IMP

Process View

Mus musculus

17 genes annotated in mouse

negative regulation of cartilage development

Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of cartilage development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of cartilage development" (in gray)

Name	Description	Probability	Func Analog Organism
Sox9	SRY-box containing gene 9	0.999
Rarg	retinoic acid receptor, gamma	0.999
Gli3	GLI-Kruppel family member GLI3	0.996	Mouse
Shh	sonic hedgehog	0.996
Fgfr2	fibroblast growth factor receptor 2	0.994
Gli2	GLI-Kruppel family member GLI2	0.992
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.986
Fgf8	fibroblast growth factor 8	0.985
Tgfbr2	transforming growth factor, beta receptor II	0.979	Mouse
Smo	smoothened homolog (Drosophila)	0.934
Bmp7	bone morphogenetic protein 7	0.909
Prrx1	paired related homeobox 1	0.864
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.862
Prrx2	paired related homeobox 2	0.844
Fgf10	fibroblast growth factor 10	0.843
Fgfr3	fibroblast growth factor receptor 3	0.769
Chrd	chordin	0.765
Acvr1	activin A receptor, type 1	0.763	Mouse
Pax3	paired box gene 3	0.747
Bmp4	bone morphogenetic protein 4	0.741
Nos3	nitric oxide synthase 3, endothelial cell	0.732
Pax2	paired box gene 2	0.718
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.701
Foxc1	forkhead box C1	0.698
Meox2	mesenchyme homeobox 2	0.677
Wnt5a	wingless-related MMTV integration site 5A	0.676	Mouse
Tgfb2	transforming growth factor, beta 2	0.667
Nodal	nodal	0.666
Vegfa	vascular endothelial growth factor A	0.557
Fzd2	frizzled homolog 2 (Drosophila)	0.532	Mouse
Foxc2	forkhead box C2	0.523
Fbn1	fibrillin 1	0.504
Tgfbr1	transforming growth factor, beta receptor I	0.494
Fgfr1	fibroblast growth factor receptor 1	0.490
Rarb	retinoic acid receptor, beta	0.478
Rara	retinoic acid receptor, alpha	0.477
Tbx1	T-box 1	0.462
Fzd1	frizzled homolog 1 (Drosophila)	0.424	Mouse
Wnt4	wingless-related MMTV integration site 4	0.422	Mouse
Hand2	heart and neural crest derivatives expressed transcript 2	0.407
Msx1	homeobox, msh-like 1	0.396
Hand1	heart and neural crest derivatives expressed transcript 1	0.368
Twist2	twist homolog 2 (Drosophila)	0.340
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.338
Smad6	MAD homolog 6 (Drosophila)	0.313
Tcfap2a	transcription factor AP-2, alpha	0.299
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.288
Dlx5	distal-less homeobox 5	0.280
Pax8	paired box gene 8	0.273
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.271
Col2a1	collagen, type II, alpha 1	0.254
Ret	ret proto-oncogene	0.244
Mrc2	mannose receptor, C type 2	0.230
Eya1	eyes absent 1 homolog (Drosophila)	0.230
Nog	noggin	0.229
Alx4	aristaless-like homeobox 4	0.207
Hoxa3	homeobox A3	0.192
Fzd8	frizzled homolog 8 (Drosophila)	0.191	Mouse
Fzd7	frizzled homolog 7 (Drosophila)	0.174	Mouse
Snai1	snail homolog 1 (Drosophila)	0.174
Eln	elastin	0.170
Smad3	MAD homolog 3 (Drosophila)	0.168
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.167
Hic1	hypermethylated in cancer 1	0.167
Nkx6-1	NK6 homeobox 1	0.163
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.161	Mouse
Hoxd13	homeobox D13	0.161
Tbx2	T-box 2	0.159
Gas1	growth arrest specific 1	0.156
Gata4	GATA binding protein 4	0.150
Lhx1	LIM homeobox protein 1	0.143
Wnt3a	wingless-related MMTV integration site 3A	0.142	Mouse
Emp2	epithelial membrane protein 2	0.141
Alx3	aristaless-like homeobox 3	0.129
Inhba	inhibin beta-A	0.127
Pax6	paired box gene 6	0.123
Col5a1	collagen, type V, alpha 1	0.123
Pax9	paired box gene 9	0.121
Hoxa2	homeobox A2	0.121
Runx2	runt related transcription factor 2	0.114
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.113	Mouse
Notch3	Notch gene homolog 3 (Drosophila)	0.109
Wnt6	wingless-related MMTV integration site 6	0.104	Mouse
Tgfb1i1	transforming growth factor beta 1 induced transcript 1	0.101
Ptch1	patched homolog 1	0.101
Aplnr	apelin receptor	0.097
Bmper	BMP-binding endothelial regulator	0.097
Col1a1	collagen, type I, alpha 1	0.097
Vangl2	vang-like 2 (van gogh, Drosophila)	0.097
Efs	embryonal Fyn-associated substrate	0.092
Ctnnb1	catenin (cadherin associated protein), beta 1	0.091
Bmp2	bone morphogenetic protein 2	0.090	Mouse
Efna4	ephrin A4	0.088
Grb10	growth factor receptor bound protein 10	0.088
Col11a1	collagen, type XI, alpha 1	0.086
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.080
Hoxb3	homeobox B3	0.078
Sox18	SRY-box containing gene 18	0.074	Mouse
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.074
Fbln5	fibulin 5	0.074	Mouse
Ptk7	PTK7 protein tyrosine kinase 7	0.074
Gli1	GLI-Kruppel family member GLI1	0.072	Mouse
Hoxa1	homeobox A1	0.072
Vax1	ventral anterior homeobox containing gene 1	0.071
Ednra	endothelin receptor type A	0.071
Fst	follistatin	0.069
Apc	adenomatosis polyposis coli	0.069
Lox	lysyl oxidase	0.068
Jag1	jagged 1	0.066
Eng	endoglin	0.066
Btbd17	BTB (POZ) domain containing 17	0.064
Foxf1a	forkhead box F1a	0.064
Npr3	natriuretic peptide receptor 3	0.064
Gpc3	glypican 3	0.063
Pthlh	parathyroid hormone-like peptide	0.063
Tcf15	transcription factor 15	0.063
Tbx3	T-box 3	0.063
Mmp2	matrix metallopeptidase 2	0.062
Pcdh12	protocadherin 12	0.061
Hes1	hairy and enhancer of split 1 (Drosophila)	0.060
Sox4	SRY-box containing gene 4	0.060	Mouse
She	src homology 2 domain-containing transforming protein E	0.060
Neurog3	neurogenin 3	0.059
Hoxb6	homeobox B6	0.057
Hoxd3	homeobox D3	0.057
Pten	phosphatase and tensin homolog	0.056
Zfp703	zinc finger protein 703	0.056
Gata6	GATA binding protein 6	0.056
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.054
En1	engrailed 1	0.054
Gdf11	growth differentiation factor 11	0.051	Mouse
Rxra	retinoid X receptor alpha	0.050
Fgf3	fibroblast growth factor 3	0.048
Nf1	neurofibromatosis 1	0.047
Ednrb	endothelin receptor type B	0.045
Fgf18	fibroblast growth factor 18	0.045
Pdgfb	platelet derived growth factor, B polypeptide	0.044
Pbx1	pre B-cell leukemia transcription factor 1	0.044
Sorbs3	sorbin and SH3 domain containing 3	0.044
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.044
Col6a2	collagen, type VI, alpha 2	0.043
Sfrp2	secreted frizzled-related protein 2	0.043
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.042
Trp63	transformation related protein 63	0.042
Gopc	golgi associated PDZ and coiled-coil motif containing	0.042
Efna2	ephrin A2	0.042
Zeb1	zinc finger E-box binding homeobox 1	0.042
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.041
Lmx1a	LIM homeobox transcription factor 1 alpha	0.041
Rbpjl	recombination signal binding protein for immunoglobulin kappa J region-like	0.041
Gdnf	glial cell line derived neurotrophic factor	0.040
Cldn5	claudin 5	0.039
Ephb3	Eph receptor B3	0.039
Ephb2	Eph receptor B2	0.039
Tbx15	T-box 15	0.039
Bnc1	basonuclin 1	0.039
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.039
Zfp503	zinc finger protein 503	0.039
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.038
Gbx2	gastrulation brain homeobox 2	0.037
Foxd2	forkhead box D2	0.037
Insm1	insulinoma-associated 1	0.037
Fgf4	fibroblast growth factor 4	0.036
Pou3f3	POU domain, class 3, transcription factor 3	0.036
Lhx3	LIM homeobox protein 3	0.036
Fgf17	fibroblast growth factor 17	0.036
Twist1	twist homolog 1 (Drosophila)	0.035
Gdf3	growth differentiation factor 3	0.035	Mouse
Tgfbr3	transforming growth factor, beta receptor III	0.035
Eda	ectodysplasin-A	0.035
T	brachyury	0.034
Epas1	endothelial PAS domain protein 1	0.034
Smoc2	SPARC related modular calcium binding 2	0.034
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.034
Fgf5	fibroblast growth factor 5	0.033
Ihh	Indian hedgehog	0.033
Angptl2	angiopoietin-like 2	0.032
Sox17	SRY-box containing gene 17	0.032	Mouse
Ntf3	neurotrophin 3	0.031
Pitx1	paired-like homeodomain transcription factor 1	0.031
Olig2	oligodendrocyte transcription factor 2	0.031
Wfikkn2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.031
Sult5a1	sulfotransferase family 5A, member 1	0.031
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.030
Ece1	endothelin converting enzyme 1	0.030
Wnt2b	wingless related MMTV integration site 2b	0.029	Mouse
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.029
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.028
Mesp1	mesoderm posterior 1	0.028
Matn4	matrilin 4	0.028
Hoxa5	homeobox A5	0.028
Smad4	MAD homolog 4 (Drosophila)	0.028
Npr2	natriuretic peptide receptor 2	0.028
Nkx3-2	NK3 homeobox 2	0.027
Tcf21	transcription factor 21	0.027
Efnb1	ephrin B1	0.027
Pitx2	paired-like homeodomain transcription factor 2	0.027
Ptrf	polymerase I and transcript release factor	0.026
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.026
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.026
Smad7	MAD homolog 7 (Drosophila)	0.026
Ldlr	low density lipoprotein receptor	0.025
Mdfi	MyoD family inhibitor	0.025
Rem1	rad and gem related GTP binding protein 1	0.025
Cd248	CD248 antigen, endosialin	0.025
Acvr2b	activin receptor IIB	0.024
Lefty1	left right determination factor 1	0.024
Hdac7	histone deacetylase 7	0.024
Fgf15	fibroblast growth factor 15	0.024
Duox2	dual oxidase 2	0.024
Kitl	kit ligand	0.024
Col1a2	collagen, type I, alpha 2	0.023
Hoxa11	homeobox A11	0.023
Arx	aristaless related homeobox	0.023
Idua	iduronidase, alpha-L-	0.023
Dhh	desert hedgehog	0.022
Fgf2	fibroblast growth factor 2	0.022
Apcdd1	adenomatosis polyposis coli down-regulated 1	0.022
Foxd3	forkhead box D3	0.022
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.022
Loxl1	lysyl oxidase-like 1	0.022
Hoxd11	homeobox D11	0.022
Cdx1	caudal type homeobox 1	0.022
Csf1	colony stimulating factor 1 (macrophage)	0.022
Acvrl1	activin A receptor, type II-like 1	0.021	Mouse
Otp	orthopedia homolog (Drosophila)	0.021
Ptch2	patched homolog 2	0.021
Msx3	homeobox, msh-like 3	0.021
Atoh7	atonal homolog 7 (Drosophila)	0.021
Emx2	empty spiracles homolog 2 (Drosophila)	0.021
Leprel2	leprecan-like 2	0.021
Adra2b	adrenergic receptor, alpha 2b	0.021
Col4a5	collagen, type IV, alpha 5	0.020
Per3	period homolog 3 (Drosophila)	0.020
Fzd6	frizzled homolog 6 (Drosophila)	0.020	Mouse
Foxn4	forkhead box N4	0.020
Col6a3	collagen, type VI, alpha 3	0.020
Gdf10	growth differentiation factor 10	0.020
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.019
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.019
Fzd10	frizzled homolog 10 (Drosophila)	0.019
Bmpr1b	bone morphogenetic protein receptor, type 1B	0.019	Mouse
Tdgf1	teratocarcinoma-derived growth factor 1	0.019
Smtn	smoothelin	0.019
Kcnk2	potassium channel, subfamily K, member 2	0.018
Crlf1	cytokine receptor-like factor 1	0.018
Axin2	axin2	0.018
Col14a1	collagen, type XIV, alpha 1	0.018
Cdh5	cadherin 5	0.018
Zic3	zinc finger protein of the cerebellum 3	0.018
Sox3	SRY-box containing gene 3	0.018	Mouse
Cdh6	cadherin 6	0.018
Msx2	homeobox, msh-like 2	0.018
Col13a1	collagen, type XIII, alpha 1	0.018
Capn6	calpain 6	0.018
Utf1	undifferentiated embryonic cell transcription factor 1	0.018
Rspo1	R-spondin homolog (Xenopus laevis)	0.018
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.018
Pitx3	paired-like homeodomain transcription factor 3	0.018
Hcrt	hypocretin	0.017
Dmrt3	doublesex and mab-3 related transcription factor 3	0.017
Hoxb4	homeobox B4	0.017
Nrtn	neurturin	0.017
Chd7	chromodomain helicase DNA binding protein 7	0.017
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.017	Mouse
Mcam	melanoma cell adhesion molecule	0.017
Pou3f1	POU domain, class 3, transcription factor 1	0.017
Plcd1	phospholipase C, delta 1	0.017
Otx2	orthodenticle homolog 2 (Drosophila)	0.017
Sall4	sal-like 4 (Drosophila)	0.017
Gdf5	growth differentiation factor 5	0.017
Barx1	BarH-like homeobox 1	0.017
Col22a1	collagen, type XXII, alpha 1	0.016
Tspan12	tetraspanin 12	0.016
Sod3	superoxide dismutase 3, extracellular	0.016
Mmp11	matrix metallopeptidase 11	0.016
Lhx6	LIM homeobox protein 6	0.016
Foxl2	forkhead box L2	0.016
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.016
Myod1	myogenic differentiation 1	0.016
Fjx1	four jointed box 1 (Drosophila)	0.016
Wnt11	wingless-related MMTV integration site 11	0.016	Mouse
Sema3b	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B	0.016
Dbp	D site albumin promoter binding protein	0.016
Bmp5	bone morphogenetic protein 5	0.016
Nrk	Nik related kinase	0.016
Flt1	FMS-like tyrosine kinase 1	0.016
Hoxd9	homeobox D9	0.016
Ephb4	Eph receptor B4	0.016
Tef	thyrotroph embryonic factor	0.016
Adcy4	adenylate cyclase 4	0.015
Nkain1	Na+/K+ transporting ATPase interacting 1	0.015
Tnxb	tenascin XB	0.015
Rgnef	Rho-guanine nucleotide exchange factor	0.015
Lef1	lymphoid enhancer binding factor 1	0.015
Fgfrl1	fibroblast growth factor receptor-like 1	0.015
Bmp8b	bone morphogenetic protein 8b	0.015
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.015
Ptprb	protein tyrosine phosphatase, receptor type, B	0.015
Thbs3	thrombospondin 3	0.015
Efnb2	ephrin B2	0.015
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.015
Fstl1	follistatin-like 1	0.015
Foxe1	forkhead box E1	0.015
Sox11	SRY-box containing gene 11	0.015	Mouse
Hoxc9	homeobox C9	0.014
Scarf2	scavenger receptor class F, member 2	0.014
Tcl1	T-cell lymphoma breakpoint 1	0.014
Lrp2	low density lipoprotein receptor-related protein 2	0.014
Zfp651	zinc finger protein 651	0.014
Obsl1	obscurin-like 1	0.014
Mfap4	microfibrillar-associated protein 4	0.014
Hoxd10	homeobox D10	0.014
Gja5	gap junction protein, alpha 5	0.014
Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.014
Wnt9a	wingless-type MMTV integration site 9A	0.014
Fhl3	four and a half LIM domains 3	0.014
Vcl	vinculin	0.013
Gja4	gap junction protein, alpha 4	0.013
Tead2	TEA domain family member 2	0.013
Bmp1	bone morphogenetic protein 1	0.013
Cdh11	cadherin 11	0.013
Isl1	ISL1 transcription factor, LIM/homeodomain	0.013
Btbd3	BTB (POZ) domain containing 3	0.013
Hoxd8	homeobox D8	0.013
Bik	BCL2-interacting killer	0.013
Bgn	biglycan	0.013
Amh	anti-Mullerian hormone	0.013
Ager	advanced glycosylation end product-specific receptor	0.013
Fgf9	fibroblast growth factor 9	0.013
Nes	nestin	0.013
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.013
Hipk3	homeodomain interacting protein kinase 3	0.013
Nkx2-1	NK2 homeobox 1	0.013	Mouse
Dlg1	discs, large homolog 1 (Drosophila)	0.013
Sox2	SRY-box containing gene 2	0.013	Mouse
Sox7	SRY-box containing gene 7	0.013	Mouse
Plxna1	plexin A1	0.012
Fzd4	frizzled homolog 4 (Drosophila)	0.012	Mouse
Alx1	ALX homeobox 1	0.012
Zfp771	zinc finger protein 771	0.012
Tgif2	TGFB-induced factor homeobox 2	0.012
Inhbb	inhibin beta-B	0.012
Thrb	thyroid hormone receptor beta	0.012	Mouse
Hhex	hematopoietically expressed homeobox	0.012
Npnt	nephronectin	0.012
Pkd1	polycystic kidney disease 1 homolog	0.012
Zfp358	zinc finger protein 358	0.012
S1pr3	sphingosine-1-phosphate receptor 3	0.012
Arhgef25	Rho guanine nucleotide exchange factor (GEF) 25	0.012
Col8a1	collagen, type VIII, alpha 1	0.012
Gja1	gap junction protein, alpha 1	0.012
Epha1	Eph receptor A1	0.011
Sox13	SRY-box containing gene 13	0.011
Gpr27	G protein-coupled receptor 27	0.011
Esr2	estrogen receptor 2 (beta)	0.011
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.011
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.011
Pdgfa	platelet derived growth factor, alpha	0.011
Tspan9	tetraspanin 9	0.011
Prkd1	protein kinase D1	0.011
Sstr5	somatostatin receptor 5	0.011
Ltbp2	latent transforming growth factor beta binding protein 2	0.011	Mouse
Cldn6	claudin 6	0.011
Rasip1	Ras interacting protein 1	0.011
Pkdcc	protein kinase domain containing, cytoplasmic	0.011
Il11	interleukin 11	0.011
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.011
Rbl2	retinoblastoma-like 2	0.011
Cilp2	cartilage intermediate layer protein 2	0.011
Bmp10	bone morphogenetic protein 10	0.011
Chrdl2	chordin-like 2	0.011
Ptgfr	prostaglandin F receptor	0.011
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.011
Mfap2	microfibrillar-associated protein 2	0.010
Hoxc5	homeobox C5	0.010
Zfpm2	zinc finger protein, multitype 2	0.010
Socs5	suppressor of cytokine signaling 5	0.010
Tead3	TEA domain family member 3	0.010
Foxh1	forkhead box H1	0.010
F2r	coagulation factor II (thrombin) receptor	0.010
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.010
Has2	hyaluronan synthase 2	0.010
Itga8	integrin alpha 8	0.010
Des	desmin	0.010
Fut7	fucosyltransferase 7	0.010
H1fx	H1 histone family, member X	0.010
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.010
Pcolce	procollagen C-endopeptidase enhancer protein	0.010