The network for 'positive regulation of rho gtpase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of rho gtpase activity

Any process that activates or increases the activity of a GTPase of the Rho family.

Homo sapiens
Name Description Probability Func Analog Organism
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.000
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 1.000
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 1.000
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.998
SH3KBP1 SH3-domain kinase binding protein 1 0.969
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.968
S100A6 S100 calcium binding protein A6 0.949
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.949
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.946
S100A11 S100 calcium binding protein A11 0.935
RHOA ras homolog gene family, member A 0.922
IGF1R insulin-like growth factor 1 receptor 0.921
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.889
S100A8 S100 calcium binding protein A8 0.874
BAIAP2 BAI1-associated protein 2 0.871
SFN stratifin 0.842
ERBB2IP erbb2 interacting protein 0.837
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.828
S100A4 S100 calcium binding protein A4 0.818
NCF2 neutrophil cytosolic factor 2 0.802
JUN jun proto-oncogene 0.792
ABI1 abl-interactor 1 0.774
S100A9 S100 calcium binding protein A9 0.772
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.772
S100B S100 calcium binding protein B 0.765
NCKAP1 NCK-associated protein 1 0.712
SOS1 son of sevenless homolog 1 (Drosophila) 0.683
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.650
TRAF5 TNF receptor-associated factor 5 0.637
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.607
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.596
FOS FBJ murine osteosarcoma viral oncogene homolog 0.578
DOCK1 dedicator of cytokinesis 1 0.571
PTPRC protein tyrosine phosphatase, receptor type, C 0.543
PKN3 protein kinase N3 0.531
PTK2 PTK2 protein tyrosine kinase 2 0.518
S100A1 S100 calcium binding protein A1 0.517
CCR5 chemokine (C-C motif) receptor 5 0.514
TSC2 tuberous sclerosis 2 0.507
GRB7 growth factor receptor-bound protein 7 0.503
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.500
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.478
SH3RF1 SH3 domain containing ring finger 1 0.474
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.472
JUP junction plakoglobin 0.469
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.456
LGALS1 lectin, galactoside-binding, soluble, 1 0.428
RND1 Rho family GTPase 1 0.426
RHOC ras homolog gene family, member C 0.424
SMAD2 SMAD family member 2 0.417
DSP desmoplakin 0.402
ATF3 activating transcription factor 3 0.399
RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) 0.398
FMNL1 formin-like 1 0.395
FLNB filamin B, beta 0.376
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.357
MARK3 MAP/microtubule affinity-regulating kinase 3 0.349
ARHGAP1 Rho GTPase activating protein 1 0.340
CCL19 chemokine (C-C motif) ligand 19 0.331
EGFR epidermal growth factor receptor 0.319
CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.290
BCAR1 breast cancer anti-estrogen resistance 1 0.284
CCL4 chemokine (C-C motif) ligand 4 0.277
NCK1 NCK adaptor protein 1 0.270
TNF tumor necrosis factor 0.268
ZMYND11 zinc finger, MYND-type containing 11 0.267
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.266
RACGAP1 Rac GTPase activating protein 1 0.246
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.245
RHOG ras homolog gene family, member G (rho G) 0.245
HCK hemopoietic cell kinase 0.245
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.243
MYO9B myosin IXB 0.240
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.239
SH3RF3 SH3 domain containing ring finger 3 0.238
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.234
ANK1 ankyrin 1, erythrocytic 0.231
CCL2 chemokine (C-C motif) ligand 2 0.229
KRT14 keratin 14 0.222
PLXNB1 plexin B1 0.214
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.213
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.208
PLXND1 plexin D1 0.204
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 0.193
DPP4 dipeptidyl-peptidase 4 0.192
TMSB4X thymosin beta 4, X-linked 0.188
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.185
SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3 0.180
SORBS1 sorbin and SH3 domain containing 1 0.177
APC adenomatous polyposis coli 0.177
TRAF1 TNF receptor-associated factor 1 0.177
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.175
ANXA2 annexin A2 0.175
EMP3 epithelial membrane protein 3 0.165
RALBP1 ralA binding protein 1 0.163
PKP4 plakophilin 4 0.155
FASLG Fas ligand (TNF superfamily, member 6) 0.149
CAPG capping protein (actin filament), gelsolin-like 0.148
MPRIP myosin phosphatase Rho interacting protein 0.145
AREG amphiregulin 0.145
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
plexB plexin B 0.880
pod1 CG4532 gene product from transcript CG4532-RF 0.794
mbc myoblast city 0.777
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.746
Sos Son of sevenless 0.661
rok Rho-kinase 0.598
Pkn Protein kinase related to protein kinase N 0.574
puc puckered 0.573
Abi Abelson interacting protein 0.475
LIMK1 LIM-kinase1 0.455
baz bazooka 0.359
RhoGEF2 CG9635 gene product from transcript CG9635-RF 0.251
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.228
neuroligin CG13772 gene product from transcript CG13772-RA 0.177
CG4853 CG4853 gene product from transcript CG4853-RA 0.176
stg string 0.144
UBL3 CG9038 gene product from transcript CG9038-RC 0.144
trio CG18214 gene product from transcript CG18214-RA 0.143
Fak56D Focal Adhesion Kinase 0.139
Wnk CG7177 gene product from transcript CG7177-RA 0.138
DAAM Dishevelled Associated Activator of Morphogenesis 0.135
RhoGAP68F CG6811 gene product from transcript CG6811-RA 0.121
Graf CG8948 gene product from transcript CG8948-RB 0.119
Wnt5 Wnt oncogene analog 5 0.108
cno canoe 0.108
Mtl Mig-2-like 0.106
Myo31DF Myosin 31DF 0.093
Vrp1 Verprolin 1 0.092
CG6051 CG6051 gene product from transcript CG6051-RB 0.090
l(2)k16918 lethal (2) k16918 0.087
bves CG32513 gene product from transcript CG32513-RA 0.086
Cip4 CG15015 gene product from transcript CG15015-RA 0.086
RhoGAP93B CG3421 gene product from transcript CG3421-RA 0.086
CG32772 CG32772 gene product from transcript CG32772-RC 0.086
Ephrin CG1862 gene product from transcript CG1862-RA 0.082
Mer Merlin 0.078
alpha-Man-IIb CG4606 gene product from transcript CG4606-RA 0.077
crb crumbs 0.076
l(3)04053 lethal (3) 04053 0.073
Drl-2 Derailed 2 0.072
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.071
CG4751 CG4751 gene product from transcript CG4751-RA 0.070
CG2991 CG2991 gene product from transcript CG2991-RA 0.069
Ras85D Ras oncogene at 85D 0.069
Rho1 CG8416 gene product from transcript CG8416-RB 0.067
tkv thickveins 0.056
Fas3 Fasciclin 3 0.055
CG15479 CG15479 gene product from transcript CG15479-RA 0.055
Rtnl1 CG33113 gene product from transcript CG33113-RF 0.055
Cad87A CG6977 gene product from transcript CG6977-RA 0.053
vav CG7893 gene product from transcript CG7893-RB 0.052
CG8155 CG8155 gene product from transcript CG8155-RA 0.050
Jra Jun-related antigen 0.050
Fim Fimbrin 0.050
dos daughter of sevenless 0.048
Lsd-2 Lipid storage droplet-2 0.048
disco disconnected 0.047
Sema-5c Semaphorin-5c 0.043
Hr96 Hormone receptor-like in 96 0.042
smo smoothened 0.041
flw flapwing 0.039
CG11033 CG11033 gene product from transcript CG11033-RB 0.039
RhoGAPp190 CG32555 gene product from transcript CG32555-RB 0.038
nwk nervous wreck 0.036
Rep Rab escort protein 0.036
CG12734 CG12734 gene product from transcript CG12734-RA 0.036
CG15365 CG15365 gene product from transcript CG15365-RA 0.035
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.035
SCAR CG4636 gene product from transcript CG4636-RA 0.035
Tre1 trapped in endoderm-1 0.034
nerfin-1 nervous fingers 1 0.034
ced-6 CG11804 gene product from transcript CG11804-RC 0.034
ida imaginal discs arrested 0.033
tay tay bridge 0.033
CG1233 CG1233 gene product from transcript CG1233-RB 0.032
tankyrase CG4719 gene product from transcript CG4719-RA 0.032
zormin CG33484 gene product from transcript CG33484-RC 0.032
Pak3 CG14895 gene product from transcript CG14895-RA 0.031
CG6707 CG6707 gene product from transcript CG6707-RA 0.030
Rala Ras-related protein 0.030
myoglianin CG1838 gene product from transcript CG1838-RD 0.029
mop myopic 0.029
Hem HEM-protein 0.029
pes peste 0.029
exex extra-extra 0.028
spz5 spatzle 5 0.028
drk downstream of receptor kinase 0.028
Pez CG9493 gene product from transcript CG9493-RA 0.027
Med Medea 0.027
CG7158 CG7158 gene product from transcript CG7158-RA 0.027
raw CG12437 gene product from transcript CG12437-RB 0.026
cv-c crossveinless c 0.025
koi klaroid 0.025
oys oysgedart 0.025
prom prominin 0.024
CG17233 CG17233 gene product from transcript CG17233-RA 0.024
Sbf SET domain binding factor 0.024
msd1 mitotic spindle density 1 0.023
Tak1 TGF-beta activated kinase 1 0.023
Dcr-1 Dicer-1 0.023
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Mus musculus
Name Description Probability Func Analog Organism
Grb2 growth factor receptor bound protein 2 0.998
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.988
Efnb2 ephrin B2 0.981
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.952
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.952
Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 0.944
Ephb2 Eph receptor B2 0.937
Rac1 RAS-related C3 botulinum substrate 1 0.934
Dlg4 discs, large homolog 4 (Drosophila) 0.934
Epha4 Eph receptor A4 0.932
Ccl2 chemokine (C-C motif) ligand 2 0.912
Nf1 neurofibromatosis 1 0.904
Cbl Casitas B-lineage lymphoma 0.833
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.803
Pxn paxillin 0.738
Apc adenomatosis polyposis coli 0.718
Vav1 vav 1 oncogene 0.705
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.703
Tgfa transforming growth factor alpha 0.700
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.692
Shc1 src homology 2 domain-containing transforming protein C1 0.670
Arrb2 arrestin, beta 2 0.652
Lepr leptin receptor 0.636
Laptm5 lysosomal-associated protein transmembrane 5 0.635
Plxna1 plexin A1 0.626
Cd37 CD37 antigen 0.610
Prkcd protein kinase C, delta 0.580
Ctnnb1 catenin (cadherin associated protein), beta 1 0.561
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.556
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.555
Selplg selectin, platelet (p-selectin) ligand 0.551
Src Rous sarcoma oncogene 0.547
Hmha1 histocompatibility (minor) HA-1 0.527
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.523
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.517
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.456
Ptk2 PTK2 protein tyrosine kinase 2 0.450
Rtkn rhotekin 0.429
Itga3 integrin alpha 3 0.424
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.417
Nrp1 neuropilin 1 0.415
Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.371
Sh3bp1 SH3-domain binding protein 1 0.371
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.367
Gab1 growth factor receptor bound protein 2-associated protein 1 0.365
Elmo1 engulfment and cell motility 1, ced-12 homolog (C. elegans) 0.361
Ntf3 neurotrophin 3 0.340
Numb numb gene homolog (Drosophila) 0.330
Arhgap21 Rho GTPase activating protein 21 0.328
Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.326
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.323
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.322
Bcr breakpoint cluster region 0.321
Nf2 neurofibromatosis 2 0.320
Ret ret proto-oncogene 0.311
Efna1 ephrin A1 0.292
Git1 G protein-coupled receptor kinase-interactor 1 0.289
Braf Braf transforming gene 0.285
Ptpre protein tyrosine phosphatase, receptor type, E 0.274
Nrp2 neuropilin 2 0.268
Prkcb protein kinase C, beta 0.255
Ptk2b PTK2 protein tyrosine kinase 2 beta 0.244
Irf5 interferon regulatory factor 5 0.240
Shh sonic hedgehog 0.232
Myo1f myosin IF 0.232
Tbx2 T-box 2 0.231
Fzd1 frizzled homolog 1 (Drosophila) 0.228
Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent 0.226
Vav2 vav 2 oncogene 0.218
Apc2 adenomatosis polyposis coli 2 0.216
Arrb1 arrestin, beta 1 0.213
Dnm1 dynamin 1 0.210
Vangl2 vang-like 2 (van gogh, Drosophila) 0.208
Sirpa signal-regulatory protein alpha 0.204
Lama5 laminin, alpha 5 0.201
Gab2 growth factor receptor bound protein 2-associated protein 2 0.200
Pvrl1 poliovirus receptor-related 1 0.194
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.185
Ccl3 chemokine (C-C motif) ligand 3 0.185
Hdac7 histone deacetylase 7 0.183
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.182
Flt1 FMS-like tyrosine kinase 1 0.172
Gpsm3 G-protein signalling modulator 3 (AGS3-like, C. elegans) 0.170
Rasgrp2 RAS, guanyl releasing protein 2 0.170
Shisa5 shisa homolog 5 (Xenopus laevis) 0.168
Agrn agrin 0.168
Sh3kbp1 SH3-domain kinase binding protein 1 0.166
Prkce protein kinase C, epsilon 0.166
Cd3e CD3 antigen, epsilon polypeptide 0.165
Lrp5 low density lipoprotein receptor-related protein 5 0.163
Stk10 serine/threonine kinase 10 0.161
Anxa2 annexin A2 0.160
Lrrk2 leucine-rich repeat kinase 2 0.160
Tcfcp2l1 transcription factor CP2-like 1 0.155
Rarg retinoic acid receptor, gamma 0.155
Tjp1 tight junction protein 1 0.154
Ednrb endothelin receptor type B 0.154
Klf3 Kruppel-like factor 3 (basic) 0.153
C77080 expressed sequence C77080 0.153
Fnbp1 formin binding protein 1 0.153
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Rattus norvegicus
Name Description Probability Func Analog Organism
Dlg3 discs, large homolog 3 (Drosophila) 0.111
Ylpm1 YLP motif containing 1 0.106
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.060
Stxbp5 syntaxin binding protein 5 (tomosyn) 0.045
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.035
Zmym4 zinc finger, MYM-type 4 0.035
Mcf2l MCF.2 cell line derived transforming sequence-like 0.035
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.034
Dock9 dedicator of cytokinesis 9 0.030
Tjp1 tight junction protein 1 0.025
Cap2 CAP, adenylate cyclase-associated protein, 2 (yeast) 0.025
Sptan1 spectrin, alpha, non-erythrocytic 1 0.023
Cdc34 cell division cycle 34 homolog (S. cerevisiae) 0.023
Klf6 Kruppel-like factor 6 0.023
Rasgrf2 RAS protein-specific guanine nucleotide-releasing factor 2 0.022
Syn2 synapsin II 0.022
Stk10 serine/threonine kinase 10 0.022
Plxnd1 plexin D1 0.021
Pik3r3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.019
Irf5 interferon regulatory factor 5 0.019
Pld2 phospholipase D2 0.018
Tek TEK tyrosine kinase, endothelial 0.018
Prx periaxin 0.018
Golgb1 golgin B1, golgi integral membrane protein 0.018
Sept10 septin 10 0.017
Plcg1 phospholipase C, gamma 1 0.017
Fgd2 FYVE, RhoGEF and PH domain containing 2 0.016
Fgfr3 fibroblast growth factor receptor 3 0.016
Bin2 bridging integrator 2 0.015
Hmha1 histocompatibility (minor) HA-1 0.015
Sh3gl2 SH3-domain GRB2-like 2 0.014
Ldlrap1 low density lipoprotein receptor adaptor protein 1 0.014
Tmprss2 transmembrane protease, serine 2 0.014
Unc13b unc-13 homolog B (C. elegans) 0.013
Rab15 RAB15, member RAS oncogene family 0.013
Pias3 protein inhibitor of activated STAT, 3 0.013
Prkcd protein kinase C, delta 0.013
Atf3 activating transcription factor 3 0.013
Dgka diacylglycerol kinase, alpha 0.012
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.012
Dll4 delta-like 4 (Drosophila) 0.012
Agrn agrin 0.012
Pde2a phosphodiesterase 2A, cGMP-stimulated 0.012
Kcnab1 potassium voltage-gated channel, shaker-related subfamily, beta member 1 0.012
Ptprs protein tyrosine phosphatase, receptor type, S 0.012
Itpr1 inositol 1,4,5-triphosphate receptor, type 1 0.012
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.011
Map4k1 mitogen activated protein kinase kinase kinase kinase 1 0.011
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.011
Zfp36 zinc finger protein 36 0.011
Lcp2 lymphocyte cytosolic protein 2 0.011
Grasp GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.010
Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 0.010
Abi3 ABI family, member 3 0.010
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.010
Cachd1 cache domain containing 1 0.010
Kif13a kinesin family member 13A 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
PKC1 Pkc1p 0.072
ROM2 Rom2p 0.070
RHO1 Rho1p 0.066
CDC24 Cdc24p 0.043
ACK1 Ack1p 0.036
MKK1 Mkk1p 0.031
BEM3 Bem3p 0.029
IRA1 Ira1p 0.027
MDS3 Mds3p 0.022
GIC2 Gic2p 0.019
GDS1 Gds1p 0.016
BST1 Bst1p 0.014
SLG1 Slg1p 0.013
SRD1 Srd1p 0.012
SIA1 Sia1p 0.012
URA3 Ura3p 0.012
TAO3 Tao3p 0.012
YLR264C-A hypothetical protein 0.012
KIC1 Kic1p 0.012
LEU2 Leu2p 0.011
YOL038C-A hypothetical protein 0.011
PRS2 Prs2p 0.011
KEL1 Kel1p 0.011
MER1 Mer1p 0.011
DOP1 Dop1p 0.011
YLR162W hypothetical protein 0.010
IQG1 Iqg1p 0.010
YNL058C hypothetical protein 0.010