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Danio rerio

11 genes annotated in zebrafish

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negative regulation of gastrulation

GO:2000542

Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of gastrulation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of gastrulation" (in gray)

Name	Description	Probability	Func Analog Organism
bmp2b	bone morphogenetic protein 2b	0.994
mespa	mesoderm posterior a	0.811	Mouse
notch2	notch homolog 2	0.774
wif1	wnt inhibitory factor 1	0.730
chd	chordin	0.704
hmx4	H6 family homeobox 4	0.665
sfrp1a	secreted frizzled-related protein 1a	0.575
foxa3	forkhead box A3	0.544
nog1	noggin 1	0.381
dkk1b	dickkopf 1b	0.368
tbx2b	T-box 2b	0.360
her7	hairy and enhancer of split related-7	0.315
fgf3	fibroblast growth factor 3	0.315
fgfr2	fibroblast growth factor receptor 2	0.303	Zebrafish
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.283
mespb	mesoderm posterior b	0.257	Mouse
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.254
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.236
foxd5	forkhead box D5	0.236
her5	hairy-related 5	0.234
gli1	GLI-Kruppel family member 1	0.219
bmp4	bone morphogenetic protein 4	0.213
pcdh8	protocadherin 8	0.211
sox17	SRY-box containing gene 17	0.199	Mouse
foxi1	forkhead box I1	0.182
flh	floating head	0.158
mxtx2	mix-type homeobox gene 2	0.154
wnt5b	wingless-type MMTV integration site family, member 5b	0.151
lft1	lefty1	0.149
ndr2	nodal-related 2	0.146
admp	anti-dorsalizing morphogenic protein	0.145	Zebrafish
has2	hyaluronan synthase 2	0.132
wnt11r	wingless-type MMTV integration site family, member 11, related	0.131
shha	sonic hedgehog a	0.129
tp63	tumor protein p63	0.117
gadd45ba	growth arrest and DNA-damage-inducible, beta a	0.117
wnt8b	wingless-type MMTV integration site family, member 8b	0.112
lama5	laminin, alpha 5	0.109
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.108
fgfrl1a	fibroblast growth factor receptor-like 1a	0.105
eve1	even-skipped-like1	0.099
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.096
bmp2a	bone morphogenetic protein 2a	0.095	Zebrafish
col14a1	collagen, type XIV, alpha 1	0.087
pnx	posterior neuron-specific homeobox	0.086
fgf8a	fibroblast growth factor 8 a	0.082
gbx2	gastrulation brain homeo box 2	0.081
og9x	OG9 homeobox gene	0.080
lft2	lefty2	0.080
fgfr1a	fibroblast growth factor receptor 1a	0.079
fzd8b	frizzled homolog 8b	0.079
tll1	tolloid-like 1	0.078
hnf1ba	HNF1 homeobox Ba	0.078
pax6b	paired box gene 6b	0.077
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.074
alas2	aminolevulinate, delta-, synthetase 2	0.072
efnb3b	ephrin B3b	0.071
tbx6	T-box gene 6	0.070
otx1a	orthodenticle homolog 1a	0.068
spon1b	spondin 1b	0.065
fzd7a	frizzled homolog 7a	0.062
rasl11b	RAS-like, family 11, member B	0.061
fgf17	fibroblast growth factor 17	0.061
fgf8b	fibroblast growth factor 8 b	0.060	Zebrafish
dcn	decorin	0.059
pcdh10b	protocadherin 10b	0.058
spns2	spinster homolog 2 (Drosophila)	0.057
sfrp2	secreted frizzled-related protein 2	0.057	Mouse
fstl1b	follistatin-like 1b	0.055
gata4	GATA-binding protein 4	0.054
boc	brother of CDO	0.054
wls	wntless homolog (Drosophila)	0.054
frzb	frizzled-related protein	0.053
twist3	twist3	0.053
sox32	SRY-box containing gene 32	0.053	Mouse
vent	ventral expressed homeobox	0.052
snai1b	snail homolog 1b (Drosophila)	0.052
ctgf	connective tissue growth factor	0.050
sparc	secreted acidic cysteine rich glycoprotein	0.050
jag1b	jagged 1b	0.049
dmrt3a	doublesex and mab-3 related transcription factor 3a	0.048
mmp14a	matrix metalloproteinase 14a (membrane-inserted)	0.047
met	met proto-oncogene (hepatocyte growth factor receptor)	0.047
col5a2l	collagen, type V, alpha 2-like	0.047	Human
ncs1a	neuronal calcium sensor 1a	0.045
msxc	muscle segment homeobox C	0.044
col1a1b	collagen, type I, alpha 1b	0.043
frem3	Fras1 related extracellular matrix 3	0.043
aldh1a3	aldehyde dehydrogenase 1 family, member A3	0.043
wnt4a	wingless-type MMTV integration site family, member 4a	0.042
tbx20	T-box 20	0.041
ephb3a	eph receptor B3a	0.041
chrna2a	cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal)	0.039
dharma	dharma	0.039
zgc:110712	zgc:110712	0.039
bmp3	bone morphogenetic protein 3	0.037	Zebrafish
tbx24	T-box 24	0.037
hbbe2	hemoglobin beta embryonic-2	0.036
vcana	versican a	0.036
lhx1b	LIM homeobox 1b	0.036
fgf24	fibroblast growth factor 24	0.035
alcamb	activated leukocyte cell adhesion molecule b	0.035
gfap	glial fibrillary acidic protein	0.035
col5a1	procollagen, type V, alpha 1	0.034	Human
prickle1a	prickle-like 1 (Drosophila) a	0.033
gata5	GATA-binding protein 5	0.033
vsx2	visual system homeobox 2	0.033	Zebrafish
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.033
cdx1a	caudal type homeo box transcription factor 1 a	0.032
wnt10a	wingless-type MMTV integration site family, member 10a	0.031
rx1	retinal homeobox gene 1	0.031
klf4	Kruppel-like factor 4	0.030	Zebrafish
hoxa11a	homeo box A11a	0.030
thbs4b	thrombospondin 4b	0.030
gdf6b	growth differentiation factor 6b	0.030	Zebrafish
hesx1	homeo box (expressed in ES cells) 1	0.030
foxb1.2	forkhead box B1.2	0.028
cx30.3	connexin 30.3	0.028
ahcyl1	S-adenosylhomocysteine hydrolase-like 1	0.028
mapk1	mitogen-activated protein kinase 1	0.028
dbx1a	developing brain homeobox 1a	0.028
LOC100000500	sclerostin-like	0.028
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.028
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.028
klf4a	Kruppel-like transcription factor 4a	0.028
her3	hairy-related 3	0.027
ihha	Indian hedgehog homolog a	0.027
epha4b	eph receptor A4b	0.027
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.027
mchr1a	melanin-concentrating hormone receptor 1a	0.026
ved	ventrally expressed dharma/bozozok antagonist	0.026
bmp7b	bone morphogenetic protein 7b	0.026	Zebrafish
grem2	gremlin 2, cysteine knot superfamily	0.026
dusp6	dual specificity phosphatase 6	0.026
foxg1a	forkhead box G1a	0.024
nkx6.1	NK6 transcription factor related, locus 1 (Drosophila)	0.024
hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.024
egr2b	early growth response 2b	0.024
fn1	fibronectin 1	0.023
tbx18	T-box 18	0.023
dab1a	disabled homolog 1a (Drosophila)	0.023
gpr126	G protein-coupled receptor 126	0.023
fgfr1b	fibroblast growth factor receptor 1b	0.022	Zebrafish
pax8	paired box gene 8	0.022
sp5l	Sp5 transcription factor-like	0.022
bmp7a	bone morphogenetic protein 7a	0.022
uts2a	urotensin 2, alpha	0.022
nkx2.2a	NK2 transcription factor related 2a	0.022
hgfa	hepatocyte growth factor a	0.021
thbs1	thrombospondin 1	0.021
ext1a	exostoses (multiple) 1a	0.020
neurog3	neurogenin 3	0.020
nkd1	naked cuticle homolog 1 (Drosophila)	0.020
sema3aa	semaphorin 3aa	0.020
cth1	cth1	0.019
ptgs1	prostaglandin-endoperoxide synthase 1	0.019
pitx3	paired-like homeodomain transcription factor 3	0.019
wu:fv91b12	wu:fv91b12	0.019
dlx4b	distal-less homeobox gene 4b	0.019
gcga	glucagon a and glucagon a-like	0.019
fzd5	frizzled homolog 5	0.019
robo2	roundabout homolog 2	0.019
vox	ventral homeobox	0.019
pax2a	paired box gene 2a	0.018
runx3	runt-related transcription factor 3	0.018
vax2	ventral anterior homeobox 2	0.018
foxd3	forkhead box D3	0.018
cdh1	cadherin 1, epithelial	0.018
sim1a	single-minded homolog 1a (Drosophila)	0.018
her1	hairy-related 1	0.018
scinla	scinderin like a	0.018
mesp2	mesoderm posterior 2 homolog (mouse)	0.018
dlx5a	distal-less homeobox gene 5a	0.017
pax2b	paired box gene 2b	0.017
wnt3a	wingless-type MMTV integration site family, member 3A	0.017
ripply2	ripply2	0.017
dbx1b	developing brain homeobox 1b	0.017
sfrp5	secreted frizzled-related protein 5	0.017
alpi	alkaline phosphatase, intestinal	0.017
raraa	retinoic acid receptor, alpha a	0.016
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.016
sema3d	semaphorin 3d	0.016
hnf4a	hepatocyte nuclear factor 4, alpha	0.016
tbx1	T-box 1	0.016
fes	feline sarcoma oncogene	0.016
LOC567678	avidin-like	0.015
emx1	empty spiracles homeobox 1	0.015
sox9b	SRY-box containing gene 9b	0.015
nkx1.2la	NK1 transcription factor related 2-like,a	0.015
opn1mw4	opsin 1 (cone pigments), medium-wave-sensitive, 4	0.015
emx3	empty spiracles homeobox 3	0.015
zgc:153154	zgc:153154	0.015
fgf19	fibroblast growth factor 19	0.015
tgfbr2	transforming growth factor, beta receptor II	0.015
efnb2a	ephrin B2a	0.015
atoh7	atonal homolog 7	0.014
ndr1	nodal-related 1	0.014
rx3	retinal homeobox gene 3	0.014
zgc:85866	zgc:85866	0.014
fzd10	frizzled homolog 10	0.014
tagln2	transgelin 2	0.014
lnx2b	ligand of numb-protein X 2b	0.014
gata2a	GATA-binding protein 2a	0.014
wnt2	wingless-type MMTV integration site family member 2	0.014
mab21l2	mab-21-like 2	0.014
smad1	MAD homolog 1 (Drosophila)	0.014
oep	one-eyed pinhead	0.014
sesn1	sestrin 1	0.014
slc8a4b	solute carrier family 8 (sodium/calcium exchanger), member 4b	0.014
eya1	eyes absent homolog 1	0.014
arl4ab	ADP-ribosylation factor-like 4ab	0.014
plagl2	pleiomorphic adenoma gene-like 2	0.013
bhlhe41	basic helix-loop-helix family, member e41	0.013
fgfr3	fibroblast growth factor receptor 3	0.013	Zebrafish
her6	hairy-related 6	0.013
eif4e1b	eukaryotic translation initiation factor 4e 1b	0.013
cyp51	cytochrome P450, family 51	0.013
ovol1	ovo-like 1 (Drosophila)	0.013
notch1b	notch homolog 1b	0.013
wu:fb80e01	wu:fb80e01	0.013
ptch1	patched 1	0.013
mc5rb	melanocortin 5b receptor	0.013
tjp1	tight junction protein 1 (zona occludens 1)	0.013
fgf10a	fibroblast growth factor 10a	0.013
syk	spleen tyrosine kinase	0.013
mapk3	mitogen-activated protein kinase 3	0.013
otpb	orthopedia homolog b	0.013
wisp1b	WNT1 inducible signaling pathway protein 1b	0.012
six4b	sine oculis homeobox homolog 4b	0.012
etv2	ets variant gene 2	0.012
zgc:111821	zgc:111821	0.012
six4a	sine oculis homeobox homolog 4a	0.012
bon	bonnie and clyde	0.012
zgc:193933	zgc:193933	0.012
hoxa2b	homeo box A2b	0.012
bmp6	bone morphogenetic protein 6	0.012	Zebrafish
bmper	BMP binding endothelial regulator	0.012
epb41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.012
notch3	notch homolog 3	0.012
fsta	follistatin a	0.012
gata3	GATA-binding protein 3	0.012
axin2	axin 2 (conductin, axil)	0.012
sptb	spectrin, beta, erythrocytic	0.012
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.012
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.012
meis2.2	myeloid ecotropic viral integration site 2.2	0.012
pth2r	parathyroid hormone 2 receptor	0.012
acvr1b	activin A receptor, type IB	0.012
sp7	Sp7 transcription factor	0.011
foxa2	forkhead box A2	0.011
nr6a1a	nuclear receptor subfamily 6, group A, member 1a	0.011
or111-10	odorant receptor, family D, subfamily 111, member 10	0.011
hdr	hematopoietic death receptor	0.011
zgc:77051	zgc:77051	0.011
hapln3	hyaluronan and proteoglycan link protein 3	0.011
col1a2	collagen, type I, alpha 2	0.011
wnt2ba	wingless-type MMTV integration site family, member 2Ba	0.011
dfna5	deafness, autosomal dominant 5	0.011
nrg2a	neuregulin 2a	0.011
ntn1a	netrin 1a	0.011
hmx3	homeo box (H6 family) 3	0.011
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.011
mdka	midkine-related growth factor	0.011
rhoub	ras homolog gene family, member Ub	0.011
spon2b	spondin 2b, extracellular matrix protein	0.011
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.011
msgn1	mesogenin 1	0.011
syce2	synaptonemal complex central element protein 2	0.011
aplnra	apelin receptor a	0.011
oprk1	opioid receptor, kappa 1	0.011
pea3	ETS-domain transcription factor pea3	0.011
sycp3l	synaptonemal complex protein 3 like	0.011
nt5c2l1	5'-nucleotidase, cytosolic II, like 1	0.010
lmo4a	LIM domain only 4a	0.010
gli3	GLI-Kruppel family member GLI3	0.010
wnt1	wingless-type MMTV integration site family, member 1	0.010
prdm1a	PR domain containing 1a, with ZNF domain	0.010
lhx1a	LIM homeobox 1a	0.010
cnr1	cannabinoid receptor 1	0.010
tbx4	T-box 4	0.010
frem2a	Fras1 related extracellular matrix protein 2a	0.010
tfe3b	transcription factor binding to IGHM enhancer 3b	0.010
atoh1b	atonal homolog 1b	0.010
tbpl2	TATA box binding protein like 2	0.010
evx2	even-skipped homeobox 2	0.010
grhl2b	grainyhead-like 2b (Drosophila)	0.010
im:7138239	im:7138239	0.010