IMP

Process View

Homo sapiens

21 genes annotated in human

intrinsic apoptotic signaling pathway in response to oxidative stress

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "intrinsic apoptotic signaling pathway in response to oxidative stress"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "intrinsic apoptotic signaling pathway in response to oxidative stress" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2L1	BCL2-like 1	1.000	Human
BCL2	B-cell CLL/lymphoma 2	0.996	Human Mouse
BAX	BCL2-associated X protein	0.966	Human
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.947
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.860
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.839
SQSTM1	sequestosome 1	0.721
STRN3	striatin, calmodulin binding protein 3	0.699
MAP2K5	mitogen-activated protein kinase kinase 5	0.637
BAD	BCL2-associated agonist of cell death	0.634
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.620
KEAP1	kelch-like ECH-associated protein 1	0.569
DAXX	death-domain associated protein	0.515
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.508
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.481
FBXO7	F-box protein 7	0.401
BID	BH3 interacting domain death agonist	0.366
XIAP	X-linked inhibitor of apoptosis	0.348
PDIA4	protein disulfide isomerase family A, member 4	0.344
WBP4	WW domain binding protein 4 (formin binding protein 21)	0.301
APAF1	apoptotic peptidase activating factor 1	0.300
FAS	Fas (TNF receptor superfamily, member 6)	0.291
ZNF746	zinc finger protein 746	0.240
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.237
VHL	von Hippel-Lindau tumor suppressor	0.229
ASB2	ankyrin repeat and SOCS box containing 2	0.221
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.218
BAG3	BCL2-associated athanogene 3	0.217
ERO1L	ERO1-like (S. cerevisiae)	0.210
SOCS1	suppressor of cytokine signaling 1	0.209
RIPK2	receptor-interacting serine-threonine kinase 2	0.200
BAK1	BCL2-antagonist/killer 1	0.196	Human
SOD1	superoxide dismutase 1, soluble	0.188
NAMPT	nicotinamide phosphoribosyltransferase	0.188
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.184
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.173
PDIA3	protein disulfide isomerase family A, member 3	0.172
TP53	tumor protein p53	0.171
EGLN1	egl nine homolog 1 (C. elegans)	0.169
STRN4	striatin, calmodulin binding protein 4	0.162
RUNX1	runt-related transcription factor 1	0.156
IFNGR1	interferon gamma receptor 1	0.129
DCTN1	dynactin 1	0.115
BIRC3	baculoviral IAP repeat containing 3	0.110
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.110
HSPB8	heat shock 22kDa protein 8	0.109
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.102
ARNT	aryl hydrocarbon receptor nuclear translocator	0.101
CREBBP	CREB binding protein	0.100
PRDX1	peroxiredoxin 1	0.089
CALR	calreticulin	0.082
FAM40B	family with sequence similarity 40, member B	0.080
KAT2B	K(lysine) acetyltransferase 2B	0.080
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.080
HSF1	heat shock transcription factor 1	0.076
EGLN3	egl nine homolog 3 (C. elegans)	0.073
EP300	E1A binding protein p300	0.070
PPIB	peptidylprolyl isomerase B (cyclophilin B)	0.070
PRDX4	peroxiredoxin 4	0.067
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.066
IL8	interleukin 8	0.064
STAT1	signal transducer and activator of transcription 1, 91kDa	0.061
BANP	BTG3 associated nuclear protein	0.060
HSP90B1	heat shock protein 90kDa beta (Grp94), member 1	0.057
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.056
HDAC1	histone deacetylase 1	0.053
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.052
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.052
CRYAB	crystallin, alpha B	0.051
STK24	serine/threonine kinase 24	0.051
TP53BP2	tumor protein p53 binding protein, 2	0.046
PRDX2	peroxiredoxin 2	0.045
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.044
CCNE1	cyclin E1	0.043
OPTN	optineurin	0.043
RNF144B	ring finger protein 144B	0.042
SOCS3	suppressor of cytokine signaling 3	0.039
EED	embryonic ectoderm development	0.039
SDCBP	syndecan binding protein (syntenin)	0.038
DAB2IP	DAB2 interacting protein	0.038
CCDC6	coiled-coil domain containing 6	0.038
CTTNBP2NL	CTTNBP2 N-terminal like	0.035
FUS	fused in sarcoma	0.034
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.034
TGIF1	TGFB-induced factor homeobox 1	0.034
RPS6KB1	ribosomal protein S6 kinase, 70kDa, polypeptide 1	0.034
GSK3B	glycogen synthase kinase 3 beta	0.034
INSR	insulin receptor	0.033
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.032
BCL2L2	BCL2-like 2	0.032	Human
VDAC1	voltage-dependent anion channel 1	0.032
ZFYVE9	zinc finger, FYVE domain containing 9	0.029
EFTUD2	elongation factor Tu GTP binding domain containing 2	0.028
HM13	histocompatibility (minor) 13	0.028
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.028
RNR2	l-rRNA	0.027
BCL2A1	BCL2-related protein A1	0.027	Human
AHR	aryl hydrocarbon receptor	0.027
LRRK2	leucine-rich repeat kinase 2	0.026
BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	0.026	Human
PINK1	PTEN induced putative kinase 1	0.025
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.025
NFIL3	nuclear factor, interleukin 3 regulated	0.025
ZC3H12A	zinc finger CCCH-type containing 12A	0.025
PHF17	PHD finger protein 17	0.025
ASB7	ankyrin repeat and SOCS box containing 7	0.025
CFLAR	CASP8 and FADD-like apoptosis regulator	0.025
DAD1	defender against cell death 1	0.023
HSPA1B	heat shock 70kDa protein 1B	0.023
IL1R1	interleukin 1 receptor, type I	0.022
UBE3A	ubiquitin protein ligase E3A	0.022
BIRC2	baculoviral IAP repeat containing 2	0.022
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.022
MEF2C	myocyte enhancer factor 2C	0.022
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.022
PARK7	Parkinson disease (autosomal recessive, early onset) 7	0.021
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.021
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.021
AR	androgen receptor	0.021
HIPK2	homeodomain interacting protein kinase 2	0.021
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.021
PSPC1	paraspeckle component 1	0.021	Human
MAX	MYC associated factor X	0.021
MAFK	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)	0.021
GCH1	GTP cyclohydrolase 1	0.020
STK25	serine/threonine kinase 25	0.020	Human
MARK1	MAP/microtubule affinity-regulating kinase 1	0.020
CTTNBP2	cortactin binding protein 2	0.020
FAM40A	family with sequence similarity 40, member A	0.020
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.020
DBN1	drebrin 1	0.020
TXN	thioredoxin	0.020
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.019
ASB6	ankyrin repeat and SOCS box containing 6	0.019
IL1B	interleukin 1, beta	0.018
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.018
TMED9	transmembrane emp24 protein transport domain containing 9	0.017
CCL20	chemokine (C-C motif) ligand 20	0.017
FOXO3	forkhead box O3	0.017
PGK1	phosphoglycerate kinase 1	0.017
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.017
CXCL3	chemokine (C-X-C motif) ligand 3	0.017
MAPK7	mitogen-activated protein kinase 7	0.017
TP63	tumor protein p63	0.017
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.016
CXCL2	chemokine (C-X-C motif) ligand 2	0.016
BIK	BCL2-interacting killer (apoptosis-inducing)	0.016
SH3GL1	SH3-domain GRB2-like 1	0.016
DIABLO	diablo, IAP-binding mitochondrial protein	0.016
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.015
SRP14	signal recognition particle 14kDa (homologous Alu RNA binding protein)	0.015
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.015
RPS27L	ribosomal protein S27-like	0.015
PACRG	PARK2 co-regulated	0.015
ZBTB16	zinc finger and BTB domain containing 16	0.015
NFE2L1	nuclear factor (erythroid-derived 2)-like 1	0.015	Human
ARRB2	arrestin, beta 2	0.015
PRAF2	PRA1 domain family, member 2	0.015
CTBP1	C-terminal binding protein 1	0.014
YY1	YY1 transcription factor	0.014
MMS22L	MMS22-like, DNA repair protein	0.014
DUSP23	dual specificity phosphatase 23	0.014
PML	promyelocytic leukemia	0.014	Mouse
ARRB1	arrestin, beta 1	0.013
OTUD4	OTU domain containing 4	0.013
HK2	hexokinase 2	0.013
NDUFA1	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa	0.013
ASB1	ankyrin repeat and SOCS box containing 1	0.013
TERT	telomerase reverse transcriptase	0.013
FOXO1	forkhead box O1	0.013
TNFAIP8	tumor necrosis factor, alpha-induced protein 8	0.013
IRS1	insulin receptor substrate 1	0.013
SPAG9	sperm associated antigen 9	0.013
HSPB2	heat shock 27kDa protein 2	0.013
MCRS1	microspherule protein 1	0.013
CTSL1	cathepsin L1	0.012
TOPORS	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	0.012
AXIN1	axin 1	0.012
EZR	ezrin	0.012
SF3B3	splicing factor 3b, subunit 3, 130kDa	0.012
ASB12	ankyrin repeat and SOCS box containing 12	0.012
SGK1	serum/glucocorticoid regulated kinase 1	0.012
COMMD1	copper metabolism (Murr1) domain containing 1	0.012
FAM65A	family with sequence similarity 65, member A	0.012
CSNK1D	casein kinase 1, delta	0.012
UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1	0.012
ATG4B	ATG4 autophagy related 4 homolog B (S. cerevisiae)	0.012
SRGN	serglycin	0.012
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.012
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.011
UVRAG	UV radiation resistance associated gene	0.011
PSEN2	presenilin 2 (Alzheimer disease 4)	0.011
ZFYVE1	zinc finger, FYVE domain containing 1	0.011
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.011
TSPYL4	TSPY-like 4	0.011
GHR	growth hormone receptor	0.011
APP	amyloid beta (A4) precursor protein	0.011
GANAB	glucosidase, alpha; neutral AB	0.011
CD274	CD274 molecule	0.011
EWSR1	Ewing sarcoma breakpoint region 1	0.011
SPOP	speckle-type POZ protein	0.011
GLRX	glutaredoxin (thioltransferase)	0.011
GYG1	glycogenin 1	0.010
EPOR	erythropoietin receptor	0.010
PRDX6	peroxiredoxin 6	0.010
HMGN2	high mobility group nucleosomal binding domain 2	0.010
ITM2C	integral membrane protein 2C	0.010
ADAM17	ADAM metallopeptidase domain 17	0.010
ZEB2	zinc finger E-box binding homeobox 2	0.010
HSPA1A	heat shock 70kDa protein 1A	0.010
UBQLN1	ubiquilin 1	0.010
NCSTN	nicastrin	0.010
FAM162A	family with sequence similarity 162, member A	0.010
HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular)	0.010