The network for 'negative regulation of ion transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of ion transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Homo sapiens
Name Description Probability Func Analog Organism
GSTM1 glutathione S-transferase mu 1 0.981
FYN FYN oncogene related to SRC, FGR, YES 0.973
INSR insulin receptor 0.906
TGFB1 transforming growth factor, beta 1 0.897
MAPT microtubule-associated protein tau 0.896
GSTM2 glutathione S-transferase mu 2 (muscle) 0.890
ACTN2 actinin, alpha 2 0.822
A2M alpha-2-macroglobulin 0.781
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.764
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.657
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.618
GSTM4 glutathione S-transferase mu 4 0.586
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.560
CSK c-src tyrosine kinase 0.554
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.544
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.537
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.525
MED15 mediator complex subunit 15 0.480
TGFBR1 transforming growth factor, beta receptor 1 0.470
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.461
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.446
SMAD2 SMAD family member 2 0.425
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.422
CAB39 calcium binding protein 39 0.399
ADORA2A adenosine A2a receptor 0.385
IL1R1 interleukin 1 receptor, type I 0.380
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.378
ADAM15 ADAM metallopeptidase domain 15 0.370
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.351
NOXA1 NADPH oxidase activator 1 0.339
HP haptoglobin 0.319
KCNA5 potassium voltage-gated channel, shaker-related subfamily, member 5 0.313
BCAR1 breast cancer anti-estrogen resistance 1 0.311
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.302
ACTN4 actinin, alpha 4 0.297
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.293
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.287
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.271
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.258
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.230
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.228
TRIM39 tripartite motif containing 39 0.224
ZYX zyxin 0.220
SPG20 spastic paraplegia 20 (Troyer syndrome) 0.215
ACTB actin, beta 0.208
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.204
SMAD7 SMAD family member 7 0.191
DCTN1 dynactin 1 0.181
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.177
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.169
PKM2 pyruvate kinase, muscle 0.167
ZNF263 zinc finger protein 263 0.163
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.163
IL1RN interleukin 1 receptor antagonist 0.163
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.163
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.162
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.159
CRH corticotropin releasing hormone 0.158
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.156
ZFYVE9 zinc finger, FYVE domain containing 9 0.153
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.153
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.151
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.145
VAC14 Vac14 homolog (S. cerevisiae) 0.143
SMAD3 SMAD family member 3 0.140
MYOZ1 myozenin 1 0.138
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.134
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.132
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.127
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.127
RNF11 ring finger protein 11 0.124
SH3RF1 SH3 domain containing ring finger 1 0.123
PTAFR platelet-activating factor receptor 0.123
PILRA paired immunoglobin-like type 2 receptor alpha 0.122
GRB10 growth factor receptor-bound protein 10 0.120
PDCD6IP programmed cell death 6 interacting protein 0.119
IL8 interleukin 8 0.109
ACVR1B activin A receptor, type IB 0.108
BCL2L1 BCL2-like 1 0.105
APOB apolipoprotein B (including Ag(x) antigen) 0.099
NCF1 neutrophil cytosolic factor 1 0.098
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.098
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.096
EPOR erythropoietin receptor 0.095
MYH9 myosin, heavy chain 9, non-muscle 0.094
FLNA filamin A, alpha 0.092
SMAD4 SMAD family member 4 0.089
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.085
TSC22D1 TSC22 domain family, member 1 0.085
APLP1 amyloid beta (A4) precursor-like protein 1 0.084
PSEN2 presenilin 2 (Alzheimer disease 4) 0.083
IL6 interleukin 6 (interferon, beta 2) 0.082
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.080
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.079
SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3 0.079
SCNN1B sodium channel, nonvoltage-gated 1, beta 0.078
KCNB1 potassium voltage-gated channel, Shab-related subfamily, member 1 0.077
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.076
CAPZB capping protein (actin filament) muscle Z-line, beta 0.074
PRKCA protein kinase C, alpha 0.074
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
vab-3 Protein VAB-3 0.053
srv-1 Protein SRV-1 0.041
cam-1 Protein CAM-1 0.040
eat-4 Protein EAT-4 0.039
inx-12 Protein INX-12 0.038
mec-2 Protein MEC-2 0.034
inx-4 Protein INX-4 0.028
glr-5 Protein GLR-5 0.026
ifd-1 Protein IFD-1 0.022
inx-3 Protein INX-3 0.021
unc-7 Protein UNC-7 0.020
gcy-28 Protein GCY-28 0.020
F52C12.4 Protein F52C12.4 0.018
inx-17 Protein INX-17 0.017
sdz-28 Protein SDZ-28 0.013
H24G06.1 Protein H24G06.1 0.013
tbh-1 Protein TBH-1 0.013
F39G3.5 Protein F39G3.5 0.012
unc-36 Protein UNC-36 0.011
vha-15 Protein VHA-15 0.011
K10D6.2 Protein K10D6.2 0.011
mec-1 Protein MEC-1 0.011
madd-4 Protein MADD-4 0.011
F42C5.9 Protein F42C5.9 0.010
egl-19 Protein EGL-19 0.010
efn-2 Protein EFN-2 0.010
che-3 Protein CHE-3 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
G-salpha60A G protein salpha 60A 0.011
myoglianin CG1838 gene product from transcript CG1838-RD 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.683
Nos3 nitric oxide synthase 3, endothelial cell 0.544
Drd2 dopamine receptor D2 0.527
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.525
Lepr leptin receptor 0.517
Ptgs2 prostaglandin-endoperoxide synthase 2 0.501
Lyz2 lysozyme 2 0.461
Nos1 nitric oxide synthase 1, neuronal 0.457
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.456
Pparg peroxisome proliferator activated receptor gamma 0.394
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.346
Ldb3 LIM domain binding 3 0.342
Tlr4 toll-like receptor 4 0.341
Ccl2 chemokine (C-C motif) ligand 2 0.314
Neurod1 neurogenic differentiation 1 0.307
Ryr2 ryanodine receptor 2, cardiac 0.303
Slc34a1 solute carrier family 34 (sodium phosphate), member 1 0.280
Trp53 transformation related protein 53 0.260
Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 0.258
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.212
Adora2a adenosine A2a receptor 0.207
Ren1 renin 1 structural 0.194
Kcnk3 potassium channel, subfamily K, member 3 0.176
Ccr2 chemokine (C-C motif) receptor 2 0.150
Slc12a1 solute carrier family 12, member 1 0.150
Nos2 nitric oxide synthase 2, inducible 0.148
Mmp9 matrix metallopeptidase 9 0.141
Pnpla2 patatin-like phospholipase domain containing 2 0.137
Pten phosphatase and tensin homolog 0.134
Adrb1 adrenergic receptor, beta 1 0.132
Neurog2 neurogenin 2 0.128
Dmd dystrophin, muscular dystrophy 0.127
Cav1 caveolin 1, caveolae protein 0.127
Lep leptin 0.109
Bdnf brain derived neurotrophic factor 0.107
Grm1 glutamate receptor, metabotropic 1 0.106
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.105
Tgfb1 transforming growth factor, beta 1 0.104
Umod uromodulin 0.104
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.100
Slc17a1 solute carrier family 17 (sodium phosphate), member 1 0.099
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.099
Prox1 prospero-related homeobox 1 0.096
Bax BCL2-associated X protein 0.093
Sgca sarcoglycan, alpha (dystrophin-associated glycoprotein) 0.090
Hrh1 histamine receptor H1 0.089
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.086
Rac1 RAS-related C3 botulinum substrate 1 0.086
Foxd2 forkhead box D2 0.079
Cd44 CD44 antigen 0.079
Npy5r neuropeptide Y receptor Y5 0.076
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.075
Pax6 paired box gene 6 0.073
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.073
Lhx6 LIM homeobox protein 6 0.071
Sgcg sarcoglycan, gamma (dystrophin-associated glycoprotein) 0.070
Dtna dystrobrevin alpha 0.070
Neurog3 neurogenin 3 0.068
Vdr vitamin D receptor 0.065
Oprk1 opioid receptor, kappa 1 0.065
Btk Bruton agammaglobulinemia tyrosine kinase 0.065
Pkd1 polycystic kidney disease 1 homolog 0.064
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.063
Mapt microtubule-associated protein tau 0.063
Prkce protein kinase C, epsilon 0.063
Onecut1 one cut domain, family member 1 0.062
Cyld cylindromatosis (turban tumor syndrome) 0.061
Cntn4 contactin 4 0.061
Emx1 empty spiracles homolog 1 (Drosophila) 0.060
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.060
Kcnb1 potassium voltage gated channel, Shab-related subfamily, member 1 0.060
Mecom MDS1 and EVI1 complex locus 0.060
Hr hairless 0.059
Wt1 Wilms tumor 1 homolog 0.058
Fbn1 fibrillin 1 0.058
Ptf1a pancreas specific transcription factor, 1a 0.057
Mdm2 transformed mouse 3T3 cell double minute 2 0.056
Clock circadian locomotor output cycles kaput 0.056
Syn2 synapsin II 0.055
Il6st interleukin 6 signal transducer 0.055
Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.054
Col1a1 collagen, type I, alpha 1 0.052
Pcdh12 protocadherin 12 0.051
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.050
Zfpm2 zinc finger protein, multitype 2 0.049
Cckbr cholecystokinin B receptor 0.049
Kl klotho 0.049
Gsx1 GS homeobox 1 0.049
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.047
Plat plasminogen activator, tissue 0.047
Slc6a18 solute carrier family 6 (neurotransmitter transporter), member 18 0.045
Upp2 uridine phosphorylase 2 0.045
Bcl2 B-cell leukemia/lymphoma 2 0.045
Ccr1l1 chemokine (C-C motif) receptor 1-like 1 0.044
Agtr1a angiotensin II receptor, type 1a 0.043
Il6 interleukin 6 0.043
Vhl von Hippel-Lindau tumor suppressor 0.042
Plau plasminogen activator, urokinase 0.041
Fgf13 fibroblast growth factor 13 0.041
Cd33 CD33 antigen 0.040
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cav1 caveolin 1, caveolae protein 0.485
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.451
Insrr insulin receptor-related receptor 0.437
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.293
Strn striatin, calmodulin binding protein 0.245
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.214
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.199
Teddm1 transmembrane epididymal protein 1 0.187
Slc6a7 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 0.187
Cckar cholecystokinin A receptor 0.178
Kl Klotho 0.172
Adora1 adenosine A1 receptor 0.160
Grm5 glutamate receptor, metabotropic 5 0.158
Oxtr oxytocin receptor 0.157
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.157
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.144
Gja1 gap junction protein, alpha 1 0.143
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.131
Cnga1 cyclic nucleotide gated channel alpha 1 0.131
Adra1a adrenergic, alpha-1A-, receptor 0.126
Dmd dystrophin 0.122
Kcnd3 potassium voltage-gated channel, Shal-related subfamily, member 3 0.118
Maoa monoamine oxidase A 0.115
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.115
Lim2 lens intrinsic membrane protein 2 0.111
Cela2a chymotrypsin-like elastase family, member 2A 0.111
Ifrd1 interferon-related developmental regulator 1 0.108
Acmsd aminocarboxymuconate semialdehyde decarboxylase 0.108
Csf1 colony stimulating factor 1 (macrophage) 0.105
Csrp3 cysteine and glycine-rich protein 3 0.104
Grm7 glutamate receptor, metabotropic 7 0.102
Myl1 myosin, light chain 1 0.099
Eef2 eukaryotic translation elongation factor 2 0.095
Fgf10 fibroblast growth factor 10 0.093
Atp7b ATPase, Cu++ transporting, beta polypeptide 0.091
Adora2a adenosine A2a receptor 0.090
Mchr1 melanin-concentrating hormone receptor 1 0.090
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.090
Ptafr platelet-activating factor receptor 0.088
Slc6a18 solute carrier family 6, member 18 0.087
Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 0.087
Vom2r27 vomeronasal 2 receptor, 27 0.084
Adrb1 adrenergic, beta-1-, receptor 0.084
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.084
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.083
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.083
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.083
LOC100362824 caveolin 2-like 0.083
Npy1r neuropeptide Y receptor Y1 0.082
Hoxb7 homeo box B7 0.081
Grifin galectin-related inter-fiber protein 0.081
Oprk1 opioid receptor, kappa 1 0.081
Rorb RAR-related orphan receptor B 0.080
Trhr thyrotropin releasing hormone receptor 0.080
Mmp8 matrix metallopeptidase 8 0.078
Ugt2b UDP glycosyltransferase 2 family, polypeptide B 0.076
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.076
Cd79b Cd79b molecule, immunoglobulin-associated beta 0.075
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.075
Cd46 CD46 molecule, complement regulatory protein 0.074
Oprm1 opioid receptor, mu 1 0.074
Slc22a2 solute carrier family 22 (organic cation transporter), member 2 0.073
Hrh3 histamine receptor H3 0.073
Errfi1 ERBB receptor feedback inhibitor 1 0.073
Fcer2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.073
Gucy2d guanylate cyclase 2d 0.072
Prkcg protein kinase C, gamma 0.072
Htr6 5-hydroxytryptamine (serotonin) receptor 6 0.072
Ptp4a1 protein tyrosine phosphatase type IVA, member 1 0.071
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.071
Prp15 proline-rich protein 15 0.070
Egr3 early growth response 3 0.070
Trhr2 thyrotropin releasing hormone receptor 2 0.069
Il2ra interleukin 2 receptor, alpha 0.069
Chrna3 cholinergic receptor, nicotinic, alpha 3 0.069
Pecam1 platelet/endothelial cell adhesion molecule 1 0.068
Cd247 Cd247 molecule 0.066
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.065
Gpr83 G protein-coupled receptor 83 0.063
Ncr1 natural cytotoxicity triggering receptor 1 0.063
Olr1078 olfactory receptor 1078 0.063
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.062
Gad2 glutamate decarboxylase 2 0.062
Cst12 cystatin 12 0.061
Tacr1 tachykinin receptor 1 0.061
Prol1 proline rich, lacrimal 1 0.061
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.061
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.060
Nlrp6 NLR family, pyrin domain containing 6 0.059
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.059
Rab1b RAB1B, member RAS oncogene family 0.059
Mos Moloney sarcoma oncogene 0.059
Nckap1 NCK-associated protein 1 0.059
Tbx1 T-box 1 0.059
Prrx1 paired related homeobox 1 0.058
Nptxr neuronal pentraxin receptor 0.058
Gipr gastric inhibitory polypeptide receptor 0.058
Fgf2 fibroblast growth factor 2 0.058
Hcrtr2 hypocretin (orexin) receptor 2 0.057
Gja3 gap junction protein, alpha 3 0.057
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism