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Homo sapiens

22 genes annotated in human

respiratory system development

The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "respiratory system development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "respiratory system development" (in gray)

Name	Description	Probability	Func Analog Organism
FHL2	four and a half LIM domains 2	0.948
FGFR2	fibroblast growth factor receptor 2	0.924	Mouse Fly
FGF1	fibroblast growth factor 1 (acidic)	0.869	Human
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.599	Fly
SMAD3	SMAD family member 3	0.565
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.537	Mouse Rat
SP1	Sp1 transcription factor	0.484	Mouse
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.444	Mouse
ENG	endoglin	0.360
TBX5	T-box 5	0.348	Mouse
BMP2	bone morphogenetic protein 2	0.342	Human Fly
FLNA	filamin A, alpha	0.293
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.292
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.290	Human
NOTCH1	notch 1	0.272	Mouse Fly
NCOA1	nuclear receptor coactivator 1	0.268
NRP1	neuropilin 1	0.244
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.241
JAG1	jagged 1	0.218
VEGFA	vascular endothelial growth factor A	0.215	Mouse Rat
BMPR1A	bone morphogenetic protein receptor, type IA	0.183	Mouse Fly
ZFYVE9	zinc finger, FYVE domain containing 9	0.178
SMAD7	SMAD family member 7	0.175
PPARA	peroxisome proliferator-activated receptor alpha	0.170
SRSF4	serine/arginine-rich splicing factor 4	0.165	Human
FGFR1	fibroblast growth factor receptor 1	0.155	Mouse Fly
CSH1	chorionic somatomammotropin hormone 1 (placental lactogen)	0.148	Rat
STRN4	striatin, calmodulin binding protein 4	0.144
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.138
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.125
GH1	growth hormone 1	0.114	Rat
COL1A1	collagen, type I, alpha 1	0.100
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.098	Mouse Fly
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.093
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.087
NCOA6	nuclear receptor coactivator 6	0.087
BMP4	bone morphogenetic protein 4	0.086
RUNX1	runt-related transcription factor 1	0.081
SFN	stratifin	0.078
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.078	Fly
NCOA2	nuclear receptor coactivator 2	0.078
COL2A1	collagen, type II, alpha 1	0.069
CTGF	connective tissue growth factor	0.068	Mouse Rat
FN1	fibronectin 1	0.068
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.063
CSNK1E	casein kinase 1, epsilon	0.063
CHD7	chromodomain helicase DNA binding protein 7	0.059
FOXD3	forkhead box D3	0.057
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.057
FGF10	fibroblast growth factor 10	0.057
STRN3	striatin, calmodulin binding protein 3	0.052
PDCD6IP	programmed cell death 6 interacting protein	0.052
JUB	jub, ajuba homolog (Xenopus laevis)	0.051
ACVR1	activin A receptor, type I	0.049
WNT1	wingless-type MMTV integration site family, member 1	0.048	Human Fly
SRI	sorcin	0.047
AR	androgen receptor	0.044
ESR1	estrogen receptor 1	0.043
CCNE1	cyclin E1	0.043
KRT8	keratin 8	0.043
RXRA	retinoid X receptor, alpha	0.042
MAX	MYC associated factor X	0.041
HCFC1	host cell factor C1 (VP16-accessory protein)	0.041
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.040
NCOR2	nuclear receptor corepressor 2	0.040	Mouse
ITGB4	integrin, beta 4	0.040	Fly
OCLN	occludin	0.040
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.040
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.039	Mouse Fly
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.038
SORBS3	sorbin and SH3 domain containing 3	0.037
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.036	Fly
TSC2	tuberous sclerosis 2	0.036
PAX8	paired box 8	0.035
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.035
FGF18	fibroblast growth factor 18	0.035
TWIST2	twist homolog 2 (Drosophila)	0.035
PDGFA	platelet-derived growth factor alpha polypeptide	0.034	Mouse
CSH2	chorionic somatomammotropin hormone 2	0.033	Rat
FBXW7	F-box and WD repeat domain containing 7	0.033	Mouse
GH2	growth hormone 2	0.032	Rat
BMP7	bone morphogenetic protein 7	0.032
UTRN	utrophin	0.031
CSHL1	chorionic somatomammotropin hormone-like 1	0.031	Rat
CYR61	cysteine-rich, angiogenic inducer, 61	0.031
MYOCD	myocardin	0.031	Mouse
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.031
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.031
TTR	transthyretin	0.030
U2AF1	U2 small nuclear RNA auxiliary factor 1	0.030
PTPRC	protein tyrosine phosphatase, receptor type, C	0.030
SMAD2	SMAD family member 2	0.030	Mouse
PDZD11	PDZ domain containing 11	0.030
NOTCH3	notch 3	0.030	Fly
WNT3A	wingless-type MMTV integration site family, member 3A	0.030
HMGA1	high mobility group AT-hook 1	0.029
TGFB1	transforming growth factor, beta 1	0.029
CHD8	chromodomain helicase DNA binding protein 8	0.029	Human
PLCG1	phospholipase C, gamma 1	0.029
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.029	Fly
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.029	Fly
PRKG1	protein kinase, cGMP-dependent, type I	0.029
PRPF38A	PRP38 pre-mRNA processing factor 38 (yeast) domain containing A	0.029
BCAR1	breast cancer anti-estrogen resistance 1	0.029
POLA2	polymerase (DNA directed), alpha 2 (70kD subunit)	0.029
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.029
FSTL1	follistatin-like 1	0.028
FGF8	fibroblast growth factor 8 (androgen-induced)	0.028
ATXN1L	ataxin 1-like	0.028
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.027
FGF2	fibroblast growth factor 2 (basic)	0.027	Human Mouse
FGF4	fibroblast growth factor 4	0.026	Human
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.026	Fly
MAML1	mastermind-like 1 (Drosophila)	0.025
NKX3-1	NK3 homeobox 1	0.024
PSEN1	presenilin 1	0.024
DMD	dystrophin	0.023
LUM	lumican	0.023
FERMT2	fermitin family member 2	0.023
GLIS2	GLIS family zinc finger 2	0.023
KAT2B	K(lysine) acetyltransferase 2B	0.022
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.022
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.022	Fly
PLEC	plectin	0.022	Fly
EGLN1	egl nine homolog 1 (C. elegans)	0.022
HSPG2	heparan sulfate proteoglycan 2	0.021
AMOT	angiomotin	0.021
STK24	serine/threonine kinase 24	0.021	Fly
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.021
TARBP2	TAR (HIV-1) RNA binding protein 2	0.021
SREBF2	sterol regulatory element binding transcription factor 2	0.021
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.020
ARNT	aryl hydrocarbon receptor nuclear translocator	0.020
PTEN	phosphatase and tensin homolog	0.020	Fly
RB1	retinoblastoma 1	0.020
LIMK1	LIM domain kinase 1	0.020
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.020
AHR	aryl hydrocarbon receptor	0.020
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.020
THBS1	thrombospondin 1	0.020
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.019
PUM1	pumilio homolog 1 (Drosophila)	0.019
FZD1	frizzled homolog 1 (Drosophila)	0.019	Rat
TGFB3	transforming growth factor, beta 3	0.019	Mouse
COL3A1	collagen, type III, alpha 1	0.019
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.019
RPTOR	regulatory associated protein of MTOR, complex 1	0.019
SNAI1	snail homolog 1 (Drosophila)	0.019	Fly
CCDC6	coiled-coil domain containing 6	0.019
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.019	Fly
SMAD4	SMAD family member 4	0.019
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.018
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.018
KRT18	keratin 18	0.018
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.018	Human Fly
CREBBP	CREB binding protein	0.018
AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	0.017
MKL1	megakaryoblastic leukemia (translocation) 1	0.017
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.017
LRP1	low density lipoprotein receptor-related protein 1	0.017
TUBB2C	tubulin, beta 2C	0.017
RARA	retinoic acid receptor, alpha	0.017	Mouse
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.017	Fly
RIC8A	resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)	0.017
FAM40B	family with sequence similarity 40, member B	0.017
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.016
HOXB5	homeobox B5	0.016
MED25	mediator complex subunit 25	0.016
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.016
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.016	Fly
FOXA2	forkhead box A2	0.016	Mouse
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.016
FGFR3	fibroblast growth factor receptor 3	0.016	Mouse Fly
S100B	S100 calcium binding protein B	0.016
IQGAP1	IQ motif containing GTPase activating protein 1	0.016
FOXF1	forkhead box F1	0.015
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.015	Fly
ARL4D	ADP-ribosylation factor-like 4D	0.015
ATF7IP	activating transcription factor 7 interacting protein	0.015
SRPK1	SRSF protein kinase 1	0.015
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.015
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.015
NCOA3	nuclear receptor coactivator 3	0.015
IFI16	interferon, gamma-inducible protein 16	0.015
RNPS1	RNA binding protein S1, serine-rich domain	0.015
FADS2	fatty acid desaturase 2	0.015
IGFBP5	insulin-like growth factor binding protein 5	0.015
SDC2	syndecan 2	0.014
PFN1	profilin 1	0.014
ATF2	activating transcription factor 2	0.014
TCF4	transcription factor 4	0.014
PPP4C	protein phosphatase 4, catalytic subunit	0.014
SFRP1	secreted frizzled-related protein 1	0.014
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.014
SCD	stearoyl-CoA desaturase (delta-9-desaturase)	0.014
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.014
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.014
HMGA2	high mobility group AT-hook 2	0.014
JAG2	jagged 2	0.013
ROCK1	Rho-associated, coiled-coil containing protein kinase 1	0.013
NRP2	neuropilin 2	0.013
CDH5	cadherin 5, type 2 (vascular endothelium)	0.013
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.013
TAOK1	TAO kinase 1	0.013
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.013	Mouse
CTTNBP2NL	CTTNBP2 N-terminal like	0.013
BMP1	bone morphogenetic protein 1	0.013
SOX1	SRY (sex determining region Y)-box 1	0.013
FADS1	fatty acid desaturase 1	0.013
FZD8	frizzled homolog 8 (Drosophila)	0.013
CD2AP	CD2-associated protein	0.013
BRD4	bromodomain containing 4	0.013
FGF3	fibroblast growth factor 3	0.013	Human
PGR	progesterone receptor	0.013
GATA4	GATA binding protein 4	0.013	Mouse
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.013	Fly
HNF4A	hepatocyte nuclear factor 4, alpha	0.013
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.013
NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	0.012
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.012
COL6A1	collagen, type VI, alpha 1	0.012
WNT11	wingless-type MMTV integration site family, member 11	0.012
PDGFC	platelet derived growth factor C	0.012
RIN1	Ras and Rab interactor 1	0.012
FUNDC2	FUN14 domain containing 2	0.012
ITGB5	integrin, beta 5	0.012	Fly
EGLN3	egl nine homolog 3 (C. elegans)	0.012
FBN1	fibrillin 1	0.012
FOXC1	forkhead box C1	0.012
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.012
TGFB2	transforming growth factor, beta 2	0.012
INPPL1	inositol polyphosphate phosphatase-like 1	0.012
SEC23A	Sec23 homolog A (S. cerevisiae)	0.012
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.012
F11R	F11 receptor	0.012
CAV1	caveolin 1, caveolae protein, 22kDa	0.011
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.011	Fly
NKX2-1	NK2 homeobox 1	0.011
SP3	Sp3 transcription factor	0.011	Mouse
MYOD1	myogenic differentiation 1	0.011
SOX2	SRY (sex determining region Y)-box 2	0.011	Mouse
CD9	CD9 molecule	0.011
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.011
EPS15	epidermal growth factor receptor pathway substrate 15	0.011
SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	0.011	Mouse Fly
SRSF6	serine/arginine-rich splicing factor 6	0.011
HOXB13	homeobox B13	0.011
NRIP1	nuclear receptor interacting protein 1	0.011
JUN	jun proto-oncogene	0.011
DLL1	delta-like 1 (Drosophila)	0.011
FGF7	fibroblast growth factor 7	0.011
CCNL1	cyclin L1	0.011
SOX9	SRY (sex determining region Y)-box 9	0.011	Mouse
GTF3C1	general transcription factor IIIC, polypeptide 1, alpha 220kDa	0.010
ZIC3	Zic family member 3 (odd-paired homolog, Drosophila)	0.010
EPHA2	EPH receptor A2	0.010
GLI2	GLI family zinc finger 2	0.010	Mouse Fly
SEC24A	SEC24 family, member A (S. cerevisiae)	0.010
DHCR24	24-dehydrocholesterol reductase	0.010
FZD7	frizzled homolog 7 (Drosophila)	0.010
TGIF1	TGFB-induced factor homeobox 1	0.010
DLX4	distal-less homeobox 4	0.010
SIRT1	sirtuin 1	0.010
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.010
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.010
CEP164	centrosomal protein 164kDa	0.010
DCN	decorin	0.010
MYOG	myogenin (myogenic factor 4)	0.010
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.010
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.010
PPID	peptidylprolyl isomerase D	0.010
NOTCH2	notch 2	0.010	Fly
ALX4	ALX homeobox 4	0.010
SRPK2	SRSF protein kinase 2	0.010
TCF12	transcription factor 12	0.010