The network for 'negative regulation of ossification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of ossification

Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation.

Mus musculus
Name Description Probability Func Analog Organism
Smad6 MAD homolog 6 (Drosophila) 0.957
Fgfr2 fibroblast growth factor receptor 2 0.948
Mef2d myocyte enhancer factor 2D 0.915
Ctnnb1 catenin (cadherin associated protein), beta 1 0.908
Notch1 Notch gene homolog 1 (Drosophila) 0.900
Sfrp2 secreted frizzled-related protein 2 0.870
Axin1 axin 1 0.867
Ret ret proto-oncogene 0.854
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.798
Smo smoothened homolog (Drosophila) 0.747
Hes1 hairy and enhancer of split 1 (Drosophila) 0.715
Notch3 Notch gene homolog 3 (Drosophila) 0.714
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.698
Gata4 GATA binding protein 4 0.692
Smad7 MAD homolog 7 (Drosophila) 0.692
Ptf1a pancreas specific transcription factor, 1a 0.681
Ltb lymphotoxin B 0.679
Isl1 ISL1 transcription factor, LIM/homeodomain 0.617
Fgfr1 fibroblast growth factor receptor 1 0.612
Bcl2 B-cell leukemia/lymphoma 2 0.600
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.587
Gli2 GLI-Kruppel family member GLI2 0.570
Gdnf glial cell line derived neurotrophic factor 0.566
Nos3 nitric oxide synthase 3, endothelial cell 0.559
Sox4 SRY-box containing gene 4 0.529
Pax6 paired box gene 6 0.520
Tcf3 transcription factor 3 0.513
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.513
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.510
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.464
Nf1 neurofibromatosis 1 0.461
Bmpr1a bone morphogenetic protein receptor, type 1A 0.452
Smad1 MAD homolog 1 (Drosophila) 0.419
Pten phosphatase and tensin homolog 0.400
Gas1 growth arrest specific 1 0.391
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.389
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.386
Otx2 orthodenticle homolog 2 (Drosophila) 0.366
Bmp4 bone morphogenetic protein 4 0.362
Neurog2 neurogenin 2 0.357
Pitx1 paired-like homeodomain transcription factor 1 0.352
Tgfb1i1 transforming growth factor beta 1 induced transcript 1 0.347
Hand1 heart and neural crest derivatives expressed transcript 1 0.347
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.346
Eda ectodysplasin-A 0.342
Hoxa1 homeobox A1 0.332
Pax3 paired box gene 3 0.324
Ccnd2 cyclin D2 0.322
Pkd1 polycystic kidney disease 1 homolog 0.321
Tal1 T-cell acute lymphocytic leukemia 1 0.308
Cyld cylindromatosis (turban tumor syndrome) 0.307
Hand2 heart and neural crest derivatives expressed transcript 2 0.303
Phox2b paired-like homeobox 2b 0.293
Igfbp5 insulin-like growth factor binding protein 5 0.293
Pcdh12 protocadherin 12 0.287
Tbx3 T-box 3 0.273
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.267
Tcfap2a transcription factor AP-2, alpha 0.267
Rnf111 ring finger 111 0.260
Vegfa vascular endothelial growth factor A 0.259
Nhlh1 nescient helix loop helix 1 0.244
Fgf8 fibroblast growth factor 8 0.244
Tgfa transforming growth factor alpha 0.238
Smad4 MAD homolog 4 (Drosophila) 0.237
Gata6 GATA binding protein 6 0.236
Shh sonic hedgehog 0.230
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.227
Ikzf1 IKAROS family zinc finger 1 0.223
Grb10 growth factor receptor bound protein 10 0.214
Mmp24 matrix metallopeptidase 24 0.214
Hoxb1 homeobox B1 0.213
Mecom MDS1 and EVI1 complex locus 0.211
Hoxa2 homeobox A2 0.206
Socs1 suppressor of cytokine signaling 1 0.204
Lta lymphotoxin A 0.202
Gpr50 G-protein-coupled receptor 50 0.201
Rhbdf1 rhomboid family 1 (Drosophila) 0.199
Sox11 SRY-box containing gene 11 0.198
Gpc3 glypican 3 0.197
Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.197
Fn1 fibronectin 1 0.197
Sox7 SRY-box containing gene 7 0.193
Foxf1a forkhead box F1a 0.191
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.190
Tcf7l1 transcription factor 7-like 1 (T-cell specific, HMG box) 0.189
Tnf tumor necrosis factor 0.189
Hhex hematopoietically expressed homeobox 0.188
Smad3 MAD homolog 3 (Drosophila) 0.186
Fzd2 frizzled homolog 2 (Drosophila) 0.184
Edar ectodysplasin-A receptor 0.183
Trp53 transformation related protein 53 0.182
Efs embryonal Fyn-associated substrate 0.180
Phox2a paired-like homeobox 2a 0.177
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.175
Dll1 delta-like 1 (Drosophila) 0.174
Zfp36l1 zinc finger protein 36, C3H type-like 1 0.174
Lef1 lymphoid enhancer binding factor 1 0.174
Gli3 GLI-Kruppel family member GLI3 0.173
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.171
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.170
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.985
CCR5 chemokine (C-C motif) receptor 5 0.974
CCL5 chemokine (C-C motif) ligand 5 0.861
CCL4 chemokine (C-C motif) ligand 4 0.836
TAL1 T-cell acute lymphocytic leukemia 1 0.735
CXCL9 chemokine (C-X-C motif) ligand 9 0.542
NCOR2 nuclear receptor corepressor 2 0.525
SKIL SKI-like oncogene 0.449
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.359
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.349
CCL22 chemokine (C-C motif) ligand 22 0.343
SMAD3 SMAD family member 3 0.259
MEF2A myocyte enhancer factor 2A 0.243
IFNG interferon, gamma 0.232
HDAC4 histone deacetylase 4 0.230
SQSTM1 sequestosome 1 0.221
INSR insulin receptor 0.202
VCAN versican 0.199
IL2RB interleukin 2 receptor, beta 0.192
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.177
CCL3 chemokine (C-C motif) ligand 3 0.154
JAG1 jagged 1 0.152
CXCL11 chemokine (C-X-C motif) ligand 11 0.142
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.138
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.134
SMAD4 SMAD family member 4 0.134
CCR1 chemokine (C-C motif) receptor 1 0.117
CCR4 chemokine (C-C motif) receptor 4 0.110
MEF2C myocyte enhancer factor 2C 0.103
CXCR6 chemokine (C-X-C motif) receptor 6 0.095
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.089
NCOR1 nuclear receptor corepressor 1 0.086
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.085
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.085
HDAC9 histone deacetylase 9 0.084
CCL2 chemokine (C-C motif) ligand 2 0.082
RUNX1 runt-related transcription factor 1 0.082
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.081
POU5F1 POU class 5 homeobox 1 0.080
CCR7 chemokine (C-C motif) receptor 7 0.078
BCL6 B-cell CLL/lymphoma 6 0.078
EPAS1 endothelial PAS domain protein 1 0.077
CXCR3 chemokine (C-X-C motif) receptor 3 0.075
ING2 inhibitor of growth family, member 2 0.073
CCR2 chemokine (C-C motif) receptor 2 0.072
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.071
CCL13 chemokine (C-C motif) ligand 13 0.070
CXCL13 chemokine (C-X-C motif) ligand 13 0.069
SETD8 SET domain containing (lysine methyltransferase) 8 0.067
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.062
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 0.062
CCND1 cyclin D1 0.062
MAML1 mastermind-like 1 (Drosophila) 0.058
CCL8 chemokine (C-C motif) ligand 8 0.056
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.056
DPP4 dipeptidyl-peptidase 4 0.053
IL10 interleukin 10 0.052
KDM2B lysine (K)-specific demethylase 2B 0.051
SMO smoothened homolog (Drosophila) 0.050
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.050
PCGF1 polycomb group ring finger 1 0.049
NOTCH1 notch 1 0.049
GATA2 GATA binding protein 2 0.046
ENG endoglin 0.046
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.046
SLAMF7 SLAM family member 7 0.044
CCL7 chemokine (C-C motif) ligand 7 0.044
IL16 interleukin 16 (lymphocyte chemoattractant factor) 0.044
CCL11 chemokine (C-C motif) ligand 11 0.043
EP300 E1A binding protein p300 0.042
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.042
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.041
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.040
HTT huntingtin 0.039
SPEN spen homolog, transcriptional regulator (Drosophila) 0.039
VHL von Hippel-Lindau tumor suppressor 0.039
IRF4 interferon regulatory factor 4 0.038
BMP1 bone morphogenetic protein 1 0.038
HIPK3 homeodomain interacting protein kinase 3 0.038
SELL selectin L 0.037
IL8 interleukin 8 0.036
TCF12 transcription factor 12 0.036
IL1B interleukin 1, beta 0.035
MYOD1 myogenic differentiation 1 0.035
ARRDC3 arrestin domain containing 3 0.034
CAPRIN2 caprin family member 2 0.034
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.034
MATK megakaryocyte-associated tyrosine kinase 0.034
PRKD2 protein kinase D2 0.033
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.032
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.032
EGLN1 egl nine homolog 1 (C. elegans) 0.031
IL1R2 interleukin 1 receptor, type II 0.031
CREBBP CREB binding protein 0.030
IL2RG interleukin 2 receptor, gamma 0.029
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.029
TGFBR1 transforming growth factor, beta receptor 1 0.029
EGLN3 egl nine homolog 3 (C. elegans) 0.029
FOXP3 forkhead box P3 0.028
SP1 Sp1 transcription factor 0.028
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nrg1 neuregulin 1 0.050
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.036
Serpina1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.030
Id1 inhibitor of DNA binding 1 0.027
Rhd Rh blood group, D antigen 0.024
Ccl4 chemokine (C-C motif) ligand 4 0.021
Jak1 Janus kinase 1 0.021
Uox urate oxidase 0.021
Fosl1 fos-like antigen 1 0.020
Id3 inhibitor of DNA binding 3 0.017
Mcam melanoma cell adhesion molecule 0.016
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.016
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.016
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.015
Ier5 immediate early response 5 0.015
Slit3 slit homolog 3 (Drosophila) 0.014
Gzmk granzyme K 0.012
Clec11a C-type lectin domain family 11, member a 0.012
Cxcl2 chemokine (C-X-C motif) ligand 2 0.012
Dock6 dedicator of cytokinesis 6 0.011
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.011
LOC689064 beta-globin 0.011
Gpr176 G protein-coupled receptor 176 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism