The network for 'cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell activation

A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.

Homo sapiens
Name Description Probability Func Analog Organism
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.000
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
LCK lymphocyte-specific protein tyrosine kinase 1.000
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.999
SYK spleen tyrosine kinase 0.999
EGFR epidermal growth factor receptor 0.999
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.999
FLNA filamin A, alpha 0.998
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.996
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.996
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.996
GRB2 growth factor receptor-bound protein 2 0.995
LAT linker for activation of T cells 0.994
PLCG1 phospholipase C, gamma 1 0.991
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.990
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.986
RUNX1 runt-related transcription factor 1 0.986
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.983
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.980
CCL5 chemokine (C-C motif) ligand 5 0.977
VCAM1 vascular cell adhesion molecule 1 0.975
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.972
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.970
CCR7 chemokine (C-C motif) receptor 7 0.965
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.964
CCR5 chemokine (C-C motif) receptor 5 0.962
FHL2 four and a half LIM domains 2 0.957
PSEN1 presenilin 1 0.953
VAV1 vav 1 guanine nucleotide exchange factor 0.941
IL2RB interleukin 2 receptor, beta 0.940
CXCL9 chemokine (C-X-C motif) ligand 9 0.933
IL10RA interleukin 10 receptor, alpha 0.931
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.930
NOTCH1 notch 1 0.928
CCL4 chemokine (C-C motif) ligand 4 0.923
HLA-DRA major histocompatibility complex, class II, DR alpha 0.920
ICAM1 intercellular adhesion molecule 1 0.920
TEK TEK tyrosine kinase, endothelial 0.919
IRF4 interferon regulatory factor 4 0.915
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.909
IL2RG interleukin 2 receptor, gamma 0.903
SOCS3 suppressor of cytokine signaling 3 0.903
CXCL10 chemokine (C-X-C motif) ligand 10 0.901
FGFR1 fibroblast growth factor receptor 1 0.898
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.896
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.894
FGFR2 fibroblast growth factor receptor 2 0.893
LST1 leukocyte specific transcript 1 0.891
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.885
IL1B interleukin 1, beta 0.885
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.882
HCK hemopoietic cell kinase 0.878
FGA fibrinogen alpha chain 0.875
IFNG interferon, gamma 0.874
CCL22 chemokine (C-C motif) ligand 22 0.863
CD63 CD63 molecule 0.859
JUN jun proto-oncogene 0.858
NCOR2 nuclear receptor corepressor 2 0.851
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.851
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.848
ABI1 abl-interactor 1 0.848
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.845
BIRC3 baculoviral IAP repeat containing 3 0.840
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.837
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.834
CD2 CD2 molecule 0.832
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.827
SLAMF1 signaling lymphocytic activation molecule family member 1 0.823
CD86 CD86 molecule 0.821
BLNK B-cell linker 0.819
B2M beta-2-microglobulin 0.818
PXN paxillin 0.802
CD28 CD28 molecule 0.801
SH2D1A SH2 domain containing 1A 0.801
IL4R interleukin 4 receptor 0.798
TAL1 T-cell acute lymphocytic leukemia 1 0.797
PML promyelocytic leukemia 0.797
AXL AXL receptor tyrosine kinase 0.797
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.795
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.794
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.780
BRCA1 breast cancer 1, early onset 0.778
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.777
CAV1 caveolin 1, caveolae protein, 22kDa 0.776
MYH9 myosin, heavy chain 9, non-muscle 0.775
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.775
STAT4 signal transducer and activator of transcription 4 0.772
ITK IL2-inducible T-cell kinase 0.766
HLA-DMB major histocompatibility complex, class II, DM beta 0.765
CCR1 chemokine (C-C motif) receptor 1 0.759
INSR insulin receptor 0.756
TLN1 talin 1 0.752
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.748
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.745
BCL2 B-cell CLL/lymphoma 2 0.742
MAPK1 mitogen-activated protein kinase 1 0.740
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.735
RB1 retinoblastoma 1 0.734
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.728
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.723
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cxcr4b chemokine (C-X-C motif), receptor 4b 0.352
fgf3 fibroblast growth factor 3 0.296
kita kit receptor a 0.237
mmp9 matrix metalloproteinase 9 0.218
pdgfaa platelet-derived growth factor alpha a 0.193
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.159
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.154
fzd7a frizzled homolog 7a 0.147
bmp2b bone morphogenetic protein 2b 0.147
tp53 tumor protein p53 0.133
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.131
lcp1 lymphocyte cytosolic plastin 1 0.129
dlc deltaC 0.113
wls wntless homolog (Drosophila) 0.090
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.089
npm1 nucleophosmin 1 0.088
sgk1 serum/glucocorticoid regulated kinase 1 0.086
runx3 runt-related transcription factor 3 0.084
cmyb transcription factor cmyb 0.080
coro1a coronin, actin binding protein, 1A 0.073
lmo4a LIM domain only 4a 0.070
tbx2b T-box 2b 0.068
id2a inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a 0.067
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.066
camk2g1 calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 0.065
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.064
wnt9b wingless-type MMTV integration site family, member 9B 0.063
copeb core promoter element binding protein 0.050
tp63 tumor protein p63 0.050
si:ch211-173o4.2 si:ch211-173o4.2 0.048
eya2 eyes absent homolog 2 (Drosophila) 0.048
rbp4 retinol binding protein 4, plasma 0.047
fn1 fibronectin 1 0.045
ryk receptor-like tyrosine kinase 0.044
il7r interleukin 7 receptor 0.043
tbx1 T-box 1 0.043
dnmt4 DNA (cytosine-5-)-methyltransferase 4 0.043
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.042
cdx1b caudal type homeobox 1 b 0.042
pcdh18b protocadherin 18b 0.041
chd chordin 0.041
axin1 axin 1 0.040
npc1 Niemann-Pick disease, type C1 0.039
tgm2b transglutaminase 2b 0.038
met met proto-oncogene (hepatocyte growth factor receptor) 0.038
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.037
mt2 metallothionein 2 0.037
capns1b calpain, small subunit 1 b 0.037
csrp1a cysteine and glycine-rich protein 1a 0.036
znf703 zinc finger protein 703 0.036
cdh1 cadherin 1, epithelial 0.036
satb2 SATB homeobox 2 0.036
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.035
cdx4 caudal type homeo box transcription factor 4 0.035
fes feline sarcoma oncogene 0.035
gdf6a growth differentiation factor 6a 0.035
notch3 notch homolog 3 0.033
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.032
zgc:64051 zgc:64051 0.031
il12bb interleukin 12B, b 0.031
elovl4b elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4b 0.030
krt18 keratin 18 0.030
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.030
ccnd1 cyclin D1 0.028
hoxd4a homeo box D4a 0.027
ptch2 patched 2 0.027
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.027
fgf8a fibroblast growth factor 8 a 0.026
runx2a runt-related transcription factor 2a 0.025
gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.025
hoxa13b homeo box A13b 0.024
alcamb activated leukocyte cell adhesion molecule b 0.024
kdrl kinase insert domain receptor like 0.024
hlxb9la homeo box HB9 like a 0.024
clic2 chloride intracellular channel 2 0.024
si:dkey-27i16.2 si:dkey-27i16.2 0.024
wnt4a wingless-type MMTV integration site family, member 4a 0.024
sult2st1 sulfotransferase family 2, cytosolic sulfotransferase 1 0.024
ripk2 receptor-interacting serine-threonine kinase 2 0.024
wnt9a wingless-type MMTV integration site family, member 9A 0.024
enc1 ectodermal-neural cortex (with BTB-like domain) 0.024
jag1b jagged 1b 0.024
srf serum response factor 0.024
si:dkey-8l13.4 si:dkey-8l13.4 0.024
otx1b orthodenticle homolog 1b 0.023
atad5a ATPase family, AAA domain containing 5a 0.023
anxa11a annexin A11a 0.023
zgc:195154 zgc:195154 0.022
mapk14a mitogen-activated protein kinase 14a 0.022
tgfbr2 transforming growth factor, beta receptor II 0.022
axin2 axin 2 (conductin, axil) 0.022
pycard PYD and CARD domain containing 0.021
hspa5 heat shock protein 5 0.021
ip6k2 inositol hexaphosphate kinase 2 0.021
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.021
ptena phosphatase and tensin homolog A 0.020
foxi3a forkhead box I3a 0.020
rpl11 ribosomal protein L11 0.020
mych myelocytomatosis oncogene homolog 0.020
btk Bruton agammaglobulinemia tyrosine kinase 0.020
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Drosophila melanogaster
Name Description Probability Func Analog Organism
wg wingless 0.628
mys myospheroid 0.598
aop anterior open 0.344
arm armadillo 0.341
shn schnurri 0.276
hth homothorax 0.197
rhea CG6831 gene product from transcript CG6831-RA 0.157
EcR Ecdysone receptor 0.140
stck steamer duck 0.134
Sema-1a CG18405 gene product from transcript CG18405-RD 0.128
RASSF8 CG5053 gene product from transcript CG5053-RA 0.124
Tl Toll 0.119
babo baboon 0.104
InR Insulin-like receptor 0.099
tsh teashirt 0.096
dx deltex 0.094
tefu telomere fusion 0.085
Rac1 CG2248 gene product from transcript CG2248-RA 0.083
pan pangolin 0.080
dpp decapentaplegic 0.078
ttv tout-velu 0.078
Ras85D Ras oncogene at 85D 0.077
put punt 0.072
DAAM Dishevelled Associated Activator of Morphogenesis 0.072
kis kismet 0.071
Egfr Epidermal growth factor receptor 0.069
mbc myoblast city 0.067
N Notch 0.067
hep hemipterous 0.066
bowl brother of odd with entrails limited 0.065
spz spatzle 0.064
Vm26Ab Vitelline membrane 26Ab 0.063
Dad Daughters against dpp 0.063
emc extra macrochaetae 0.061
hipk homeodomain interacting protein kinase 0.056
Mcr Macroglobulin complement-related 0.055
rut rutabaga 0.054
Su(H) Suppressor of Hairless 0.046
bs blistered 0.046
Cdc42 CG12530 gene product from transcript CG12530-RA 0.045
pll pelle 0.045
Cdk4 Cyclin-dependent kinase 4 0.044
l(2)gl lethal (2) giant larvae 0.043
Rab5 Rab-protein 5 0.043
Stat92E Signal-transducer and activator of transcription protein at 92E 0.042
Mpk2 CG5475 gene product from transcript CG5475-RB 0.042
dia diaphanous 0.041
Tak1 TGF-beta activated kinase 1 0.041
Ubqn Ubiquilin 0.041
CdsA CDP diglyceride synthetase 0.041
Ras64B Ras oncogene at 64B 0.040
ik2 IkappaB kinase-like 2 0.039
bsk basket 0.039
Adf1 Adh transcription factor 1 0.039
mol moladietz 0.038
Ced-12 CG5336 gene product from transcript CG5336-RA 0.038
Sra-1 specifically Rac1-associated protein 1 0.037
drk downstream of receptor kinase 0.036
Pp2B-14D Protein phosphatase 2B at 14D 0.035
Akt1 CG4006 gene product from transcript CG4006-RA 0.033
dco discs overgrown 0.033
lace CG4162 gene product from transcript CG4162-RA 0.033
sqh spaghetti squash 0.032
brat brain tumor 0.032
ttk tramtrack 0.032
S6kII RPS6-protein kinase-II 0.032
CG32810 CG32810 gene product from transcript CG32810-RB 0.031
lqf liquid facets 0.029
Myo31DF Myosin 31DF 0.029
Mad Mothers against dpp 0.029
cnk connector enhancer of ksr 0.029
sina seven in absentia 0.027
Toll-7 CG8595 gene product from transcript CG8595-RA 0.027
stau staufen 0.026
egh egghead 0.026
Tab2 TAK1-associated binding protein 2 0.024
mib1 mind bomb 1 0.024
tub tube 0.023
Mnn1 Menin 1 0.022
btl breathless 0.021
wntD wnt inhibitor of Dorsal 0.021
fs(1)M3 female sterile (1) M3 0.021
Gs1 Glutamine synthetase 1 0.020
hb hunchback 0.020
nub nubbin 0.020
CG4168 CG4168 gene product from transcript CG4168-RA 0.020
wts warts 0.020
Traf6 TNF-receptor-associated factor 6 0.020
klu klumpfuss 0.020
slmb supernumerary limbs 0.020
Pez CG9493 gene product from transcript CG9493-RA 0.019
A2bp1 Ataxin-2 binding protein 1 0.019
Vm26Aa Vitelline membrane 26Aa 0.018
tai taiman 0.017
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.017
Vrp1 Verprolin 1 0.017
mei-41 meiotic 41 0.017
Toll-6 CG7250 gene product from transcript CG7250-RA 0.017
Pvr PDGF- and VEGF-receptor related 0.017
Mer Merlin 0.017
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ptafr platelet-activating factor receptor 0.943
Cd2 Cd2 molecule 0.939
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.906
Ptprc protein tyrosine phosphatase, receptor type, C 0.854
RT1-Ba RT1 class II, locus Ba 0.801
Gzmk granzyme K 0.783
Clec9a C-type lectin domain family 9, member a 0.747
Cd53 Cd53 molecule 0.743
Plek pleckstrin 0.699
Cd4 Cd4 molecule 0.684
Cd37 CD37 molecule 0.663
Cd247 Cd247 molecule 0.659
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.639
Lyz2 lysozyme 2 0.635
Casp1 caspase 1 0.634
Sell selectin L 0.623
Ccr5 chemokine (C-C motif) receptor 5 0.586
Inpp5d inositol polyphosphate-5-phosphatase D 0.567
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.501
Ly86 lymphocyte antigen 86 0.480
Hck hemopoietic cell kinase 0.465
Cd3g CD3 molecule, gamma 0.454
Tagln transgelin 0.449
Cxcr4 chemokine (C-X-C motif) receptor 4 0.448
Bin2 bridging integrator 2 0.432
Vcam1 vascular cell adhesion molecule 1 0.421
C5ar1 complement component 5a receptor 1 0.416
Tgfbr2 transforming growth factor, beta receptor II 0.392
Mt1a metallothionein 1a 0.391
Cd5 Cd5 molecule 0.371
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.359
Prm2 protamine 2 0.358
Nkg7 natural killer cell group 7 sequence 0.356
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.350
Rac2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.345
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.342
Evi2a ecotropic viral integration site 2A 0.337
Mcpt2 mast cell protease 2 0.332
Iapp islet amyloid polypeptide 0.318
Lst1 leukocyte specific transcript 1 0.311
Calcrl calcitonin receptor-like 0.305
Il2rb interleukin 2 receptor, beta 0.297
Cxcr5 chemokine (C-X-C motif) receptor 5 0.292
Ptpn7 protein tyrosine phosphatase, non-receptor type 7 0.285
Bgn biglycan 0.282
Klhl6 kelch-like 6 (Drosophila) 0.277
RT1-Da RT1 class II, locus Da 0.277
Anxa5 annexin A5 0.275
Il7r interleukin 7 receptor 0.273
Itgb1 integrin, beta 1 0.272
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.268
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.268
Itgad integrin, alpha D 0.267
Scn11a sodium channel, voltage-gated, type XI, alpha 0.264
Il1b interleukin 1 beta 0.263
Spn sialophorin 0.258
Hcls1 hematopoietic cell specific Lyn substrate 1 0.254
Itgb7 integrin, beta 7 0.254
Tpm2 tropomyosin 2, beta 0.253
Acta2 smooth muscle alpha-actin 0.249
Ccl3 chemokine (C-C motif) ligand 3 0.244
RT1-Db1 RT1 class II, locus Db1 0.242
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.240
Faslg Fas ligand (TNF superfamily, member 6) 0.240
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.239
Csn2 casein beta 0.237
Il8rb interleukin 8 receptor, beta 0.234
Il1r1 interleukin 1 receptor, type I 0.224
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.223
Calm2 calmodulin 2 0.223
Pld4 phospholipase D family, member 4 0.221
Kcnq2 potassium voltage-gated channel, KQT-like subfamily, member 2 0.221
Actb actin, beta 0.218
Klrb1a killer cell lectin-like receptor subfamily B, member 1A 0.209
Ctss cathepsin S 0.208
Prp15 proline-rich protein 15 0.207
Cfp complement factor properdin 0.205
Gmfg glia maturation factor, gamma 0.205
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.204
Xcl1 chemokine (C motif) ligand 1 0.203
Cxcr3 chemokine (C-X-C motif) receptor 3 0.201
Met met proto-oncogene 0.197
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.196
Anxa2 annexin A2 0.193
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.192
Tcrb T-cell receptor beta chain 0.191
Igh-6 immunoglobulin heavy chain 6 0.190
Oprm1 opioid receptor, mu 1 0.189
Homer3 homer homolog 3 (Drosophila) 0.185
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.185
Npy5r neuropeptide Y receptor Y5 0.185
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.184
Csf1 colony stimulating factor 1 (macrophage) 0.183
Zbp1 Z-DNA binding protein 1 0.182
Gimap4 GTPase, IMAP family member 4 0.178
Cd38 CD38 molecule 0.177
Myo1f myosin IF 0.176
Tgfbr3 transforming growth factor, beta receptor III 0.173
Myo1g myosin IG 0.173
Cd86 CD86 molecule 0.173
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism