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Homo sapiens

26 genes annotated in human

skeletal muscle organ development

The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "skeletal muscle organ development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "skeletal muscle organ development" (in gray)

Name	Description	Probability	Func Analog Organism
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.992	Fly
TTN	titin	0.861
FLNA	filamin A, alpha	0.675
JUN	jun proto-oncogene	0.580
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.575
EP300	E1A binding protein p300	0.356	Mouse
FHL2	four and a half LIM domains 2	0.343
JAG1	jagged 1	0.301
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.251
FN1	fibronectin 1	0.201
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.196
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.177	Human Mouse
AR	androgen receptor	0.173
MEF2C	myocyte enhancer factor 2C	0.133
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.123
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.123
TGFB1	transforming growth factor, beta 1	0.117
HDAC4	histone deacetylase 4	0.112	Mouse
RB1	retinoblastoma 1	0.109	Mouse
IGF2	insulin-like growth factor 2 (somatomedin A)	0.101
IGF1R	insulin-like growth factor 1 receptor	0.097
RANBP9	RAN binding protein 9	0.094
ANXA2	annexin A2	0.088
NOTCH1	notch 1	0.087
EGFR	epidermal growth factor receptor	0.081
TRIM63	tripartite motif containing 63	0.081
FBLN1	fibulin 1	0.081
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.080
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.080	Fly
APP	amyloid beta (A4) precursor protein	0.078
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.076
BMPR1A	bone morphogenetic protein receptor, type IA	0.076
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.074	Mouse
ITGB4	integrin, beta 4	0.072	Fly
PSEN1	presenilin 1	0.072
MYH7B	myosin, heavy chain 7B, cardiac muscle, beta	0.071
SMAD1	SMAD family member 1	0.070
ADAM19	ADAM metallopeptidase domain 19	0.062
POU5F1	POU class 5 homeobox 1	0.060
ATF3	activating transcription factor 3	0.059	Mouse
NCOR1	nuclear receptor corepressor 1	0.058
ESR1	estrogen receptor 1	0.055
SPTBN1	spectrin, beta, non-erythrocytic 1	0.055
ITSN1	intersectin 1 (SH3 domain protein)	0.054
BCL6	B-cell CLL/lymphoma 6	0.054
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.054
TRIO	triple functional domain (PTPRF interacting)	0.054
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.053
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.053
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.052
RBPMS	RNA binding protein with multiple splicing	0.050
VCL	vinculin	0.049
PALLD	palladin, cytoskeletal associated protein	0.048
GSK3B	glycogen synthase kinase 3 beta	0.046
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.045
DDIT3	DNA-damage-inducible transcript 3	0.045	Mouse
NOTCH3	notch 3	0.042	Human Fly
NCOA3	nuclear receptor coactivator 3	0.042
HIPK2	homeodomain interacting protein kinase 2	0.042
CREBBP	CREB binding protein	0.042
ESR2	estrogen receptor 2 (ER beta)	0.042
MYOD1	myogenic differentiation 1	0.041	Zebrafish Mouse Fly
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.041
LAMB1	laminin, beta 1	0.040
AHNAK	AHNAK nucleoprotein	0.040
FYN	FYN oncogene related to SRC, FGR, YES	0.038
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.037
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.037
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.036
SMAD3	SMAD family member 3	0.036
EGR3	early growth response 3	0.035
QKI	quaking homolog, KH domain RNA binding (mouse)	0.035	Zebrafish Fly
TLN1	talin 1	0.033
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.033	Zebrafish
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.033
COL4A5	collagen, type IV, alpha 5	0.033	Fly
MAPK8	mitogen-activated protein kinase 8	0.032
JUNB	jun B proto-oncogene	0.032
SMAD2	SMAD family member 2	0.031
EGR1	early growth response 1	0.031	Mouse
SIRT1	sirtuin 1	0.031
PLEC	plectin	0.031
JUND	jun D proto-oncogene	0.031
GSN	gelsolin	0.030
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.030
YAP1	Yes-associated protein 1	0.030
MTMR12	myotubularin related protein 12	0.029
HSPG2	heparan sulfate proteoglycan 2	0.029
ILK	integrin-linked kinase	0.029	Zebrafish Rat Fly
DMD	dystrophin	0.028	Mouse
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.027
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.027
APC	adenomatous polyposis coli	0.027
DBP	D site of albumin promoter (albumin D-box) binding protein	0.026
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.026	Fly
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.025	Mouse
IGFBP5	insulin-like growth factor binding protein 5	0.025	Human Rat
PTCH1	patched 1	0.025
DOCK1	dedicator of cytokinesis 1	0.025	Fly
NEB	nebulin	0.025
SF1	splicing factor 1	0.025
ACTA2	actin, alpha 2, smooth muscle, aorta	0.025
FADD	Fas (TNFRSF6)-associated via death domain	0.025
MEF2A	myocyte enhancer factor 2A	0.025	Human Fly
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.024
TNNI1	troponin I type 1 (skeletal, slow)	0.024
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.024
PAX3	paired box 3	0.024
LMNA	lamin A/C	0.023
TGFB2	transforming growth factor, beta 2	0.023	Human Rat
COL1A1	collagen, type I, alpha 1	0.023
TCF4	transcription factor 4	0.023
COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	0.022
NCOR2	nuclear receptor corepressor 2	0.022
ENG	endoglin	0.022
CNOT8	CCR4-NOT transcription complex, subunit 8	0.021
DTNA	dystrobrevin, alpha	0.021
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.021
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.021
SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.021
LRP6	low density lipoprotein receptor-related protein 6	0.021
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.020
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.020
JAG2	jagged 2	0.020
AHR	aryl hydrocarbon receptor	0.020
NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	0.020
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.020
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.019
DUSP1	dual specificity phosphatase 1	0.019
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.019
GFI1B	growth factor independent 1B transcription repressor	0.019
EGR2	early growth response 2	0.019	Mouse
COL4A6	collagen, type IV, alpha 6	0.019	Fly
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.019
RANBP2	RAN binding protein 2	0.019
TESK1	testis-specific kinase 1	0.019
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.019
PTEN	phosphatase and tensin homolog	0.018
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.018
BAIAP2	BAI1-associated protein 2	0.018
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.018
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.018
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.017
NCK2	NCK adaptor protein 2	0.017
ONECUT1	one cut homeobox 1	0.017
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.017
LOX	lysyl oxidase	0.017
SMAD4	SMAD family member 4	0.017
PARVA	parvin, alpha	0.016	Fly
SOX10	SRY (sex determining region Y)-box 10	0.016
SPRY2	sprouty homolog 2 (Drosophila)	0.016
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.016
TNKS2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	0.016
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.016
IRS1	insulin receptor substrate 1	0.016
COL4A2	collagen, type IV, alpha 2	0.016
CAV1	caveolin 1, caveolae protein, 22kDa	0.016	Mouse
CTGF	connective tissue growth factor	0.016
INO80B	INO80 complex subunit B	0.016
FOXC1	forkhead box C1	0.016	Human
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.016
CLOCK	clock homolog (mouse)	0.015
IQGAP1	IQ motif containing GTPase activating protein 1	0.015
MYOG	myogenin (myogenic factor 4)	0.015	Zebrafish Mouse Fly
BTG2	BTG family, member 2	0.015	Human Mouse
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.015
LBX1	ladybird homeobox 1	0.015	Fly
ELMO1	engulfment and cell motility 1	0.015	Fly
UBASH3B	ubiquitin associated and SH3 domain containing B	0.015
CDX2	caudal type homeobox 2	0.015
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.015
FSTL1	follistatin-like 1	0.015
PBX1	pre-B-cell leukemia homeobox 1	0.015
ADAM15	ADAM metallopeptidase domain 15	0.015
HDAC9	histone deacetylase 9	0.015	Mouse
RICTOR	RPTOR independent companion of MTOR, complex 2	0.015
HIC1	hypermethylated in cancer 1	0.014
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.014	Fly
TIMP3	TIMP metallopeptidase inhibitor 3	0.014
CSNK1G3	casein kinase 1, gamma 3	0.014
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.014
FAS	Fas (TNF receptor superfamily, member 6)	0.014
CYR61	cysteine-rich, angiogenic inducer, 61	0.014
SETD8	SET domain containing (lysine methyltransferase) 8	0.014
CYTH1	cytohesin 1	0.014
DLL1	delta-like 1 (Drosophila)	0.014
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.014
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.013
ZFYVE9	zinc finger, FYVE domain containing 9	0.013
TBX1	T-box 1	0.013	Human
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.013
SMAD6	SMAD family member 6	0.013
BMP2	bone morphogenetic protein 2	0.013	Human
SMAD9	SMAD family member 9	0.013
SYK	spleen tyrosine kinase	0.013
HBP1	HMG-box transcription factor 1	0.013
TNNI2	troponin I type 2 (skeletal, fast)	0.013
SORBS3	sorbin and SH3 domain containing 3	0.013
SMAD7	SMAD family member 7	0.013
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.013
DTNB	dystrobrevin, beta	0.013
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.013
ARRDC3	arrestin domain containing 3	0.013
NCKAP1	NCK-associated protein 1	0.013
SOX2	SRY (sex determining region Y)-box 2	0.013
FBN1	fibrillin 1	0.013
TGFBI	transforming growth factor, beta-induced, 68kDa	0.013
NCOA1	nuclear receptor coactivator 1	0.013
EIF2C3	eukaryotic translation initiation factor 2C, 3	0.013
SPECC1L	sperm antigen with calponin homology and coiled-coil domains 1-like	0.013
ATXN1	ataxin 1	0.012
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.012	Zebrafish
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.012	Fly
ATN1	atrophin 1	0.012
MCAM	melanoma cell adhesion molecule	0.012
MSN	moesin	0.012
KLF9	Kruppel-like factor 9	0.012
FZD8	frizzled homolog 8 (Drosophila)	0.012
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.012
PAK4	p21 protein (Cdc42/Rac)-activated kinase 4	0.012
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.012
ADAM12	ADAM metallopeptidase domain 12	0.012
SOS1	son of sevenless homolog 1 (Drosophila)	0.012
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.012	Mouse
NGF	nerve growth factor (beta polypeptide)	0.012
NAP1L1	nucleosome assembly protein 1-like 1	0.011
PTRF	polymerase I and transcript release factor	0.011
BARX1	BARX homeobox 1	0.011
HOXB9	homeobox B9	0.011
EPS8	epidermal growth factor receptor pathway substrate 8	0.011
PTPRF	protein tyrosine phosphatase, receptor type, F	0.011
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.011
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.011
CXCL11	chemokine (C-X-C motif) ligand 11	0.011
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.011
SIM2	single-minded homolog 2 (Drosophila)	0.011
HSPH1	heat shock 105kDa/110kDa protein 1	0.011
KLF5	Kruppel-like factor 5 (intestinal)	0.011	Mouse
MATR3	matrin 3	0.011
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.011
LUC7L2	LUC7-like 2 (S. cerevisiae)	0.011
BGN	biglycan	0.011
ACTN3	actinin, alpha 3	0.011
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.011
POU4F2	POU class 4 homeobox 2	0.011
PRLHR	prolactin releasing hormone receptor	0.011
PNRC1	proline-rich nuclear receptor coactivator 1	0.011
TAGLN	transgelin	0.011
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.011
COL14A1	collagen, type XIV, alpha 1	0.010
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.010
FAM46A	family with sequence similarity 46, member A	0.010
LIMS1	LIM and senescent cell antigen-like domains 1	0.010
DMPK	dystrophia myotonica-protein kinase	0.010
FZD1	frizzled homolog 1 (Drosophila)	0.010
TMSB4X	thymosin beta 4, X-linked	0.010
HMGA2	high mobility group AT-hook 2	0.010
CHRNA1	cholinergic receptor, nicotinic, alpha 1 (muscle)	0.010
TNRC6B	trinucleotide repeat containing 6B	0.010
SIX2	SIX homeobox 2	0.010
MAPT	microtubule-associated protein tau	0.010
TBX2	T-box 2	0.010
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.010
MYO10	myosin X	0.010
EGLN1	egl nine homolog 1 (C. elegans)	0.010
CKM	creatine kinase, muscle	0.010
TGFBR1	transforming growth factor, beta receptor 1	0.010