IMP

Process View

Mus musculus

12 genes annotated in mouse

Multi-species View

negative thymic t cell selection

GO:0045060

The process of elimination of immature T cells in the thymus which react strongly with self-antigens.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative thymic t cell selection"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative thymic t cell selection" (in gray)

Name	Description	Probability	Func Analog Organism
Ptprc	protein tyrosine phosphatase, receptor type, C	0.995
Ccr2	chemokine (C-C motif) receptor 2	0.988	Mouse
Fyn	Fyn proto-oncogene	0.985
Cd19	CD19 antigen	0.952
Gli3	GLI-Kruppel family member GLI3	0.872
Lat	linker for activation of T cells	0.815
Lck	lymphocyte protein tyrosine kinase	0.802
Cd28	CD28 antigen	0.789
Foxp3	forkhead box P3	0.752
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.612
Icos	inducible T-cell co-stimulator	0.587	Mouse
Cxcr3	chemokine (C-X-C motif) receptor 3	0.587	Mouse
H2-Aa	histocompatibility 2, class II antigen A, alpha	0.571
Itgal	integrin alpha L	0.527
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.514
Cd96	CD96 antigen	0.497
Cd44	CD44 antigen	0.492
Il27ra	interleukin 27 receptor, alpha	0.489
Lyz2	lysozyme 2	0.468
Ccr6	chemokine (C-C motif) receptor 6	0.404	Mouse
Cd4	CD4 antigen	0.404
Cd247	CD247 antigen	0.396
Itk	IL2-inducible T-cell kinase	0.396
H2-Eb1	histocompatibility 2, class II antigen E beta	0.386
Itgax	integrin alpha X	0.372
Cd5	CD5 antigen	0.364
Ifng	interferon gamma	0.350
Ccl2	chemokine (C-C motif) ligand 2	0.350
Fas	Fas (TNF receptor superfamily member 6)	0.347
Tnf	tumor necrosis factor	0.331
Cd7	CD7 antigen	0.316
Il2rb	interleukin 2 receptor, beta chain	0.289
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.275
Cd3e	CD3 antigen, epsilon polypeptide	0.274
Cd6	CD6 antigen	0.263
Cd22	CD22 antigen	0.258
Igk	immunoglobulin kappa chain complex	0.247
Tcra	T-cell receptor alpha chain	0.244
Cd3g	CD3 antigen, gamma polypeptide	0.236	Mouse
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.222
Zap70	zeta-chain (TCR) associated protein kinase	0.207
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.196
Cd2	CD2 antigen	0.195
Ccr5	chemokine (C-C motif) receptor 5	0.193	Mouse
Tlr4	toll-like receptor 4	0.192
Efna1	ephrin A1	0.188
Fcrla	Fc receptor-like A	0.185
Cxcl13	chemokine (C-X-C motif) ligand 13	0.176
Igh	immunoglobulin heavy chain complex	0.170
Batf	basic leucine zipper transcription factor, ATF-like	0.170
Xcr1	chemokine (C motif) receptor 1	0.163	Mouse
Sh2d1a	SH2 domain protein 1A	0.159
Cd3d	CD3 antigen, delta polypeptide	0.153	Mouse
Ccl3	chemokine (C-C motif) ligand 3	0.152
Fgfr2	fibroblast growth factor receptor 2	0.149
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.135	Mouse
Ccr7	chemokine (C-C motif) receptor 7	0.131
Ctsw	cathepsin W	0.122
Blk	B lymphoid kinase	0.119
Vav1	vav 1 oncogene	0.117
Gli2	GLI-Kruppel family member GLI2	0.117	Mouse
Cd8b1	CD8 antigen, beta chain 1	0.108
Ltb	lymphotoxin B	0.105
Inpp5d	inositol polyphosphate-5-phosphatase D	0.105
Gzmb	granzyme B	0.104
Sh2d2a	SH2 domain protein 2A	0.097
Ikzf1	IKAROS family zinc finger 1	0.092
Gimap7	GTPase, IMAP family member 7	0.083
Mmp9	matrix metallopeptidase 9	0.078
Prdm1	PR domain containing 1, with ZNF domain	0.077
H2-DMa	histocompatibility 2, class II, locus DMa	0.077
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.077
Il18rap	interleukin 18 receptor accessory protein	0.074
Pdcd1	programmed cell death 1	0.072
Cbl	Casitas B-lineage lymphoma	0.066
Ifngr1	interferon gamma receptor 1	0.064
S1pr4	sphingosine-1-phosphate receptor 4	0.063
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.061
H2-Ob	histocompatibility 2, O region beta locus	0.060
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.057
Il7r	interleukin 7 receptor	0.057
Ciita	class II transactivator	0.056
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.056
Pou2af1	POU domain, class 2, associating factor 1	0.055
Sit1	suppression inducing transmembrane adaptor 1	0.053
Ptprn	protein tyrosine phosphatase, receptor type, N	0.051
Ccr1	chemokine (C-C motif) receptor 1	0.049	Mouse
Gimap3	GTPase, IMAP family member 3	0.048
Irf4	interferon regulatory factor 4	0.047
Il18r1	interleukin 18 receptor 1	0.046
Rhoh	ras homolog gene family, member H	0.046
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.045
Ptpre	protein tyrosine phosphatase, receptor type, E	0.045	Mouse
Socs1	suppressor of cytokine signaling 1	0.045
Casp8	caspase 8	0.045
Hr	hairless	0.044
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.044
Itgb2	integrin beta 2	0.040
Cd8a	CD8 antigen, alpha chain	0.040
Tspo2	translocator protein 2	0.039
Il1r1	interleukin 1 receptor, type I	0.038
Gzma	granzyme A	0.038
Nkg7	natural killer cell group 7 sequence	0.037
Cxcr4	chemokine (C-X-C motif) receptor 4	0.037	Mouse
Grb2	growth factor receptor bound protein 2	0.037
Twist2	twist homolog 2 (Drosophila)	0.036
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.036
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.035
Ptch1	patched homolog 1	0.035
Cd160	CD160 antigen	0.034
Ccl5	chemokine (C-C motif) ligand 5	0.034
Itgae	integrin alpha E, epithelial-associated	0.034
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.033
H2-DMb2	histocompatibility 2, class II, locus Mb2	0.033
Cxcr6	chemokine (C-X-C motif) receptor 6	0.032	Mouse
Slamf1	signaling lymphocytic activation molecule family member 1	0.031
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.031
Icam1	intercellular adhesion molecule 1	0.031
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.029
Fasl	Fas ligand (TNF superfamily, member 6)	0.029
Lta	lymphotoxin A	0.028
Tbx21	T-box 21	0.028
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.028
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.028
Cd37	CD37 antigen	0.028
H2-Oa	histocompatibility 2, O region alpha locus	0.026
Insm1	insulinoma-associated 1	0.025
Elf4	E74-like factor 4 (ets domain transcription factor)	0.025
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.025
Cd27	CD27 antigen	0.025
Fgf9	fibroblast growth factor 9	0.025
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.024
Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	0.024
Slamf6	SLAM family member 6	0.024
Rasa3	RAS p21 protein activator 3	0.023
Ccl22	chemokine (C-C motif) ligand 22	0.023
Fgfr3	fibroblast growth factor receptor 3	0.022
Ncr1	natural cytotoxicity triggering receptor 1	0.022
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.021
Gzmk	granzyme K	0.021
Pten	phosphatase and tensin homolog	0.021
Prkcq	protein kinase C, theta	0.021
Cbln1	cerebellin 1 precursor protein	0.021
Lair1	leukocyte-associated Ig-like receptor 1	0.021
Il4	interleukin 4	0.020
Nckap1l	NCK associated protein 1 like	0.020
Rgs14	regulator of G-protein signaling 14	0.020
Prkcd	protein kinase C, delta	0.020
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.020
Il6st	interleukin 6 signal transducer	0.019
H2-Eb2	histocompatibility 2, class II antigen E beta2	0.019
Sox9	SRY-box containing gene 9	0.019
Cytip	cytohesin 1 interacting protein	0.018
Xcl1	chemokine (C motif) ligand 1	0.018
Pla2g2d	phospholipase A2, group IID	0.018
Klra9	killer cell lectin-like receptor subfamily A, member 9	0.018
Prf1	perforin 1 (pore forming protein)	0.018
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.018
Tnfrsf18	tumor necrosis factor receptor superfamily, member 18	0.018
Apln	apelin	0.018
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.018
Lrmp	lymphoid-restricted membrane protein	0.017
Myo1f	myosin IF	0.016
Cd40	CD40 antigen	0.016
Ar	androgen receptor	0.016
Ikzf4	IKAROS family zinc finger 4	0.016
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.016
Igj	immunoglobulin joining chain	0.016
C3	complement component 3	0.015
Apoe	apolipoprotein E	0.015
Kcnk4	potassium channel, subfamily K, member 4	0.015
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.015
Il2rg	interleukin 2 receptor, gamma chain	0.015
Nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.015
Cd180	CD180 antigen	0.014
Spry4	sprouty homolog 4 (Drosophila)	0.014
Ly9	lymphocyte antigen 9	0.014
Txk	TXK tyrosine kinase	0.014
Sla2	Src-like-adaptor 2	0.014
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.014
Kcnk7	potassium channel, subfamily K, member 7	0.014
Th	tyrosine hydroxylase	0.013
Lepr	leptin receptor	0.013
Adora2a	adenosine A2a receptor	0.013
Clec2i	C-type lectin domain family 2, member i	0.013
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.013
Bnc1	basonuclin 1	0.013
Lamc3	laminin gamma 3	0.012
Bmp7	bone morphogenetic protein 7	0.012
Stat4	signal transducer and activator of transcription 4	0.012
Bach2	BTB and CNC homology 2	0.012
Col4a3	collagen, type IV, alpha 3	0.012
Il10ra	interleukin 10 receptor, alpha	0.012
Map4k2	mitogen-activated protein kinase kinase kinase kinase 2	0.012
Il2	interleukin 2	0.012
Wipf1	WAS/WASL interacting protein family, member 1	0.012
Sspo	SCO-spondin	0.012
Gdnf	glial cell line derived neurotrophic factor	0.012
Cd79b	CD79B antigen	0.011
Tnip1	TNFAIP3 interacting protein 1	0.011
Chst3	carbohydrate (chondroitin 6/keratan) sulfotransferase 3	0.011
Dock2	dedicator of cyto-kinesis 2	0.011
Ren1	renin 1 structural	0.011
Stc2	stanniocalcin 2	0.011
Plau	plasminogen activator, urokinase	0.011
Abcg1	ATP-binding cassette, sub-family G (WHITE), member 1	0.011
Fgf10	fibroblast growth factor 10	0.011
Sell	selectin, lymphocyte	0.011
Tlr2	toll-like receptor 2	0.011
Lef1	lymphoid enhancer binding factor 1	0.011
Gimap4	GTPase, IMAP family member 4	0.010
Shh	sonic hedgehog	0.010
Foxc1	forkhead box C1	0.010
Cd84	CD84 antigen	0.010
Efnb2	ephrin B2	0.010
Slc30a3	solute carrier family 30 (zinc transporter), member 3	0.010
Cst7	cystatin F (leukocystatin)	0.010
Was	Wiskott-Aldrich syndrome homolog (human)	0.010
Zfp36	zinc finger protein 36	0.010
Gpr132	G protein-coupled receptor 132	0.010
Fosb	FBJ osteosarcoma oncogene B	0.010