IMP
Process View
positive regulation of mammary gland involution
Any process that activates or increases the frequency, rate or extent of mammary gland involution.
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Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of mammary gland involution"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Trp53 | transformation related protein 53 | 1.000 | ||
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 1.000 | ||
| Rxra | retinoid X receptor alpha | 0.970 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.958 | Mouse | |
| Esr1 | estrogen receptor 1 (alpha) | 0.928 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.826 | ||
| Lepr | leptin receptor | 0.816 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.585 | ||
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.580 | ||
| Pten | phosphatase and tensin homolog | 0.576 | ||
| Skil | SKI-like | 0.553 | ||
| Vhl | von Hippel-Lindau tumor suppressor | 0.487 | ||
| Tgfb1 | transforming growth factor, beta 1 | 0.472 | ||
| Kit | kit oncogene | 0.374 | ||
| Lep | leptin | 0.361 | ||
| Bax | BCL2-associated X protein | 0.294 | ||
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.290 | ||
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.279 | ||
| Insr | insulin receptor | 0.260 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.248 | ||
| Ncoa3 | nuclear receptor coactivator 3 | 0.235 | ||
| Pmaip1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.198 | ||
| Igh | immunoglobulin heavy chain complex | 0.198 | ||
| Pck1 | phosphoenolpyruvate carboxykinase 1, cytosolic | 0.183 | ||
| Bak1 | BCL2-antagonist/killer 1 | 0.176 | Mouse | |
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.164 | ||
| Nf1 | neurofibromatosis 1 | 0.143 | ||
| Vegfa | vascular endothelial growth factor A | 0.134 | ||
| Csf1 | colony stimulating factor 1 (macrophage) | 0.131 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.128 | ||
| Wt1 | Wilms tumor 1 homolog | 0.104 | ||
| Apoe | apolipoprotein E | 0.088 | ||
| Pax2 | paired box gene 2 | 0.086 | ||
| Mtor | mechanistic target of rapamycin (serine/threonine kinase) | 0.084 | ||
| Col1a1 | collagen, type I, alpha 1 | 0.083 | ||
| Daxx | Fas death domain-associated protein | 0.081 | ||
| Cd19 | CD19 antigen | 0.079 | ||
| Rara | retinoic acid receptor, alpha | 0.079 | ||
| Fas | Fas (TNF receptor superfamily member 6) | 0.079 | ||
| Cav1 | caveolin 1, caveolae protein | 0.073 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.072 | ||
| Lyz2 | lysozyme 2 | 0.071 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.066 | ||
| Crim1 | cysteine rich transmembrane BMP regulator 1 (chordin like) | 0.060 | ||
| Lif | leukemia inhibitory factor | 0.058 | ||
| Vav2 | vav 2 oncogene | 0.054 | ||
| Pparg | peroxisome proliferator activated receptor gamma | 0.054 | Mouse | |
| Nos2 | nitric oxide synthase 2, inducible | 0.050 | ||
| Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.048 | ||
| Lyst | lysosomal trafficking regulator | 0.045 | ||
| Bbc3 | BCL2 binding component 3 | 0.043 | ||
| Nos1 | nitric oxide synthase 1, neuronal | 0.043 | ||
| Bid | BH3 interacting domain death agonist | 0.041 | ||
| Irf8 | interferon regulatory factor 8 | 0.041 | ||
| Nfe2l2 | nuclear factor, erythroid derived 2, like 2 | 0.040 | ||
| Gdnf | glial cell line derived neurotrophic factor | 0.039 | ||
| Braf | Braf transforming gene | 0.039 | ||
| Prkci | protein kinase C, iota | 0.038 | ||
| Tlr4 | toll-like receptor 4 | 0.037 | ||
| Tlr2 | toll-like receptor 2 | 0.036 | ||
| Hr | hairless | 0.036 | ||
| Agt | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.036 | ||
| Abcc2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.035 | ||
| Sult1b1 | sulfotransferase family 1B, member 1 | 0.035 | ||
| Gata6 | GATA binding protein 6 | 0.034 | ||
| Pkd1 | polycystic kidney disease 1 homolog | 0.034 | ||
| Gata4 | GATA binding protein 4 | 0.034 | ||
| Dicer1 | Dicer1, Dcr-1 homolog (Drosophila) | 0.034 | ||
| Trim25 | tripartite motif-containing 25 | 0.032 | ||
| Tcrd | T-cell receptor delta chain | 0.032 | ||
| Tssc4 | tumor-suppressing subchromosomal transferable fragment 4 | 0.032 | ||
| Ret | ret proto-oncogene | 0.032 | ||
| Mfn2 | mitofusin 2 | 0.030 | ||
| Tnfrsf11a | tumor necrosis factor receptor superfamily, member 11a | 0.030 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.030 | ||
| Fam83h | family with sequence similarity 83, member H | 0.029 | ||
| Agtr1a | angiotensin II receptor, type 1a | 0.028 | ||
| Tcrb | T-cell receptor beta chain | 0.028 | ||
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.027 | ||
| Stk11 | serine/threonine kinase 11 | 0.026 | ||
| Klf6 | Kruppel-like factor 6 | 0.026 | ||
| Gnas | GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus | 0.026 | ||
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.025 | ||
| Otp | orthopedia homolog (Drosophila) | 0.025 | ||
| Pfn1 | profilin 1 | 0.025 | ||
| Nr1h4 | nuclear receptor subfamily 1, group H, member 4 | 0.025 | Mouse | |
| Apoa4 | apolipoprotein A-IV | 0.024 | ||
| Pxn | paxillin | 0.024 | ||
| Spry4 | sprouty homolog 4 (Drosophila) | 0.024 | ||
| Fam83g | family with sequence similarity 83, member G | 0.024 | ||
| Nr5a2 | nuclear receptor subfamily 5, group A, member 2 | 0.024 | ||
| Midn | midnolin | 0.024 | ||
| Zbtb7a | zinc finger and BTB domain containing 7a | 0.024 | ||
| Nans | N-acetylneuraminic acid synthase (sialic acid synthase) | 0.023 | ||
| Bcl2l1 | BCL2-like 1 | 0.023 | Mouse | |
| Mapk13 | mitogen-activated protein kinase 13 | 0.023 | ||
| Lmna | lamin A | 0.022 | ||
| Pnpla2 | patatin-like phospholipase domain containing 2 | 0.022 | ||
| Ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 0.022 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.022 | ||
| Tgfbr2 | transforming growth factor, beta receptor II | 0.021 | ||
| Prdm16 | PR domain containing 16 | 0.021 | ||
| Myc | myelocytomatosis oncogene | 0.021 | ||
| Relb | avian reticuloendotheliosis viral (v-rel) oncogene related B | 0.021 | ||
| Thra | thyroid hormone receptor alpha | 0.020 | ||
| Ppargc1a | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | 0.020 | ||
| Ehd4 | EH-domain containing 4 | 0.020 | ||
| Fabp1 | fatty acid binding protein 1, liver | 0.020 | ||
| Fam3b | family with sequence similarity 3, member B | 0.020 | ||
| Egfr | epidermal growth factor receptor | 0.020 | ||
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.020 | ||
| Tnip1 | TNFAIP3 interacting protein 1 | 0.020 | ||
| Dok1 | docking protein 1 | 0.020 | ||
| Mitf | microphthalmia-associated transcription factor | 0.020 | ||
| Slc39a1 | solute carrier family 39 (zinc transporter), member 1 | 0.019 | ||
| Arpc3 | actin related protein 2/3 complex, subunit 3 | 0.019 | ||
| Cish | cytokine inducible SH2-containing protein | 0.019 | ||
| Rdh16 | retinol dehydrogenase 16 | 0.019 | ||
| Mmp9 | matrix metallopeptidase 9 | 0.019 | ||
| Sik3 | SIK family kinase 3 | 0.019 | ||
| Rxrg | retinoid X receptor gamma | 0.019 | ||
| Rab17 | RAB17, member RAS oncogene family | 0.019 | ||
| P2ry2 | purinergic receptor P2Y, G-protein coupled 2 | 0.019 | ||
| Mafk | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) | 0.019 | ||
| Ehd3 | EH-domain containing 3 | 0.019 | ||
| Fam20c | family with sequence similarity 20, member C | 0.018 | ||
| Ppard | peroxisome proliferator activator receptor delta | 0.018 | Mouse | |
| Nubp1 | nucleotide binding protein 1 | 0.018 | ||
| Nr1i2 | nuclear receptor subfamily 1, group I, member 2 | 0.018 | Mouse | |
| Mgmt | O-6-methylguanine-DNA methyltransferase | 0.018 | ||
| Apc | adenomatosis polyposis coli | 0.018 | ||
| Slc22a18 | solute carrier family 22 (organic cation transporter), member 18 | 0.018 | ||
| Nr0b2 | nuclear receptor subfamily 0, group B, member 2 | 0.018 | ||
| Nfkbia | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.018 | ||
| Adipoq | adiponectin, C1Q and collagen domain containing | 0.018 | ||
| Slc26a1 | solute carrier family 26 (sulfate transporter), member 1 | 0.018 | ||
| Cd44 | CD44 antigen | 0.018 | ||
| Lrp5 | low density lipoprotein receptor-related protein 5 | 0.017 | ||
| Arpc4 | actin related protein 2/3 complex, subunit 4 | 0.017 | ||
| Kcnd3 | potassium voltage-gated channel, Shal-related family, member 3 | 0.017 | ||
| Gcgr | glucagon receptor | 0.017 | ||
| Hpd | 4-hydroxyphenylpyruvic acid dioxygenase | 0.017 | ||
| Scd1 | stearoyl-Coenzyme A desaturase 1 | 0.017 | ||
| Foxp3 | forkhead box P3 | 0.017 | ||
| Aldob | aldolase B, fructose-bisphosphate | 0.017 | ||
| Tert | telomerase reverse transcriptase | 0.017 | ||
| Spp1 | secreted phosphoprotein 1 | 0.017 | ||
| Cyp2d26 | cytochrome P450, family 2, subfamily d, polypeptide 26 | 0.017 | ||
| Ikzf1 | IKAROS family zinc finger 1 | 0.016 | ||
| Aprt | adenine phosphoribosyl transferase | 0.016 | ||
| Ren1 | renin 1 structural | 0.016 | ||
| Aph1a | anterior pharynx defective 1a homolog (C. elegans) | 0.016 | ||
| Maff | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) | 0.016 | ||
| Slc12a1 | solute carrier family 12, member 1 | 0.016 | ||
| Khk | ketohexokinase | 0.016 | ||
| Plxna1 | plexin A1 | 0.016 | ||
| Gdf15 | growth differentiation factor 15 | 0.016 | ||
| Ep300 | E1A binding protein p300 | 0.016 | ||
| Sdsl | serine dehydratase-like | 0.016 | ||
| Irs2 | insulin receptor substrate 2 | 0.015 | ||
| Ahsg | alpha-2-HS-glycoprotein | 0.015 | ||
| Ldlr | low density lipoprotein receptor | 0.015 | ||
| E2f1 | E2F transcription factor 1 | 0.015 | ||
| Lgr4 | leucine-rich repeat-containing G protein-coupled receptor 4 | 0.015 | ||
| Gck | glucokinase | 0.015 | ||
| Phlda2 | pleckstrin homology-like domain, family A, member 2 | 0.015 | ||
| Pax8 | paired box gene 8 | 0.015 | ||
| Psen1 | presenilin 1 | 0.015 | ||
| Acsm3 | acyl-CoA synthetase medium-chain family member 3 | 0.015 | ||
| Fbp2 | fructose bisphosphatase 2 | 0.015 | ||
| Adam17 | a disintegrin and metallopeptidase domain 17 | 0.014 | ||
| Alpl | alkaline phosphatase, liver/bone/kidney | 0.014 | ||
| Ern1 | endoplasmic reticulum (ER) to nucleus signalling 1 | 0.014 | ||
| Gja1 | gap junction protein, alpha 1 | 0.014 | ||
| Bcl3 | B-cell leukemia/lymphoma 3 | 0.014 | ||
| Gadd45a | growth arrest and DNA-damage-inducible 45 alpha | 0.014 | ||
| Mocs1 | molybdenum cofactor synthesis 1 | 0.014 | ||
| Epha2 | Eph receptor A2 | 0.014 | ||
| Hnf4a | hepatic nuclear factor 4, alpha | 0.014 | ||
| Stat6 | signal transducer and activator of transcription 6 | 0.014 | ||
| Hsd3b3 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 | 0.014 | ||
| Kl | klotho | 0.014 | ||
| Slc3a1 | solute carrier family 3, member 1 | 0.014 | ||
| Rrp36 | ribosomal RNA processing 36 homolog (S. cerevisiae) | 0.014 | ||
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.014 | ||
| Fosl2 | fos-like antigen 2 | 0.013 | ||
| Lipa | lysosomal acid lipase A | 0.013 | ||
| Cftr | cystic fibrosis transmembrane conductance regulator homolog | 0.013 | ||
| Bach1 | BTB and CNC homology 1 | 0.013 | ||
| Thbs1 | thrombospondin 1 | 0.013 | ||
| Rint1 | RAD50 interactor 1 | 0.013 | ||
| Dvl3 | dishevelled 3, dsh homolog (Drosophila) | 0.013 | ||
| Adra1b | adrenergic receptor, alpha 1b | 0.013 | ||
| Hgd | homogentisate 1, 2-dioxygenase | 0.013 | ||
| Vasp | vasodilator-stimulated phosphoprotein | 0.013 | ||
| Vav3 | vav 3 oncogene | 0.013 | ||
| Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | 0.013 | ||
| Mybl2 | myeloblastosis oncogene-like 2 | 0.013 | ||
| Socs1 | suppressor of cytokine signaling 1 | 0.013 | ||
| Rab4b | RAB4B, member RAS oncogene family | 0.013 | ||
| Mettl1 | methyltransferase like 1 | 0.013 | ||
| Pim1 | proviral integration site 1 | 0.013 | ||
| Junb | Jun-B oncogene | 0.012 | ||
| Iyd | iodotyrosine deiodinase | 0.012 | ||
| Efna5 | ephrin A5 | 0.012 | ||
| Sardh | sarcosine dehydrogenase | 0.012 | ||
| Cdhr5 | cadherin-related family member 5 | 0.012 | ||
| Zbtb7b | zinc finger and BTB domain containing 7B | 0.012 | ||
| Asxl1 | additional sex combs like 1 (Drosophila) | 0.012 | ||
| Cdc42se1 | CDC42 small effector 1 | 0.012 | ||
| Igf2bp2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.012 | ||
| Fabp2 | fatty acid binding protein 2, intestinal | 0.012 | ||
| Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 0.012 | ||
| Mark4 | MAP/microtubule affinity-regulating kinase 4 | 0.012 | ||
| Src | Rous sarcoma oncogene | 0.012 | ||
| Btg1 | B-cell translocation gene 1, anti-proliferative | 0.012 | ||
| Lipe | lipase, hormone sensitive | 0.012 | ||
| Ltbr | lymphotoxin B receptor | 0.011 | ||
| Stk4 | serine/threonine kinase 4 | 0.011 | ||
| Azgp1 | alpha-2-glycoprotein 1, zinc | 0.011 | ||
| Wwtr1 | WW domain containing transcription regulator 1 | 0.011 | ||
| Abcg8 | ATP-binding cassette, sub-family G (WHITE), member 8 | 0.011 | ||
| Agrp | agouti related protein | 0.011 | ||
| Sntb2 | syntrophin, basic 2 | 0.011 | ||
| Sfn | stratifin | 0.011 | ||
| Gnmt | glycine N-methyltransferase | 0.011 | ||
| Hoxb13 | homeobox B13 | 0.011 | ||
| Huwe1 | HECT, UBA and WWE domain containing 1 | 0.011 | ||
| Cdkn2c | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.011 | ||
| Cideb | cell death-inducing DNA fragmentation factor, alpha subunit-like effector B | 0.011 | ||
| Slc7a1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.011 | ||
| Fam83f | family with sequence similarity 83, member F | 0.011 | ||
| Furin | furin (paired basic amino acid cleaving enzyme) | 0.011 | ||
| Mxd1 | MAX dimerization protein 1 | 0.011 | ||
| Il6st | interleukin 6 signal transducer | 0.011 | ||
| Foxn1 | forkhead box N1 | 0.010 | ||
| Cyp3a13 | cytochrome P450, family 3, subfamily a, polypeptide 13 | 0.010 | ||
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.010 | ||
| Xpa | xeroderma pigmentosum, complementation group A | 0.010 | ||
| Erbb2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.010 | ||
| Cyp3a16 | cytochrome P450, family 3, subfamily a, polypeptide 16 | 0.010 | ||
| Bcl6 | B-cell leukemia/lymphoma 6 | 0.010 | ||
| Slc6a4 | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | 0.010 | ||
| Pdzk1 | PDZ domain containing 1 | 0.010 | ||
| Slc6a8 | solute carrier family 6 (neurotransmitter transporter, creatine), member 8 | 0.010 | ||
| Tnfsf11 | tumor necrosis factor (ligand) superfamily, member 11 | 0.010 | ||
| Sh3pxd2a | SH3 and PX domains 2A | 0.010 | ||
| Klk1b4 | kallikrein 1-related pepidase b4 | 0.010 | ||
| Aqp7 | aquaporin 7 | 0.010 | ||
| Sult1d1 | sulfotransferase family 1D, member 1 | 0.010 | ||
| Thrb | thyroid hormone receptor beta | 0.010 | ||
| Cdk6 | cyclin-dependent kinase 6 | 0.010 | ||
| C8g | complement component 8, gamma polypeptide | 0.010 | ||
| Ggt1 | gamma-glutamyltransferase 1 | 0.010 | ||
| Lrrc8a | leucine rich repeat containing 8A | 0.010 | ||
| Hoxd11 | homeobox D11 | 0.010 | ||
| Cbl | Casitas B-lineage lymphoma | 0.010 | ||
| Cyp2b10 | cytochrome P450, family 2, subfamily b, polypeptide 10 | 0.010 | ||
| Vil1 | villin 1 | 0.010 |