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Homo sapiens

27 genes annotated in human

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leukocyte mediated cytotoxicity

GO:0001909

The directed killing of a target cell by a leukocyte.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "leukocyte mediated cytotoxicity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "leukocyte mediated cytotoxicity" (in gray)

Name	Description	Probability	Func Analog Organism
B2M	beta-2-microglobulin	0.968	Mouse
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.962	Rat
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.939	Mouse
HLA-C	major histocompatibility complex, class I, C	0.864	Human
HLA-A	major histocompatibility complex, class I, A	0.824
HLA-B	major histocompatibility complex, class I, B	0.737
FASLG	Fas ligand (TNF superfamily, member 6)	0.728
IL8	interleukin 8	0.724
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.666
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.590
CXCL3	chemokine (C-X-C motif) ligand 3	0.557	Mouse
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.544
PILRA	paired immunoglobin-like type 2 receptor alpha	0.511
TAPBP	TAP binding protein (tapasin)	0.508
HLA-F	major histocompatibility complex, class I, F	0.505	Human
HLA-G	major histocompatibility complex, class I, G	0.498	Human
CCL4	chemokine (C-C motif) ligand 4	0.441	Human
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.430	Human
CCR1	chemokine (C-C motif) receptor 1	0.394
HLA-E	major histocompatibility complex, class I, E	0.389
IL2RB	interleukin 2 receptor, beta	0.383
SLAMF1	signaling lymphocytic activation molecule family member 1	0.372
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.307
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.293
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.271
CCL5	chemokine (C-C motif) ligand 5	0.257	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.201
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.189	Mouse
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.187
LCK	lymphocyte-specific protein tyrosine kinase	0.172
FAS	Fas (TNF receptor superfamily, member 6)	0.167
SRGN	serglycin	0.162
CCL13	chemokine (C-C motif) ligand 13	0.156	Human
CXCL2	chemokine (C-X-C motif) ligand 2	0.150	Mouse
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.140	Human
CCR7	chemokine (C-C motif) receptor 7	0.139
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.133	Mouse
IFNG	interferon, gamma	0.128
DPP4	dipeptidyl-peptidase 4	0.128
ARRB1	arrestin, beta 1	0.116	Human
SNAP23	synaptosomal-associated protein, 23kDa	0.110
PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	0.102
CD2	CD2 molecule	0.101
ICAM1	intercellular adhesion molecule 1	0.100
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.097	Human
CD84	CD84 molecule	0.090
IL23A	interleukin 23, alpha subunit p19	0.088	Mouse
CXCL10	chemokine (C-X-C motif) ligand 10	0.087
SYK	spleen tyrosine kinase	0.085
CCR5	chemokine (C-C motif) receptor 5	0.084
GZMK	granzyme K (granzyme 3; tryptase II)	0.081
PTAFR	platelet-activating factor receptor	0.077
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.077
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.075
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.075	Human
NKG7	natural killer cell group 7 sequence	0.064
PVRL4	poliovirus receptor-related 4	0.064
GARS	glycyl-tRNA synthetase	0.064
KLRC3	killer cell lectin-like receptor subfamily C, member 3	0.064	Human
PRF1	perforin 1 (pore forming protein)	0.063
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.062
TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.057	Mouse Rat
LGALS3	lectin, galactoside-binding, soluble, 3	0.056
CD33	CD33 molecule	0.052
IL18RAP	interleukin 18 receptor accessory protein	0.048
PVRL3	poliovirus receptor-related 3	0.047	Human
CCL7	chemokine (C-C motif) ligand 7	0.047	Human
TJP1	tight junction protein 1 (zona occludens 1)	0.045
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.044	Human
CCL8	chemokine (C-C motif) ligand 8	0.044	Human
KLRC2	killer cell lectin-like receptor subfamily C, member 2	0.043	Human
IGSF6	immunoglobulin superfamily, member 6	0.040
INSR	insulin receptor	0.039
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.038
HK3	hexokinase 3 (white cell)	0.038
CXCL11	chemokine (C-X-C motif) ligand 11	0.038
GNLY	granulysin	0.038
SIGLEC7	sialic acid binding Ig-like lectin 7	0.037
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.036	Mouse
VCAM1	vascular cell adhesion molecule 1	0.036
IL1B	interleukin 1, beta	0.036
CD72	CD72 molecule	0.034
CD22	CD22 molecule	0.034
IL1RN	interleukin 1 receptor antagonist	0.033
TYMP	thymidine phosphorylase	0.033
GPR65	G protein-coupled receptor 65	0.031
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.030
PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.030
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.029
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.029
CFLAR	CASP8 and FADD-like apoptosis regulator	0.028
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.028
FPR3	formyl peptide receptor 3	0.028
EPOR	erythropoietin receptor	0.028
RAB14	RAB14, member RAS oncogene family	0.028
CD8A	CD8a molecule	0.028
NLRP3	NLR family, pyrin domain containing 3	0.028
CXCL13	chemokine (C-X-C motif) ligand 13	0.027
ITM2B	integral membrane protein 2B	0.027
VAMP4	vesicle-associated membrane protein 4	0.027
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.026
CLEC10A	C-type lectin domain family 10, member A	0.026
MARS	methionyl-tRNA synthetase	0.026
SLAMF8	SLAM family member 8	0.026
MLPH	melanophilin	0.026
XCL2	chemokine (C motif) ligand 2	0.026	Human
STAP2	signal transducing adaptor family member 2	0.026
CXCL5	chemokine (C-X-C motif) ligand 5	0.025	Mouse
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.025
PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	0.025
STAT4	signal transducer and activator of transcription 4	0.025
IL6	interleukin 6 (interferon, beta 2)	0.024
XCL1	chemokine (C motif) ligand 1	0.024
TLR2	toll-like receptor 2	0.024
TNF	tumor necrosis factor	0.024
CD163	CD163 molecule	0.024
ITK	IL2-inducible T-cell kinase	0.023
IRF2	interferon regulatory factor 2	0.023
KLRF1	killer cell lectin-like receptor subfamily F, member 1	0.023
GPR171	G protein-coupled receptor 171	0.022
UBD	ubiquitin D	0.022
BCL2A1	BCL2-related protein A1	0.022
SNX3	sorting nexin 3	0.021
GCH1	GTP cyclohydrolase 1	0.021
NSF	N-ethylmaleimide-sensitive factor	0.021
TXN	thioredoxin	0.021
VSIG4	V-set and immunoglobulin domain containing 4	0.021
CCL22	chemokine (C-C motif) ligand 22	0.021	Human
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.021
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.020
CCL20	chemokine (C-C motif) ligand 20	0.020	Human
PLEK	pleckstrin	0.020
IDO1	indoleamine 2,3-dioxygenase 1	0.020
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.020
RNASE3	ribonuclease, RNase A family, 3	0.019
BIRC3	baculoviral IAP repeat containing 3	0.019
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.019
CCL2	chemokine (C-C motif) ligand 2	0.019	Human
IL7R	interleukin 7 receptor	0.018	Mouse
ZNF259	zinc finger protein 259	0.018
CAV1	caveolin 1, caveolae protein, 22kDa	0.018
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.018
IRF1	interferon regulatory factor 1	0.018
CCR2	chemokine (C-C motif) receptor 2	0.018
SELE	selectin E	0.018
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.018
CCL3	chemokine (C-C motif) ligand 3	0.017	Human
ASAH1	N-acylsphingosine amidohydrolase (acid ceramidase) 1	0.017
WARS	tryptophanyl-tRNA synthetase	0.017
CCR4	chemokine (C-C motif) receptor 4	0.017
CCL19	chemokine (C-C motif) ligand 19	0.017	Human
CST7	cystatin F (leukocystatin)	0.017
MAPK10	mitogen-activated protein kinase 10	0.017
ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	0.017
STX6	syntaxin 6	0.017
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	0.017	Human
SOD1	superoxide dismutase 1, soluble	0.016
GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)	0.016
CD160	CD160 molecule	0.016
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.016
IL7	interleukin 7	0.016
S100A12	S100 calcium binding protein A12	0.016
DARC	Duffy blood group, chemokine receptor	0.016
CH25H	cholesterol 25-hydroxylase	0.015
TARS	threonyl-tRNA synthetase	0.015
TREM1	triggering receptor expressed on myeloid cells 1	0.015
TLR8	toll-like receptor 8	0.015
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.015
CD48	CD48 molecule	0.015
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.015
CKS2	CDC28 protein kinase regulatory subunit 2	0.015
KLRC4	killer cell lectin-like receptor subfamily C, member 4	0.015	Human
IL18R1	interleukin 18 receptor 1	0.015
SIRPB1	signal-regulatory protein beta 1	0.015
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.015
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.015
CD226	CD226 molecule	0.014
TXK	TXK tyrosine kinase	0.014
YARS	tyrosyl-tRNA synthetase	0.014
FCAR	Fc fragment of IgA, receptor for	0.014	Human
ICOS	inducible T-cell co-stimulator	0.014
CTSS	cathepsin S	0.014
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.014
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.014
MTHFD2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	0.014
CARS	cysteinyl-tRNA synthetase	0.014
IFI30	interferon, gamma-inducible protein 30	0.014
SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	0.014
HFE	hemochromatosis	0.014	Human
ASNS	asparagine synthetase (glutamine-hydrolyzing)	0.014
CD80	CD80 molecule	0.014
JAK2	Janus kinase 2	0.013
ADAMDEC1	ADAM-like, decysin 1	0.013
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.013	Human
CCL11	chemokine (C-C motif) ligand 11	0.013	Human
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.013
TNFRSF21	tumor necrosis factor receptor superfamily, member 21	0.013
IL15RA	interleukin 15 receptor, alpha	0.013
RNF146	ring finger protein 146	0.013
AOAH	acyloxyacyl hydrolase (neutrophil)	0.013
LILRB4	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	0.012	Human
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.012
SIGLEC10	sialic acid binding Ig-like lectin 10	0.012
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.012
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.012
LAMP3	lysosomal-associated membrane protein 3	0.012
TRIM38	tripartite motif containing 38	0.012
MYO5A	myosin VA (heavy chain 12, myoxin)	0.011
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.011
IRS1	insulin receptor substrate 1	0.011
CCR3	chemokine (C-C motif) receptor 3	0.011
NCSTN	nicastrin	0.011
CSK	c-src tyrosine kinase	0.011
GLA	galactosidase, alpha	0.011
VNN2	vanin 2	0.011
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.011
CMKLR1	chemokine-like receptor 1	0.011
SIGLEC9	sialic acid binding Ig-like lectin 9	0.011
ZBP1	Z-DNA binding protein 1	0.011
TBX21	T-box 21	0.011
PGK1	phosphoglycerate kinase 1	0.011
CST3	cystatin C	0.011
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.011
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.011
CD1C	CD1c molecule	0.011
IL32	interleukin 32	0.010
MARCO	macrophage receptor with collagenous structure	0.010
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.010
PFN1	profilin 1	0.010
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.010
ARL8B	ADP-ribosylation factor-like 8B	0.010
HCP5	HLA complex P5	0.010
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.010
CCL17	chemokine (C-C motif) ligand 17	0.010	Human
VAMP8	vesicle-associated membrane protein 8 (endobrevin)	0.010
IL12RB1	interleukin 12 receptor, beta 1	0.010
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.010
RNF13	ring finger protein 13	0.010