs2	prostaglandin-endoperoxide synthase 2	0.049	Human
Neurog2	neurogenin 2	0.049	Mouse
Dll1	delta-like 1 (Drosophila)	0.048
Fgf8	fibroblast growth factor 8	0.046
Tsc1	tuberous sclerosis 1	0.046	Fly
Neurod4	neurogenic differentiation 4	0.045	Mouse
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.044
Mapkap1	mitogen-activated protein kinase associated protein 1	0.043
Onecut1	one cut domain, family member 1	0.042
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.041
Ptf1a	pancreas specific transcription factor, 1a	0.040	Mouse
Hdac1	histone deacetylase 1	0.039
Nf1	neurofibromatosis 1	0.038
Lhx3	LIM homeobox protein 3	0.038
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.037
Cd36	CD36 antigen	0.036
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.035
Lama5	laminin, alpha 5	0.035
Acot13	acyl-CoA thioesterase 13	0.034
Gja1	gap junction protein, alpha 1	0.034
Psen2	presenilin 2	0.034
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.033
Epas1	endothelial PAS domain protein 1	0.033	Human Mouse Fly
Fgf15	fibroblast growth factor 15	0.032
Hoxa1	homeobox A1	0.032
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.032
Skil	SKI-like	0.031
Clock	circadian locomotor output cycles kaput	0.030
Smad3	MAD homolog 3 (Drosophila)	0.029
Nos2	nitric oxide synthase 2, inducible	0.029
Myod1	myogenic differentiation 1	0.029
Hoxc5	homeobox C5	0.029
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.029
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.029
Mecom	MDS1 and EVI1 complex locus	0.028
Sfrp2	secreted frizzled-related protein 2	0.028
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.028
Plat	plasminogen activator, tissue	0.026
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.026
ND6	NADH dehydrogenase subunit 6	0.026
En1	engrailed 1	0.025
Tcfap2a	transcription factor AP-2, alpha	0.025
Arx	aristaless related homeobox	0.025
Tbr1	T-box brain gene 1	0.025
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.024	Rat
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.024
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.024
Tert	telomerase reverse transcriptase	0.024
Ltbp1	latent transforming growth factor beta binding protein 1	0.024
Igh	immunoglobulin heavy chain complex	0.024
Ep300	E1A binding protein p300	0.024
Lyz2	lysozyme 2	0.023
Spry4	sprouty homolog 4 (Drosophila)	0.023
Gnrh1	gonadotropin releasing hormone 1	0.023
Ppara	peroxisome proliferator activated receptor alpha	0.023	Mouse
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.023
Irs2	insulin receptor substrate 2	0.023
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.023
Fbxw7	F-box and WD-40 domain protein 7	0.023
Lrp8	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	0.022
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.022
Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.022
Lepr	leptin receptor	0.022
Xpa	xeroderma pigmentosum, complementation group A	0.022
Prkab1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.022
Fzd4	frizzled homolog 4 (Drosophila)	0.022
Timp1	tissue inhibitor of metalloproteinase 1	0.022
Hipk1	homeodomain interacting protein kinase 1	0.021
Srrm4	serine/arginine repetitive matrix 4	0.021
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.021
Rrm2b	ribonucleotide reductase M2 B (TP53 inducible)	0.021
Cav1	caveolin 1, caveolae protein	0.021
Edar	ectodysplasin-A receptor	0.021
Efs	embryonal Fyn-associated substrate	0.020
Psen1	presenilin 1	0.020
Bcl2l1	BCL2-like 1	0.020	Mouse
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.020	Rat
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.020
Bak1	BCL2-antagonist/killer 1	0.020	Mouse
Ebf3	early B-cell factor 3	0.019
Epha2	Eph receptor A2	0.019
Ccl2	chemokine (C-C motif) ligand 2	0.019
Tgfb1	transforming growth factor, beta 1	0.019
Snai1	snail homolog 1 (Drosophila)	0.019
Smn1	survival motor neuron 1	0.018
Phox2b	paired-like homeobox 2b	0.018
Vldlr	very low density lipoprotein receptor	0.018	Rat
Wnt6	wingless-related MMTV integration site 6	0.018
Accn1	amiloride-sensitive cation channel 1, neuronal (degenerin)	0.018
Robo3	roundabout homolog 3 (Drosophila)	0.018
Lhx6	LIM homeobox protein 6	0.018
Hoxb9	homeobox B9	0.018
Hbegf	heparin-binding EGF-like growth factor	0.018
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.018
Asna1	arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)	0.018
Bhlhe40	basic helix-loop-helix family, member e40	0.017
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.017
Ece1	endothelin converting enzyme 1	0.017
Cyr61	cysteine rich protein 61	0.017
Dok1	docking protein 1	0.017
Lhx9	LIM homeobox protein 9	0.017
Rptor	regulatory associated protein of MTOR, complex 1	0.017
Map1lc3b	microtubule-associated protein 1 light chain 3 beta	0.017
Egfr	epidermal growth factor receptor	0.017
Mfn2	mitofusin 2	0.017
Prkcc	protein kinase C, gamma	0.017
Insm1	insulinoma-associated 1	0.017
Sox1	SRY-box containing gene 1	0.016
Dlx2	distal-less homeobox 2	0.016
Socs3	suppressor of cytokine signaling 3	0.016
Sim2	single-minded homolog 2 (Drosophila)	0.016	Mouse
Pou3f1	POU domain, class 3, transcription factor 1	0.016
Stip1	stress-induced phosphoprotein 1	0.016
Myc	myelocytomatosis oncogene	0.016
Tcrd	T-cell receptor delta chain	0.016
Ranbp9	RAN binding protein 9	0.016
Ntf3	neurotrophin 3	0.016
Slc4a8	solute carrier family 4 (anion exchanger), member 8	0.016
Plk4	polo-like kinase 4 (Drosophila)	0.016
Tal2	T-cell acute lymphocytic leukemia 2	0.016	Mouse
Ephb2	Eph receptor B2	0.016
Dmd	dystrophin, muscular dystrophy	0.016
Sox3	SRY-box containing gene 3	0.016
Crb2	crumbs homolog 2 (Drosophila)	0.016
Fgf4	fibroblast growth factor 4	0.015
Jam3	junction adhesion molecule 3	0.015
Prkci	protein kinase C, iota	0.015
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.015	Human
Plcd1	phospholipase C, delta 1	0.015
Sp3	trans-acting transcription factor 3	0.015
Emx1	empty spiracles homolog 1 (Drosophila)	0.015
Flnc	filamin C, gamma	0.015
Chrnb2	cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)	0.015
Grpr	gastrin releasing peptide receptor	0.015
Mlf2	myeloid leukemia factor 2	0.015
Hand2	heart and neural crest derivatives expressed transcript 2	0.015	Mouse
Ttn	titin	0.014
Hnf4a	hepatic nuclear factor 4, alpha	0.014
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.014
Stc2	stanniocalcin 2	0.014
Stc1	stanniocalcin 1	0.014	Rat
D4Wsu53e	DNA segment, Chr 4, Wayne State University 53, expressed	0.014
Prox1	prospero-related homeobox 1	0.014
Fgf23	fibroblast growth factor 23	0.014
Mark2	MAP/microtubule affinity-regulating kinase 2	0.014
Cdx2	caudal type homeobox 2	0.014
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.014
Grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.014
Bbc3	BCL2 binding component 3	0.014
Adra2a	adrenergic receptor, alpha 2a	0.014
Was	Wiskott-Aldrich syndrome homolog (human)	0.014
Ush1c	Usher syndrome 1C homolog (human)	0.014
Hoxd13	homeobox D13	0.013
Nphs2	nephrosis 2 homolog, podocin (human)	0.013
Dusp1	dual specificity phosphatase 1	0.013
Atg13	ATG13 autophagy related 13 homolog (S. cerevisiae)	0.013
Foxc2	forkhead box C2	0.013
Ptk2	PTK2 protein tyrosine kinase 2	0.013
Ppp5c	protein phosphatase 5, catalytic subunit	0.013
Homer1	homer homolog 1 (Drosophila)	0.013
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.013
Trim47	tripartite motif-containing 47	0.013
Irx4	Iroquois related homeobox 4 (Drosophila)	0.013
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.013
Hadh	hydroxyacyl-Coenzyme A dehydrogenase	0.013
Pou3f2	POU domain, class 3, transcription factor 2	0.013
Calr	calreticulin	0.013
Tcf21	transcription factor 21	0.013
Map3k6	mitogen-activated protein kinase kinase kinase 6	0.013
Egfl7	EGF-like domain 7	0.013
Pafah1b2	platelet-activating factor acetylhydrolase, isoform 1b, subunit 2	0.013
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.013
Zfpm2	zinc finger protein, multitype 2	0.013
Tcrb	T-cell receptor beta chain	0.013
Grm1	glutamate receptor, metabotropic 1	0.013
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.013
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.013
Rgs16	regulator of G-protein signaling 16	0.013
Pxn	paxillin	0.013
Sh3pxd2b	SH3 and PX domains 2B	0.012
P4htm	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	0.012
Rbl1	retinoblastoma-like 1 (p107)	0.012
Pvr	poliovirus receptor	0.012
Meox1	mesenchyme homeobox 1	0.012
Neurod6	neurogenic differentiation 6	0.012	Mouse
Adam17	a disintegrin and metallopeptidase domain 17	0.012
Gypa	glycophorin A	0.012
Hdac2	histone deacetylase 2	0.012
Tbx18	T-box18	0.012
Sik3	SIK family kinase 3	0.012
Prkce	protein kinase C, epsilon	0.012
Twist1	twist homolog 1 (Drosophila)	0.012
Dhh	desert hedgehog	0.012
Zic2	zinc finger protein of the cerebellum 2	0.012
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.012
Ptrf	polymerase I and transcript release factor	0.012
Mixl1	Mix1 homeobox-like 1 (Xenopus laevis)	0.012
Dpf1	D4, zinc and double PHD fingers family 1	0.012
Wwtr1	WW domain containing transcription regulator 1	0.012
Junb	Jun-B oncogene	0.012
Gck	glucokinase	0.012
Fosl1	fos-like antigen 1	0.012
Mrpl12	mitochondrial ribosomal protein L12	0.012
Atxn1	ataxin 1	0.012
Mt2	metallothionein 2	0.012
Pou4f3	POU domain, class 4, transcription factor 3	0.011
Hif3a	hypoxia inducible factor 3, alpha subunit	0.011	Mouse Fly
F11r	F11 receptor	0.011
Tcf15	transcription factor 15	0.011	Mouse
Ptk2b	PTK2 protein tyrosine kinase 2 beta	0.011
Ednra	endothelin receptor type A	0.011
Mrpl4	mitochondrial ribosomal protein L4	0.011
Hsph1	heat shock 105kDa/110kDa protein 1	0.011
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.011
Kcnk3	potassium channel, subfamily K, member 3	0.011
Gfpt2	glutamine fructose-6-phosphate transaminase 2	0.011
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.011
Rdh10	retinol dehydrogenase 10 (all-trans)	0.011
Canx	calnexin	0.011
Fermt3	fermitin family homolog 3 (Drosophila)	0.011
Cntn1	contactin 1	0.011
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.011
Cxcr4	chemokine (C-X-C motif) receptor 4	0.011
Lhx1	LIM homeobox protein 1	0.011
Ush1g	Usher syndrome 1G homolog (human)	0.011
Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	0.011
Rictor	RPTOR independent companion of MTOR, complex 2	0.011
Ch25h	cholesterol 25-hydroxylase	0.011
Fosb	FBJ osteosarcoma oncogene B	0.011
Mrps21	mitochondrial ribosomal protein S21	0.011
Akr1b8	aldo-keto reductase family 1, member B8	0.011
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.011
Selp	selectin, platelet	0.011
Cyp24a1	cytochrome P450, family 24, subfamily a, polypeptide 1	0.010
Echs1	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial	0.010
Mgrn1	mahogunin, ring finger 1	0.010
Efna2	ephrin A2	0.010
Wasf1	WASP family 1	0.010
Notch4	Notch gene homolog 4 (Drosophila)	0.010	Mouse
E2f1	E2F transcription factor 1	0.010
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.010
Acvr1	activin A receptor, type 1	0.010
Klf6	Kruppel-like factor 6	0.010
Nrp1	neuropilin 1	0.010
Herc1	hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1	0.010
Krt20	keratin 20	0.010
Rora	RAR-related orphan receptor alpha	0.010	Human
Sp1	trans-acting transcription factor 1	0.010
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.010
Zic3	zinc finger protein of the cerebellum 3	0.010
Lpin1	lipin 1	0.010
Prph2	peripherin 2	0.010
Pax6	paired box gene 6	0.010
Cpeb3	cytoplasmic polyadenylation element binding protein 3	0.010	Mouse
Barx2	BarH-like homeobox 2	0.010
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.010
Neurog3	neurogenin 3	0.010	Mouse
Aplp2	amyloid beta (A4) precursor-like protein 2	0.010
Mab21l2	mab-21-like 2 (C. elegans)	0.010
Clk4	CDC like kinase 4	0.010