The network for 'regulation of fever generation by regulation of prostaglandin secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of fever generation by regulation of prostaglandin secretion

Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell.

Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 0.997
Lta lymphotoxin A 0.982
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.973
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.963
Ifng interferon gamma 0.893
Il10 interleukin 10 0.846
Ltb lymphotoxin B 0.640
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.499
Cd19 CD19 antigen 0.474
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.284
Cd40 CD40 antigen 0.173
Cxcl13 chemokine (C-X-C motif) ligand 13 0.172
Il7 interleukin 7 0.161
Ikzf1 IKAROS family zinc finger 1 0.110
Il4 interleukin 4 0.107
Cxcr5 chemokine (C-X-C motif) receptor 5 0.105
Il6 interleukin 6 0.101
Nos2 nitric oxide synthase 2, inducible 0.080
Ccl2 chemokine (C-C motif) ligand 2 0.076
Bcl3 B-cell leukemia/lymphoma 3 0.073
Csf1 colony stimulating factor 1 (macrophage) 0.064
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.063
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.059
Igh immunoglobulin heavy chain complex 0.051
Gpr132 G protein-coupled receptor 132 0.051
Tox thymocyte selection-associated high mobility group box 0.049
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.042
Ccl4 chemokine (C-C motif) ligand 4 0.041
Socs1 suppressor of cytokine signaling 1 0.038
Icos inducible T-cell co-stimulator 0.035
Ptgs2 prostaglandin-endoperoxide synthase 2 0.034
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.034
Cd40lg CD40 ligand 0.034
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.033
Il1r1 interleukin 1 receptor, type I 0.030
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.027
Btk Bruton agammaglobulinemia tyrosine kinase 0.026
Traf6 TNF receptor-associated factor 6 0.026
Fas Fas (TNF receptor superfamily member 6) 0.025
Il2 interleukin 2 0.024
Il1b interleukin 1 beta 0.024
Pou2af1 POU domain, class 2, associating factor 1 0.021
Il1rn interleukin 1 receptor antagonist 0.020
Traf2 TNF receptor-associated factor 2 0.020
Tlr4 toll-like receptor 4 0.020
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.020
Irg1 immunoresponsive gene 1 0.019
Il2rg interleukin 2 receptor, gamma chain 0.018
Il12b interleukin 12b 0.017
Ubd ubiquitin D 0.017
Spp1 secreted phosphoprotein 1 0.016
Rel reticuloendotheliosis oncogene 0.015
Prf1 perforin 1 (pore forming protein) 0.015
Ikbkg inhibitor of kappaB kinase gamma 0.014
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.014
Cd28 CD28 antigen 0.014
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.014
Gzmb granzyme B 0.014
Pdcd1 programmed cell death 1 0.013
Ccr7 chemokine (C-C motif) receptor 7 0.013
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.013
Cd160 CD160 antigen 0.012
Myd88 myeloid differentiation primary response gene 88 0.012
Batf2 basic leucine zipper transcription factor, ATF-like 2 0.012
Cxcl2 chemokine (C-X-C motif) ligand 2 0.012
Bcl6 B-cell leukemia/lymphoma 6 0.011
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.011
Itk IL2-inducible T-cell kinase 0.011
Tnfsf8 tumor necrosis factor (ligand) superfamily, member 8 0.011
Cd80 CD80 antigen 0.010
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.010
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism