The network for 'mononuclear cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mononuclear cell proliferation

The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.

Homo sapiens
Name Description Probability Func Analog Organism
SYK spleen tyrosine kinase 0.996
LCK lymphocyte-specific protein tyrosine kinase 0.994
PTPRC protein tyrosine phosphatase, receptor type, C 0.992
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.992
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.991
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.989
BCL2 B-cell CLL/lymphoma 2 0.980
FGFR2 fibroblast growth factor receptor 2 0.967
BIRC3 baculoviral IAP repeat containing 3 0.966
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.959
HLA-DRA major histocompatibility complex, class II, DR alpha 0.937
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.934
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.924
IL4R interleukin 4 receptor 0.906
TRAF1 TNF receptor-associated factor 1 0.899
CD2 CD2 molecule 0.892
HLA-DMA major histocompatibility complex, class II, DM alpha 0.881
HLA-B major histocompatibility complex, class I, B 0.880
CD80 CD80 molecule 0.862
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.859
ICAM1 intercellular adhesion molecule 1 0.819
PLCG1 phospholipase C, gamma 1 0.816
HLA-F major histocompatibility complex, class I, F 0.800
EGFR epidermal growth factor receptor 0.794
BTN3A3 butyrophilin, subfamily 3, member A3 0.789
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.788
ABI1 abl-interactor 1 0.785
LAT linker for activation of T cells 0.770
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.754
CCR7 chemokine (C-C motif) receptor 7 0.749
CD86 CD86 molecule 0.734
SOCS3 suppressor of cytokine signaling 3 0.734
HLA-G major histocompatibility complex, class I, G 0.718
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.710
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.690
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.689
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.686
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.673
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.665
FYB FYN binding protein 0.659
BTN3A2 butyrophilin, subfamily 3, member A2 0.649
CD247 CD247 molecule 0.609
NCF4 neutrophil cytosolic factor 4, 40kDa 0.598
HLA-A major histocompatibility complex, class I, A 0.588
B2M beta-2-microglobulin 0.568
XIAP X-linked inhibitor of apoptosis 0.544
CCR5 chemokine (C-C motif) receptor 5 0.542
IRF4 interferon regulatory factor 4 0.542
CCL4 chemokine (C-C motif) ligand 4 0.540
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.536
BCL10 B-cell CLL/lymphoma 10 0.533
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.525
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.521
IL2RG interleukin 2 receptor, gamma 0.517
SH2D1A SH2 domain containing 1A 0.514
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.510
IL2RB interleukin 2 receptor, beta 0.510
HLA-C major histocompatibility complex, class I, C 0.504
BCL2L1 BCL2-like 1 0.497
CD52 CD52 molecule 0.469
TANK TRAF family member-associated NFKB activator 0.460
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.455
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.454
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.447
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.442
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.436
HLA-E major histocompatibility complex, class I, E 0.434
JAK1 Janus kinase 1 0.428
MYD88 myeloid differentiation primary response gene (88) 0.422
GRB2 growth factor receptor-bound protein 2 0.412
BTN3A1 butyrophilin, subfamily 3, member A1 0.410
CCL22 chemokine (C-C motif) ligand 22 0.399
FGFR1 fibroblast growth factor receptor 1 0.389
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.385
FGF1 fibroblast growth factor 1 (acidic) 0.373
VAV1 vav 1 guanine nucleotide exchange factor 0.370
STAT4 signal transducer and activator of transcription 4 0.367
APH1A anterior pharynx defective 1 homolog A (C. elegans) 0.359
BCL2A1 BCL2-related protein A1 0.359
TFF1 trefoil factor 1 0.357
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.354
SLA Src-like-adaptor 0.347
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.345
SIGLEC7 sialic acid binding Ig-like lectin 7 0.336
BAX BCL2-associated X protein 0.336
HCK hemopoietic cell kinase 0.335
IFNG interferon, gamma 0.329
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) 0.315
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.311
RUNX1 runt-related transcription factor 1 0.311
IL1B interleukin 1, beta 0.305
BLNK B-cell linker 0.304
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.298
ACVR1B activin A receptor, type IB 0.295
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.294
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.294
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.289
CCR1 chemokine (C-C motif) receptor 1 0.288
INSR insulin receptor 0.281
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.276
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
fgf8a fibroblast growth factor 8 a 0.869
kita kit receptor a 0.508
mmp9 matrix metalloproteinase 9 0.480
il6r interleukin 6 receptor 0.435
ptch2 patched 2 0.374
shha sonic hedgehog a 0.256
ocrl oculocerebrorenal syndrome of Lowe 0.235
tlr3 toll-like receptor 3 0.221
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.221
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.211
foxd3 forkhead box D3 0.205
cdx4 caudal type homeo box transcription factor 4 0.200
tbp TATA box binding protein 0.185
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.183
bmp1a bone morphogenetic protein 1a 0.176
gmps guanine monphosphate synthetase 0.164
ahcy S-adenosylhomocysteine hydrolase 0.163
stc1l stanniocalcin 1, like 0.158
lft1 lefty1 0.155
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.153
erbb3a v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a 0.148
il7r interleukin 7 receptor 0.145
sbno2b strawberry notch homolog 2b 0.142
runx2a runt-related transcription factor 2a 0.141
LOC100003514 protein kinase C alpha type-like 0.136
rag1 recombination activating gene 1 0.131
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.126
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.121
mmp15b matrix metallopeptidase 15b 0.120
cdh1 cadherin 1, epithelial 0.120
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.116
dntt deoxynucleotidyltransferase, terminal 0.114
tmem144b transmembrane protein 144b 0.112
ca2 carbonic anhydrase II 0.111
c1qc complement component 1, q subcomponent, C chain 0.103
alk anaplastic lymphoma kinase (Ki-1) 0.102
flh floating head 0.100
jak3 Janus kinase 3 (a protein tyrosine kinase, leukocyte) 0.099
emx2 empty spiracles homeobox 2 0.098
disc1 disrupted in schizophrenia 1 0.096
mt2 metallothionein 2 0.096
igf2b insulin-like growth factor 2b 0.095
zgc:172101 zgc:172101 0.094
arrb2b arrestin, beta 2b 0.091
tlr2 toll-like receptor 2 0.090
mst1rb macrophage stimulating 1 receptor (c-met-related tyrosine kinase), b 0.090
ddr2b discoidin domain receptor family, member 2b 0.088
kbp kif1-binding protein 0.087
pdzrn3 PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3 0.087
fgf20a fibroblast growth factor 20a 0.086
myod1 myogenic differentiation 1 0.084
hbaa1 hemoglobin alpha adult-1 0.084
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.083
ptk6a PTK6 protein tyrosine kinase 6a 0.082
tlr20a toll-like receptor 20a 0.082
phf6 PHD finger protein 6 0.082
cxcr4b chemokine (C-X-C motif), receptor 4b 0.082
cpox coproporphyrinogen oxidase 0.081
ivns1abpa influenza virus NS1A binding protein a 0.081
efna2 ephrin A2 0.081
pitx2 paired-like homeodomain transcription factor 2 0.080
csrp1a cysteine and glycine-rich protein 1a 0.080
hspa5 heat shock protein 5 0.080
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.079
axin2 axin 2 (conductin, axil) 0.078
taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto 0.073
btr16 bloodthirsty-related gene family, member 16 0.072
LOC555739 serine/threonine-protein kinase LMTK1-like 0.072
cd40lg CD40 ligand 0.071
zgc:66449 zgc:66449 0.071
gpr126 G protein-coupled receptor 126 0.070
sc:d411 sc:d411 0.070
boc brother of CDO 0.070
ahcyl1 S-adenosylhomocysteine hydrolase-like 1 0.070
cmyb transcription factor cmyb 0.070
angptl3 angiopoietin-like 3 0.069
epha4a eph receptor A4a 0.069
cdh2 cadherin 2, neuronal 0.068
nap1l1 nucleosome assembly protein 1, like 1 0.068
atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.067
cyp1d1 cytochrome P450, family 1, subfamily D, polypeptide 1 0.067
rpl7a ribosomal protein L7a 0.067
foxa2 forkhead box A2 0.067
dnm2 dynamin 2 0.067
lgals2a lectin, galactoside-binding, soluble, 2a 0.066
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.066
ripk2 receptor-interacting serine-threonine kinase 2 0.066
csf3r colony stimulating factor 3 receptor (granulocyte) 0.066
bmp2b bone morphogenetic protein 2b 0.065
zgc:56039 zgc:56039 0.065
tgfb1a transforming growth factor, beta 1a 0.064
zgc:77714 zgc:77714 0.064
pdss1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.064
zgc:55461 zgc:55461 0.064
foxi2 forkhead box I2 0.064
hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.064
itga2b integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) 0.063
impdh1b inosine 5'-phosphate dehydrogenase 1b 0.062
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.062
elovl1b elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b 0.062
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Da RT1 class II, locus Da 0.908
Cd37 CD37 molecule 0.785
Hck hemopoietic cell kinase 0.599
RT1-Db1 RT1 class II, locus Db1 0.528
RT1-DMb RT1 class II, locus DMb 0.382
Ptprc protein tyrosine phosphatase, receptor type, C 0.289
Cd247 Cd247 molecule 0.196
Cd2 Cd2 molecule 0.142
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.137
Il1r1 interleukin 1 receptor, type I 0.135
Ciita class II, major histocompatibility complex, transactivator 0.134
Bin2 bridging integrator 2 0.131
RT1-Ba RT1 class II, locus Ba 0.125
Fgfr2 fibroblast growth factor receptor 2 0.120
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.106
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.102
Cd44 Cd44 molecule 0.093
Cd86 CD86 molecule 0.086
Lcp2 lymphocyte cytosolic protein 2 0.083
Tas2r123 taste receptor, type 2, member 123 0.080
Cd38 CD38 molecule 0.080
Il10 interleukin 10 0.074
Plau plasminogen activator, urokinase 0.073
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.073
Il18 interleukin 18 0.069
Mvp major vault protein 0.069
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.067
Ptafr platelet-activating factor receptor 0.064
Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.063
RT1-DMa RT1 class II, locus DMa 0.059
Gpr20 G protein-coupled receptor 20 0.059
Skap2 src kinase associated phosphoprotein 2 0.058
Scn11a sodium channel, voltage-gated, type XI, alpha 0.058
Ly86 lymphocyte antigen 86 0.057
Anxa2 annexin A2 0.056
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.056
Casp1 caspase 1 0.056
Lcp1 lymphocyte cytosolic protein 1 0.053
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.049
Inpp5d inositol polyphosphate-5-phosphatase D 0.047
Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 0.045
Tgfbr2 transforming growth factor, beta receptor II 0.044
Lef1 lymphoid enhancer binding factor 1 0.044
Laptm5 lysosomal protein transmembrane 5 0.043
Ctss cathepsin S 0.043
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.042
Cd4 Cd4 molecule 0.041
Cfp complement factor properdin 0.041
Cd5 Cd5 molecule 0.039
Lst1 leukocyte specific transcript 1 0.039
Fcer1g Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.039
Il1b interleukin 1 beta 0.038
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.038
Prlhr prolactin releasing hormone receptor 0.038
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.038
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.037
Taok1 TAO kinase 1 0.036
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.036
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.035
Icos inducible T-cell co-stimulator 0.035
Cd53 Cd53 molecule 0.034
Cd200r1 CD200 receptor 1 0.033
Zbp1 Z-DNA binding protein 1 0.033
Gzmk granzyme K 0.032
Arhgap4 Rho GTPase activating protein 4 0.032
Fgb fibrinogen beta chain 0.032
Nr5a2 nuclear receptor subfamily 5, group A, member 2 0.032
Hrh4 histamine receptor H4 0.032
Mmp10 matrix metallopeptidase 10 0.031
Cntn1 contactin 1 0.031
Adora3 adenosine A3 receptor 0.030
Met met proto-oncogene 0.030
Reg3b regenerating islet-derived 3 beta 0.030
Lilrb3l leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like 0.030
Prr13 proline rich 13 0.030
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.029
Gmfg glia maturation factor, gamma 0.029
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.029
Serpinb1a serine (or cysteine) proteinase inhibitor, clade B, member 1a 0.029
LOC100361706 lambda-chain C1-region-like 0.029
Tgfbr3 transforming growth factor, beta receptor III 0.028
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.028
Plcg2 phospholipase C, gamma 2 0.028
Hn1 hematological and neurological expressed 1 0.027
Pmfbp1 polyamine modulated factor 1 binding protein 1 0.027
Gzmb granzyme B 0.026
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.026
Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.026
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.026
Arpc1b actin related protein 2/3 complex, subunit 1B 0.025
Il4 interleukin 4 0.025
Vav1 vav 1 guanine nucleotide exchange factor 0.025
Fosl1 fos-like antigen 1 0.025
Il2rb interleukin 2 receptor, beta 0.025
LOC100361571 keratin associated protein 1-3-like 0.024
Aif1 allograft inflammatory factor 1 0.024
Prrx1 paired related homeobox 1 0.024
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.024
Kcnk10 potassium channel, subfamily K, member 10 0.023
Kcnv1 potassium channel, subfamily V, member 1 0.023
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism