IMP

Process View

Mus musculus

17 genes annotated in mouse

positive regulation of syncytium formation by plasma membrane fusion

Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of syncytium formation by plasma membrane fusion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of syncytium formation by plasma membrane fusion" (in gray)

Name	Description	Probability	Func Analog Organism
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.960
Ccl2	chemokine (C-C motif) ligand 2	0.944
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.943	Mouse
Mapk14	mitogen-activated protein kinase 14	0.911
Ifng	interferon gamma	0.867
Ccl7	chemokine (C-C motif) ligand 7	0.838	Mouse
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.695
Il1rn	interleukin 1 receptor antagonist	0.683
Tnf	tumor necrosis factor	0.676	Mouse
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.577
Ccl4	chemokine (C-C motif) ligand 4	0.490	Mouse
Cxcl2	chemokine (C-X-C motif) ligand 2	0.455	Mouse
Socs1	suppressor of cytokine signaling 1	0.361
Ccr1	chemokine (C-C motif) receptor 1	0.318
Mapk11	mitogen-activated protein kinase 11	0.311	Mouse
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.310	Mouse
Cxcl1	chemokine (C-X-C motif) ligand 1	0.305	Mouse
Ikzf1	IKAROS family zinc finger 1	0.269
Il1b	interleukin 1 beta	0.267
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.257
Ccl12	chemokine (C-C motif) ligand 12	0.226	Mouse
Ccl3	chemokine (C-C motif) ligand 3	0.217
Selp	selectin, platelet	0.206
Cd40	CD40 antigen	0.194
Irg1	immunoresponsive gene 1	0.192
Ch25h	cholesterol 25-hydroxylase	0.185
Cxcl13	chemokine (C-X-C motif) ligand 13	0.184
Nphs2	nephrosis 2 homolog, podocin (human)	0.181
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.168	Mouse
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.150
Il6	interleukin 6	0.148
Msr1	macrophage scavenger receptor 1	0.142
Ltb	lymphotoxin B	0.139
Fas	Fas (TNF receptor superfamily member 6)	0.139
Il2rb	interleukin 2 receptor, beta chain	0.129
Cd14	CD14 antigen	0.121
Vegfa	vascular endothelial growth factor A	0.117
Atf2	activating transcription factor 2	0.114
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.113
Ccr2	chemokine (C-C motif) receptor 2	0.112
Clec4d	C-type lectin domain family 4, member d	0.110
Mapk8ip3	mitogen-activated protein kinase 8 interacting protein 3	0.106
Bcl3	B-cell leukemia/lymphoma 3	0.106
Ccl8	chemokine (C-C motif) ligand 8	0.102
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.101
Ccl17	chemokine (C-C motif) ligand 17	0.100
Il2rg	interleukin 2 receptor, gamma chain	0.095
Il10ra	interleukin 10 receptor, alpha	0.095
C3ar1	complement component 3a receptor 1	0.093
Cd28	CD28 antigen	0.091
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.091
Klc1	kinesin light chain 1	0.088
Fcgr1	Fc receptor, IgG, high affinity I	0.086
Cd80	CD80 antigen	0.086
Il2	interleukin 2	0.085
Ptgir	prostaglandin I receptor (IP)	0.084
Lta	lymphotoxin A	0.083	Mouse
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.081
Mapkapk2	MAP kinase-activated protein kinase 2	0.080
Csf1	colony stimulating factor 1 (macrophage)	0.077
Bcl2	B-cell leukemia/lymphoma 2	0.076
Mmp12	matrix metallopeptidase 12	0.075
Ilk	integrin linked kinase	0.074
Il10	interleukin 10	0.073
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.072
Folr2	folate receptor 2 (fetal)	0.067
Cxcl9	chemokine (C-X-C motif) ligand 9	0.058
Saa3	serum amyloid A 3	0.057
Lag3	lymphocyte-activation gene 3	0.056
C5ar1	complement component 5a receptor 1	0.055
Slfn4	schlafen 4	0.053
Slamf8	SLAM family member 8	0.051
Tlr4	toll-like receptor 4	0.049
Lmx1b	LIM homeobox transcription factor 1 beta	0.048
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.046
Niacr1	niacin receptor 1	0.045
D930020E02Rik	RIKEN cDNA D930020E02 gene	0.044
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.044
Tcf3	transcription factor 3	0.044
Tlr2	toll-like receptor 2	0.043
Lyz2	lysozyme 2	0.043
Ccr5	chemokine (C-C motif) receptor 5	0.043
Ubd	ubiquitin D	0.042
Il7	interleukin 7	0.042
Lilrb4	leukocyte immunoglobulin-like receptor, subfamily B, member 4	0.042
Cxcl17	chemokine (C-X-C motif) ligand 17	0.039
Myo1c	myosin IC	0.039
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.038
Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.038
Mmp3	matrix metallopeptidase 3	0.037
Il4	interleukin 4	0.036
Gdf15	growth differentiation factor 15	0.036
Ccl9	chemokine (C-C motif) ligand 9	0.036	Mouse
Gdnf	glial cell line derived neurotrophic factor	0.036
Cd86	CD86 antigen	0.035
Mx2	myxovirus (influenza virus) resistance 2	0.035
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.035
Ccl11	chemokine (C-C motif) ligand 11	0.035
Cd151	CD151 antigen	0.035	Mouse
Atf3	activating transcription factor 3	0.035
Iigp1	interferon inducible GTPase 1	0.034
Lama5	laminin, alpha 5	0.034
Il3	interleukin 3	0.033
Htra3	HtrA serine peptidase 3	0.031
Ptgs2	prostaglandin-endoperoxide synthase 2	0.031
Mgmt	O-6-methylguanine-DNA methyltransferase	0.030
Rel	reticuloendotheliosis oncogene	0.030
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.029
Rapsn	receptor-associated protein of the synapse	0.029
Vhl	von Hippel-Lindau tumor suppressor	0.027
Mmp13	matrix metallopeptidase 13	0.027
Il1a	interleukin 1 alpha	0.027
Gzmb	granzyme B	0.027
Tnfaip2	tumor necrosis factor, alpha-induced protein 2	0.027
Mknk2	MAP kinase-interacting serine/threonine kinase 2	0.026
F10	coagulation factor X	0.026
Ciita	class II transactivator	0.026
Gm11428	predicted gene 11428	0.026
Snx20	sorting nexin 20	0.026
Stat6	signal transducer and activator of transcription 6	0.026
Il12b	interleukin 12b	0.025
Vcl	vinculin	0.024
Col4a3	collagen, type IV, alpha 3	0.024
Ccl22	chemokine (C-C motif) ligand 22	0.023	Mouse
Cd160	CD160 antigen	0.022
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.022
Prkci	protein kinase C, iota	0.022
Plaur	plasminogen activator, urokinase receptor	0.022
Cyp24a1	cytochrome P450, family 24, subfamily a, polypeptide 1	0.022
Gzmk	granzyme K	0.022
Wt1	Wilms tumor 1 homolog	0.021
Itga3	integrin alpha 3	0.021
Timp1	tissue inhibitor of metalloproteinase 1	0.021
Notch4	Notch gene homolog 4 (Drosophila)	0.021
Ms4a7	membrane-spanning 4-domains, subfamily A, member 7	0.021
Dab2	disabled homolog 2 (Drosophila)	0.021
Fli1	Friend leukemia integration 1	0.020
Cxcl5	chemokine (C-X-C motif) ligand 5	0.020	Mouse
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.020
Sele	selectin, endothelial cell	0.020
Rab3il1	RAB3A interacting protein (rabin3)-like 1	0.020
Il1rl1	interleukin 1 receptor-like 1	0.019
Il4ra	interleukin 4 receptor, alpha	0.019
Pdcd1	programmed cell death 1	0.019
Tbxas1	thromboxane A synthase 1, platelet	0.019
Lif	leukemia inhibitory factor	0.019
Clcnka	chloride channel Ka	0.019
Nos2	nitric oxide synthase 2, inducible	0.019
Mpeg1	macrophage expressed gene 1	0.019
Rgs16	regulator of G-protein signaling 16	0.019
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.019
Cxcl10	chemokine (C-X-C motif) ligand 10	0.018	Mouse
Sfpi1	SFFV proviral integration 1	0.018
Il18rap	interleukin 18 receptor accessory protein	0.018
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.018
Tnfsf8	tumor necrosis factor (ligand) superfamily, member 8	0.018
Pitx1	paired-like homeodomain transcription factor 1	0.018
Sftpd	surfactant associated protein D	0.018
Il22	interleukin 22	0.018
Ctss	cathepsin S	0.017
Rpl36a	ribosomal protein L36A	0.017
Irf5	interferon regulatory factor 5	0.017
Snai1	snail homolog 1 (Drosophila)	0.017
Cma1	chymase 1, mast cell	0.017
Hoxd12	homeobox D12	0.017
Mefv	Mediterranean fever	0.017
Fosl1	fos-like antigen 1	0.017
Gzmc	granzyme C	0.016
Csf3	colony stimulating factor 3 (granulocyte)	0.016
Rrm2b	ribonucleotide reductase M2 B (TP53 inducible)	0.016
Mlph	melanophilin	0.016
Icos	inducible T-cell co-stimulator	0.016
Prkce	protein kinase C, epsilon	0.016
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.016
Lepr	leptin receptor	0.016
Spag9	sperm associated antigen 9	0.016
Aoah	acyloxyacyl hydrolase	0.015
Slfn1	schlafen 1	0.015
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.015
H2-M9	histocompatibility 2, M region locus 9	0.015
Ltbr	lymphotoxin B receptor	0.015
Muc5b	mucin 5, subtype B, tracheobronchial	0.015
Cxcr5	chemokine (C-X-C motif) receptor 5	0.015
Clec4e	C-type lectin domain family 4, member e	0.015
Wnt10a	wingless related MMTV integration site 10a	0.015
Il2ra	interleukin 2 receptor, alpha chain	0.014
Lcp1	lymphocyte cytosolic protein 1	0.014
Gpr35	G protein-coupled receptor 35	0.014
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.014
Cyp4f18	cytochrome P450, family 4, subfamily f, polypeptide 18	0.014
F13a1	coagulation factor XIII, A1 subunit	0.014
Ccl5	chemokine (C-C motif) ligand 5	0.014
Ccrl2	chemokine (C-C motif) receptor-like 2	0.014
Tox	thymocyte selection-associated high mobility group box	0.014
Batf	basic leucine zipper transcription factor, ATF-like	0.014
Capn2	calpain 2	0.014
Zc3h12a	zinc finger CCCH type containing 12A	0.014
Retnla	resistin like alpha	0.014
Podxl	podocalyxin-like	0.013
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.013
S100a9	S100 calcium binding protein A9 (calgranulin B)	0.013
Mapk12	mitogen-activated protein kinase 12	0.013	Mouse
Slfn2	schlafen 2	0.013
Apobr	apolipoprotein B receptor	0.013
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.013
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.013
Nlrp3	NLR family, pyrin domain containing 3	0.013
Slc15a3	solute carrier family 15, member 3	0.013
Cd274	CD274 antigen	0.013
Kcne4	potassium voltage-gated channel, Isk-related subfamily, gene 4	0.013
Phlda3	pleckstrin homology-like domain, family A, member 3	0.013
Bcl6b	B-cell CLL/lymphoma 6, member B	0.013
Sh2d2a	SH2 domain protein 2A	0.013
Rnase4	ribonuclease, RNase A family 4	0.013
Tgfb3	transforming growth factor, beta 3	0.013
Rgs1	regulator of G-protein signaling 1	0.013
Mrc1	mannose receptor, C type 1	0.012
Angptl2	angiopoietin-like 2	0.012
Nppb	natriuretic peptide type B	0.012
Bdkrb1	bradykinin receptor, beta 1	0.012
Il17a	interleukin 17A	0.012
Gbp2	guanylate binding protein 2	0.012
Ccl6	chemokine (C-C motif) ligand 6	0.012	Mouse
Osmr	oncostatin M receptor	0.012
Gp49a	glycoprotein 49 A	0.012
Sftpa1	surfactant associated protein A1	0.012
Gabrp	gamma-aminobutyric acid (GABA) A receptor, pi	0.012
Kcnj1	potassium inwardly-rectifying channel, subfamily J, member 1	0.012
Ccl20	chemokine (C-C motif) ligand 20	0.012	Mouse
Foxc2	forkhead box C2	0.012
Il1r2	interleukin 1 receptor, type II	0.012
Xcl1	chemokine (C motif) ligand 1	0.012
Cxcl16	chemokine (C-X-C motif) ligand 16	0.012
St3gal1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	0.012
Myof	myoferlin	0.011
Fpr2	formyl peptide receptor 2	0.011
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.011
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.011
Srgn	serglycin	0.011
Slpi	secretory leukocyte peptidase inhibitor	0.011
AI607873	expressed sequence AI607873	0.011
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.011
Tgm2	transglutaminase 2, C polypeptide	0.011
Rsad2	radical S-adenosyl methionine domain containing 2	0.011
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.011
Adcy4	adenylate cyclase 4	0.011
Msn	moesin	0.011
Ptges	prostaglandin E synthase	0.011
P2ry2	purinergic receptor P2Y, G-protein coupled 2	0.011
Hrh2	histamine receptor H2	0.011
Plek	pleckstrin	0.011
Gbp1	guanylate binding protein 1	0.011
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.011
Kera	keratocan	0.010
LOC100504404	h-2 class II histocompatibility antigen, E-K alpha chain-like	0.010
Cxcl3	chemokine (C-X-C motif) ligand 3	0.010
Clec4a2	C-type lectin domain family 4, member a2	0.010
Pkp3	plakophilin 3	0.010
Smarcd3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.010
Il3ra	interleukin 3 receptor, alpha chain	0.010
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.010
Ncf4	neutrophil cytosolic factor 4	0.010
Slamf7	SLAM family member 7	0.010
Art5	ADP-ribosyltransferase 5	0.010
Vcam1	vascular cell adhesion molecule 1	0.010
Dmbt1	deleted in malignant brain tumors 1	0.010
Dusp2	dual specificity phosphatase 2	0.010
Mmp9	matrix metallopeptidase 9	0.010