The network for 'regulation of ossification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of ossification

Any process that modulates the frequency, rate or extent of bone formation.

Homo sapiens
Name Description Probability Func Analog Organism
EP300 E1A binding protein p300 1.000
SMAD2 SMAD family member 2 0.997
CCR5 chemokine (C-C motif) receptor 5 0.993
SKIL SKI-like oncogene 0.987
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.985
SMAD4 SMAD family member 4 0.975
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.971
CCL5 chemokine (C-C motif) ligand 5 0.969
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.965
FBLN1 fibulin 1 0.963
JUN jun proto-oncogene 0.952
SMAD3 SMAD family member 3 0.951
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.937
BMPR1A bone morphogenetic protein receptor, type IA 0.918
BMP2 bone morphogenetic protein 2 0.917
HDAC4 histone deacetylase 4 0.894
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.888
POU3F2 POU class 3 homeobox 2 0.866
CXCL9 chemokine (C-X-C motif) ligand 9 0.826
NOTCH1 notch 1 0.805
ESR1 estrogen receptor 1 0.792
SP1 Sp1 transcription factor 0.792
JAG1 jagged 1 0.779
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.763
TGFB1 transforming growth factor, beta 1 0.736
NCOR2 nuclear receptor corepressor 2 0.722
IFITM3 interferon induced transmembrane protein 3 (1-8U) 0.717
TP53 tumor protein p53 0.641
NOTCH3 notch 3 0.624
SOCS3 suppressor of cytokine signaling 3 0.622
FKBP1A FK506 binding protein 1A, 12kDa 0.600
NCOR1 nuclear receptor corepressor 1 0.589
MEIS2 Meis homeobox 2 0.563
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.555
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.502
ENG endoglin 0.497
ATF3 activating transcription factor 3 0.491
SMAD7 SMAD family member 7 0.489
BCL6 B-cell CLL/lymphoma 6 0.483
HIPK2 homeodomain interacting protein kinase 2 0.482
FN1 fibronectin 1 0.478
FSTL1 follistatin-like 1 0.477
EGR1 early growth response 1 0.463
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.458
CTGF connective tissue growth factor 0.451
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.425
CCL22 chemokine (C-C motif) ligand 22 0.421
GABARAP GABA(A) receptor-associated protein 0.415
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.409
CCL3 chemokine (C-C motif) ligand 3 0.396
COL1A2 collagen, type I, alpha 2 0.386
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.381
FZD1 frizzled homolog 1 (Drosophila) 0.372
MEF2A myocyte enhancer factor 2A 0.368
SKI v-ski sarcoma viral oncogene homolog (avian) 0.363
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.362
STAT4 signal transducer and activator of transcription 4 0.361
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.361
JUP junction plakoglobin 0.351
CCL4 chemokine (C-C motif) ligand 4 0.347
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.346
BMP1 bone morphogenetic protein 1 0.322
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.314
BMP7 bone morphogenetic protein 7 0.307
CXXC5 CXXC finger protein 5 0.303
COL6A1 collagen, type VI, alpha 1 0.301
FBN1 fibrillin 1 0.301
KDM2B lysine (K)-specific demethylase 2B 0.300
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.300
ACVR1 activin A receptor, type I 0.296
TGFB3 transforming growth factor, beta 3 0.294
CAV1 caveolin 1, caveolae protein, 22kDa 0.292
FOS FBJ murine osteosarcoma viral oncogene homolog 0.280
MYOD1 myogenic differentiation 1 0.278
VCAN versican 0.275
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.271
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.267
YAP1 Yes-associated protein 1 0.256
TCF4 transcription factor 4 0.250
NRP1 neuropilin 1 0.248
CCL2 chemokine (C-C motif) ligand 2 0.242
GATA2 GATA binding protein 2 0.241
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.231
IGFBP3 insulin-like growth factor binding protein 3 0.230
MEF2C myocyte enhancer factor 2C 0.229
PTPRC protein tyrosine phosphatase, receptor type, C 0.228
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.217
SMAD6 SMAD family member 6 0.217
IFNG interferon, gamma 0.208
HDAC9 histone deacetylase 9 0.207
CREBBP CREB binding protein 0.202
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.196
TGFBR1 transforming growth factor, beta receptor 1 0.192
EPAS1 endothelial PAS domain protein 1 0.192
FGF1 fibroblast growth factor 1 (acidic) 0.189
CCR1 chemokine (C-C motif) receptor 1 0.188
CCR4 chemokine (C-C motif) receptor 4 0.186
IL2RB interleukin 2 receptor, beta 0.186
NOG noggin 0.186
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.182
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.871
col1a1a collagen, type I, alpha 1a 0.655
col1a2 collagen, type I, alpha 2 0.563
sox9a SRY-box containing gene 9a 0.471
pitx3 paired-like homeodomain transcription factor 3 0.370
runx2b runt-related transcription factor 2b 0.329
col5a1 procollagen, type V, alpha 1 0.292
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.271
kdrl kinase insert domain receptor like 0.189
wnt5b wingless-type MMTV integration site family, member 5b 0.186
col10a1 collagen, type X, alpha 1 0.120
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.086
runx2a runt-related transcription factor 2a 0.077
epha4a eph receptor A4a 0.073
notch3 notch homolog 3 0.056
wnt9a wingless-type MMTV integration site family, member 9A 0.054
dusp6 dual specificity phosphatase 6 0.051
rargb retinoic acid receptor, gamma b 0.049
jag1b jagged 1b 0.046
sox9b SRY-box containing gene 9b 0.040
tbx1 T-box 1 0.033
dkk1b dickkopf 1b 0.032
xylt1 xylosyltransferase 1 0.031
chd chordin 0.029
apoeb apolipoprotein Eb 0.027
twist1a twist1a 0.026
bmper BMP binding endothelial regulator 0.026
pkd2 polycystic kidney disease 2 0.024
wnt3 wingless-type MMTV integration site family, member 3 0.023
sox3 SRY-box containing gene 3 0.021
gyltl1b glycosyltransferase-like 1b 0.020
mef2ca myocyte enhancer factor 2ca 0.019
dlx4a distal-less homeobox gene 4a 0.019
tcf12 transcription factor 12 0.018
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.018
cmyb transcription factor cmyb 0.016
fstl1b follistatin-like 1b 0.016
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.016
zgc:158603 zgc:158603 0.016
zgc:85866 zgc:85866 0.015
col5a2l collagen, type V, alpha 2-like 0.015
notch2 notch homolog 2 0.015
sparc secreted acidic cysteine rich glycoprotein 0.015
foxn4 forkhead box N4 0.015
bmp1a bone morphogenetic protein 1a 0.014
arl4ab ADP-ribosylation factor-like 4ab 0.014
dlx2a distal-less homeobox gene 2a 0.014
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.014
wnt11r wingless-type MMTV integration site family, member 11, related 0.013
igf1rb insulin-like growth factor 1b receptor 0.013
ptgs2a prostaglandin-endoperoxide synthase 2a 0.013
gli2a GLI-Kruppel family member GLI2a 0.012
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.012
mxi1 max interacting protein 0.012
fli1a friend leukemia integration 1a 0.011
dcn decorin 0.011
rasl11b RAS-like, family 11, member B 0.011
dlx3b distal-less homeobox gene 3b 0.011
shha sonic hedgehog a 0.011
gpc4 glypican 4 0.010
foxi1 forkhead box I1 0.010
itga3b integrin, alpha 3b 0.010
twist2 twist2 0.010
col2a1a collagen type II, alpha-1a 0.010
wnt9b wingless-type MMTV integration site family, member 9B 0.010
klf4 Kruppel-like factor 4 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.983
Notch1 Notch gene homolog 1 (Drosophila) 0.980
Pthlh parathyroid hormone-like peptide 0.952
Smad6 MAD homolog 6 (Drosophila) 0.949
Fgf8 fibroblast growth factor 8 0.940
Gli2 GLI-Kruppel family member GLI2 0.932
Tgfb2 transforming growth factor, beta 2 0.922
Prrx2 paired related homeobox 2 0.897
Nodal nodal 0.845
Fgfr3 fibroblast growth factor receptor 3 0.830
Runx2 runt related transcription factor 2 0.818
Eya1 eyes absent 1 homolog (Drosophila) 0.777
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.777
Smad3 MAD homolog 3 (Drosophila) 0.774
Fgfr1 fibroblast growth factor receptor 1 0.764
Gli1 GLI-Kruppel family member GLI1 0.758
Lef1 lymphoid enhancer binding factor 1 0.745
Kl klotho 0.743
Twist1 twist homolog 1 (Drosophila) 0.732
Pten phosphatase and tensin homolog 0.728
Ntf3 neurotrophin 3 0.718
Fzd1 frizzled homolog 1 (Drosophila) 0.718
Sfrp2 secreted frizzled-related protein 2 0.715
Hoxa2 homeobox A2 0.701
Ctnnb1 catenin (cadherin associated protein), beta 1 0.685
Gli3 GLI-Kruppel family member GLI3 0.685
Gata4 GATA binding protein 4 0.684
Dll1 delta-like 1 (Drosophila) 0.683
Pax2 paired box gene 2 0.665
Axin1 axin 1 0.655
Smad7 MAD homolog 7 (Drosophila) 0.646
Csf1 colony stimulating factor 1 (macrophage) 0.644
Fgf15 fibroblast growth factor 15 0.633
Pax3 paired box gene 3 0.625
Prrx1 paired related homeobox 1 0.616
Hand1 heart and neural crest derivatives expressed transcript 1 0.614
Smad4 MAD homolog 4 (Drosophila) 0.598
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.597
Ret ret proto-oncogene 0.595
Bmpr1a bone morphogenetic protein receptor, type 1A 0.590
Nos3 nitric oxide synthase 3, endothelial cell 0.588
Zic3 zinc finger protein of the cerebellum 3 0.586
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.577
Acvr1 activin A receptor, type 1 0.572
Trp53 transformation related protein 53 0.541
Pkd1 polycystic kidney disease 1 homolog 0.534
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.515
Ptgs2 prostaglandin-endoperoxide synthase 2 0.512
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.508
Edn3 endothelin 3 0.503
Zfpm2 zinc finger protein, multitype 2 0.495
Ncoa3 nuclear receptor coactivator 3 0.469
Epas1 endothelial PAS domain protein 1 0.463
Gdnf glial cell line derived neurotrophic factor 0.462
Mndal myeloid nuclear differentiation antigen like 0.450
Pou3f3 POU domain, class 3, transcription factor 3 0.449
Fgf18 fibroblast growth factor 18 0.442
Vdr vitamin D receptor 0.440
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.437
Smo smoothened homolog (Drosophila) 0.437
Alx4 aristaless-like homeobox 4 0.431
Msx1 homeobox, msh-like 1 0.429
Eda ectodysplasin-A 0.424
Hes1 hairy and enhancer of split 1 (Drosophila) 0.424
Cd80 CD80 antigen 0.424
Notch3 Notch gene homolog 3 (Drosophila) 0.416
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.411
Smad2 MAD homolog 2 (Drosophila) 0.404
Acan aggrecan 0.403
Robo3 roundabout homolog 3 (Drosophila) 0.403
Foxd3 forkhead box D3 0.397
Ptch2 patched homolog 2 0.394
Bmp5 bone morphogenetic protein 5 0.392
Efs embryonal Fyn-associated substrate 0.392
Col13a1 collagen, type XIII, alpha 1 0.392
Thbs1 thrombospondin 1 0.389
Tcf4 transcription factor 4 0.388
Gja1 gap junction protein, alpha 1 0.385
Neurog3 neurogenin 3 0.383
Gpr50 G-protein-coupled receptor 50 0.382
Zic1 zinc finger protein of the cerebellum 1 0.380
Ptgir prostaglandin I receptor (IP) 0.377
Gpc3 glypican 3 0.374
Adra2a adrenergic receptor, alpha 2a 0.373
Nkx2-2 NK2 transcription factor related, locus 2 (Drosophila) 0.373
Tbx2 T-box 2 0.371
Foxf1a forkhead box F1a 0.364
Fzd2 frizzled homolog 2 (Drosophila) 0.362
Pax9 paired box gene 9 0.362
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.348
Twist2 twist homolog 2 (Drosophila) 0.347
Tgfb1i1 transforming growth factor beta 1 induced transcript 1 0.344
Foxd2 forkhead box D2 0.340
Smad1 MAD homolog 1 (Drosophila) 0.335
Fgf10 fibroblast growth factor 10 0.331
Bdkrb2 bradykinin receptor, beta 2 0.326
Rara retinoic acid receptor, alpha 0.325
Bcl2 B-cell leukemia/lymphoma 2 0.325
Ednrb endothelin receptor type B 0.321
Neurod1 neurogenic differentiation 1 0.319
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Rattus norvegicus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.612
Cd40lg CD40 ligand 0.258
Jak1 Janus kinase 1 0.244
Olr1500 olfactory receptor 1500 0.242
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.196
Plau plasminogen activator, urokinase 0.174
Adam7 ADAM metallopeptidase domain 7 0.172
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.163
Prl prolactin 0.160
Foxe3 forkhead box E3 0.148
Cxcl2 chemokine (C-X-C motif) ligand 2 0.143
Fgf10 fibroblast growth factor 10 0.136
Ptgs2 prostaglandin-endoperoxide synthase 2 0.136
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.127
Fgf22 fibroblast growth factor 22 0.126
Mmp23 matrix metallopeptidase 23 0.123
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.123
Npy5r neuropeptide Y receptor Y5 0.119
Defb22 defensin beta 22 0.111
Id1 inhibitor of DNA binding 1 0.110
Pmch pro-melanin-concentrating hormone 0.109
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.101
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.099
Ampd1 adenosine monophosphate deaminase 1 (isoform M) 0.098
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.098
Has2 hyaluronan synthase 2 0.094
Mc5r melanocortin 5 receptor 0.092
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.091
Cpxm2 carboxypeptidase X (M14 family), member 2 0.088
Prrx1 paired related homeobox 1 0.088
Zic1 Zic family member 1 (odd-paired homolog, Drosophila) 0.087
Edn1 endothelin 1 0.085
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.080
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.080
Prss1 protease, serine, 1 (trypsin 1) 0.078
Il4 interleukin 4 0.078
Selp selectin P 0.077
Hdgfl1 hepatoma derived growth factor-like 1 0.076
Mas1 MAS1 oncogene 0.076
Insrr insulin receptor-related receptor 0.076
Syt8 synaptotagmin VIII 0.073
Pip prolactin induced protein 0.073
Tcf3 transcription factor 3 0.072
Fam65a family with sequence similarity 65, member A 0.071
Prl7a3 prolactin family 7, subfamily a, member 3 0.071
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.070
Id3 inhibitor of DNA binding 3 0.070
Pth parathyroid hormone 0.068
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.068
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.068
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.067
Phlda1 pleckstrin homology-like domain, family A, member 1 0.067
Bcl2 B-cell CLL/lymphoma 2 0.066
Ctsj cathepsin J 0.066
Pth2r parathyroid hormone 2 receptor 0.065
Lepr leptin receptor 0.064
Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.064
Trh thyrotropin releasing hormone 0.064
Clph casein-like phosphoprotein 0.063
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.063
Il6 interleukin 6 0.062
Grm5 glutamate receptor, metabotropic 5 0.061
Tgfb2 transforming growth factor, beta 2 0.060
Usp25 ubiquitin specific peptidase 25 0.060
Folh1 folate hydrolase 1 0.059
Oprm1 opioid receptor, mu 1 0.058
Col5a1 collagen, type V, alpha 1 0.058
Pax8 paired box 8 0.057
Atf3 activating transcription factor 3 0.057
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.056
Jak2 Janus kinase 2 0.056
Hbe2 hemoglobin, epsilon 2 0.055
Kl Klotho 0.055
Cd52 CD52 antigen 0.054
Eln elastin 0.054
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.054
Cga glycoprotein hormones, alpha polypeptide 0.052
Slit3 slit homolog 3 (Drosophila) 0.052
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.052
Fosl1 fos-like antigen 1 0.052
Ccl4 chemokine (C-C motif) ligand 4 0.052
Serpinb2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.051
Notch2 Notch homolog 2 (Drosophila) 0.051
Jub jub, ajuba homolog (Xenopus laevis) 0.051
Boc biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein 0.050
Prol1 proline rich, lacrimal 1 0.050
Vcan versican 0.049
Igfbp3 insulin-like growth factor binding protein 3 0.049
Znf503 zinc finger protein 503 0.049
Mcpt1 mast cell protease 1 0.049
Asph aspartate-beta-hydroxylase 0.048
Sycp1 synaptonemal complex protein 1 0.048
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.048
Fgfr1 Fibroblast growth factor receptor 1 0.047
Fgf18 fibroblast growth factor 18 0.047
Dbp D site of albumin promoter (albumin D-box) binding protein 0.047
Myh9 myosin, heavy chain 9, non-muscle 0.046
Col12a1 collagen, type XII, alpha 1 0.046
Tas2r105 taste receptor, type 2, member 105 0.046
Gabra2 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2 0.045
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism