The network for 'activation of innate immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

activation of innate immune response

Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.

Mus musculus
Name Description Probability Func Analog Organism
Myd88 myeloid differentiation primary response gene 88 1.000
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 1.000
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 1.000
Traf6 TNF receptor-associated factor 6 1.000
Casp4 caspase 4, apoptosis-related cysteine peptidase 1.000
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.999
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.998
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.998
Tnf tumor necrosis factor 0.991
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.988
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.987
Axl AXL receptor tyrosine kinase 0.986
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.985
Trim30a tripartite motif-containing 30A 0.978
Irf7 interferon regulatory factor 7 0.977
Ikbkg inhibitor of kappaB kinase gamma 0.962
Casp1 caspase 1 0.960
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.959
Unc93b1 unc-93 homolog B1 (C. elegans) 0.957
Gbp7 guanylate binding protein 7 0.956
Gnrh1 gonadotropin releasing hormone 1 0.954
Zbp1 Z-DNA binding protein 1 0.952
Birc3 baculoviral IAP repeat-containing 3 0.937
Cd180 CD180 antigen 0.936
Grb2 growth factor receptor bound protein 2 0.935
Tlr4 toll-like receptor 4 0.932
Chuk conserved helix-loop-helix ubiquitous kinase 0.929
Cd40 CD40 antigen 0.923
Parp14 poly (ADP-ribose) polymerase family, member 14 0.922
Pyhin1 pyrin and HIN domain family, member 1 0.919
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.905
Irf9 interferon regulatory factor 9 0.904
Mapk14 mitogen-activated protein kinase 14 0.897
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.881
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.876
Cd33 CD33 antigen 0.867
Ifi44 interferon-induced protein 44 0.847
Sykb spleen tyrosine kinase 0.845
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.840
Emr4 EGF-like module containing, mucin-like, hormone receptor-like sequence 4 0.837
Pten phosphatase and tensin homolog 0.822
Ticam1 toll-like receptor adaptor molecule 1 0.822
Gbp3 guanylate binding protein 3 0.821
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.818
Ldb3 LIM domain binding 3 0.811
BC013712 cDNA sequence BC013712 0.798
Trim30d tripartite motif-containing 30D 0.789
Ncr1 natural cytotoxicity triggering receptor 1 0.778
Irak3 interleukin-1 receptor-associated kinase 3 0.776
Rsad2 radical S-adenosyl methionine domain containing 2 0.774
Mndal myeloid nuclear differentiation antigen like 0.731
Gbp5 guanylate binding protein 5 0.718
Esr1 estrogen receptor 1 (alpha) 0.715
BC006779 cDNA sequence BC006779 0.707
Cd80 CD80 antigen 0.706
Tnfaip2 tumor necrosis factor, alpha-induced protein 2 0.701
Traf3ip2 TRAF3 interacting protein 2 0.693
Bcl3 B-cell leukemia/lymphoma 3 0.687
Cd86 CD86 antigen 0.685
Oasl2 2'-5' oligoadenylate synthetase-like 2 0.681
Ifi203 interferon activated gene 203 0.675
Irgm1 immunity-related GTPase family M member 1 0.673
Ikbkb inhibitor of kappaB kinase beta 0.669
Cd14 CD14 antigen 0.658
Rel reticuloendotheliosis oncogene 0.649
Slamf8 SLAM family member 8 0.648
Ltbr lymphotoxin B receptor 0.635
Tyro3 TYRO3 protein tyrosine kinase 3 0.632
Uba7 ubiquitin-like modifier activating enzyme 7 0.631
Igh immunoglobulin heavy chain complex 0.628
Ccl4 chemokine (C-C motif) ligand 4 0.625
Irg1 immunoresponsive gene 1 0.620
Pilrb1 paired immunoglobin-like type 2 receptor beta 1 0.613
Gab1 growth factor receptor bound protein 2-associated protein 1 0.585
Stx11 syntaxin 11 0.583
Clec4e C-type lectin domain family 4, member e 0.581
Rtp4 receptor transporter protein 4 0.558
Irf5 interferon regulatory factor 5 0.555
Irgm2 immunity-related GTPase family M member 2 0.550
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.540
Naip6 NLR family, apoptosis inhibitory protein 6 0.536
Mnda myeloid cell nuclear differentiation antigen 0.525
Ifit1 interferon-induced protein with tetratricopeptide repeats 1 0.522
Reg1 regenerating islet-derived 1 0.522
Nlrp3 NLR family, pyrin domain containing 3 0.516
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.511
Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.508
Gbp2 guanylate binding protein 2 0.496
Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 0.492
Il1rn interleukin 1 receptor antagonist 0.481
Cd300ld CD300 molecule-like family member d 0.478
Arrb1 arrestin, beta 1 0.474
Tlr8 toll-like receptor 8 0.473
Klra2 killer cell lectin-like receptor, subfamily A, member 2 0.473
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.470
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.468
Csf1 colony stimulating factor 1 (macrophage) 0.464
Stat3 signal transducer and activator of transcription 3 0.461
Traf2 TNF receptor-associated factor 2 0.459
Btk Bruton agammaglobulinemia tyrosine kinase 0.458
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
nod1 nucleotide-binding oligomerization domain containing 1 0.836
tlr9 toll-like receptor 9 0.358
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.259
tnfb tumor necrosis factor b (TNF superfamily, member 2) 0.210
pdcd2 programmed cell death 2 0.137
rel v-rel reticuloendotheliosis viral oncogene homolog 0.137
LOC100151531 zinc finger protein Gfi-1b-like 0.118
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.096
LOC557072 caspase recruitment domain-containing protein 11-like 0.094
wu:fb80e01 wu:fb80e01 0.085
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.063
LOC100000934 hypothetical protein LOC100000934 0.062
itga2b integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) 0.052
hspa9 heat shock protein 9 0.052
ip6k2 inositol hexaphosphate kinase 2 0.042
tlr18 toll-like receptor 18 0.040
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.032
hdr hematopoietic death receptor 0.031
rrp12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.030
epas1b endothelial PAS domain protein 1b 0.026
ecscr endothelial cell-specific chemotaxis regulator 0.026
rrm2b ribonucleotide reductase M2 b 0.025
LOC566708 FL cytokine receptor-like 0.025
si:dkey-236e20.6 si:dkey-236e20.6 0.023
fxr2 fragile X mental retardation, autosomal homolog 2 0.023
twist2 twist2 0.022
LOC100534776 toll-like receptor 7-like 0.021
tlr2 toll-like receptor 2 0.020
tirap toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.020
sb:cb134 sb:cb134 0.019
rhag Rhesus blood group-associated glycoprotein 0.019
fam20b family with sequence similarity 20, member B (H. sapiens) 0.019
ticam1 toll-like receptor adaptor molecule 1 0.018
tlr20a toll-like receptor 20a 0.017
nos2a nitric oxide synthase 2a, inducible 0.016
tufm Tu translation elongation factor, mitochondrial 0.015
gadd45bb growth arrest and DNA-damage-inducible, beta b 0.015
zgc:110340 zgc:110340 0.014
rhogb ras homolog gene family, member Gb 0.014
cpox coproporphyrinogen oxidase 0.013
tlr21 toll-like receptor 21 0.013
sb:cb429 sb:cb429 0.012
foxi3a forkhead box I3a 0.011
gip gastric inhibitory polypeptide 0.011
tlr20f toll-like receptor 20f 0.011
vcanb versican b 0.011
stc1l stanniocalcin 1, like 0.011
fn1b fibronectin 1b 0.010
tlr4bb toll-like receptor 4b, duplicate b 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
PGRP-LC Peptidoglycan recognition protein LC 0.996
AttA Attacin-A 0.981
grass Gram-positive Specific Serine protease 0.978
SPE Spatzle-Processing Enzyme 0.951
Rel Relish 0.915
DptB Diptericin B 0.905
PGRP-SA Peptidoglycan recognition protein SA 0.848
Spn27A Serpin 27A 0.823
modSP modular serine protease 0.814
Mtk Metchnikowin 0.750
18w 18 wheeler 0.698
Dredd Death related ced-3/Nedd2-like protein 0.689
IM1 Immune induced molecule 1 0.663
PGRP-SD CG7496 gene product from transcript CG7496-RA 0.644
CG15065 CG15065 gene product from transcript CG15065-RA 0.640
AttC Attacin-C 0.632
Toll-6 CG7250 gene product from transcript CG7250-RA 0.584
Toll-7 CG8595 gene product from transcript CG8595-RA 0.579
PGRP-LB Peptidoglycan recognition protein LB 0.568
GNBP1 Gram-negative bacteria binding protein 1 0.464
imd immune deficiency 0.461
Drs Drosomycin 0.444
Duox Dual oxidase 0.384
IM2 Immune induced molecule 2 0.375
spz spatzle 0.363
IM10 Immune induced molecule 10 0.358
Myd88 CG2078 gene product from transcript CG2078-RA 0.358
CG15067 CG15067 gene product from transcript CG15067-RA 0.358
pirk poor Imd response upon knock-in 0.358
GNBP3 Gram-negative bacteria binding protein 3 0.332
Irc Immune-regulated catalase 0.323
IM4 Immune induced molecule 4 0.315
Tl Toll 0.315
CG5791 CG5791 gene product from transcript CG5791-RA 0.313
CG18594 CG18594 gene product from transcript CG18594-RA 0.309
CG18067 CG18067 gene product from transcript CG18067-RA 0.299
CG32185 CG32185 gene product from transcript CG32185-RA 0.276
IM23 Immune induced molecule 23 0.263
Nrx-IV Neurexin IV 0.254
PGRP-SB1 CG9681 gene product from transcript CG9681-RA 0.243
pck pickel 0.241
Cat Catalase 0.225
Hcf Host cell factor 0.216
ird5 immune response deficient 5 0.210
eater CG6124 gene product from transcript CG6124-RB 0.205
Spn1 Serine protease inhibitor 1 0.203
Sp7 Serine protease 7 0.191
CG16836 CG16836 gene product from transcript CG16836-RA 0.187
PGRP-LF Peptidoglycan recognition protein LF 0.174
Timp Tissue inhibitor of metalloproteases 0.158
spirit Serine Protease Immune Response Integrator 0.140
Gadd45 CG11086 gene product from transcript CG11086-RA 0.139
Pli Pellino 0.138
plexB plexin B 0.137
CG15917 CG15917 gene product from transcript CG15917-RA 0.127
Tsp42Ec Tetraspanin 42Ec 0.123
Spn88Eb Serpin 88Eb 0.120
TepIII Thiolester containing protein III 0.117
fon fondue 0.116
CG5778 CG5778 gene product from transcript CG5778-RB 0.115
BG4 CG12297 gene product from transcript CG12297-RA 0.113
key kenny 0.106
grn grain 0.097
CG16713 CG16713 gene product from transcript CG16713-RA 0.096
CG13422 CG13422 gene product from transcript CG13422-RA 0.094
Mmp1 Matrix metalloproteinase 1 0.094
upd2 unpaired 2 0.093
PRL-1 CG4993 gene product from transcript CG4993-RB 0.089
p38b CG7393 gene product from transcript CG7393-RA 0.089
CG16718 CG16718 gene product from transcript CG16718-RA 0.088
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.087
psh persephone 0.087
ras raspberry 0.086
CG9184 CG9184 gene product from transcript CG9184-RB 0.085
LIMK1 LIM-kinase1 0.084
sinu sinuous 0.082
l(3)mbn lethal (3) malignant blood neoplasm 0.080
Dpt Diptericin 0.079
Dro Drosocin 0.078
Nhe3 Na[+]/H[+] hydrogen exchanger 3 0.076
spheroide CG9675 gene product from transcript CG9675-RA 0.076
Krn Keren 0.075
ds dachsous 0.074
CG15152 CG15152 gene product from transcript CG15152-RA 0.073
CG6038 CG6038 gene product from transcript CG6038-RA 0.071
rt rotated abdomen 0.070
CG10650 CG10650 gene product from transcript CG10650-RA 0.068
burs bursicon 0.066
CecC Cecropin C 0.065
Akt1 CG4006 gene product from transcript CG4006-RA 0.064
CG18480 CG18480 gene product from transcript CG18480-RA 0.064
CG12974 CG12974 gene product from transcript CG12974-RA 0.063
CG6361 CG6361 gene product from transcript CG6361-RA 0.063
CG5390 CG5390 gene product from transcript CG5390-RA 0.062
Sox14 Sox box protein 14 0.062
CG13323 CG13323 gene product from transcript CG13323-RA 0.060
PGRP-SC2 CG14745 gene product from transcript CG14745-RA 0.060
AGO2 Argonaute 2 0.060
bbg big bang 0.059
CG9917 CG9917 gene product from transcript CG9917-RA 0.055
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Homo sapiens
Name Description Probability Func Analog Organism
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 1.000
IRAK1 interleukin-1 receptor-associated kinase 1 1.000
BIRC3 baculoviral IAP repeat containing 3 1.000
MYD88 myeloid differentiation primary response gene (88) 1.000
TRAF6 TNF receptor-associated factor 6 1.000
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 1.000
IRAK2 interleukin-1 receptor-associated kinase 2 0.999
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.999
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.997
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.997
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.995
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.993
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.984
TNIP2 TNFAIP3 interacting protein 2 0.983
TLR4 toll-like receptor 4 0.979
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.975
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.964
TRAF1 TNF receptor-associated factor 1 0.954
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.924
RIPK2 receptor-interacting serine-threonine kinase 2 0.914
S100A1 S100 calcium binding protein A1 0.913
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.900
BIRC2 baculoviral IAP repeat containing 2 0.893
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.874
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.864
TNIP1 TNFAIP3 interacting protein 1 0.839
MAPK14 mitogen-activated protein kinase 14 0.827
S100A16 S100 calcium binding protein A16 0.821
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.813
SAMD9 sterile alpha motif domain containing 9 0.808
NLRC4 NLR family, CARD domain containing 4 0.805
TRAF3 TNF receptor-associated factor 3 0.771
CYLD cylindromatosis (turban tumor syndrome) 0.737
S100A14 S100 calcium binding protein A14 0.708
IFIH1 interferon induced with helicase C domain 1 0.688
TMEM173 transmembrane protein 173 0.686
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.683
TRIM22 tripartite motif containing 22 0.646
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.624
S100B S100 calcium binding protein B 0.613
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.602
S100A6 S100 calcium binding protein A6 0.590
LRRK2 leucine-rich repeat kinase 2 0.566
ARRB1 arrestin, beta 1 0.557
TRAF2 TNF receptor-associated factor 2 0.463
TRIM21 tripartite motif containing 21 0.460
BTN3A3 butyrophilin, subfamily 3, member A3 0.452
BCL3 B-cell CLL/lymphoma 3 0.425
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.394
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.373
TLR2 toll-like receptor 2 0.360
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.355
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.352
SP100 SP100 nuclear antigen 0.348
IRF7 interferon regulatory factor 7 0.347
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.343
RARA retinoic acid receptor, alpha 0.329
XIAP X-linked inhibitor of apoptosis 0.326
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.318
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.318
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.308
BTN3A2 butyrophilin, subfamily 3, member A2 0.307
NMI N-myc (and STAT) interactor 0.282
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.275
IRAK4 interleukin-1 receptor-associated kinase 4 0.261
MEFV Mediterranean fever 0.225
CCR2 chemokine (C-C motif) receptor 2 0.225
ZNF263 zinc finger protein 263 0.209
TRIM5 tripartite motif containing 5 0.208
MAVS mitochondrial antiviral signaling protein 0.207
RXRA retinoid X receptor, alpha 0.203
SP110 SP110 nuclear body protein 0.201
IFI44 interferon-induced protein 44 0.190
BTN3A1 butyrophilin, subfamily 3, member A1 0.187
PYDC2 pyrin domain containing 2 0.187
PML promyelocytic leukemia 0.187
CD80 CD80 molecule 0.183
TRIM38 tripartite motif containing 38 0.182
GBP1 guanylate binding protein 1, interferon-inducible 0.181
PARP12 poly (ADP-ribose) polymerase family, member 12 0.180
STRN striatin, calmodulin binding protein 0.176
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.172
PELI3 pellino homolog 3 (Drosophila) 0.172
DTX3L deltex 3-like (Drosophila) 0.166
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.162
STAT1 signal transducer and activator of transcription 1, 91kDa 0.157
SAMD9L sterile alpha motif domain containing 9-like 0.154
IRAK3 interleukin-1 receptor-associated kinase 3 0.154
SBF1 SET binding factor 1 0.149
AGER advanced glycosylation end product-specific receptor 0.149
TRIM25 tripartite motif containing 25 0.148
CARD11 caspase recruitment domain family, member 11 0.141
CTSS cathepsin S 0.140
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.139
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.134
IGSF6 immunoglobulin superfamily, member 6 0.129
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.128
IL15 interleukin 15 0.127
GBP3 guanylate binding protein 3 0.126
SMS spermine synthase 0.123
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Rattus norvegicus
Name Description Probability Func Analog Organism
Dbp D site of albumin promoter (albumin D-box) binding protein 0.432
Pcm1 pericentriolar material 1 0.052
Fcgr1a Fc fragment of IgG, high affinity Ia, receptor (CD64) 0.048
Zfp36 zinc finger protein 36 0.039
Il1b interleukin 1 beta 0.032
Ccl4 chemokine (C-C motif) ligand 4 0.029
Arl11 ADP-ribosylation factor-like 11 0.017
Tlr4 toll-like receptor 4 0.016
Tlr2 toll-like receptor 2 0.015
Cd86 CD86 molecule 0.012
Slamf9 SLAM family member 9 0.011
Aga aspartylglucosaminidase 0.011
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.011
Lpl lipoprotein lipase 0.011
LOC24906 RoBo-1 0.011
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.010
Hcls1 hematopoietic cell specific Lyn substrate 1 0.010
Parp9 poly (ADP-ribose) polymerase family, member 9 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism