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Danio rerio

18 genes annotated in zebrafish

mapk cascade

An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mapk cascade"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "mapk cascade" (in gray)

Name	Description	Probability	Func Analog Organism
foxd3	forkhead box D3	0.277
spry4	sprouty (Drosophila) homolog 4	0.197	Mouse
ephb4b	eph receptor B4b	0.161
yes1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.138
dkk1b	dickkopf 1b	0.125
crip2	cysteine-rich protein 2	0.124	Zebrafish
tagln2	transgelin 2	0.123	Zebrafish
fn1	fibronectin 1	0.115
gdf6a	growth differentiation factor 6a	0.104
efnb2a	ephrin B2a	0.103
hif1ab	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b	0.103
kdrl	kinase insert domain receptor like	0.078	Fly
alcama	activated leukocyte cell adhesion molecule a	0.073
mstnb	myostatin b	0.070
fzd7a	frizzled homolog 7a	0.068
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.065
wu:fv91b12	wu:fv91b12	0.064
smad9	MAD homolog 9 (Drosophila)	0.063
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.060
zbtb4	zinc finger and BTB domain containing 4	0.058
sox9b	SRY-box containing gene 9b	0.056
igf1	insulin-like growth factor 1	0.055
smad1	MAD homolog 1 (Drosophila)	0.054	Mouse
ywhae1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	0.054	Fly
tnfrsfa	tumor necrosis factor receptor superfamily, member a	0.054
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.050
brd4	bromodomain containing 4	0.050
igf1rb	insulin-like growth factor 1b receptor	0.049	Human Mouse
rag1	recombination activating gene 1	0.048
LOC100537975	thyroid receptor-interacting protein 11-like	0.047
fgf3	fibroblast growth factor 3	0.047
her9	hairy-related 9	0.047
odc1	ornithine decarboxylase 1	0.045
shha	sonic hedgehog a	0.045
flh	floating head	0.044
ptk2.1	protein tyrosine kinase 2a	0.043	Rat Fly
jag2	jagged 2	0.041
wnt5a	wingless-type MMTV integration site family, member 5a	0.039
nod1	nucleotide-binding oligomerization domain containing 1	0.039
arhgef7b	Rho guanine nucleotide exchange factor (GEF) 7b	0.039
junb	jun B proto-oncogene	0.038
esr1	estrogen receptor 1	0.038	Rat
furina	furin (paired basic amino acid cleaving enzyme) a	0.037
rhoab	ras homolog gene family, member Ab	0.037
ved	ventrally expressed dharma/bozozok antagonist	0.036
vipr2	vasoactive intestinal peptide receptor 2	0.036
nrg2a	neuregulin 2a	0.036
brd2a	bromodomain-containing 2a	0.036
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.035
jun	jun proto-oncogene	0.034	Fly
ldb1a	LIM-domain binding factor 1a	0.034
oprd1b	opioid receptor, delta 1b	0.034
ywhabb	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b	0.032
tbx1	T-box 1	0.031	Mouse
tpm4	tropomyosin 4	0.031
csrp1a	cysteine and glycine-rich protein 1a	0.031
ptena	phosphatase and tensin homolog A	0.031
sulf1	sulfatase 1	0.030
runx3	runt-related transcription factor 3	0.030
mapk6	mitogen-activated protein kinase 6	0.030	Mouse
nrp2a	neuropilin 2a	0.029
jag1b	jagged 1b	0.028
bdnf	brain-derived neurotrophic factor	0.028
traf4a	tnf receptor-associated factor 4a	0.028	Fly
adra2b	adrenergic, alpha-2B-, receptor	0.028	Mouse
ywhai	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide	0.028	Fly
cxcl12b	chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)	0.028
wnt4a	wingless-type MMTV integration site family, member 4a	0.027
crestin	crestin	0.027
plcb3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.027
olfm1a	olfactomedin 1a	0.027
mapk3	mitogen-activated protein kinase 3	0.026	Human Yeast Mouse Rat Worm Fly
spry2	sprouty homolog 2	0.026
mbtps1	membrane-bound transcription factor protease, site 1	0.026
csnk1g2a	casein kinase 1, gamma 2a	0.026
tp53	tumor protein p53	0.026
wnt3	wingless-type MMTV integration site family, member 3	0.026
ahcyl1	S-adenosylhomocysteine hydrolase-like 1	0.026
bnc2	basonuclin 2	0.026
mpped2	metallophosphoesterase domain containing 2	0.025
frzb	frizzled-related protein	0.025	Rat
tlr21	toll-like receptor 21	0.025
csnk1da	casein kinase 1, delta a	0.025
myca	myelocytomatosis oncogene a	0.025
her6	hairy-related 6	0.024
mapk1	mitogen-activated protein kinase 1	0.024	Human Yeast Mouse Rat Worm Fly
gapdhs	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	0.024
osr1	odd-skipped related 1 (Drosophila)	0.024
gbx2	gastrulation brain homeo box 2	0.024
ntrk2a	neurotrophic tyrosine kinase, receptor, type 2a	0.024
fes	feline sarcoma oncogene	0.023
sox10	SRY-box containing gene 10	0.023
card9	caspase recruitment domain family, member 9	0.023	Mouse
th	tyrosine hydroxylase	0.023
cdipt	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)	0.023
plagl2	pleiomorphic adenoma gene-like 2	0.023
mcoln1	mucolipin 1	0.023
twist1a	twist1a	0.023
met	met proto-oncogene (hepatocyte growth factor receptor)	0.023
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.023
il6st	interleukin 6 signal transducer	0.023
gclc	glutamate-cysteine ligase, catalytic subunit	0.022
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.022
notch3	notch homolog 3	0.022
igf2b	insulin-like growth factor 2b	0.021	Human
kbp	kif1-binding protein	0.021
dzip1	DAZ interacting protein 1	0.021
rarga	retinoic acid receptor gamma a	0.021
ephb4a	eph receptor B4a	0.021
nras	neuroblastoma RAS viral (v-ras) oncogene homolog	0.021	Fly
adra2c	adrenergic, alpha-2C-, receptor	0.021
fas	Fas (TNF receptor superfamily, member 6)	0.021
zgc:91870	zgc:91870	0.021
fzd8a	frizzled homolog 8a	0.021	Mouse
vegfab	vascular endothelial growth factor Ab	0.021	Human Mouse
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.021
egr1	early growth response 1	0.020	Worm
wt1b	wilms tumor 1b	0.020
atp6v0d1	ATPase, H+ transporting, V0 subunit D isoform 1	0.020
vegfc	vascular endothelial growth factor c	0.020
ripk2	receptor-interacting serine-threonine kinase 2	0.020
xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5	0.020
lef1	lymphocyte enhancer binding factor 1	0.020
kdr	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.020	Human Fly
lamc1	laminin, gamma 1	0.020
ddr2b	discoidin domain receptor family, member 2b	0.020
atp2b1a	ATPase, Ca++ transporting, plasma membrane 1a	0.020
phox2b	paired-like homeobox 2b	0.019
nt5e	5'-nucleotidase, ecto (CD73)	0.019
mapk12	mitogen-activated protein kinase 12	0.019	Yeast Zebrafish Rat Worm Fly
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.019
uts2a	urotensin 2, alpha	0.019
arl4ab	ADP-ribosylation factor-like 4ab	0.019
etv5a	ets variant 5a	0.019
mxa	myxovirus (influenza) resistance A	0.019
atp6v1h	ATPase, H+ transporting, lysosomal, V1 subunit H	0.018
hk1	hexokinase 1	0.018
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.018
si:dkey-236e20.2	si:dkey-236e20.2	0.018
flt1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.018	Human Rat Fly
pknox1.2	pbx/knotted 1 homeobox 1.2	0.018
stau2	staufen, RNA binding protein, homolog 2 (Drosophila)	0.018
psen1	presenilin 1	0.018	Mouse
nrg1	neuregulin 1	0.018	Mouse
nadl1.2	neural adhesion molecule L1.2	0.018
abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.017
wnt10a	wingless-type MMTV integration site family, member 10a	0.017
six4b	sine oculis homeobox homolog 4b	0.017
gadd45g	growth arrest and DNA-damage-inducible, gamma	0.017	Human Mouse
si:dkeyp-22b2.3	si:dkeyp-22b2.3	0.017
notch2	notch homolog 2	0.017
zgc:66427	zgc:66427	0.017
map3k4	mitogen activated protein kinase kinase kinase 4	0.017	Human Mouse Fly
si:ch211-212m21.5	si:ch211-212m21.5	0.017
kiss1rb	KISS1 receptor b	0.017	Rat
cx30.3	connexin 30.3	0.017
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.017
sox7	SRY-box containing gene 7	0.017
tcf12	transcription factor 12	0.017
bambia	BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a	0.017
ube2nb	ubiquitin-conjugating enzyme E2Nb	0.017	Fly
pdgfaa	platelet-derived growth factor alpha a	0.017	Human
mapk4	mitogen-activated protein kinase 4	0.017
cav1	caveolin 1	0.016	Mouse
LOC557072	caspase recruitment domain-containing protein 11-like	0.016
pycard	PYD and CARD domain containing	0.016	Human Mouse
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.016	Fly
phlda2	pleckstrin homology-like domain, family A, member 2	0.016
nrp1a	neuropilin 1a	0.016	Mouse
cnn2	calponin 2	0.016
LOC569128	hypothetical protein LOC569128	0.016
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.016
copb2	coatomer protein complex, subunit beta 2	0.016
tob1a	transducer of ERBB2, 1a	0.016
atp2b4	ATPase, Ca++ transporting, plasma membrane 4	0.015
mchr1b	melanin-concentrating hormone receptor 1b	0.015
ccbe1	collagen and calcium binding EGF domains 1	0.015
lama4	laminin, alpha 4	0.015
dip2c	DIP2 disco-interacting protein 2 homolog C (Drosophila)	0.015
f2r	coagulation factor II (thrombin) receptor	0.015	Human Mouse Rat
mapk7	mitogen-activated protein kinase 7	0.015	Rat
erbb3a	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a	0.015
il6r	interleukin 6 receptor	0.015	Human
acvr1l	activin A receptor, type I like	0.015
fgfr1b	fibroblast growth factor receptor 1b	0.015	Human Mouse Fly
yap1	Yes-associated protein 1	0.015
mdm2	transformed 3T3 cell double minute 2 homolog (mouse)	0.014
nod2	nucleotide-binding oligomerization domain containing 2	0.014	Mouse
adrb2a	adrenergic receptor, beta 2a	0.014
gh1	growth hormone 1	0.014
tmem2	transmembrane protein 2	0.014
erbb3b	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b	0.014
tpm3	tropomyosin 3	0.014
pak2a	p21 (CDKN1A)-activated kinase 2a	0.014	Yeast
nf1a	neurofibromin 1a	0.014
ywhabl	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like	0.014	Fly
wtip	Wilms tumor 1 interacting protein	0.014
aox3	aldehyde oxidase 3	0.014
sepw1	selenoprotein W, 1	0.014
ywhaba	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a	0.014	Fly
sox4a	SRY-box containing gene 4a	0.014
ntrk1	neurotrophic tyrosine kinase, receptor, type 1	0.014
smad2	MAD homolog 2 (Drosophila)	0.014
emx3	empty spiracles homeobox 3	0.014
dct	dopachrome tautomerase	0.014
zic3	zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)	0.014
dharma	dharma	0.014
lmo4a	LIM domain only 4a	0.014
prkaa1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.013
meis1	myeloid ecotropic viral integration 1	0.013
rspo3	R-spondin 3 homolog (Xenopus laevis)	0.013
oxtl	oxytocin-like	0.013
tnfa	tumor necrosis factor a (TNF superfamily, member 2)	0.013	Mouse Fly
sox4b	SRY-box containing gene 4b	0.013
furinb	furin (paired basic amino acid cleaving enzyme) b	0.013
zgc:86598	zgc:86598	0.013
ifnphi1	interferon phi 1	0.013
st8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.013
lta4h	leukotriene A4 hydrolase	0.013
sult6b1	sulfotransferase family, cytosolic, 6b, member 1	0.013
itgb1a	integrin, beta 1a	0.013
fgfrl1a	fibroblast growth factor receptor-like 1a	0.013
zgc:91860	zgc:91860	0.013
fgfr2	fibroblast growth factor receptor 2	0.013	Human Mouse Fly
myh11a	myosin, heavy polypeptide 11, smooth muscle a	0.013
diaph2	diaphanous homolog 2 (Drosophila)	0.013
vasa	vasa homolog	0.013
zgc:55558	zgc:55558	0.013	Fly
avpl	arginine vasopressin-like	0.013
cdc42	cell division cycle 42	0.013	Mouse Rat
hspa4a	heat shock protein 4a	0.013
onecut1	one cut domain, family member 1	0.013
cmyb	transcription factor cmyb	0.013
llgl2	lethal giant larvae homolog 2 (Drosophila)	0.013
cyp1b1	cytochrome P450, family 1, subfamily B, polypeptide 1	0.012
junbl	jun B proto-oncogene, like	0.012
hmx1	H6 homeo box 1	0.012
adipor2	adiponectin receptor 2	0.012
si:ch1073-351m12.1	si:ch1073-351m12.1	0.012
smad7	MAD, mothers against decapentaplegic homolog 7 (Drosophila)	0.012
tlr9	toll-like receptor 9	0.012
gpr126	G protein-coupled receptor 126	0.012
matn4	matrilin 4	0.012
si:ch211-195h23.3	si:ch211-195h23.3	0.012
gstp1	glutathione S-transferase pi	0.012	Human Mouse
podxl	podocalyxin-like	0.012
ube4b	ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)	0.012
mc4r	melanocortin 4 receptor	0.012
tnc	tenascin C	0.012
tie2	endothelium-specific receptor tyrosine kinase 2	0.012	Human
cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.012
gpib	glucose phosphate isomerase b	0.012
fgf13b	fibroblast growth factor 13b	0.012
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.012
hhip	hedgehog interacting protein	0.012
zgc:63840	zgc:63840	0.012
hbegfa	heparin-binding EGF-like growth factor a	0.012
ncf1	neutrophil cytosolic factor 1	0.012
ip6k2	inositol hexaphosphate kinase 2	0.012
zgc:91930	zgc:91930	0.012
col7a1l	collagen type VII alpha 1-like	0.012
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.012
ext1a	exostoses (multiple) 1a	0.012
tpst1	tyrosylprotein sulfotransferase 1	0.011
lama5	laminin, alpha 5	0.011
arhgap29b	Rho GTPase activating protein 29b	0.011
lass2	LAG1 homolog, ceramide synthase 2 (S. cerevisiae)	0.011
igfbp1a	insulin-like growth factor binding protein 1a	0.011
xirp1	xin actin-binding repeat containing 1	0.011
inhbaa	inhibin, beta Aa	0.011
metrn	meteorin, glial cell differentiation regulator	0.011
h2afv	H2A histone family, member V	0.011
ret1	receptor tyrosine kinase	0.011	Mouse
plcg1	phospholipase C, gamma 1	0.011
sox32	SRY-box containing gene 32	0.011
si:dkeyp-50f5.1	si:dkeyp-50f5.1	0.011
hs3st1l1	heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like1	0.011
btk	Bruton agammaglobulinemia tyrosine kinase	0.011
foxi1	forkhead box I1	0.011
snai1b	snail homolog 1b (Drosophila)	0.011
atf3	activating transcription factor 3	0.011
lhcgr	luteinizing hormone/choriogonadotropin receptor	0.011
tph2	tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)	0.011
tnfsf10l3	tumor necrosis factor (ligand) superfamily, member 10 like 3	0.011	Fly
neo1	neogenin 1	0.011
zgc:110340	zgc:110340	0.011
ptrfb	polymerase I and transcript release factor b	0.011
copeb	core promoter element binding protein	0.011
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.011
zgc:77456	zgc:77456	0.011
si:dkey-19f21.3	si:dkey-19f21.3	0.011
pcf11	cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)	0.011
cd63	Cd63 antigen	0.011
rnf41	ring finger protein 41	0.011	Human
egfl6	EGF-like-domain, multiple 6	0.011
tlr3	toll-like receptor 3	0.011	Mouse
stm	starmaker	0.011
LOC556764	similar to Probable RNA-dependent helicase p72 (DEAD-box protein p72) (DEAD-box protein 17)	0.011
ctgf	connective tissue growth factor	0.011	Human
dio2	deiodinase, iodothyronine, type II	0.011
cdx4	caudal type homeo box transcription factor 4	0.010
pafah1b1b	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b	0.010	Mouse
erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog	0.010	Human Rat
LOC566708	FL cytokine receptor-like	0.010
ctsba	cathepsin B, a	0.010
LOC563527	brain-specific angiogenesis inhibitor 1-like	0.010
il1b	interleukin 1, beta and interleukin 1, beta	0.010	Human Mouse Rat
rcor1	REST corepressor 1	0.010
ikzf1	IKAROS family zinc finger 1 (Ikaros)	0.010
sept7b	septin 7b	0.010
pax7b	paired box gene 7b	0.010
evx1	even-skipped homeobox 1	0.010
sp2	sp2 transcription factor	0.010
LOC797331	novel protein similar to vertebrate solute carrier family 12, (potassium-chloride transporter) member 5 (SLC12A5)	0.010
ppp3cb	protein phosphatase 3, catalytic subunit, beta isozyme	0.010
zgc:195154	zgc:195154	0.010
tbx2b	T-box 2b	0.010
fgfr3	fibroblast growth factor receptor 3	0.010	Human Mouse Fly
hmx3	homeo box (H6 family) 3	0.010
ntn1b	netrin 1b	0.010
flncb	filamin C, gamma b (actin binding protein 280)	0.010
cx27.5	connexin 27.5	0.010
zorba	Orb/CPEB-related RNA-binding protein	0.010