IMP

Process View

Danio rerio

2 genes annotated in zebrafish

radial glial cell differentiation

The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "radial glial cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "radial glial cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
fzd8a	frizzled homolog 8a	0.973
notch3	notch homolog 3	0.968	Zebrafish
dla	deltaA	0.725
her6	hairy-related 6	0.720
fzd7a	frizzled homolog 7a	0.642
axin2	axin 2 (conductin, axil)	0.617
fzd7b	frizzled homolog 7b	0.614	Zebrafish
sox2	SRY-box containing gene 2	0.554
her15.1	hairy and enhancer of split-related 15.1	0.537	Rat
sfrp1a	secreted frizzled-related protein 1a	0.533
her12	hairy-related 12	0.476	Rat
pea3	ETS-domain transcription factor pea3	0.473
notch1a	notch homolog 1a	0.444
dlc	deltaC	0.430
eya1	eyes absent homolog 1	0.420
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.382
cdh2	cadherin 2, neuronal	0.288
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.275
foxc1a	forkhead box C1a	0.213
dld	deltaD	0.199
notch2	notch homolog 2	0.192	Zebrafish
ascl1b	achaete-scute complex-like 1b (Drosophila)	0.189
fgf3	fibroblast growth factor 3	0.187
lmo4a	LIM domain only 4a	0.173
jag1b	jagged 1b	0.172
gli2a	GLI-Kruppel family member GLI2a	0.165
tcf7l1a	transcription factor 7-like 1a (T-cell specific, HMG-box)	0.163
stm	starmaker	0.161
ephb4a	eph receptor B4a	0.158
dag1	dystroglycan 1	0.151
sox3	SRY-box containing gene 3	0.149
pak1	p21/Cdc42/Rac1-activated kinase 1	0.147
ephb3a	eph receptor B3a	0.146
cxcr4b	chemokine (C-X-C motif), receptor 4b	0.135
msi1	musashi homolog 1 (Drosophila)	0.132
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.131
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.126
klf4	Kruppel-like factor 4	0.119
crabp2b	cellular retinoic acid binding protein 2, b	0.115
wif1	wnt inhibitory factor 1	0.113
sesn1	sestrin 1	0.111
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.110
ephb4b	eph receptor B4b	0.104
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.104
dlb	deltaB	0.103
nrarpa	notch-regulated ankyrin repeat protein a	0.101
lamc1	laminin, gamma 1	0.099
wls	wntless homolog (Drosophila)	0.097
scube2	signal peptide, CUB domain, EGF-like 2	0.093
elmo1	engulfment and cell motility 1 (ced-12 homolog, C. elegans)	0.093
gyltl1b	glycosyltransferase-like 1b	0.090
tpbgl	trophoblast glycoprotein-like	0.089
six1b	sine oculis homeobox homolog 1b	0.086
tcf7	transcription factor 7 (T-cell specific, HMG-box)	0.085
neurog1	neurogenin 1	0.085
six2a	sine oculis-related homeobox 2a	0.084
wnt5b	wingless-type MMTV integration site family, member 5b	0.082
six4b	sine oculis homeobox homolog 4b	0.082
ptpra	protein tyrosine phosphatase, receptor type, A	0.081
brd2a	bromodomain-containing 2a	0.075
otx1b	orthodenticle homolog 1b	0.071
fgfr1a	fibroblast growth factor receptor 1a	0.069
rorb	RAR-related orphan receptor B	0.069
hsp47	heat shock protein 47	0.068
nrarpb	notch-regulated ankyrin repeat protein b	0.068
lft1	lefty1	0.066
gro1	groucho 1	0.064
fzd2	frizzled homolog 2	0.064	Zebrafish
bmp4	bone morphogenetic protein 4	0.063
traf4a	tnf receptor-associated factor 4a	0.063
her1	hairy-related 1	0.061
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.058
twist2	twist2	0.055
hesx1	homeo box (expressed in ES cells) 1	0.053
fgf17	fibroblast growth factor 17	0.050
twist1a	twist1a	0.049
hoxa13b	homeo box A13b	0.048
jag2	jagged 2	0.047
ccnd1	cyclin D1	0.047
wnt11	wingless-type MMTV integration site family, member 11	0.046
mmp14a	matrix metalloproteinase 14a (membrane-inserted)	0.046
znf703	zinc finger protein 703	0.046
fezf2	FEZ family zinc finger 2	0.046
eya2	eyes absent homolog 2 (Drosophila)	0.046
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.045
mmp2	matrix metalloproteinase 2	0.045
tmpoa	thymopoietin a	0.044
amotl2a	angiomotin like 2a	0.044
ptch1	patched 1	0.044
gro2	groucho 2	0.043
rxrga	retinoid x receptor, gamma a	0.043
sox11a	SRY-box containing gene 11a	0.042
arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.042
tbx6	T-box gene 6	0.042
mib	mind bomb	0.040
efnb3b	ephrin B3b	0.040
hes6	hairy and enhancer of split 6 (Drosophila)	0.039
acvr1b	activin A receptor, type IB	0.039
sulf1	sulfatase 1	0.038
lama5	laminin, alpha 5	0.037
snai2	snail homolog 2 (Drosophila)	0.035
has2	hyaluronan synthase 2	0.035
pmp22a	peripheral myelin protein 22a	0.035
rad21	RAD21 homolog (S. pombe)	0.034
atp1b1a	ATPase, Na+/K+ transporting, beta 1a polypeptide	0.034
rarab	retinoic acid receptor, alpha b	0.034
cd99l2	CD99 antigen-like 2	0.034
mych	myelocytomatosis oncogene homolog	0.033
gbx1	gastrulation brain homeobox 1	0.032
kal1b	Kallmann syndrome 1b sequence	0.032
dmrta2	doublesex and mab-3 related transcription factor like family A2	0.032
robo3	roundabout homolog 3	0.032
cyp19a1b	cytochrome P450, family 19, subfamily A, polypeptide 1b	0.031
id3	inhibitor of DNA binding 3	0.031
sepn1	selenoprotein N, 1	0.031
dbx1a	developing brain homeobox 1a	0.031
ets1a	v-ets erythroblastosis virus E26 oncogene homolog 1a	0.030
sh3gl1b	SH3-domain GRB2-like 1b	0.030
fzd10	frizzled homolog 10	0.030	Zebrafish
lamb1a	laminin, beta 1a	0.028
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.028
gli1	GLI-Kruppel family member 1	0.028
rarga	retinoic acid receptor gamma a	0.027
foxa2	forkhead box A2	0.027
her8a	hairy-related 8a	0.027
prox1	prospero-related homeobox gene 1	0.027
id1	inhibitor of DNA binding 1	0.027
cbfb	core-binding factor, beta subunit	0.027
bmper	BMP binding endothelial regulator	0.026
arl4ab	ADP-ribosylation factor-like 4ab	0.026
hoxb1a	homeo box B1a	0.026
hs6st2	heparan sulfate 6-O-sulfotransferase 2	0.026
lhx5	LIM homeobox 5	0.026
alpi	alkaline phosphatase, intestinal	0.026
fgfr1b	fibroblast growth factor receptor 1b	0.025
pkd2	polycystic kidney disease 2	0.025
LOC100007758	novel protein similar to vertebrate SLIT and NTRK-like family, member 3 (SLITRK3)	0.025
sox19a	SRY-box containing gene 19a	0.025
zic6	zic family member 6	0.025
sox21b	SRY-box containing gene 21 b	0.025
met	met proto-oncogene (hepatocyte growth factor receptor)	0.025
plekhh1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.024
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.024
efna5a	ephrin A5a	0.024
zfp36l1b	zinc finger protein 36, C3H type-like 1b	0.024
si:ch211-212m21.5	si:ch211-212m21.5	0.024
gsc	goosecoid	0.024
homez	homeodomain leucine zipper gene	0.024
smo	smoothened homolog (Drosophila)	0.024
rest	RE1-silencing transcription factor	0.023
epha7	eph receptor A7	0.023
tbx1	T-box 1	0.023
ptprk	protein tyrosine phosphatase, receptor type, K	0.023
vsx2	visual system homeobox 2	0.023
spry2	sprouty homolog 2	0.022
foxn4	forkhead box N4	0.022
tmem2	transmembrane protein 2	0.022
hoxd13a	homeo box D13a	0.022
olig2	oligodendrocyte lineage transcription factor 2	0.021
gli3	GLI-Kruppel family member GLI3	0.021
otx2	orthodenticle homolog 2	0.021
pald	paladin	0.021
sb:cb134	sb:cb134	0.021
fstl1a	follistatin-like 1a	0.020
her9	hairy-related 9	0.020
hmgcrb	3-hydroxy-3-methylglutaryl-Coenzyme A reductase b	0.020
fgfr4	fibroblast growth factor receptor 4	0.020
tert	telomerase reverse transcriptase	0.020
nkx2.2b	NK2 transcription factor related 2b	0.020
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.020
prom1a	prominin 1a	0.019
LOC100333872	alpha-N-acetylneuraminide alpha-2,8-sialyltransferase-like	0.019
tagln2	transgelin 2	0.019
bmp2b	bone morphogenetic protein 2b	0.019
enc1	ectodermal-neural cortex (with BTB-like domain)	0.019
sb:cb176	sb:cb176	0.019
mpped2	metallophosphoesterase domain containing 2	0.019
cpn1	carboxypeptidase N, polypeptide 1	0.018
wu:fb09h07	wu:fb09h07	0.018
gfap	glial fibrillary acidic protein	0.018
im:7141132	im:7141132	0.018
lima1	LIM domain and actin binding 1	0.018
efnb2a	ephrin B2a	0.018
plagx	pleiomorphic adenoma gene X	0.018
lhx2b	LIM homeobox 2b	0.018
fzd6	frizzled homolog 6 (Drosophila)	0.017
cdh1	cadherin 1, epithelial	0.017
zgc:66441	zgc:66441	0.017
gltscr1	glioma tumor suppressor candidate region gene 1	0.017
prcp	prolylcarboxypeptidase (angiotensinase C)	0.017
greb1	growth regulation by estrogen in breast cancer 1	0.017
sox21a	SRY-box containing gene 21a	0.016
osr2	odd-skipped related 2 (Drosophila)	0.016
mtmr8	myotubularin related protein 8	0.016
zfp36l1a	zinc finger protein 36, C3H type-like 1a	0.016
lhx1a	LIM homeobox 1a	0.016
her2	hairy-related 2	0.016
tacc2	transforming, acidic coiled-coil containing protein 2	0.016
hoxc4a	homeo box C4a	0.016
ihha	Indian hedgehog homolog a	0.015
gata1a	GATA binding protein 1a	0.015
tnikb	TRAF2 and NCK interacting kinase b	0.015
nkx3.2	NK3 homeobox 2	0.015
etv2	ets variant gene 2	0.015
vangl2	vang-like 2 (van gogh, Drosophila)	0.014
col4a5	collagen, type IV, alpha 5 (Alport syndrome)	0.014
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.014
creb1	cAMP responsive element binding protein 1	0.014
dbh	dopamine beta hydroxylase	0.014
gdnf	glial cell derived neurotrophic factor	0.014
dlx5a	distal-less homeobox gene 5a	0.014
dlx2a	distal-less homeobox gene 2a	0.014
pppde1	PPPDE peptidase domain containing 1	0.014
dnmt8	DNA (cytosine-5-)-methyltransferase 8	0.014
wu:fc18d04	wu:fc18d04	0.013
plcg1	phospholipase C, gamma 1	0.013
mmp15b	matrix metallopeptidase 15b	0.013
anxa5b	annexin A5b	0.013
epha2	eph receptor A2	0.013
nkx2.1a	NK2 homeobox 1a	0.013
otx1a	orthodenticle homolog 1a	0.013
etv5a	ets variant 5a	0.013
ncor1	nuclear receptor co-repressor 1	0.013
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.013
lfng	lunatic fringe homolog	0.013
lhx9	LIM homeobox 9	0.013
ripply1	ripply1	0.013
mesp2	mesoderm posterior 2 homolog (mouse)	0.013
pdcd4a	programmed cell death 4a	0.013
hnf1bb	HNF1 homeobox Bb	0.012
zgc:63569	zgc:63569	0.012
hoxc8a	homeo box C8a	0.012
foxp2	forkhead box P2	0.012
plxna3	plexin A3	0.012
ptbp1b	polypyrimidine tract binding protein 1b	0.012
heyl	hairy/enhancer-of-split related with YRPW motif-like	0.012
dusp1	dual specificity phosphatase 1	0.012
prickle2	prickle-like 2 (Drosophila)	0.012
dkk1b	dickkopf 1b	0.012
prkaa1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.012
igfbp3	insulin-like growth factor binding protein 3	0.012
per2	period homolog 2 (Drosophila)	0.012
hs6st1a	heparan sulfate 6-O-sulfotransferase 1a	0.012
pbx4	pre-B-cell leukemia transcription factor 4	0.012
hoxb5a	homeo box B5a	0.012
rtn4rl2b	reticulon 4 receptor-like 2b	0.012
ctsk	cathepsin K	0.012
si:ch73-60e21.1	si:ch73-60e21.1	0.012
itgav	integrin, alpha V	0.011
cnp	2',3'-cyclic nucleotide 3' phosphodiesterase	0.011
her3	hairy-related 3	0.011
pcsk5a	proprotein convertase subtilisin/kexin type 5a	0.011
sox11b	SRY-box containing gene 11b	0.011
dlx4b	distal-less homeobox gene 4b	0.011
trnau1apl	tRNA selenocysteine 1 associated protein 1, like	0.011
col5a2l	collagen, type V, alpha 2-like	0.011
kdr	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.011
ryk	receptor-like tyrosine kinase	0.011
tjp1	tight junction protein 1 (zona occludens 1)	0.011
nkx2.1b	NK2 homeobox 1b	0.011
micall2a	mical-like 2a	0.011
clic4	chloride intracellular channel 4	0.011
zgc:110307	zgc:110307	0.011
znf503	zinc finger protein 503	0.011
klf2a	Kruppel-like factor 2a	0.011
esama	endothelial cell adhesion molecule a	0.011
eomesa	eomesodermin homolog a	0.011
flh	floating head	0.011
ldb1a	LIM-domain binding factor 1a	0.011
pacsin3	protein kinase C and casein kinase substrate in neurons 3	0.011
ankrd6	ankyrin repeat domain 6	0.010
tbx2b	T-box 2b	0.010
jag1a	jagged 1a	0.010
lin28a	lin-28 homolog A (C. elegans)	0.010
foxj1a	forkhead box J1a	0.010
lbr	lamin B receptor	0.010
tbx16	T-box gene 16	0.010
dkk2	dickkopf homolog 2 (Xenopus laevis)	0.010
axin1	axin 1	0.010
hprt1l	hypoxanthine phosphoribosyltransferase 1, like	0.010
pcdh17	protocadherin 17	0.010
seph	selenoprotein H	0.010
zswim5	zinc finger, SWIM-type containing 5	0.010