IMP

Process View

Homo sapiens

31 genes annotated in human

Multi-species View

negative regulation of cell division

GO:0051782

Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of cell division"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of cell division" (in gray)

Name	Description	Probability	Func Analog Organism
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.649	Fly
TOLLIP	toll interacting protein	0.467
E2F7	E2F transcription factor 7	0.344	Mouse
NCAPG	non-SMC condensin I complex, subunit G	0.262	Yeast
SMC4	structural maintenance of chromosomes 4	0.197
E2F8	E2F transcription factor 8	0.185	Mouse
BMPR1A	bone morphogenetic protein receptor, type IA	0.178
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.166	Fly
BRCA1	breast cancer 1, early onset	0.137
FGF1	fibroblast growth factor 1 (acidic)	0.136
CDK2	cyclin-dependent kinase 2	0.132
NCAPH	non-SMC condensin I complex, subunit H	0.131
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.114	Yeast
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.108
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.100
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.096
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.094	Yeast
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.089
SMC2	structural maintenance of chromosomes 2	0.070	Yeast
CBX5	chromobox homolog 5	0.069
BMPR1B	bone morphogenetic protein receptor, type IB	0.065
NCAPD2	non-SMC condensin I complex, subunit D2	0.063	Yeast
BRCA2	breast cancer 2, early onset	0.058
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.058
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.056
CEP55	centrosomal protein 55kDa	0.054
SMC3	structural maintenance of chromosomes 3	0.053
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.051
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.044	Yeast
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.043
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.040
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.039
AURKB	aurora kinase B	0.037
CCNB1	cyclin B1	0.036
HUS1	HUS1 checkpoint homolog (S. pombe)	0.035
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.034
KIF18A	kinesin family member 18A	0.034
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.033	Yeast
WRN	Werner syndrome, RecQ helicase-like	0.033
CCNA2	cyclin A2	0.032
NOG	noggin	0.032
TTK	TTK protein kinase	0.031	Yeast
PPP5C	protein phosphatase 5, catalytic subunit	0.031
SKA3	spindle and kinetochore associated complex subunit 3	0.030
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.030
FGF10	fibroblast growth factor 10	0.030
CASC5	cancer susceptibility candidate 5	0.029
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.028
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.027
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.027
TSG101	tumor susceptibility gene 101	0.027
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.027
DYDC1	DPY30 domain containing 1	0.027
ZWINT	ZW10 interactor	0.027
DEPDC1	DEP domain containing 1	0.027
CENPE	centromere protein E, 312kDa	0.027	Mouse
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.027
SKA1	spindle and kinetochore associated complex subunit 1	0.027
SKA2	spindle and kinetochore associated complex subunit 2	0.026
CHMP1A	chromatin modifying protein 1A	0.026
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.025
BLM	Bloom syndrome, RecQ helicase-like	0.025
ATF5	activating transcription factor 5	0.025
POLR2C	polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	0.025
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.023
FGFR1	fibroblast growth factor receptor 1	0.023
HUWE1	HECT, UBA and WWE domain containing 1	0.023
SPC24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.022
H2AFX	H2A histone family, member X	0.022
RAD51AP1	RAD51 associated protein 1	0.021
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.021
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.021
TOP3A	topoisomerase (DNA) III alpha	0.021
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.021
PLK1	polo-like kinase 1	0.020
BCL2L1	BCL2-like 1	0.020
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.020
BCL2	B-cell CLL/lymphoma 2	0.019
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.019
ANAPC11	anaphase promoting complex subunit 11	0.019
CSNK2B	casein kinase 2, beta polypeptide	0.019
ATMIN	ATM interactor	0.018
HERC2	hect domain and RLD 2	0.018
POMP	proteasome maturation protein	0.018
STIL	SCL/TAL1 interrupting locus	0.018
KRT8	keratin 8	0.018
PTK2	PTK2 protein tyrosine kinase 2	0.018
CENPF	centromere protein F, 350/400kDa (mitosin)	0.018
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.017
KIF14	kinesin family member 14	0.017
PPME1	protein phosphatase methylesterase 1	0.017
ANKRD52	ankyrin repeat domain 52	0.017
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.017
FANCD2	Fanconi anemia, complementation group D2	0.017
NOMO1	NODAL modulator 1	0.017
FXR2	fragile X mental retardation, autosomal homolog 2	0.017
CLSPN	claspin	0.016
LBR	lamin B receptor	0.016
FBXO5	F-box protein 5	0.016
MSH6	mutS homolog 6 (E. coli)	0.016
MBD1	methyl-CpG binding domain protein 1	0.016
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.016
NASP	nuclear autoantigenic sperm protein (histone-binding)	0.016
SGOL1	shugoshin-like 1 (S. pombe)	0.016
CDKN3	cyclin-dependent kinase inhibitor 3	0.015
KIF11	kinesin family member 11	0.015
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.015
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.015
HIST1H4A	histone cluster 1, H4a	0.015
MAD2L1BP	MAD2L1 binding protein	0.015
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.015
DBF4	DBF4 homolog (S. cerevisiae)	0.015
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.015	Mouse
BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	0.015	Worm Fly
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.015	Yeast
KAT5	K(lysine) acetyltransferase 5	0.015
DUSP5	dual specificity phosphatase 5	0.014
DSN1	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.014
CBX1	chromobox homolog 1	0.014
PPP4C	protein phosphatase 4, catalytic subunit	0.014	Yeast
NCAPG2	non-SMC condensin II complex, subunit G2	0.014
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.013
ADRB2	adrenergic, beta-2-, receptor, surface	0.013
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.013
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.013
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.013
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.013
MTF2	metal response element binding transcription factor 2	0.013
INCENP	inner centromere protein antigens 135/155kDa	0.013
USP49	ubiquitin specific peptidase 49	0.013	Human
BAX	BCL2-associated X protein	0.013
MIS18BP1	MIS18 binding protein 1	0.013
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.013
BAG2	BCL2-associated athanogene 2	0.012
PARP3	poly (ADP-ribose) polymerase family, member 3	0.012
RAD51L3	RAD51-like 3 (S. cerevisiae)	0.012
CHD4	chromodomain helicase DNA binding protein 4	0.012
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.012
ATAD2	ATPase family, AAA domain containing 2	0.012
CHMP1B	chromatin modifying protein 1B	0.012
RAD21	RAD21 homolog (S. pombe)	0.012
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.012
FGFR3	fibroblast growth factor receptor 3	0.012	Mouse
TP53BP1	tumor protein p53 binding protein 1	0.012
FHL1	four and a half LIM domains 1	0.012
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.012
USP44	ubiquitin specific peptidase 44	0.012
BMP4	bone morphogenetic protein 4	0.012
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.012
SGOL2	shugoshin-like 2 (S. pombe)	0.012
NUF2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.012
CCNE2	cyclin E2	0.012	Fly
CSNK2A2	casein kinase 2, alpha prime polypeptide	0.011
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.011
EGR1	early growth response 1	0.011
ANAPC7	anaphase promoting complex subunit 7	0.011
FGFR2	fibroblast growth factor receptor 2	0.011	Mouse
SLC39A7	solute carrier family 39 (zinc transporter), member 7	0.011
AXIN2	axin 2	0.011
USP54	ubiquitin specific peptidase 54	0.011
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.011
CCNB2	cyclin B2	0.011
FGF7	fibroblast growth factor 7	0.011
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.011
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.011
HIST1H1E	histone cluster 1, H1e	0.011
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.011
MDC1	mediator of DNA-damage checkpoint 1	0.011
RAB18	RAB18, member RAS oncogene family	0.010
MAX	MYC associated factor X	0.010
HIST1H4F	histone cluster 1, H4f	0.010
ZNF828	zinc finger protein 828	0.010
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.010
SH3GL2	SH3-domain GRB2-like 2	0.010
TCF4	transcription factor 4	0.010
ANAPC4	anaphase promoting complex subunit 4	0.010
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.010
ZW10	ZW10, kinetochore associated, homolog (Drosophila)	0.010
L3MBTL1	l(3)mbt-like 1 (Drosophila)	0.010
PRRC2C	proline-rich coiled-coil 2C	0.010
STAMBP	STAM binding protein	0.010
C13orf34	chromosome 13 open reading frame 34	0.010
AP2M1	adaptor-related protein complex 2, mu 1 subunit	0.010
CREBBP	CREB binding protein	0.010