IMP

Process View

Homo sapiens

20 genes annotated in human

response to alkaloid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to alkaloid"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to alkaloid" (in gray)

Name	Description	Probability	Func Analog Organism
TP53	tumor protein p53	0.997	Rat
BCL2L1	BCL2-like 1	0.994	Human Mouse
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.974
GSTM1	glutathione S-transferase mu 1	0.915	Human
ESR1	estrogen receptor 1	0.895
BCL2	B-cell CLL/lymphoma 2	0.844
BRCA1	breast cancer 1, early onset	0.823
GSTM2	glutathione S-transferase mu 2 (muscle)	0.756
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.646
DRD2	dopamine receptor D2	0.617	Human Mouse Rat
NCOR2	nuclear receptor corepressor 2	0.491
BAX	BCL2-associated X protein	0.476	Human Rat
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.378
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.349
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.309
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.295
XIAP	X-linked inhibitor of apoptosis	0.250
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.224
LAT	linker for activation of T cells	0.217
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.208
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.192
UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	0.187
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.186
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.178
GSTM4	glutathione S-transferase mu 4	0.176	Human
PLAUR	plasminogen activator, urokinase receptor	0.167
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.164
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.151
DLG4	discs, large homolog 4 (Drosophila)	0.148
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.140
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.140	Rat
BLM	Bloom syndrome, RecQ helicase-like	0.140
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.139
CRHR1	corticotropin releasing hormone receptor 1	0.139	Rat
TGFB1	transforming growth factor, beta 1	0.137
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	0.137
WRN	Werner syndrome, RecQ helicase-like	0.132
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.127
CRH	corticotropin releasing hormone	0.124	Rat
MPDZ	multiple PDZ domain protein	0.119
HDAC3	histone deacetylase 3	0.118
SP1	Sp1 transcription factor	0.113
TICAM2	toll-like receptor adaptor molecule 2	0.101
TCP1	t-complex 1	0.099
BAK1	BCL2-antagonist/killer 1	0.098
ADORA2A	adenosine A2a receptor	0.091	Rat
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.090
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.089
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.088
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.080
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.080
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.078
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.078	Human
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.071
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.069	Rat
BAD	BCL2-associated agonist of cell death	0.068
ACACA	acetyl-CoA carboxylase alpha	0.068
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.067
ITGB1BP3	integrin beta 1 binding protein 3	0.065
PRSS2	protease, serine, 2 (trypsin 2)	0.057
HDAC1	histone deacetylase 1	0.049	Rat
HSPA1B	heat shock 70kDa protein 1B	0.049
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.047
ALDH1A1	aldehyde dehydrogenase 1 family, member A1	0.046
PPARA	peroxisome proliferator-activated receptor alpha	0.046	Rat
MSH6	mutS homolog 6 (E. coli)	0.045
HIPK2	homeodomain interacting protein kinase 2	0.044
DUSP23	dual specificity phosphatase 23	0.044
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.043
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.042
ACVR1B	activin A receptor, type IB	0.042
VAC14	Vac14 homolog (S. cerevisiae)	0.040
AKAP1	A kinase (PRKA) anchor protein 1	0.040
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.040
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.039
CCR5	chemokine (C-C motif) receptor 5	0.038
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.037
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.035
IL1R1	interleukin 1 receptor, type I	0.035
BRCA2	breast cancer 2, early onset	0.034
HNF4A	hepatocyte nuclear factor 4, alpha	0.034
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.034
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.034
BCL2A1	BCL2-related protein A1	0.033
TRADD	TNFRSF1A-associated via death domain	0.033
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.033
GRB10	growth factor receptor-bound protein 10	0.033
ATR	ataxia telangiectasia and Rad3 related	0.032	Fly
NCL	nucleolin	0.031
TIMP2	TIMP metallopeptidase inhibitor 2	0.031
PTPRB	protein tyrosine phosphatase, receptor type, B	0.029
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.029
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.029
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.028
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.027
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.027	Rat
SPRR2A	small proline-rich protein 2A	0.027
ICAM1	intercellular adhesion molecule 1	0.027
WT1	Wilms tumor 1	0.027
PML	promyelocytic leukemia	0.026
ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.026
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.026
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.025
NGF	nerve growth factor (beta polypeptide)	0.025
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.024	Human
PTPN2	protein tyrosine phosphatase, non-receptor type 2	0.024
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.024
SMC1A	structural maintenance of chromosomes 1A	0.024
PLAT	plasminogen activator, tissue	0.024
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.023
CYR61	cysteine-rich, angiogenic inducer, 61	0.023
SNAI1	snail homolog 1 (Drosophila)	0.023
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.023	Rat
THBS1	thrombospondin 1	0.023
HDAC2	histone deacetylase 2	0.023
MATK	megakaryocyte-associated tyrosine kinase	0.023
SOCS3	suppressor of cytokine signaling 3	0.023
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.022
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.022
AKAP2	A kinase (PRKA) anchor protein 2	0.022
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.022
THBS2	thrombospondin 2	0.021
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.021
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.020	Rat
BCL6	B-cell CLL/lymphoma 6	0.020
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.020
AKAP6	A kinase (PRKA) anchor protein 6	0.019
ESRRG	estrogen-related receptor gamma	0.019
TGFBR1	transforming growth factor, beta receptor 1	0.019
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	0.019	Human
XPO1	exportin 1 (CRM1 homolog, yeast)	0.019
NCOR1	nuclear receptor corepressor 1	0.019
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.019	Human
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.018
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.018
CCL4	chemokine (C-C motif) ligand 4	0.017
APP	amyloid beta (A4) precursor protein	0.017
HUWE1	HECT, UBA and WWE domain containing 1	0.017
GSK3B	glycogen synthase kinase 3 beta	0.017
EGR3	early growth response 3	0.017
SFN	stratifin	0.017
JDP2	Jun dimerization protein 2	0.017
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.017
ARRB2	arrestin, beta 2	0.016
CLSPN	claspin	0.016
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.016
MYL4	myosin, light chain 4, alkali; atrial, embryonic	0.016
FGFR1	fibroblast growth factor receptor 1	0.016
TACR1	tachykinin receptor 1	0.016	Rat
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.016
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.016	Rat
PDCD6IP	programmed cell death 6 interacting protein	0.015
INHBA	inhibin, beta A	0.015
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.015
PARP1	poly (ADP-ribose) polymerase 1	0.015
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.015
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.015
RBBP8	retinoblastoma binding protein 8	0.014
IL8	interleukin 8	0.014
PICK1	protein interacting with PRKCA 1	0.014
BCL3	B-cell CLL/lymphoma 3	0.014
BCL2L2	BCL2-like 2	0.014	Human
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.014
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.014
BID	BH3 interacting domain death agonist	0.014
FANCD2	Fanconi anemia, complementation group D2	0.014
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.014
RAD52	RAD52 homolog (S. cerevisiae)	0.014
PFN1	profilin 1	0.014
HDAC7	histone deacetylase 7	0.014
BMP8A	bone morphogenetic protein 8a	0.014
TP53BP2	tumor protein p53 binding protein, 2	0.014
DCLRE1C	DNA cross-link repair 1C	0.014
IGF2R	insulin-like growth factor 2 receptor	0.014
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.014
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.013
SSTR3	somatostatin receptor 3	0.013
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.013
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.013
CCL2	chemokine (C-C motif) ligand 2	0.013
EGFR	epidermal growth factor receptor	0.013
ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	0.013
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.013
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.013
BIK	BCL2-interacting killer (apoptosis-inducing)	0.013
S100B	S100 calcium binding protein B	0.013
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.013
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.013	Rat
S100A4	S100 calcium binding protein A4	0.012
BCAR1	breast cancer anti-estrogen resistance 1	0.012
LY96	lymphocyte antigen 96	0.012
MDC1	mediator of DNA-damage checkpoint 1	0.012
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.012
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	0.012
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.011	Fly
GSTM3	glutathione S-transferase mu 3 (brain)	0.011	Human
OR2AG1	olfactory receptor, family 2, subfamily AG, member 1	0.011
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.011
CDH5	cadherin 5, type 2 (vascular endothelium)	0.011
RHO	rhodopsin	0.011
SETD7	SET domain containing (lysine methyltransferase) 7	0.011
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.011
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.011
ARRDC3	arrestin domain containing 3	0.011
PPP4C	protein phosphatase 4, catalytic subunit	0.011
PAX8	paired box 8	0.010
TERF2	telomeric repeat binding factor 2	0.010
CNTFR	ciliary neurotrophic factor receptor	0.010
EED	embryonic ectoderm development	0.010
CXCR5	chemokine (C-X-C motif) receptor 5	0.010
NCF4	neutrophil cytosolic factor 4, 40kDa	0.010
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.010
SLC6A7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.010
HES1	hairy and enhancer of split 1, (Drosophila)	0.010
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.010