The network for 'positive regulation of hormone secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of hormone secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.

Mus musculus
Name Description Probability Func Analog Organism
Nos3 nitric oxide synthase 3, endothelial cell 0.825
Bglap bone gamma carboxyglutamate protein 0.813
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.737
C1qa complement component 1, q subcomponent, alpha polypeptide 0.719
Nf1 neurofibromatosis 1 0.637
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.622
Sox11 SRY-box containing gene 11 0.595
Eda ectodysplasin-A 0.565
Aldoa aldolase A, fructose-bisphosphate 0.555
Ret ret proto-oncogene 0.532
Bglap2 bone gamma-carboxyglutamate protein 2 0.523
Lef1 lymphoid enhancer binding factor 1 0.479
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.460
Tnf tumor necrosis factor 0.443
Zeb1 zinc finger E-box binding homeobox 1 0.422
Fshr follicle stimulating hormone receptor 0.419
Bmp4 bone morphogenetic protein 4 0.369
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.367
Arrb1 arrestin, beta 1 0.328
Irs2 insulin receptor substrate 2 0.322
Ldb3 LIM domain binding 3 0.316
Lta lymphotoxin A 0.312
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.308
Ikzf1 IKAROS family zinc finger 1 0.306
Ltb lymphotoxin B 0.295
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.290
Esr1 estrogen receptor 1 (alpha) 0.286
Prlr prolactin receptor 0.277
Lepr leptin receptor 0.272
Socs1 suppressor of cytokine signaling 1 0.270
Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 0.259
Ednrb endothelin receptor type B 0.251
Gck glucokinase 0.250
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.248
Pkm2 pyruvate kinase, muscle 0.246
Cd40 CD40 antigen 0.242
Lep leptin 0.239
Epor erythropoietin receptor 0.236
Hand1 heart and neural crest derivatives expressed transcript 1 0.234
Cxcl13 chemokine (C-X-C motif) ligand 13 0.224
Pdx1 pancreatic and duodenal homeobox 1 0.224
Barx2 BarH-like homeobox 2 0.221
Traf6 TNF receptor-associated factor 6 0.221
Gprc6a G protein-coupled receptor, family C, group 6, member A 0.218
Ppy pancreatic polypeptide 0.217
Src Rous sarcoma oncogene 0.215
Wwox WW domain-containing oxidoreductase 0.210
Tcf7 transcription factor 7, T-cell specific 0.209
Arrb2 arrestin, beta 2 0.204
Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C 0.203
Pthlh parathyroid hormone-like peptide 0.202
Coro1b coronin, actin binding protein 1B 0.197
Bsg basigin 0.194
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.191
Gpi1 glucose phosphate isomerase 1 0.190
Hprt hypoxanthine guanine phosphoribosyl transferase 0.187
Ghr growth hormone receptor 0.181
Kl klotho 0.180
Azgp1 alpha-2-glycoprotein 1, zinc 0.177
Lmx1b LIM homeobox transcription factor 1 beta 0.176
Igh immunoglobulin heavy chain complex 0.176
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.175
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.163
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.160
Adra2a adrenergic receptor, alpha 2a 0.159
Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 0.157
Olfr71 olfactory receptor 71 0.153
Tox thymocyte selection-associated high mobility group box 0.152
Lhx3 LIM homeobox protein 3 0.150
Adra2b adrenergic receptor, alpha 2b 0.149
Cxcr5 chemokine (C-X-C motif) receptor 5 0.148
Wnt4 wingless-related MMTV integration site 4 0.146
Meox2 mesenchyme homeobox 2 0.145
Ntf3 neurotrophin 3 0.144
Pigr polymeric immunoglobulin receptor 0.144
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.143
Atoh7 atonal homolog 7 (Drosophila) 0.140
Krt72-ps keratin 72, pseudogene 0.135
Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 0.134
Fgf23 fibroblast growth factor 23 0.134
Nkx6-1 NK6 homeobox 1 0.133
Sox4 SRY-box containing gene 4 0.132
Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 0.129
Akr1c6 aldo-keto reductase family 1, member C6 0.129
Sox2 SRY-box containing gene 2 0.129
Fgf8 fibroblast growth factor 8 0.129
Ifng interferon gamma 0.129
Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.129
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.127
Otp orthopedia homolog (Drosophila) 0.125
Gata4 GATA binding protein 4 0.125
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.124
Hrg histidine-rich glycoprotein 0.121
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.119
Cyp2c39 cytochrome P450, family 2, subfamily c, polypeptide 39 0.117
Ins2 insulin II 0.117
Isl1 ISL1 transcription factor, LIM/homeodomain 0.116
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.116
Cyp3a25 cytochrome P450, family 3, subfamily a, polypeptide 25 0.114
Amh anti-Mullerian hormone 0.114
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
cyp-35A2 Protein CYP-35A2 0.416
cyp-35C1 Protein CYP-35C1 0.103
cyp-35A4 Protein CYP-35A4 0.085
CELE_C08E8.4 Protein C08E8.4 0.029
oac-46 Protein OAC-46 0.027
CELE_C29F7.2 Protein C29F7.2 0.027
cyp-35A3 Protein CYP-35A3 0.026
cyp-33C9 Protein CYP-33C9 0.023
unc-43 Protein UNC-43 0.022
cyp-35A5 Protein CYP-35A5 0.022
F08G5.6 Protein F08G5.6 0.021
ugt-22 Protein UGT-22 0.020
gpd-3 Protein GPD-3 0.019
T16G1.6 Protein T16G1.6 0.019
unc-32 Protein UNC-32 0.019
W01A11.1 Protein W01A11.1 0.017
ugt-16 Protein UGT-16 0.017
pkg-1 Protein PKG-1 0.016
ist-1 Protein IST-1 0.015
lit-1 Protein LIT-1 0.015
rrc-1 Protein RRC-1 0.015
got-2.2 Protein GOT-2.2 0.015
C27B7.7 Protein C27B7.7 0.014
CELE_F27D4.6 Protein F27D4.6 0.014
dyf-11 Protein DYF-11 0.013
nhr-220 Protein NHR-220 0.013
acs-1 Protein ACS-1 0.013
C34D10.1 Protein C34D10.1 0.013
cdr-1 Protein CDR-1 0.013
cyp-33E1 Protein CYP-33E1 0.013
inx-19 Protein INX-19 0.013
F35G2.5 Protein F35G2.5 0.013
F13H6.3 Protein F13H6.3 0.013
CELE_B0238.1 Protein B0238.1 0.013
act-3 Protein ACT-3 0.013
D2013.6 Protein D2013.6 0.013
CELE_Y57G11C.15 Protein Y57G11C.15 0.012
pyc-1 Protein PYC-1 0.012
F58B4.5 Protein F58B4.5 0.012
gei-18 Protein GEI-18 0.012
C29F3.7 Protein C29F3.7 0.012
CELE_C08F11.3 Protein C08F11.3 0.012
unc-80 Protein UNC-80 0.012
asm-3 Protein ASM-3 0.012
pxd-1 Protein PXD-1 0.012
grd-12 Protein GRD-12 0.011
unc-9 Protein UNC-9 0.011
T02B5.3 Protein T02B5.3 0.011
lin-11 Protein LIN-11 0.011
F21A3.2 Protein F21A3.2 0.011
cyp-33C4 Protein CYP-33C4 0.011
pcca-1 Protein PCCA-1 0.011
nhr-206 Protein NHR-206 0.011
F47B8.4 Protein F47B8.4 0.011
arrd-17 Protein ARRD-17 0.011
anc-1 Protein ANC-1 0.011
F46F3.3 Protein F46F3.3 0.011
coq-1 Protein COQ-1 0.011
cyp-35B1 Protein CYP-35B1 0.011
K05B2.4 Protein K05B2.4 0.011
CELE_Y47G6A.18 Protein Y47G6A.18 0.011
F57B10.3 Protein F57B10.3 0.011
unc-47 Protein UNC-47 0.010
F43C11.7 Protein F43C11.7 0.010
ugt-1 Protein UGT-1 0.010
CELE_T19C9.8 Protein T19C9.8 0.010
gst-4 Protein GST-4 0.010
glr-4 Protein GLR-4 0.010
CELE_H25K10.1 Protein H25K10.1 0.010
skr-5 Protein SKR-5 0.010
ugt-9 Protein UGT-9 0.010
eya-1 Protein EYA-1 0.010
glr-1 Protein GLR-1 0.010
nhr-132 Protein NHR-132 0.010
gsp-1 Protein GSP-1 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
ex expanded 0.014
nej nejire 0.013
CG34139 CG34139 gene product from transcript CG34139-RD 0.012
svp seven up 0.012
CG42672 CG42672 gene product from transcript CG42672-RD 0.012
mtt mangetout 0.012
Ipp Inositol polyphosphate 1-phosphatase 0.012
grp grapes 0.011
hth homothorax 0.011
Mekk1 CG7717 gene product from transcript CG7717-RB 0.011
kay kayak 0.011
cad caudal 0.011
Octbeta2R CG33976 gene product from transcript CG33976-RA 0.011
NPFR1 neuropeptide F receptor 0.011
Gr43a Gustatory receptor 43a 0.010
HDAC6 CG6170 gene product from transcript CG6170-RA 0.010
toy twin of eyeless 0.010
rtGEF rho-type guanine exchange factor 0.010
GluRIIA Glutamate receptor IIA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.970
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.946
C1QA complement component 1, q subcomponent, A chain 0.932
TEK TEK tyrosine kinase, endothelial 0.829
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.723
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.681
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.577
INSR insulin receptor 0.575
FGA fibrinogen alpha chain 0.558
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.494
SNAP23 synaptosomal-associated protein, 23kDa 0.494
HLA-DRA major histocompatibility complex, class II, DR alpha 0.470
HLA-DMA major histocompatibility complex, class II, DM alpha 0.412
HCK hemopoietic cell kinase 0.384
FGB fibrinogen beta chain 0.383
IGF1R insulin-like growth factor 1 receptor 0.333
HLA-DMB major histocompatibility complex, class II, DM beta 0.312
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.273
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.200
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.194
HNF4A hepatocyte nuclear factor 4, alpha 0.170
GRB10 growth factor receptor-bound protein 10 0.160
GRB2 growth factor receptor-bound protein 2 0.160
VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.146
CAPNS1 calpain, small subunit 1 0.146
BLNK B-cell linker 0.145
GRB7 growth factor receptor-bound protein 7 0.140
FGG fibrinogen gamma chain 0.140
PSEN2 presenilin 2 (Alzheimer disease 4) 0.131
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.129
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.127
C1QC complement component 1, q subcomponent, C chain 0.125
CLASP1 cytoplasmic linker associated protein 1 0.122
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.119
SNAP25 synaptosomal-associated protein, 25kDa 0.117
SYK spleen tyrosine kinase 0.099
GOLGA2 golgin A2 0.092
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.085
C1QB complement component 1, q subcomponent, B chain 0.081
TTR transthyretin 0.070
CRHR1 corticotropin releasing hormone receptor 1 0.065
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.065
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.064
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.062
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.060
WIPF1 WAS/WASL interacting protein family, member 1 0.058
ADORA2A adenosine A2a receptor 0.057
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.054
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.054
IRS1 insulin receptor substrate 1 0.043
SH2B1 SH2B adaptor protein 1 0.041
SPDEF SAM pointed domain containing ets transcription factor 0.036
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.036
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.034
SMAD2 SMAD family member 2 0.033
APOA1 apolipoprotein A-I 0.033
MARCO macrophage receptor with collagenous structure 0.031
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.031
NCK1 NCK adaptor protein 1 0.029
ESRRG estrogen-related receptor gamma 0.029
IRF2 interferon regulatory factor 2 0.028
SSTR3 somatostatin receptor 3 0.028
YY1 YY1 transcription factor 0.026
RUSC2 RUN and SH3 domain containing 2 0.026
NSF N-ethylmaleimide-sensitive factor 0.025
GLIS2 GLIS family zinc finger 2 0.024
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.024
HIPK2 homeodomain interacting protein kinase 2 0.024
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.023
MYO6 myosin VI 0.023
CREBBP CREB binding protein 0.022
HIC1 hypermethylated in cancer 1 0.021
JAK1 Janus kinase 1 0.020
SSTR2 somatostatin receptor 2 0.020
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.020
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.020
BCR breakpoint cluster region 0.020
PLCG1 phospholipase C, gamma 1 0.019
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.019
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.019
GNMT glycine N-methyltransferase 0.018
MAPK10 mitogen-activated protein kinase 10 0.018
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.018
OCRL oculocerebrorenal syndrome of Lowe 0.018
GAS7 growth arrest-specific 7 0.018
LAT linker for activation of T cells 0.018
FYN FYN oncogene related to SRC, FGR, YES 0.018
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.017
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.017
STAT5B signal transducer and activator of transcription 5B 0.017
DRD2 dopamine receptor D2 0.017
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.017
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.017
EGFR epidermal growth factor receptor 0.016
ITK IL2-inducible T-cell kinase 0.016
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.016
GCKR glucokinase (hexokinase 4) regulator 0.016
SVOP SV2 related protein homolog (rat) 0.016
CCK cholecystokinin 0.016
STAT5A signal transducer and activator of transcription 5A 0.015
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Rattus norvegicus
Name Description Probability Func Analog Organism
Glp1r glucagon-like peptide 1 receptor 0.315
Prss3 protease, serine, 3 0.301
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.254
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.234
G6pc glucose-6-phosphatase, catalytic subunit 0.223
Robo1 roundabout homolog 1 (Drosophila) 0.213
Scn10a sodium channel, voltage-gated, type X, alpha subunit 0.191
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.154
Acrv1 acrosomal vesicle protein 1 0.152
Phkg1 phosphorylase kinase, gamma 1 0.140
Il4 interleukin 4 0.137
Ush1c Usher syndrome 1C homolog (human) 0.133
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.129
Plin perilipin 0.128
Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.116
Th tyrosine hydroxylase 0.110
Tff3 trefoil factor 3, intestinal 0.108
Prlhr prolactin releasing hormone receptor 0.106
Mamdc4 MAM domain containing 4 0.103
Gad2 glutamate decarboxylase 2 0.102
Mlxipl MLX interacting protein-like 0.098
Crhbp corticotropin releasing hormone binding protein 0.097
Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) 0.094
Acsl4 acyl-CoA synthetase long-chain family member 4 0.092
Btc betacellulin 0.090
Slc5a2 solute carrier family 5 (sodium/glucose cotransporter), member 2 0.088
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.088
Htr3a 5-hydroxytryptamine (serotonin) receptor 3a 0.086
Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 0.084
Hcrtr1 hypocretin (orexin) receptor 1 0.084
Casp3 caspase 3 0.084
Clcnka chloride channel Ka 0.083
Cnga1 cyclic nucleotide gated channel alpha 1 0.079
Rbp3 retinol binding protein 3, interstitial 0.076
Insr insulin receptor 0.076
Tnp1 transition protein 1 0.075
Htr1b 5-hydroxytryptamine (serotonin) receptor 1B 0.074
Bcan brevican 0.074
Il1r1 interleukin 1 receptor, type I 0.072
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.072
Itih4 inter alpha-trypsin inhibitor, heavy chain 4 0.072
Aqp2 aquaporin 2 (collecting duct) 0.071
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.070
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.069
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.068
Apoa4 apolipoprotein A-IV 0.067
Rgs9 regulator of G-protein signaling 9 0.067
Gal galanin prepropeptide 0.067
Nrg1 neuregulin 1 0.066
Hcrt hypocretin 0.066
Ppara peroxisome proliferator activated receptor alpha 0.066
Iapp islet amyloid polypeptide 0.065
Prlr prolactin receptor 0.064
Htr2a 5-hydroxytryptamine (serotonin) receptor 2A 0.064
Trhr thyrotropin releasing hormone receptor 0.063
Olr1496 olfactory receptor 1496 0.063
Il9r interleukin 9 receptor 0.063
Necab2 N-terminal EF-hand calcium binding protein 2 0.062
Grk1 G protein-coupled receptor kinase 1 0.060
Csf1 colony stimulating factor 1 (macrophage) 0.060
Hand2 heart and neural crest derivatives expressed 2 0.060
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.060
Svs3a seminal vesicle secretory protein 3A 0.060
Csn2 casein beta 0.059
Cga glycoprotein hormones, alpha polypeptide 0.059
Smgb neonatal submandibular gland protein B 0.058
Phox2a paired-like homeobox 2a 0.058
Hrh3 histamine receptor H3 0.058
F2rl1 coagulation factor II (thrombin) receptor-like 1 0.058
Pzp pregnancy-zone protein 0.058
Esr2 estrogen receptor 2 (ER beta) 0.058
Chrm2 cholinergic receptor, muscarinic 2 0.058
Itgb7 integrin, beta 7 0.057
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.057
Pcsk1 proprotein convertase subtilisin/kexin type 1 0.056
Alb albumin 0.056
Dll3 delta-like 3 (Drosophila) 0.056
Dnase1 deoxyribonuclease I 0.055
Capn9 calpain 9 0.055
Hcrtr2 hypocretin (orexin) receptor 2 0.055
Vom2r53 vomeronasal 2 receptor, 53 0.054
Nfasc neurofascin 0.054
Actr2 ARP2 actin-related protein 2 homolog (yeast) 0.054
Kiss1r KISS1 receptor 0.054
Fgf2 fibroblast growth factor 2 0.053
Kcnmb1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 0.053
Ins2 insulin 2 0.053
Prph2 peripherin 2 0.053
Smcp sperm mitochondria-associated cysteine-rich protein 0.053
Hr hairless 0.052
Ces1c carboxylesterase 1C 0.052
Sst somatostatin 0.051
Acaa1b acetyl-Coenzyme A acyltransferase 1B 0.051
Tshb thyroid stimulating hormone, beta 0.050
Faslg Fas ligand (TNF superfamily, member 6) 0.050
Cryba2 crystallin, beta A2 0.049
Ube2d4 ubiquitin-conjugating enzyme E2D 4 0.049
Abhd4 abhydrolase domain containing 4 0.049
Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 0.048
Ncan neurocan 0.048
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism