IMP

Process View

Mus musculus

18 genes annotated in mouse

activin receptor signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "activin receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "activin receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Nodal	nodal	0.999
Smad3	MAD homolog 3 (Drosophila)	0.972	Human
Foxh1	forkhead box H1	0.964
Smad4	MAD homolog 4 (Drosophila)	0.955
Tgfbr2	transforming growth factor, beta receptor II	0.912	Mouse
Acvr1	activin A receptor, type 1	0.824
Pbx1	pre B-cell leukemia transcription factor 1	0.812
Bmp4	bone morphogenetic protein 4	0.719
Gdf1	growth differentiation factor 1	0.599
Fst	follistatin	0.590	Human
Pitx2	paired-like homeodomain transcription factor 2	0.525
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.518
Gli3	GLI-Kruppel family member GLI3	0.491
Inhba	inhibin beta-A	0.478	Human
Acvr2a	activin receptor IIA	0.454	Human Rat
Gata4	GATA binding protein 4	0.430
Foxc1	forkhead box C1	0.403
Zic3	zinc finger protein of the cerebellum 3	0.395
Fgfr2	fibroblast growth factor receptor 2	0.363
Tgfbr1	transforming growth factor, beta receptor I	0.282	Mouse Fly
Shh	sonic hedgehog	0.272
Fgf8	fibroblast growth factor 8	0.244
Hoxa13	homeobox A13	0.234
Axin1	axin 1	0.215
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.214	Mouse
Cfc1	cripto, FRL-1, cryptic family 1	0.213
Apc	adenomatosis polyposis coli	0.185
Smad7	MAD homolog 7 (Drosophila)	0.182	Human
Chrd	chordin	0.174
Tgfbr3	transforming growth factor, beta receptor III	0.159
Smad6	MAD homolog 6 (Drosophila)	0.130
Gsc	goosecoid homeobox	0.122
Wnt5a	wingless-related MMTV integration site 5A	0.119
Acvr2b	activin receptor IIB	0.115	Human
Inhbb	inhibin beta-B	0.113	Human
Amhr2	anti-Mullerian hormone type 2 receptor	0.107	Mouse
Kiss1	KiSS-1 metastasis-suppressor	0.106
Hoxd13	homeobox D13	0.106
Zfpm2	zinc finger protein, multitype 2	0.094
Trp63	transformation related protein 63	0.088
Foxf1a	forkhead box F1a	0.086
Smad2	MAD homolog 2 (Drosophila)	0.083	Human
Dnahc5	dynein, axonemal, heavy chain 5	0.083
Megf8	multiple EGF-like-domains 8	0.083
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.080
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.079
Ar	androgen receptor	0.078
Nog	noggin	0.077
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.077
Fgfr1	fibroblast growth factor receptor 1	0.075
Npc1	Niemann Pick type C1	0.074
Hand2	heart and neural crest derivatives expressed transcript 2	0.073
Shc3	src homology 2 domain-containing transforming protein C3	0.068
Runx2	runt related transcription factor 2	0.068
Ghr	growth hormone receptor	0.066
Pten	phosphatase and tensin homolog	0.064
Dhh	desert hedgehog	0.063
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.062
Mstn	myostatin	0.061
Fzd7	frizzled homolog 7 (Drosophila)	0.061
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.060
Pax3	paired box gene 3	0.057
Msx2	homeobox, msh-like 2	0.057
Zfp592	zinc finger protein 592	0.056
Lrp2	low density lipoprotein receptor-related protein 2	0.054
Tcte3	t-complex-associated testis expressed 3	0.054
Ctnnb1	catenin (cadherin associated protein), beta 1	0.053
Irs2	insulin receptor substrate 2	0.053	Fly
Hoxa1	homeobox A1	0.052
Foxo3	forkhead box O3	0.052	Fly
Klf3	Kruppel-like factor 3 (basic)	0.051
Esr2	estrogen receptor 2 (beta)	0.050
Bmpr1b	bone morphogenetic protein receptor, type 1B	0.049	Mouse
Spry4	sprouty homolog 4 (Drosophila)	0.049
Axin2	axin2	0.049
Fgf15	fibroblast growth factor 15	0.048
Gpc3	glypican 3	0.047
Wnt4	wingless-related MMTV integration site 4	0.046
Tmeff2	transmembrane protein with EGF-like and two follistatin-like domains 2	0.044
Btbd17	BTB (POZ) domain containing 17	0.044
Nptx2	neuronal pentraxin 2	0.043
Myod1	myogenic differentiation 1	0.043
Pbx3	pre B-cell leukemia transcription factor 3	0.041
Nos3	nitric oxide synthase 3, endothelial cell	0.040
Irs1	insulin receptor substrate 1	0.039	Fly
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.039
Angpt1	angiopoietin 1	0.038
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.038
Tdgf1	teratocarcinoma-derived growth factor 1	0.037
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.037
Fmn1	formin 1	0.037
Ntf3	neurotrophin 3	0.037
Pgr	progesterone receptor	0.037
Npr3	natriuretic peptide receptor 3	0.036
Tbx3	T-box 3	0.036
Barx1	BarH-like homeobox 1	0.036
Trp53	transformation related protein 53	0.035
Prrx1	paired related homeobox 1	0.035
Sox9	SRY-box containing gene 9	0.033
Hoxa9	homeobox A9	0.033
Foxa2	forkhead box A2	0.032
Thbd	thrombomodulin	0.032
Hand1	heart and neural crest derivatives expressed transcript 1	0.032
Chst8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	0.032
Pou3f3	POU domain, class 3, transcription factor 3	0.032
Sox15	SRY-box containing gene 15	0.031
Gata6	GATA binding protein 6	0.031
Gdf3	growth differentiation factor 3	0.030
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.030
Fgf9	fibroblast growth factor 9	0.029
Fshr	follicle stimulating hormone receptor	0.029
Zeb1	zinc finger E-box binding homeobox 1	0.029
Sox3	SRY-box containing gene 3	0.028
Esr1	estrogen receptor 1 (alpha)	0.028
Nppc	natriuretic peptide type C	0.028
Tgfb2	transforming growth factor, beta 2	0.028	Fly
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.027	Mouse
Prlr	prolactin receptor	0.027
Tgfa	transforming growth factor alpha	0.027
En1	engrailed 1	0.027
Tcf21	transcription factor 21	0.026
Gdf9	growth differentiation factor 9	0.026
Neo1	neogenin	0.026
Fgf5	fibroblast growth factor 5	0.026	Mouse
Smo	smoothened homolog (Drosophila)	0.026
Tcl1	T-cell lymphoma breakpoint 1	0.026
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.026
Tbx1	T-box 1	0.026
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.026
Kcnd2	potassium voltage-gated channel, Shal-related family, member 2	0.025
Acvr1b	activin A receptor, type 1B	0.025
Fzd4	frizzled homolog 4 (Drosophila)	0.025
Mgat3	mannoside acetylglucosaminyltransferase 3	0.025
Esx1	extraembryonic, spermatogenesis, homeobox 1	0.024
Ppp1ca	protein phosphatase 1, catalytic subunit, alpha isoform	0.024
Bdkrb2	bradykinin receptor, beta 2	0.024
Nfia	nuclear factor I/A	0.024
Cntfr	ciliary neurotrophic factor receptor	0.024
Utf1	undifferentiated embryonic cell transcription factor 1	0.024
Kif1b	kinesin family member 1B	0.023
Hoxa11	homeobox A11	0.023
Jag1	jagged 1	0.023
Padi3	peptidyl arginine deiminase, type III	0.023
Prrx2	paired related homeobox 2	0.022
Socs5	suppressor of cytokine signaling 5	0.022
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.022
Wnt8a	wingless-related MMTV integration site 8A	0.022
Tbx15	T-box 15	0.022
Lefty1	left right determination factor 1	0.022
Bmp2	bone morphogenetic protein 2	0.022
Fgf4	fibroblast growth factor 4	0.022	Mouse
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.022
Zyx	zyxin	0.021
Snai1	snail homolog 1 (Drosophila)	0.021
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.021	Mouse
Epha3	Eph receptor A3	0.021
Hoxb4	homeobox B4	0.021
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.021
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.020
Dll1	delta-like 1 (Drosophila)	0.020
Gab1	growth factor receptor bound protein 2-associated protein 1	0.020
Twist2	twist homolog 2 (Drosophila)	0.020
Ptprb	protein tyrosine phosphatase, receptor type, B	0.020
Cdh3	cadherin 3	0.020
Diablo	diablo homolog (Drosophila)	0.020
Hoxd11	homeobox D11	0.020
Npr2	natriuretic peptide receptor 2	0.020
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.020
Shc1	src homology 2 domain-containing transforming protein C1	0.020
Bmp8b	bone morphogenetic protein 8b	0.020	Mouse
Wnt3	wingless-related MMTV integration site 3	0.020
Dnahc11	dynein, axonemal, heavy chain 11	0.020
Gab2	growth factor receptor bound protein 2-associated protein 2	0.019
Mark1	MAP/microtubule affinity-regulating kinase 1	0.019
Slc25a48	solute carrier family 25, member 48	0.019
Sh2b3	SH2B adaptor protein 3	0.019
Rbl2	retinoblastoma-like 2	0.019
Tulp2	tubby-like protein 2	0.019
Fgfbp1	fibroblast growth factor binding protein 1	0.019
Gata5	GATA binding protein 5	0.019
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.019
Kit	kit oncogene	0.018
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.018
Tcf7	transcription factor 7, T-cell specific	0.018
Fosl2	fos-like antigen 2	0.018
Tex19.1	testis expressed gene 19.1	0.018
Grem2	gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)	0.018
Hoxd9	homeobox D9	0.018
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.018
Lep	leptin	0.018
Gli2	GLI-Kruppel family member GLI2	0.018
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.018
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.018
Creb1	cAMP responsive element binding protein 1	0.018
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.018
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.017
Lox	lysyl oxidase	0.017
Rhox6	reproductive homeobox 6	0.017
Dact3	dapper homolog 3, antagonist of beta-catenin (xenopus)	0.017
Alx4	aristaless-like homeobox 4	0.017
Arpm1	actin related protein M1	0.017
Kcnk3	potassium channel, subfamily K, member 3	0.017
Sall4	sal-like 4 (Drosophila)	0.017
Pkd2	polycystic kidney disease 2	0.017
Scn7a	sodium channel, voltage-gated, type VII, alpha	0.016
Mid2	midline 2	0.016
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.016
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.016
Xiap	X-linked inhibitor of apoptosis	0.016
Nuak1	NUAK family, SNF1-like kinase, 1	0.016
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.016
Hoxa6	homeobox A6	0.016
Rarb	retinoic acid receptor, beta	0.016
Slc5a11	solute carrier family 5 (sodium/glucose cotransporter), member 11	0.016
Cdh11	cadherin 11	0.016
Fgfr3	fibroblast growth factor receptor 3	0.016
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.016
Lepr	leptin receptor	0.016
Gdf11	growth differentiation factor 11	0.015
Bmp7	bone morphogenetic protein 7	0.015	Mouse
Adra1a	adrenergic receptor, alpha 1a	0.015
Foxo4	forkhead box O4	0.015	Fly
Mesp1	mesoderm posterior 1	0.015
Per3	period homolog 3 (Drosophila)	0.015
Fzd1	frizzled homolog 1 (Drosophila)	0.015
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.015
Tll2	tolloid-like 2	0.015
Itgb3	integrin beta 3	0.015
Adra2b	adrenergic receptor, alpha 2b	0.015
Rxra	retinoid X receptor alpha	0.015
Nr6a1	nuclear receptor subfamily 6, group A, member 1	0.015
Thbs1	thrombospondin 1	0.015
Msx1	homeobox, msh-like 1	0.015
Edn2	endothelin 2	0.015
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.015
Mybph	myosin binding protein H	0.015
Zbtb7a	zinc finger and BTB domain containing 7a	0.015
Angpt4	angiopoietin 4	0.015
Cckbr	cholecystokinin B receptor	0.015
Adcy9	adenylate cyclase 9	0.014
Mme	membrane metallo endopeptidase	0.014
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.014
Epha4	Eph receptor A4	0.014
Rgs4	regulator of G-protein signaling 4	0.014
Disp1	dispatched homolog 1 (Drosophila)	0.014
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.014
Kcnk2	potassium channel, subfamily K, member 2	0.014
Myog	myogenin	0.014
Npas1	neuronal PAS domain protein 1	0.014
Kitl	kit ligand	0.014
Cacnb2	calcium channel, voltage-dependent, beta 2 subunit	0.014
Fgf7	fibroblast growth factor 7	0.014	Mouse
Dlgap4	discs, large homolog-associated protein 4 (Drosophila)	0.014
Hist1h1t	histone cluster 1, H1t	0.014
Fign	fidgetin	0.014
Rhob	ras homolog gene family, member B	0.014
Sall1	sal-like 1 (Drosophila)	0.014
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.014
Klf13	Kruppel-like factor 13	0.014
Dtna	dystrobrevin alpha	0.014
Il6st	interleukin 6 signal transducer	0.014
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.014
Hrh1	histamine receptor H1	0.013
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.013
Mmp16	matrix metallopeptidase 16	0.013
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.013
Plekha5	pleckstrin homology domain containing, family A member 5	0.013
Wnt6	wingless-related MMTV integration site 6	0.013
Crebbp	CREB binding protein	0.013
Tcfap2c	transcription factor AP-2, gamma	0.013
Cer1	cerberus 1 homolog (Xenopus laevis)	0.013
Adcyap1r1	adenylate cyclase activating polypeptide 1 receptor 1	0.013
Foxd3	forkhead box D3	0.013
Csf1	colony stimulating factor 1 (macrophage)	0.013
Smurf1	SMAD specific E3 ubiquitin protein ligase 1	0.013
Grb10	growth factor receptor bound protein 10	0.013
Stc2	stanniocalcin 2	0.013
Kif3a	kinesin family member 3A	0.013
Ncoa1	nuclear receptor coactivator 1	0.013
Insr	insulin receptor	0.013
Drd4	dopamine receptor D4	0.013
Fgf12	fibroblast growth factor 12	0.012	Mouse
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.012
Rasgrp1	RAS guanyl releasing protein 1	0.012
Mdfi	MyoD family inhibitor	0.012
Pgap1	post-GPI attachment to proteins 1	0.012
Nfib	nuclear factor I/B	0.012
Fjx1	four jointed box 1 (Drosophila)	0.012
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.012
Vangl2	vang-like 2 (van gogh, Drosophila)	0.012
Lefty2	left-right determination factor 2	0.012	Mouse
Trh	thyrotropin releasing hormone	0.012
Plxna2	plexin A2	0.012
Sav1	salvador homolog 1 (Drosophila)	0.012
Rims4	regulating synaptic membrane exocytosis 4	0.012
Emp2	epithelial membrane protein 2	0.012
Tlx1	T-cell leukemia, homeobox 1	0.012
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.012
Ece1	endothelin converting enzyme 1	0.012
Fzd9	frizzled homolog 9 (Drosophila)	0.012
Npas2	neuronal PAS domain protein 2	0.012
Rasl11b	RAS-like, family 11, member B	0.012
Igfbp6	insulin-like growth factor binding protein 6	0.012
Dpep1	dipeptidase 1 (renal)	0.012
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.012
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.012
Rac1	RAS-related C3 botulinum substrate 1	0.012
Lhx1	LIM homeobox protein 1	0.012
Cdx1	caudal type homeobox 1	0.012
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.012
Epha1	Eph receptor A1	0.012
Trove2	TROVE domain family, member 2	0.012
Cpeb1	cytoplasmic polyadenylation element binding protein 1	0.012
Chrdl2	chordin-like 2	0.012
Zfp503	zinc finger protein 503	0.011
Gjb4	gap junction protein, beta 4	0.011
Vipr1	vasoactive intestinal peptide receptor 1	0.011
Wnt2b	wingless related MMTV integration site 2b	0.011
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.011
Crxos1	Crx opposite strand transcript 1	0.011
Cdk14	cyclin-dependent kinase 14	0.011
Bmp6	bone morphogenetic protein 6	0.011	Mouse
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.011
Gdf5	growth differentiation factor 5	0.011	Mouse
Fgf14	fibroblast growth factor 14	0.011	Mouse
Tsx	testis specific X-linked gene	0.011
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.011
Edn3	endothelin 3	0.011
Bptf	bromodomain PHD finger transcription factor	0.011
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.011
Ank	progressive ankylosis	0.011
Gtf2ird1	general transcription factor II I repeat domain-containing 1	0.011
Srcin1	SRC kinase signaling inhibitor 1	0.011
Lyzl4	lysozyme-like 4	0.011
Homer1	homer homolog 1 (Drosophila)	0.011
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.011
Fam151a	family with sequence simliarity 151, member A	0.011
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.011
Cnn1	calponin 1	0.011
Ptch1	patched homolog 1	0.011
Zfp36l2	zinc finger protein 36, C3H type-like 2	0.011
Lhfp	lipoma HMGIC fusion partner	0.011
Gja3	gap junction protein, alpha 3	0.011
Fgf11	fibroblast growth factor 11	0.011
Hipk3	homeodomain interacting protein kinase 3	0.011
Epn2	epsin 2	0.011
Cacng6	calcium channel, voltage-dependent, gamma subunit 6	0.011
Crabp2	cellular retinoic acid binding protein II	0.011
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.011
Eng	endoglin	0.011
Zfp521	zinc finger protein 521	0.011
Sh3pxd2a	SH3 and PX domains 2A	0.011
Lrp6	low density lipoprotein receptor-related protein 6	0.011
Lman1l	lectin, mannose-binding 1 like	0.011
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.010
Celf4	CUGBP, Elav-like family member 4	0.010
Prkg1	protein kinase, cGMP-dependent, type I	0.010
Apob	apolipoprotein B	0.010
Zscan2	zinc finger and SCAN domain containing 2	0.010
Nos2	nitric oxide synthase 2, inducible	0.010
Crlf1	cytokine receptor-like factor 1	0.010
Barx2	BarH-like homeobox 2	0.010
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.010
Fxyd2	FXYD domain-containing ion transport regulator 2	0.010
Eya4	eyes absent 4 homolog (Drosophila)	0.010
Igfals	insulin-like growth factor binding protein, acid labile subunit	0.010