The network for 'epithelium development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

epithelium development

The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.

Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 1.000
ESR1 estrogen receptor 1 1.000
FN1 fibronectin 1 1.000
SFN stratifin 1.000
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 1.000
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.999
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.999
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.998
CAV1 caveolin 1, caveolae protein, 22kDa 0.998
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.998
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.998
GRB2 growth factor receptor-bound protein 2 0.997
HTT huntingtin 0.997
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.996
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.996
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.995
SP1 Sp1 transcription factor 0.993
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.989
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.988
IQGAP1 IQ motif containing GTPase activating protein 1 0.987
JAG1 jagged 1 0.987
RARA retinoic acid receptor, alpha 0.984
FGFR2 fibroblast growth factor receptor 2 0.983
RB1 retinoblastoma 1 0.982
PTK2 PTK2 protein tyrosine kinase 2 0.980
THBS1 thrombospondin 1 0.977
COL1A1 collagen, type I, alpha 1 0.975
SMAD7 SMAD family member 7 0.972
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.972
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.968
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.967
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.963
NOTCH1 notch 1 0.956
COL4A1 collagen, type IV, alpha 1 0.952
PKP3 plakophilin 3 0.948
FGFR1 fibroblast growth factor receptor 1 0.937
TRIM29 tripartite motif containing 29 0.932
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.930
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.930
FLNA filamin A, alpha 0.926
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.925
HNF4A hepatocyte nuclear factor 4, alpha 0.922
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.914
DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 0.910
CTGF connective tissue growth factor 0.907
ITGB4 integrin, beta 4 0.904
PKP1 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) 0.895
NCOR2 nuclear receptor corepressor 2 0.888
MET met proto-oncogene (hepatocyte growth factor receptor) 0.888
MYOD1 myogenic differentiation 1 0.882
COL4A2 collagen, type IV, alpha 2 0.881
RUNX1 runt-related transcription factor 1 0.877
ERBB2IP erbb2 interacting protein 0.876
FOXA2 forkhead box A2 0.875
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.872
ANXA1 annexin A1 0.868
GRB7 growth factor receptor-bound protein 7 0.864
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.863
SMAD9 SMAD family member 9 0.863
IGFBP3 insulin-like growth factor binding protein 3 0.863
LAD1 ladinin 1 0.862
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.861
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.859
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.858
IGF1R insulin-like growth factor 1 receptor 0.848
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.840
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.840
MYH9 myosin, heavy chain 9, non-muscle 0.838
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.837
DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 0.836
KRT8 keratin 8 0.832
NOTCH3 notch 3 0.827
TIMP3 TIMP metallopeptidase inhibitor 3 0.824
KLK10 kallikrein-related peptidase 10 0.824
BMP7 bone morphogenetic protein 7 0.813
TAL1 T-cell acute lymphocytic leukemia 1 0.811
FERMT2 fermitin family member 2 0.811
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.807
GJB3 gap junction protein, beta 3, 31kDa 0.806
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.806
PAX3 paired box 3 0.798
KRT5 keratin 5 0.795
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.793
BBS10 Bardet-Biedl syndrome 10 0.787
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.784
CDX2 caudal type homeobox 2 0.784
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.783
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.779
TP63 tumor protein p63 0.775
CTSA cathepsin A 0.775
SRPK2 SRSF protein kinase 2 0.773
PSEN1 presenilin 1 0.768
CREBBP CREB binding protein 0.768
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.767
SIRT1 sirtuin 1 0.765
RHOA ras homolog gene family, member A 0.761
HOXB5 homeobox B5 0.757
FMR1 fragile X mental retardation 1 0.755
ARHGAP1 Rho GTPase activating protein 1 0.752
SPTBN1 spectrin, beta, non-erythrocytic 1 0.752
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
pha-4 Protein PHA-4 0.938
egl-18 Protein EGL-18 0.716
egl-27 Protein EGL-27 0.653
soc-2 Protein SOC-2 0.604
mab-5 Protein MAB-5 0.567
ldb-1 Protein LDB-1 0.557
fln-2 Protein FLN-2 0.531
egl-46 Protein EGL-46 0.529
hlh-2 Protein HLH-2 0.529
sma-6 Protein SMA-6 0.528
bar-1 Protein BAR-1 0.516
epi-1 Protein EPI-1 0.503
smp-1 Protein SMP-1 0.489
unc-73 Protein UNC-73 0.489
rig-6 Protein RIG-6 0.470
vab-3 Protein VAB-3 0.453
sqv-4 Protein SQV-4 0.433
myo-3 Protein MYO-3 0.408
ten-1 Protein TEN-1 0.375
hlh-1 Protein HLH-1 0.362
apl-1 Protein APL-1 0.354
K10C3.4 Protein K10C3.4 0.341
vab-1 Protein VAB-1 0.327
atn-1 Protein ATN-1 0.320
lir-1 Protein LIR-1 0.306
nhr-67 Protein NHR-67 0.303
plc-1 Protein PLC-1 0.287
xpo-1 Protein XPO-1 0.279
svh-2 Protein SVH-2 0.274
pal-1 Protein PAL-1 0.262
ceh-20 Protein CEH-20 0.260
lin-17 Protein LIN-17 0.243
elt-2 Protein ELT-2 0.235
egl-15 Protein EGL-15 0.220
cnd-1 Protein CND-1 0.213
elt-6 Protein ELT-6 0.209
syg-2 Protein SYG-2 0.208
C49G7.1 Protein C49G7.1 0.207
pdfr-1 Protein PDFR-1 0.202
unc-98 Protein UNC-98 0.201
osm-3 Protein OSM-3 0.192
pxf-1 Protein PXF-1 0.191
lag-1 Protein LAG-1 0.191
lin-45 Protein LIN-45 0.190
cpr-4 Protein CPR-4 0.189
pry-1 Protein PRY-1 0.186
unc-6 Protein UNC-6 0.180
bam-2 Protein BAM-2 0.178
imb-2 Protein IMB-2 0.177
mes-4 Protein MES-4 0.176
che-13 Protein CHE-13 0.176
sma-1 Protein SMA-1 0.173
hda-1 Protein HDA-1 0.172
magi-1 Protein MAGI-1 0.169
lam-2 Protein LAM-2 0.165
unc-53 Protein UNC-53 0.164
T28F4.1 Protein T28F4.1 0.161
let-60 Protein LET-60 0.159
tra-1 Protein TRA-1 0.157
zfp-1 Protein ZFP-1 0.157
ncam-1 Protein NCAM-1 0.153
Y44E3A.6 Protein Y44E3A.6 0.153
mlc-5 Protein MLC-5 0.152
pqn-51 Protein PQN-51 0.145
sem-5 Protein SEM-5 0.143
bus-8 Protein BUS-8 0.135
R10E12.2 Protein R10E12.2 0.133
cas-1 Protein CAS-1 0.132
ina-1 Protein INA-1 0.130
lin-11 Protein LIN-11 0.129
unc-40 Protein UNC-40 0.127
C54E4.2 Protein C54E4.2 0.127
egl-5 Protein EGL-5 0.125
unc-32 Protein UNC-32 0.121
sax-3 Protein SAX-3 0.119
par-6 Protein PAR-6 0.119
goa-1 Protein GOA-1 0.118
vab-10 Protein VAB-10 0.118
unc-130 Protein UNC-130 0.117
F33H2.3 Protein F33H2.3 0.116
cki-1 Protein CKI-1 0.116
mom-2 Protein MOM-2 0.114
sdn-1 Protein SDN-1 0.113
elc-1 Protein ELC-1 0.111
F29B9.8 Protein F29B9.8 0.110
lst-4 Protein LST-4 0.109
ptp-3 Protein PTP-3 0.109
flt-1 Protein FLT-1 0.107
inx-3 Protein INX-3 0.107
tag-260 Protein TAG-260 0.105
nhr-25 Protein NHR-25 0.104
hmr-1 Protein HMR-1 0.104
cdc-42 Protein CDC-42 0.100
lit-1 Protein LIT-1 0.100
lst-1 Protein LST-1 0.100
lin-53 Protein LIN-53 0.100
C07E3.3 Protein C07E3.3 0.099
idh-1 Protein IDH-1 0.099
lin-14 Protein LIN-14 0.098
sgk-1 Protein SGK-1 0.098
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ifitm3 interferon induced transmembrane protein 3 0.617
Itgb1 integrin, beta 1 0.606
Fat2 FAT tumor suppressor homolog 2 (Drosophila) 0.523
Lims1 LIM and senescent cell antigen-like domains 1 0.492
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.489
Anxa2 annexin A2 0.486
Baiap2 BAI1-associated protein 2 0.446
Cyp51 cytochrome P450, family 51 0.445
S100a11 S100 calcium binding protein A11 (calizzarin) 0.439
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.425
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.380
Vim vimentin 0.368
Edn1 endothelin 1 0.349
Sqle squalene epoxidase 0.338
Ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.330
Hand2 heart and neural crest derivatives expressed 2 0.324
Pfn1 profilin 1 0.303
Tcf4 transcription factor 4 0.301
Slit3 slit homolog 3 (Drosophila) 0.289
Agtr1b angiotensin II receptor, type 1b 0.289
Robo1 roundabout homolog 1 (Drosophila) 0.286
Gja5 gap junction protein, alpha 5 0.279
Tgfbr3 transforming growth factor, beta receptor III 0.265
Myh9 myosin, heavy chain 9, non-muscle 0.260
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.247
St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.246
Anxa5 annexin A5 0.238
Cga glycoprotein hormones, alpha polypeptide 0.236
Rara retinoic acid receptor, alpha 0.230
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.225
Ednrb endothelin receptor type B 0.221
Tacr1 tachykinin receptor 1 0.219
Gata6 GATA binding protein 6 0.215
Col12a1 collagen, type XII, alpha 1 0.210
Litaf lipopolysaccharide-induced TNF factor 0.207
S100a10 S100 calcium binding protein A10 0.203
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.202
Smad7 SMAD family member 7 0.202
Arhgap23 Rho GTPase activating protein 23 0.199
Foxe1 forkhead box E1 (thyroid transcription factor 2) 0.196
Dchs1 dachsous 1 (Drosophila) 0.193
Atp7b ATPase, Cu++ transporting, beta polypeptide 0.190
Evpl envoplakin 0.190
RGD1304644 similar to RIKEN cDNA 2310046K01 0.190
Bmpr1a bone morphogenetic protein receptor, type IA 0.189
Hbg1 hemoglobin, gamma A 0.188
Foxd3 forkhead box D3 0.187
Dlg1 discs, large homolog 1 (Drosophila) 0.185
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.183
Foxa3 forkhead box A3 0.176
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.175
Hr hairless 0.174
LOC246267 resection-induced TPI (rs11) 0.174
Sprr1al small proline-rich protein 1A-like 0.172
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.169
Unc5b unc-5 homolog B (C. elegans) 0.168
Jak1 Janus kinase 1 0.167
Sdcbp syndecan binding protein 0.163
Onecut1 one cut homeobox 1 0.163
Fut1 fucosyltransferase 1 0.162
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.162
Grm5 glutamate receptor, metabotropic 5 0.161
Tgfbr2 transforming growth factor, beta receptor II 0.160
Ednra endothelin receptor type A 0.160
Pde5a phosphodiesterase 5A, cGMP-specific 0.160
Lama5 laminin, alpha 5 0.157
Fstl1 follistatin-like 1 0.157
Bmp4 bone morphogenetic protein 4 0.156
Ager advanced glycosylation end product-specific receptor 0.154
Gja4 gap junction protein, alpha 4 0.151
Grin1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.151
Stc1 stanniocalcin 1 0.150
Dmkn dermokine 0.148
Loxl1 lysyl oxidase-like 1 0.147
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.146
Ncam1 neural cell adhesion molecule 1 0.144
Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.143
Svs4 seminal vesicle secretory protein 4 0.141
Sgp158 proline-rich glycoprotein (sgp158) 0.139
Bmp3 bone morphogenetic protein 3 0.138
Calu calumenin 0.138
Irs1 insulin receptor substrate 1 0.137
P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 0.135
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.134
Csrp1 cysteine and glycine-rich protein 1 0.134
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.134
Pou3f2 POU class 3 homeobox 2 0.133
Calcb calcitonin-related polypeptide, beta 0.131
Fgfr2 fibroblast growth factor receptor 2 0.131
Acta2 smooth muscle alpha-actin 0.130
Adarb2 adenosine deaminase, RNA-specific, B2 0.129
Runx1 runt-related transcription factor 1 0.129
Phox2a paired-like homeobox 2a 0.128
Cish cytokine inducible SH2-containing protein 0.127
Syt4 synaptotagmin IV 0.127
Fyn FYN oncogene related to SRC, FGR, YES 0.127
Cdk2 cyclin dependent kinase 2 0.126
Arf6 ADP-ribosylation factor 6 0.126
Svs1 seminal vesicle secretory protein 1 0.126
Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.125
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism