IMP

Process View

Homo sapiens

19 genes annotated in human

cell migration involved in sprouting angiogenesis

GO:0002042

The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cell migration involved in sprouting angiogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cell migration involved in sprouting angiogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
JAG1	jagged 1	1.000	Human
VEGFA	vascular endothelial growth factor A	1.000
FGFR2	fibroblast growth factor receptor 2	0.999
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.999
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.999
NOTCH1	notch 1	0.999
EGR1	early growth response 1	0.995	Human
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.992	Mouse
NOTCH3	notch 3	0.937	Human
KLF4	Kruppel-like factor 4 (gut)	0.936
NRP1	neuropilin 1	0.936	Mouse
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.924
EGR3	early growth response 3	0.889
FGFR1	fibroblast growth factor receptor 1	0.885
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.882
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.867	Human
ENG	endoglin	0.865
NCOR2	nuclear receptor corepressor 2	0.859
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.817	Mouse
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.815
FGF1	fibroblast growth factor 1 (acidic)	0.811	Human
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.723
EGR2	early growth response 2	0.696	Human
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.678	Human
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.652	Human
PLCG1	phospholipase C, gamma 1	0.650
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.637
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.589
JUN	jun proto-oncogene	0.572
IER2	immediate early response 2	0.515
LCK	lymphocyte-specific protein tyrosine kinase	0.482
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.456
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.420
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.381
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.364
DUSP1	dual specificity phosphatase 1	0.356
MEF2C	myocyte enhancer factor 2C	0.337
EFNA1	ephrin-A1	0.314
CD247	CD247 molecule	0.279
BCL6	B-cell CLL/lymphoma 6	0.271
EFNA5	ephrin-A5	0.261	Human
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.242
GRB7	growth factor receptor-bound protein 7	0.239
CYR61	cysteine-rich, angiogenic inducer, 61	0.228
CTGF	connective tissue growth factor	0.226
FN1	fibronectin 1	0.216	Zebrafish
HSPG2	heparan sulfate proteoglycan 2	0.209
EPHA7	EPH receptor A7	0.201	Human
DLL1	delta-like 1 (Drosophila)	0.200	Human
KLF6	Kruppel-like factor 6	0.195	Human
ATF3	activating transcription factor 3	0.194
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.175	Zebrafish
THBS1	thrombospondin 1	0.157
FGF10	fibroblast growth factor 10	0.154	Human
LAT	linker for activation of T cells	0.148
FGF7	fibroblast growth factor 7	0.147	Human
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.144
FAF1	Fas (TNFRSF6) associated factor 1	0.137
FBLN1	fibulin 1	0.133
FOSL2	FOS-like antigen 2	0.130
FHL2	four and a half LIM domains 2	0.125
JAG2	jagged 2	0.122	Human
MAPK7	mitogen-activated protein kinase 7	0.117
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.103
MKL1	megakaryoblastic leukemia (translocation) 1	0.100
HES1	hairy and enhancer of split 1, (Drosophila)	0.097
PSEN2	presenilin 2 (Alzheimer disease 4)	0.097
NOTCH2	notch 2	0.096	Human
PGF	placental growth factor	0.087	Human
EGFR	epidermal growth factor receptor	0.087
FLNA	filamin A, alpha	0.086
PXN	paxillin	0.084
JUNB	jun B proto-oncogene	0.079
CPE	carboxypeptidase E	0.076
ZNF746	zinc finger protein 746	0.075
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.072
TGFB1	transforming growth factor, beta 1	0.071
HDAC4	histone deacetylase 4	0.071	Human
LTBP4	latent transforming growth factor beta binding protein 4	0.065
EFNB2	ephrin-B2	0.065
PDGFA	platelet-derived growth factor alpha polypeptide	0.061	Human
PDGFC	platelet derived growth factor C	0.061
ITGA6	integrin, alpha 6	0.061
NCK2	NCK adaptor protein 2	0.060
ATN1	atrophin 1	0.058
GEM	GTP binding protein overexpressed in skeletal muscle	0.057
FLT4	fms-related tyrosine kinase 4	0.056
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.056
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.055
EHMT2	euchromatic histone-lysine N-methyltransferase 2	0.054
FOXP3	forkhead box P3	0.053
EMP1	epithelial membrane protein 1	0.052
GDF9	growth differentiation factor 9	0.048
BTG2	BTG family, member 2	0.048
ZNF331	zinc finger protein 331	0.047
GFI1B	growth factor independent 1B transcription repressor	0.047
MYOCD	myocardin	0.046
EPHA3	EPH receptor A3	0.042	Human
MAML1	mastermind-like 1 (Drosophila)	0.041
VEGFC	vascular endothelial growth factor C	0.041	Human
PTPRB	protein tyrosine phosphatase, receptor type, B	0.041
SLIT2	slit homolog 2 (Drosophila)	0.040
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.040
COL6A1	collagen, type VI, alpha 1	0.039
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.038
NRP2	neuropilin 2	0.037
TGFB2	transforming growth factor, beta 2	0.037
RHOB	ras homolog gene family, member B	0.036
COL5A1	collagen, type V, alpha 1	0.036
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.036
SIK1	salt-inducible kinase 1	0.035
LDLR	low density lipoprotein receptor	0.035
TLN1	talin 1	0.035
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.035
RGS2	regulator of G-protein signaling 2, 24kDa	0.033
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.033
PPP1R15A	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.032
EGFL7	EGF-like-domain, multiple 7	0.032
PGR	progesterone receptor	0.032
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.031
MARK2	MAP/microtubule affinity-regulating kinase 2	0.031
ASRGL1	asparaginase like 1	0.031
FGF2	fibroblast growth factor 2 (basic)	0.030
EPHB3	EPH receptor B3	0.030	Human
COL1A1	collagen, type I, alpha 1	0.030
STC1	stanniocalcin 1	0.029
CD63	CD63 molecule	0.029
SNAI1	snail homolog 1 (Drosophila)	0.028
COL2A1	collagen, type II, alpha 1	0.027
IRS2	insulin receptor substrate 2	0.027
XIAP	X-linked inhibitor of apoptosis	0.026
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.026
BHLHE40	basic helix-loop-helix family, member e40	0.025
TNC	tenascin C	0.025
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.025
MYOG	myogenin (myogenic factor 4)	0.025
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.025
CDH5	cadherin 5, type 2 (vascular endothelium)	0.025
FGFR3	fibroblast growth factor receptor 3	0.024
MEF2A	myocyte enhancer factor 2A	0.023
DUSP2	dual specificity phosphatase 2	0.023
TIMP3	TIMP metallopeptidase inhibitor 3	0.023
DPP4	dipeptidyl-peptidase 4	0.023
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.023
TGFB3	transforming growth factor, beta 3	0.022
SGK1	serum/glucocorticoid regulated kinase 1	0.022
HBEGF	heparin-binding EGF-like growth factor	0.022
HDAC3	histone deacetylase 3	0.022
RDH11	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	0.022
ANXA1	annexin A1	0.021
BBS10	Bardet-Biedl syndrome 10	0.021
VCL	vinculin	0.021
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.021
COL4A1	collagen, type IV, alpha 1	0.020
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.020
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.019
THBD	thrombomodulin	0.019
FZD4	frizzled homolog 4 (Drosophila)	0.019
UBASH3B	ubiquitin associated and SH3 domain containing B	0.019
NOTCH4	notch 4	0.019	Human
KLF2	Kruppel-like factor 2 (lung)	0.018	Human
DCN	decorin	0.018
CD9	CD9 molecule	0.018
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.018
CD34	CD34 molecule	0.018
CSRNP1	cysteine-serine-rich nuclear protein 1	0.018
SEMA3F	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.018
PDE4B	phosphodiesterase 4B, cAMP-specific	0.018
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.018
SOX11	SRY (sex determining region Y)-box 11	0.018
EPHB2	EPH receptor B2	0.017	Human
STX5	syntaxin 5	0.017
PRKD2	protein kinase D2	0.017
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.017
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.017
DUSP6	dual specificity phosphatase 6	0.017
DUSP5	dual specificity phosphatase 5	0.017
BMP4	bone morphogenetic protein 4	0.016
NOV	nephroblastoma overexpressed gene	0.016
CAV1	caveolin 1, caveolae protein, 22kDa	0.016
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.016
NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)	0.016
SOX9	SRY (sex determining region Y)-box 9	0.016
BAD	BCL2-associated agonist of cell death	0.016
EPHA4	EPH receptor A4	0.016	Human
COL1A2	collagen, type I, alpha 2	0.016
ACVRL1	activin A receptor type II-like 1	0.016
AES	amino-terminal enhancer of split	0.015
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.015
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.015
IGFBP3	insulin-like growth factor binding protein 3	0.015
EDN1	endothelin 1	0.015
GATA2	GATA binding protein 2	0.015
SH3BP2	SH3-domain binding protein 2	0.015
MMP19	matrix metallopeptidase 19	0.015
IGF1	insulin-like growth factor 1 (somatomedin C)	0.014
EMCN	endomucin	0.014
MKL2	MKL/myocardin-like 2	0.014
IGFBP5	insulin-like growth factor binding protein 5	0.014
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.014
ERRFI1	ERBB receptor feedback inhibitor 1	0.014
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.014
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.013
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.013
ILK	integrin-linked kinase	0.013
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.013
PDE4D	phosphodiesterase 4D, cAMP-specific	0.013
LAMA4	laminin, alpha 4	0.013
HAS2	hyaluronan synthase 2	0.013
TRAF7	TNF receptor-associated factor 7	0.013
MYOD1	myogenic differentiation 1	0.012
CD83	CD83 molecule	0.012
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.012
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.012	Rat
PTK2	PTK2 protein tyrosine kinase 2	0.012
LMO2	LIM domain only 2 (rhombotin-like 1)	0.012
PCDH9	protocadherin 9	0.012
RND3	Rho family GTPase 3	0.012
SYN2	synapsin II	0.012
SFRP1	secreted frizzled-related protein 1	0.012
PECAM1	platelet/endothelial cell adhesion molecule	0.012
ZNF71	zinc finger protein 71	0.012
RBMS3	RNA binding motif, single stranded interacting protein 3	0.012
ANGPTL2	angiopoietin-like 2	0.012
LTBP2	latent transforming growth factor beta binding protein 2	0.012
ANGPT1	angiopoietin 1	0.012
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.012
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.012
FOXF1	forkhead box F1	0.012
BMP2	bone morphogenetic protein 2	0.012
TRIB1	tribbles homolog 1 (Drosophila)	0.011
CXCL12	chemokine (C-X-C motif) ligand 12	0.011	Zebrafish
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.011
CTBP1	C-terminal binding protein 1	0.011
FGFBP1	fibroblast growth factor binding protein 1	0.011
PER1	period homolog 1 (Drosophila)	0.011
AHNAK	AHNAK nucleoprotein	0.011
S1PR1	sphingosine-1-phosphate receptor 1	0.011
TEK	TEK tyrosine kinase, endothelial	0.011
EPHB4	EPH receptor B4	0.011
TSC2	tuberous sclerosis 2	0.011
CXCL2	chemokine (C-X-C motif) ligand 2	0.011
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.011
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.011	Human
TSC22D3	TSC22 domain family, member 3	0.011
ITGA8	integrin, alpha 8	0.010
TAL1	T-cell acute lymphocytic leukemia 1	0.010
KLF9	Kruppel-like factor 9	0.010
DLL4	delta-like 4 (Drosophila)	0.010
BAIAP2	BAI1-associated protein 2	0.010
SLCO2A1	solute carrier organic anion transporter family, member 2A1	0.010
COL3A1	collagen, type III, alpha 1	0.010
PRRX1	paired related homeobox 1	0.010
MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	0.010
BTG1	B-cell translocation gene 1, anti-proliferative	0.010
GRB10	growth factor receptor-bound protein 10	0.010