The network for 'biomineral tissue development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

biomineral tissue development

Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation.

Mus musculus
Name Description Probability Func Analog Organism
Fgf8 fibroblast growth factor 8 0.965
Tbx3 T-box 3 0.875
Bmp4 bone morphogenetic protein 4 0.853
Tgfbr2 transforming growth factor, beta receptor II 0.850
Dlx5 distal-less homeobox 5 0.845
Nodal nodal 0.840
Col1a1 collagen, type I, alpha 1 0.829
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.823
Prrx2 paired related homeobox 2 0.815
Pax8 paired box gene 8 0.788
Pthlh parathyroid hormone-like peptide 0.779
Bcl2 B-cell leukemia/lymphoma 2 0.758
Gdf3 growth differentiation factor 3 0.735
Smo smoothened homolog (Drosophila) 0.725
Runx2 runt related transcription factor 2 0.724
Scn5a sodium channel, voltage-gated, type V, alpha 0.720
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.700
Wt1 Wilms tumor 1 homolog 0.690
Nos3 nitric oxide synthase 3, endothelial cell 0.649
Pax2 paired box gene 2 0.648
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.631
Hic1 hypermethylated in cancer 1 0.620
Prrx1 paired related homeobox 1 0.590
Amelx amelogenin X chromosome 0.585
Fgfr2 fibroblast growth factor receptor 2 0.581
Fgf10 fibroblast growth factor 10 0.581
Hand1 heart and neural crest derivatives expressed transcript 1 0.571
Gata6 GATA binding protein 6 0.564
Gli2 GLI-Kruppel family member GLI2 0.563
Fgf4 fibroblast growth factor 4 0.545
Lhx6 LIM homeobox protein 6 0.544
Nf1 neurofibromatosis 1 0.532
Lum lumican 0.529
Alx4 aristaless-like homeobox 4 0.500
Smad6 MAD homolog 6 (Drosophila) 0.476
Lepr leptin receptor 0.450
Smad3 MAD homolog 3 (Drosophila) 0.449
Alx3 aristaless-like homeobox 3 0.416
Gata4 GATA binding protein 4 0.408
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.399
Fgfr1 fibroblast growth factor receptor 1 0.385
Bgn biglycan 0.379
Ret ret proto-oncogene 0.368
Gli1 GLI-Kruppel family member GLI1 0.338
Mmp2 matrix metallopeptidase 2 0.331
Wnt6 wingless-related MMTV integration site 6 0.328
Apc adenomatosis polyposis coli 0.323
Shh sonic hedgehog 0.322
Tgfb2 transforming growth factor, beta 2 0.320
Sox9 SRY-box containing gene 9 0.319
Eln elastin 0.313
Bmp5 bone morphogenetic protein 5 0.305
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.302
Fgfr3 fibroblast growth factor receptor 3 0.298
Loxl1 lysyl oxidase-like 1 0.290
Tgfb3 transforming growth factor, beta 3 0.290
Lhx1 LIM homeobox protein 1 0.288
Ltbp2 latent transforming growth factor beta binding protein 2 0.268
Hoxa1 homeobox A1 0.267
Fut1 fucosyltransferase 1 0.256
Sall1 sal-like 1 (Drosophila) 0.252
Bdkrb2 bradykinin receptor, beta 2 0.250
Smad7 MAD homolog 7 (Drosophila) 0.247
Hoxb1 homeobox B1 0.245
Hoxd13 homeobox D13 0.239
Sall4 sal-like 4 (Drosophila) 0.237
Lmx1a LIM homeobox transcription factor 1 alpha 0.231
Tgfb1i1 transforming growth factor beta 1 induced transcript 1 0.228
Tpo thyroid peroxidase 0.225
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.214
Aebp1 AE binding protein 1 0.214
Bmp2 bone morphogenetic protein 2 0.213
Il6st interleukin 6 signal transducer 0.211
Islr immunoglobulin superfamily containing leucine-rich repeat 0.207
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.206
Col1a2 collagen, type I, alpha 2 0.202
Gpc3 glypican 3 0.201
Pitx3 paired-like homeodomain transcription factor 3 0.198
Esr1 estrogen receptor 1 (alpha) 0.197
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.196
Fgf3 fibroblast growth factor 3 0.195
Inhba inhibin beta-A 0.194
Pou3f1 POU domain, class 3, transcription factor 1 0.192
Foxf1a forkhead box F1a 0.191
Hba-x hemoglobin X, alpha-like embryonic chain in Hba complex 0.190
Tbx5 T-box 5 0.188
Pax9 paired box gene 9 0.187
Nanog Nanog homeobox 0.187
Zic3 zinc finger protein of the cerebellum 3 0.186
Foxh1 forkhead box H1 0.185
Lep leptin 0.185
Drd2 dopamine receptor D2 0.184
Smad4 MAD homolog 4 (Drosophila) 0.184
Smad1 MAD homolog 1 (Drosophila) 0.182
Hand2 heart and neural crest derivatives expressed transcript 2 0.181
Tbx2 T-box 2 0.179
Pten phosphatase and tensin homolog 0.178
Thrb thyroid hormone receptor beta 0.177
Msx1 homeobox, msh-like 1 0.177
Fmod fibromodulin 0.176
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.738
bmp4 bone morphogenetic protein 4 0.469
col10a1 collagen, type X, alpha 1 0.399
col5a1 procollagen, type V, alpha 1 0.353
acvr2b activin receptor IIb 0.254
mmp15b matrix metallopeptidase 15b 0.209
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.142
spry4 sprouty (Drosophila) homolog 4 0.112
prdm5 PR domain containing 5 0.112
irf6 interferon regulatory factor 6 0.105
col1a2 collagen, type I, alpha 2 0.104
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.092
trim71 tripartite motif-containing 71 0.091
fn1 fibronectin 1 0.080
rargb retinoic acid receptor, gamma b 0.073
mecom MDS1 and EVI1 complex locus 0.073
col5a2l collagen, type V, alpha 2-like 0.070
acvr2a activin receptor IIa 0.066
runx1 runt-related transcription factor 1 0.065
bmp2a bone morphogenetic protein 2a 0.061
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.060
axin1 axin 1 0.060
rxraa retinoid X receptor, alpha a 0.055
robo3 roundabout homolog 3 0.051
LOC100536439 parathyroid hormone-related protein-like 0.050
zgc:111821 zgc:111821 0.049
tjp1 tight junction protein 1 (zona occludens 1) 0.049
dlx4a distal-less homeobox gene 4a 0.048
LOC100002342 carboxypeptidase A6-like 0.047
foxe1 forkhead box E1 (thyroid transcription factor 2) 0.046
unc5c unc-5 homolog C (C. elegans) 0.043
cmyb transcription factor cmyb 0.043
wnt5b wingless-type MMTV integration site family, member 5b 0.037
bon bonnie and clyde 0.037
sec31a sec31 homolog A (S. cerevisiae) 0.037
smoc2 secreted modular calcium binding protein 2 0.037
wnt10a wingless-type MMTV integration site family, member 10a 0.037
ntla no tail a 0.036
pkd2 polycystic kidney disease 2 0.036
dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.036
gpr126 G protein-coupled receptor 126 0.035
tbx5a T-box 5a 0.035
egr2b early growth response 2b 0.034
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.034
dlx5a distal-less homeobox gene 5a 0.033
cdh2 cadherin 2, neuronal 0.033
mmp9 matrix metalloproteinase 9 0.033
tnnt2a troponin T2a, cardiac 0.032
mgp matrix Gla protein 0.032
mtp microsomal triglyceride transfer protein 0.032
dusp6 dual specificity phosphatase 6 0.032
chpf chondroitin polymerizing factor 0.032
hoxa13b homeo box A13b 0.031
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.030
LOC556849 ectonucleoside triphosphate diphosphohydrolase 5-like 0.030
ptpra protein tyrosine phosphatase, receptor type, A 0.030
prmt1 protein arginine methyltransferase 1 0.030
fgfr3 fibroblast growth factor receptor 3 0.030
enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.029
disp1 dispatched homolog 1 (Drosophila) 0.029
zgc:77051 zgc:77051 0.029
twist2 twist2 0.029
col11a2 collagen type XI alpha-2 0.028
tbx1 T-box 1 0.028
msxd muscle segment homeobox D 0.027
hhex hematopoietically expressed homeobox 0.027
surf4l surfeit gene 4, like 0.027
vcanb versican b 0.027
tp63 tumor protein p63 0.026
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.026
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.025
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.025
xylt1 xylosyltransferase 1 0.025
acvr1l activin A receptor, type I like 0.024
tuba8l3 tubulin, alpha 8 like 3 0.024
fzd7a frizzled homolog 7a 0.024
sox11b SRY-box containing gene 11b 0.023
spns2 spinster homolog 2 (Drosophila) 0.023
foxi1 forkhead box I1 0.023
raraa retinoic acid receptor, alpha a 0.023
smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.023
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.023
vmhc ventricular myosin heavy chain 0.022
jag1b jagged 1b 0.022
nog3 noggin 3 0.022
itga3b integrin, alpha 3b 0.022
mapk6 mitogen-activated protein kinase 6 0.021
ntn2 netrin 2 0.021
wnt11r wingless-type MMTV integration site family, member 11, related 0.021
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.021
plod2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.021
lats1 LATS, large tumor suppressor, homolog 1 (Drosophila) 0.021
smad9 MAD homolog 9 (Drosophila) 0.021
appb amyloid beta (A4) precursor protein b 0.020
aqp1a.1 aquaporin 1a, tandem duplicate 1 0.020
bcl2 B-cell leukemia/lymphoma 2 0.019
tmem2 transmembrane protein 2 0.019
fgf20a fibroblast growth factor 20a 0.019
gata5 GATA-binding protein 5 0.019
ambpl alpha-1-microglobulin/bikunin precursor, like 0.018
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CCR5 chemokine (C-C motif) receptor 5 0.999
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.985
COL1A1 collagen, type I, alpha 1 0.968
TGFB1 transforming growth factor, beta 1 0.947
COL6A1 collagen, type VI, alpha 1 0.850
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.820
FSTL1 follistatin-like 1 0.799
IL8 interleukin 8 0.779
DCN decorin 0.739
COL3A1 collagen, type III, alpha 1 0.713
CCL5 chemokine (C-C motif) ligand 5 0.676
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.610
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.602
SMAD7 SMAD family member 7 0.599
ENG endoglin 0.592
TGFB3 transforming growth factor, beta 3 0.583
CCL4 chemokine (C-C motif) ligand 4 0.557
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.524
FGF1 fibroblast growth factor 1 (acidic) 0.515
FKBP1A FK506 binding protein 1A, 12kDa 0.475
TJP1 tight junction protein 1 (zona occludens 1) 0.475
BMPR1A bone morphogenetic protein receptor, type IA 0.470
IL6 interleukin 6 (interferon, beta 2) 0.413
CCL22 chemokine (C-C motif) ligand 22 0.406
CXCL9 chemokine (C-X-C motif) ligand 9 0.394
BMPR1B bone morphogenetic protein receptor, type IB 0.383
COL5A2 collagen, type V, alpha 2 0.366
COL1A2 collagen, type I, alpha 2 0.358
BMP2 bone morphogenetic protein 2 0.334
LOX lysyl oxidase 0.291
ELN elastin 0.291
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.278
CCR7 chemokine (C-C motif) receptor 7 0.274
CXCL12 chemokine (C-X-C motif) ligand 12 0.253
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.243
GDF5 growth differentiation factor 5 0.235
HDAC4 histone deacetylase 4 0.233
IFNG interferon, gamma 0.231
DPT dermatopontin 0.222
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.209
PVRL4 poliovirus receptor-related 4 0.207
POSTN periostin, osteoblast specific factor 0.202
FGF10 fibroblast growth factor 10 0.200
COL18A1 collagen, type XVIII, alpha 1 0.177
COL6A2 collagen, type VI, alpha 2 0.175
KDM2B lysine (K)-specific demethylase 2B 0.173
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.172
COL5A1 collagen, type V, alpha 1 0.165
CCL11 chemokine (C-C motif) ligand 11 0.155
CCR4 chemokine (C-C motif) receptor 4 0.155
NCOR2 nuclear receptor corepressor 2 0.154
CCL13 chemokine (C-C motif) ligand 13 0.147
PCGF1 polycomb group ring finger 1 0.134
ARRDC3 arrestin domain containing 3 0.134
CXCL13 chemokine (C-X-C motif) ligand 13 0.134
MXRA5 matrix-remodelling associated 5 0.134
IRF4 interferon regulatory factor 4 0.129
CCL7 chemokine (C-C motif) ligand 7 0.122
FGF21 fibroblast growth factor 21 0.122
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.118
CCL20 chemokine (C-C motif) ligand 20 0.118
WISP1 WNT1 inducible signaling pathway protein 1 0.118
COL6A3 collagen, type VI, alpha 3 0.115
PLXDC1 plexin domain containing 1 0.115
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.111
GATA2 GATA binding protein 2 0.106
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.106
VCAN versican 0.105
CCL3 chemokine (C-C motif) ligand 3 0.103
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.100
COL2A1 collagen, type II, alpha 1 0.099
PCOLCE procollagen C-endopeptidase enhancer 0.098
COL14A1 collagen, type XIV, alpha 1 0.098
THBS2 thrombospondin 2 0.097
SETD8 SET domain containing (lysine methyltransferase) 8 0.089
ISLR immunoglobulin superfamily containing leucine-rich repeat 0.089
CCL19 chemokine (C-C motif) ligand 19 0.088
IL10 interleukin 10 0.088
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.087
MATK megakaryocyte-associated tyrosine kinase 0.086
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.085
TAL1 T-cell acute lymphocytic leukemia 1 0.085
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.085
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.085
TM4SF1 transmembrane 4 L six family member 1 0.084
CCL2 chemokine (C-C motif) ligand 2 0.083
TGFBR1 transforming growth factor, beta receptor 1 0.082
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.082
WNT2 wingless-type MMTV integration site family member 2 0.082
ADAM12 ADAM metallopeptidase domain 12 0.081
FOXF2 forkhead box F2 0.080
PTGIS prostaglandin I2 (prostacyclin) synthase 0.079
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.079
OLFML3 olfactomedin-like 3 0.079
LUM lumican 0.078
MMP11 matrix metallopeptidase 11 (stromelysin 3) 0.076
DPP4 dipeptidyl-peptidase 4 0.075
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.074
FGF7 fibroblast growth factor 7 0.074
IL2RB interleukin 2 receptor, beta 0.070
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col5a1 collagen, type V, alpha 1 0.075
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.026
Soat1 sterol O-acyltransferase 1 0.022
Vcan versican 0.022
Smad7 SMAD family member 7 0.019
Alas2 aminolevulinate, delta-, synthase 2 0.018
Fgfr1 Fibroblast growth factor receptor 1 0.017
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.015
Fbn1 fibrillin 1 0.015
Jak1 Janus kinase 1 0.015
Lox lysyl oxidase 0.014
Pspn persephin 0.013
Cd44 Cd44 molecule 0.013
Col3a1 collagen, type III, alpha 1 0.013
Gna15 guanine nucleotide binding protein, alpha 15 0.013
Aspn asporin 0.012
Slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 0.012
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.011
Jak2 Janus kinase 2 0.011
Lig3 ligase III, DNA, ATP-dependent 0.011
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.011
Dlg3 discs, large homolog 3 (Drosophila) 0.010
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.010
Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism