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Danio rerio

11 genes annotated in zebrafish

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negative regulation of mitotic cell cycle

GO:0045930

Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of mitotic cell cycle"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of mitotic cell cycle" (in gray)

Name	Description	Probability	Func Analog Organism
wnt5b	wingless-type MMTV integration site family, member 5b	0.768	Zebrafish
mapk3	mitogen-activated protein kinase 3	0.729	Worm
ccnb1	cyclin B1	0.481	Human
wnt11r	wingless-type MMTV integration site family, member 11, related	0.404	Zebrafish
ccna2	cyclin A2	0.255
cx30.3	connexin 30.3	0.226
ccnb2	cyclin B2	0.212
erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog	0.187	Fly
mos	v-mos Moloney murine sarcoma viral oncogene homolog	0.178
plk1	polo-like kinase 1 (Drosophila)	0.159	Human
gro1	groucho 1	0.144
g2e3	G2/M-phase specific E3 ubiquitin ligase	0.143
cdt1	chromatin licensing and DNA replication factor 1	0.141
stil	TAL1 (SCL) interrupting locus	0.136	Mouse
sass6	spindle assembly 6 homolog (C. elegans)	0.132
si:ch211-244o22.2	si:ch211-244o22.2	0.132
ptmaa	prothymosin, alpha a	0.131
LOC566708	FL cytokine receptor-like	0.131
ywhaqb	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b	0.125
zgc:56200	zgc:56200	0.121
pcsk5b	proprotein convertase subtilisin/kexin type 5b	0.120
ccne	cyclin E	0.110	Worm Fly
csnk1da	casein kinase 1, delta a	0.108
mcm5	MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)	0.106
si:ch211-69g19.2	si:ch211-69g19.2	0.105
mcl1b	myeloid cell leukemia sequence 1b	0.104
orc1	origin recognition complex, subunit 1	0.101
tp53	tumor protein p53	0.100	Human Mouse
gmnn	geminin, DNA replication inhibitor	0.099
smad9	MAD homolog 9 (Drosophila)	0.092	Worm Fly
ahctf1	AT hook containing transcription factor 1	0.092
sox2	SRY-box containing gene 2	0.089
zgc:65861	zgc:65861	0.088
caprin1a	cell cycle associated protein 1a	0.086
ywhabb	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b	0.086
cstf1	cleavage stimulation factor, 3' pre-RNA, subunit 1	0.085
dtl	denticleless homolog (Drosophila)	0.081
mmp2	matrix metalloproteinase 2	0.079
ywhabl	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like	0.079
kif23	kinesin family member 23	0.077
map2k4a	mitogen-activated protein kinase kinase 4a	0.076
ccnd1	cyclin D1	0.075	Human
bmp2b	bone morphogenetic protein 2b	0.073
hmgcrb	3-hydroxy-3-methylglutaryl-Coenzyme A reductase b	0.072
rhoab	ras homolog gene family, member Ab	0.071
twist1a	twist1a	0.071
tgfb3	transforming growth factor, beta 3	0.071
fabp7a	fatty acid binding protein 7, brain, a	0.070
cxcl12a	chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)	0.069
ywhaba	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a	0.067
zgc:153910	zgc:153910	0.065
rpa1	replication protein A1	0.063
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.062
zff9	zinc finger protein 9	0.061
si:ch211-173o4.2	si:ch211-173o4.2	0.059
rest	RE1-silencing transcription factor	0.059
h1fx	H1 histone family, member X	0.059	Worm
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.058
ywhaqa	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a	0.058
spock3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	0.055
orc6	origin recognition complex, subunit 6	0.055
pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.054
adipor2	adiponectin receptor 2	0.053
alcamb	activated leukocyte cell adhesion molecule b	0.052
cand1	cullin-associated and neddylation-dissociated 1	0.052
dharma	dharma	0.051
rrm1	ribonucleotide reductase M1 polypeptide	0.050
snrpc	small nuclear ribonucleoprotein polypeptide C	0.049
atrx	alpha thalassemia/mental retardation syndrome X-linked homolog (human)	0.049
pbx4	pre-B-cell leukemia transcription factor 4	0.049
wdhd1	WD repeat and HMG-box DNA binding protein 1	0.048
rqcd1	RCD1 required for cell differentiation1 homolog (S. pombe)	0.047
tbx5a	T-box 5a	0.045
mcl1a	myeloid cell leukemia sequence 1a	0.045
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.044
vcana	versican a	0.044
bcl2l1	bcl2-like 1	0.043	Human Zebrafish
atoh7	atonal homolog 7	0.043
zgc:174506	zgc:174506	0.042
rpa3	replication protein A3	0.042
wnt4a	wingless-type MMTV integration site family, member 4a	0.042	Zebrafish
ube2g2	ubiquitin-conjugating enzyme E2G 2	0.042
nusap1	nucleolar and spindle associated protein 1	0.041
map2k6	mitogen-activated protein kinase kinase 6	0.040
acvr1l	activin A receptor, type I like	0.039
fgf17	fibroblast growth factor 17	0.039
zgc:101598	zgc:101598	0.039
large	like-glycosyltransferase	0.038
rpl7a	ribosomal protein L7a	0.038
rbpms2	RNA binding protein with multiple splicing 2	0.038
si:ch211-215h6.2	si:ch211-215h6.2	0.037
smc4	structural maintenance of chromosomes 4	0.037
ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.037	Yeast
spry4	sprouty (Drosophila) homolog 4	0.037
smc1al	structural maintenance of chromosomes 1A, like	0.037	Human
lpp	LIM domain containing preferred translocation partner in lipoma	0.036
kpna2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.036
tgfbr2	transforming growth factor, beta receptor II	0.036
emx2	empty spiracles homeobox 2	0.034
arl4ab	ADP-ribosylation factor-like 4ab	0.033
cul3a	cullin 3a	0.033
rbl1	retinoblastoma-like 1 (p107)	0.033	Fly
si:dkey-42i9.4	si:dkey-42i9.4	0.033
trip13	thyroid hormone receptor interactor 13	0.032
nasp	nuclear autoantigenic sperm protein (histone-binding)	0.032
zgc:77235	zgc:77235	0.032
ncapg	non-SMC condensin I complex, subunit G	0.030
wls	wntless homolog (Drosophila)	0.030
zgc:113183	zgc:113183	0.030
sumo3a	SMT3 suppressor of mif two 3 homolog 3a	0.030
aurkb	aurora kinase B	0.030	Yeast
lamb2	laminin, beta 2 (laminin S)	0.029
id1	inhibitor of DNA binding 1	0.028	Zebrafish
sfrp1a	secreted frizzled-related protein 1a	0.028
wnt7ba	wingless-type MMTV integration site family, member 7Ba	0.028	Zebrafish
cops3	COP9 constitutive photomorphogenic homolog subunit 3	0.027
gpr126	G protein-coupled receptor 126	0.027
dusp1	dual specificity phosphatase 1	0.027
sp2	sp2 transcription factor	0.027
vox	ventral homeobox	0.027
srsf1a	serine/arginine-rich splicing factor 1a	0.027	Fly
LOC100001530	isotocin receptor-like 2	0.027
oprm1	opioid receptor, mu 1	0.026
grem1a	gremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis)	0.026
cdca8	cell division cycle associated 8	0.026
wnt9a	wingless-type MMTV integration site family, member 9A	0.025	Zebrafish
zgc:110434	zgc:110434	0.025
pou5f1	POU domain, class 5, transcription factor 1	0.025
map1lc3b	microtubule-associated protein 1 light chain 3 beta	0.025
kif14	kinesin family member 14	0.025
birc5a	baculoviral IAP repeat-containing 5a	0.024
melk	maternal embryonic leucine zipper kinase	0.023
lrp2	low density lipoprotein-related protein 2	0.023
mapk7	mitogen-activated protein kinase 7	0.023
rtkn2	rhotekin 2	0.023
faua	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed a	0.022
ppp2r5eb	protein phosphatase 2, regulatory subunit B', epsilon isoform b	0.022
eif3ha	eukaryotic translation initiation factor 3, subunit H, a	0.022
bcl2	B-cell leukemia/lymphoma 2	0.022	Zebrafish Mouse
mastl	microtubule associated serine/threonine kinase-like	0.022
ncapd2	non-SMC condensin I complex, subunit D2	0.022
zgc:110380	zgc:110380	0.022	Worm
arhgap11a	Rho GTPase activating protein 11A	0.022
gro2	groucho 2	0.021
ints6	integrator complex subunit 6	0.021
im:7140452	im:7140452	0.021
sox32	SRY-box containing gene 32	0.021
hug	HuG	0.021
wnt10b	wingless-type MMTV integration site family, member 10b	0.021	Zebrafish
snrpd1	small nuclear ribonucleoprotein D1 polypeptide	0.021
tbc1d23	TBC1 domain family, member 23	0.020
sae1	SUMO1 activating enzyme subunit 1	0.020
wif1	wnt inhibitory factor 1	0.020
si:ch211-59d15.5	si:ch211-59d15.5	0.020
dct	dopachrome tautomerase	0.020
hells	helicase, lymphoid-specific	0.020
cxcr4b	chemokine (C-X-C motif), receptor 4b	0.019
mmgt1	membrane magnesium transporter 1	0.019
celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.019
elk4	ELK4, ETS-domain protein	0.019
terf1	telomeric repeat binding factor (NIMA-interacting) 1	0.019
wnt3a	wingless-type MMTV integration site family, member 3A	0.019	Zebrafish
brd2a	bromodomain-containing 2a	0.018
zgc:110540	zgc:110540	0.018
zgc:55461	zgc:55461	0.018
numbl	numb homolog (Drosophila)-like	0.018
skp2	S-phase kinase-associated protein 2 (p45)	0.018
csnk1g2a	casein kinase 1, gamma 2a	0.017
LOC796298	isotocin receptor-like 1	0.017
rarga	retinoic acid receptor gamma a	0.017
wnt16	wingless-type MMTV integration site family, member 16	0.017
cep55l	centrosomal protein 55 like	0.017
nrg1	neuregulin 1	0.017
mapk1	mitogen-activated protein kinase 1	0.017	Worm
kpna3	karyopherin (importin) alpha 3	0.017	Fly
twist1b	twist1b	0.017
efnb2a	ephrin B2a	0.016
flh	floating head	0.016
lef1	lymphocyte enhancer binding factor 1	0.016
fen1	flap structure-specific endonuclease 1	0.016
ywhae1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1	0.016	Fly
ppp1r12a	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.016
ercc2	excision repair cross-complementing rodent repair deficiency, complementation group 2	0.016
erbb3a	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a	0.015	Fly
dlc	deltaC	0.015
nuf2	NUF2, NDC80 kinetochore complex component, homolog	0.015
ube2i2	ubiquitin-conjugating enzyme E2I2	0.015	Fly
gins3	GINS complex subunit 3	0.015
smad7	MAD, mothers against decapentaplegic homolog 7 (Drosophila)	0.015
fanci	Fanconi anemia, complementation group I	0.015
zmynd11	zinc finger, MYND domain containing 11	0.015
wnt5a	wingless-type MMTV integration site family, member 5a	0.015	Zebrafish
ing5b	inhibitor of growth family, member 5b	0.015
zbtb4	zinc finger and BTB domain containing 4	0.015
fgf3	fibroblast growth factor 3	0.015
mapk12	mitogen-activated protein kinase 12	0.015
lsm8	LSM8 homolog, U6 small nuclear RNA associated	0.015
bnip3lb	BCL2/adenovirus E1B interacting protein 3-like b	0.015
bmp1a	bone morphogenetic protein 1a	0.014
rpl6	ribosomal protein L6	0.014
odc1	ornithine decarboxylase 1	0.014
paf1	paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.014
si:zfos-47c12.1	si:zfos-47c12.1	0.014
cct8	chaperonin containing TCP1, subunit 8 (theta)	0.014
aggf1	angiogenic factor with G patch and FHA domains 1	0.014
mllt11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11	0.014
srrt	serrate RNA effector molecule homolog (Arabidopsis)	0.014
buc	bucky ball	0.014
ephb4b	eph receptor B4b	0.014
wrb	tryptophan rich basic protein	0.014
prkaa1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.014	Worm
mecom	MDS1 and EVI1 complex locus	0.014
tbx1	T-box 1	0.014
pole	polymerase (DNA directed), epsilon	0.014	Yeast
slbp	stem-loop binding protein	0.014
baxa	bcl2-associated X protein, a	0.014	Zebrafish
krcp	kelch repeat-containing protein	0.013
dzip1	DAZ interacting protein 1	0.013
ergic2	ERGIC and golgi 2	0.013
dkk1b	dickkopf 1b	0.013
lhx2b	LIM homeobox 2b	0.013
bcam	basal cell adhesion molecule (Lutheran blood group)	0.013
whsc1	Wolf-Hirschhorn syndrome candidate 1	0.013
naa15b	N(alpha)-acetyltransferase 15, NatA auxiliary subunit b	0.013
limk1	LIM domain kinase 1	0.013
lrrc40	leucine rich repeat containing 40	0.013
kbp	kif1-binding protein	0.013
zgc:55813	zgc:55813	0.013
haus6	HAUS augmin-like complex, subunit 6	0.013
wnt1	wingless-type MMTV integration site family, member 1	0.013	Zebrafish
pif1	PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)	0.013
erbb3b	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b	0.013	Fly
dnmt5	DNA (cytosine-5-)-methyltransferase 5	0.012
hist2h2l	histone 2, H2, like	0.012
sid4	secreted immunoglobulin domain 4	0.012
zc3h13	zinc finger CCCH-type containing 13	0.012
ntla	no tail a	0.012
rps6ka3a	ribosomal protein S6 kinase, polypeptide 3a	0.012
suv39h1b	suppressor of variegation 3-9 homolog 1b	0.012
smarcb1a	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a	0.012
fbxw2	F-box and WD repeat domain containing 2	0.012
wdr76	WD repeat domain 76	0.012
cox4i2	cytochrome c oxidase subunit IV isoform 2	0.012
ube2i	ubiquitin-conjugating enzyme E2I	0.012	Fly
dnmt1	DNA (cytosine-5-)-methyltransferase 1	0.012
cdk8	cyclin-dependent kinase 8	0.012	Fly
dbr1	debranching enzyme homolog 1 (S. cerevisiae)	0.012
mcm6	MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae)	0.012
dag1	dystroglycan 1	0.012
oep	one-eyed pinhead	0.012
dusp4	dual specificity phosphatase 4	0.012
phrf1	PHD and ring finger domains 1	0.012
notch1a	notch homolog 1a	0.012
crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.011
gmfb	glia maturation factor, beta	0.011
ncaph	non-SMC condensin I complex, subunit H	0.011
cdc42	cell division cycle 42	0.011
hist2h3ca1	histone 2, H3ca1	0.011
dck	deoxycytidine kinase	0.011
emx3	empty spiracles homeobox 3	0.011
ptp4a3	protein tyrosine phosphatase type IVA, member 3	0.011
slc25a44b	solute carrier family 25, member 44 b	0.011
irf2bp2a	interferon regulatory factor 2 binding protein 2a	0.011
cdk2	cyclin-dependent kinase 2	0.011	Yeast
id2a	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a	0.011
zgc:110113	zgc:110113	0.011
usp4	ubiquitin specific protease 4 (proto-oncogene)	0.011
dlat	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	0.011
ppp4ca	protein phosphatase 4 (formerly X), catalytic subunit a	0.011
mbtps1	membrane-bound transcription factor protease, site 1	0.011
ddb2	damage-specific DNA binding protein 2	0.011
lrwd1	leucine-rich repeats and WD repeat domain containing 1	0.011
adipor1b	adiponectin receptor 1b	0.011
rasl11b	RAS-like, family 11, member B	0.011
prkrir	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	0.011
zgc:86764	zgc:86764	0.011
pknox1.2	pbx/knotted 1 homeobox 1.2	0.011
tbx22	T-box 22	0.011
fryl	furry homolog-like (Drosophila)	0.011
hat1	histone acetyltransferase 1	0.011
map2k4b	mitogen-activated protein kinase kinase 4b	0.011
eif2d	eukaryotic translation initiation factor 2D	0.011
tia1	cytotoxic granule-associated RNA binding protein 1	0.011
tubgcp2	tubulin, gamma complex associated protein 2	0.011
zgc:101616	zgc:101616	0.010
trmt2a	trm2 tRNA methyltransferase 2 homolog A (S. cerevisiae)	0.010
mobkl3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	0.010
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.010
wnt3	wingless-type MMTV integration site family, member 3	0.010	Zebrafish
hmx1	H6 homeo box 1	0.010
wnt10a	wingless-type MMTV integration site family, member 10a	0.010	Zebrafish
depdc1a	DEP domain containing 1a	0.010
vps26bl	vacuolar protein sorting 26 homolog B, like	0.010
smad3b	MAD, mothers against decapentaplegic homolog 3b (Drosophila)	0.010	Human Worm
wdr18	WD repeat domain 18	0.010
dda1	DET1 and DDB1 associated 1	0.010
hspb1	heat shock protein, alpha-crystallin-related, 1	0.010
cdk7	cyclin-dependent kinase 7	0.010
dlb	deltaB	0.010
acp5a	acid phosphatase 5a, tartrate resistant	0.010
birc5b	baculoviral IAP repeat-containing 5B	0.010