IMP

Process View

Mus musculus

20 genes annotated in mouse

Multi-species View

regulation of leukocyte degranulation

GO:0043300

Any process that modulates the frequency, rate, or extent of leukocyte degranulation.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of leukocyte degranulation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of leukocyte degranulation" (in gray)

Name	Description	Probability	Func Analog Organism
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.911
Cd247	CD247 antigen	0.503	Mouse
Ptprc	protein tyrosine phosphatase, receptor type, C	0.492
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.453	Mouse
Ikzf1	IKAROS family zinc finger 1	0.396
Ifng	interferon gamma	0.391
Il4	interleukin 4	0.384
Inpp5d	inositol polyphosphate-5-phosphatase D	0.384
Grb2	growth factor receptor bound protein 2	0.344
Mefv	Mediterranean fever	0.295
Cd22	CD22 antigen	0.291
Il2rb	interleukin 2 receptor, beta chain	0.278
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.258	Mouse
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.233
Prdm1	PR domain containing 1, with ZNF domain	0.205
Ccr2	chemokine (C-C motif) receptor 2	0.163
Fcgr1	Fc receptor, IgG, high affinity I	0.151	Mouse
Tyrobp	TYRO protein tyrosine kinase binding protein	0.141
C5ar1	complement component 5a receptor 1	0.117
Met	met proto-oncogene	0.117
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.116
S1pr4	sphingosine-1-phosphate receptor 4	0.111
Ncr1	natural cytotoxicity triggering receptor 1	0.109
Cbl	Casitas B-lineage lymphoma	0.109
Ptk2	PTK2 protein tyrosine kinase 2	0.099
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.095
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.094
Dok1	docking protein 1	0.090
Il27ra	interleukin 27 receptor, alpha	0.087
AF251705	cDNA sequence AF251705	0.085	Mouse
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.080
Cd4	CD4 antigen	0.079
Ccl2	chemokine (C-C motif) ligand 2	0.079
Stat6	signal transducer and activator of transcription 6	0.075
Grap2	GRB2-related adaptor protein 2	0.074
Cd40	CD40 antigen	0.073
C3ar1	complement component 3a receptor 1	0.071
Ccr5	chemokine (C-C motif) receptor 5	0.070	Mouse
Ccl3	chemokine (C-C motif) ligand 3	0.070
Fasl	Fas ligand (TNF superfamily, member 6)	0.069
Trem3	triggering receptor expressed on myeloid cells 3	0.068
Nfam1	Nfat activating molecule with ITAM motif 1	0.067
Selp	selectin, platelet	0.066
Cd7	CD7 antigen	0.066
Cxcr3	chemokine (C-X-C motif) receptor 3	0.063	Mouse
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.062
Lck	lymphocyte protein tyrosine kinase	0.059	Mouse
Hcst	hematopoietic cell signal transducer	0.059
Itk	IL2-inducible T-cell kinase	0.059
Mmp9	matrix metallopeptidase 9	0.057
Itgax	integrin alpha X	0.056
Blk	B lymphoid kinase	0.056	Mouse
Was	Wiskott-Aldrich syndrome homolog (human)	0.055
Cd44	CD44 antigen	0.054
Snai1	snail homolog 1 (Drosophila)	0.053
Il2	interleukin 2	0.052
Ccr1	chemokine (C-C motif) receptor 1	0.052	Mouse
Ly9	lymphocyte antigen 9	0.052
Zap70	zeta-chain (TCR) associated protein kinase	0.052	Mouse
Clec4n	C-type lectin domain family 4, member n	0.051
Mb	myoglobin	0.050
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.050
Pdcd1	programmed cell death 1	0.049
Fas	Fas (TNF receptor superfamily member 6)	0.048
Nos2	nitric oxide synthase 2, inducible	0.044
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.044
Galnt6	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6	0.044
Hmox1	heme oxygenase (decycling) 1	0.043
Igh	immunoglobulin heavy chain complex	0.043
4632428N05Rik	RIKEN cDNA 4632428N05 gene	0.043
Cd6	CD6 antigen	0.043
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.041
Clnk	cytokine-dependent hematopoietic cell linker	0.041
Myo1f	myosin IF	0.040
Lat	linker for activation of T cells	0.039
Sit1	suppression inducing transmembrane adaptor 1	0.037
Xcr1	chemokine (C motif) receptor 1	0.035	Mouse
Icos	inducible T-cell co-stimulator	0.035
Csf1r	colony stimulating factor 1 receptor	0.035
Hlx	H2.0-like homeobox	0.034
Lyl1	lymphoblastomic leukemia 1	0.033
Tbxas1	thromboxane A synthase 1, platelet	0.033
Clec4d	C-type lectin domain family 4, member d	0.033
Ccr6	chemokine (C-C motif) receptor 6	0.032	Mouse
Hcls1	hematopoietic cell specific Lyn substrate 1	0.032
Bex6	brain expressed gene 6	0.032
Wisp2	WNT1 inducible signaling pathway protein 2	0.031
Ciita	class II transactivator	0.031
Cxcr2	chemokine (C-X-C motif) receptor 2	0.030	Mouse
Il18rap	interleukin 18 receptor accessory protein	0.030
Trpv1	transient receptor potential cation channel, subfamily V, member 1	0.030
Cd28	CD28 antigen	0.029
Il10ra	interleukin 10 receptor, alpha	0.029
Rgs14	regulator of G-protein signaling 14	0.029
Ifngr1	interferon gamma receptor 1	0.028
Ptgir	prostaglandin I receptor (IP)	0.028
Ager	advanced glycosylation end product-specific receptor	0.028
Itgb3	integrin beta 3	0.028
Ncf1	neutrophil cytosolic factor 1	0.027
Cd180	CD180 antigen	0.027
Ptpre	protein tyrosine phosphatase, receptor type, E	0.027
Abcg3	ATP-binding cassette, sub-family G (WHITE), member 3	0.026
Prg3	proteoglycan 3	0.026
Entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.026
Lair1	leukocyte-associated Ig-like receptor 1	0.025
Cd300lb	CD300 antigen like family member B	0.025	Mouse
Gpr182	G protein-coupled receptor 182	0.025
Itgam	integrin alpha M	0.025
Ccl17	chemokine (C-C motif) ligand 17	0.025
Sell	selectin, lymphocyte	0.024
Plcg2	phospholipase C, gamma 2	0.024
Cd8a	CD8 antigen, alpha chain	0.024
Cd19	CD19 antigen	0.023
Pou2af1	POU domain, class 2, associating factor 1	0.023
Pou2f2	POU domain, class 2, transcription factor 2	0.023
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.023
Ccl4	chemokine (C-C motif) ligand 4	0.023
Cd160	CD160 antigen	0.023
Cx3cr1	chemokine (C-X3-C) receptor 1	0.023	Mouse
Hrh1	histamine receptor H1	0.023
Cd3e	CD3 antigen, epsilon polypeptide	0.022
H2-Ob	histocompatibility 2, O region beta locus	0.022
Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	0.022
Irf5	interferon regulatory factor 5	0.022
Sfpi1	SFFV proviral integration 1	0.022
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.022
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.021
Pxn	paxillin	0.021
Il1b	interleukin 1 beta	0.021
Mmp8	matrix metallopeptidase 8	0.021
Cst7	cystatin F (leukocystatin)	0.021
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.020
Plbd2	phospholipase B domain containing 2	0.020
Gab2	growth factor receptor bound protein 2-associated protein 2	0.020
Cnr2	cannabinoid receptor 2 (macrophage)	0.020
Batf	basic leucine zipper transcription factor, ATF-like	0.019
Tbx21	T-box 21	0.019
Khdrbs1	KH domain containing, RNA binding, signal transduction associated 1	0.019
Lcp2	lymphocyte cytosolic protein 2	0.019
Art2a-ps	ADP-ribosyltransferase 2a, pseudogene	0.018
Msr1	macrophage scavenger receptor 1	0.018
Hck	hemopoietic cell kinase	0.018	Mouse
Fgf7	fibroblast growth factor 7	0.018
Skap2	src family associated phosphoprotein 2	0.018
Ly6d	lymphocyte antigen 6 complex, locus D	0.018
Folr2	folate receptor 2 (fetal)	0.018
Bcar1	breast cancer anti-estrogen resistance 1	0.018
Prkce	protein kinase C, epsilon	0.017
Sirpa	signal-regulatory protein alpha	0.017
Cd38	CD38 antigen	0.017
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.017
Fpr1	formyl peptide receptor 1	0.016
Igk	immunoglobulin kappa chain complex	0.016
Cybb	cytochrome b-245, beta polypeptide	0.016
Ms4a1	membrane-spanning 4-domains, subfamily A, member 1	0.016
Cd14	CD14 antigen	0.016
Sele	selectin, endothelial cell	0.016
Dock1	dedicator of cytokinesis 1	0.016
Gzmk	granzyme K	0.016
Gna15	guanine nucleotide binding protein, alpha 15	0.016
Lyz2	lysozyme 2	0.016
Snx20	sorting nexin 20	0.016
Gm14548	predicted gene 14548	0.016
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.016
Cd96	CD96 antigen	0.016
Ptafr	platelet-activating factor receptor	0.016
Fcrl1	Fc receptor-like 1	0.015
Il7r	interleukin 7 receptor	0.015
Cmklr1	chemokine-like receptor 1	0.015
Mcoln2	mucolipin 2	0.015
Pilrb1	paired immunoglobin-like type 2 receptor beta 1	0.015
Itgb2	integrin beta 2	0.015
Dok3	docking protein 3	0.015
Ifnar1	interferon (alpha and beta) receptor 1	0.014
Ptpra	protein tyrosine phosphatase, receptor type, A	0.014
Itgae	integrin alpha E, epithelial-associated	0.014
Muc13	mucin 13, epithelial transmembrane	0.014
Cd5l	CD5 antigen-like	0.014
Sh2d2a	SH2 domain protein 2A	0.014
Adam8	a disintegrin and metallopeptidase domain 8	0.014
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2	0.014
Cd2	CD2 antigen	0.014
Cd300ld	CD300 molecule-like family member d	0.014	Mouse
Ggt5	gamma-glutamyltransferase 5	0.014
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.014
Irg1	immunoresponsive gene 1	0.014
Fgd3	FYVE, RhoGEF and PH domain containing 3	0.014
Ctsw	cathepsin W	0.014
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.014
Plekho2	pleckstrin homology domain containing, family O member 2	0.014
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.014
Cr2	complement receptor 2	0.014
Gpr132	G protein-coupled receptor 132	0.014
Tlr4	toll-like receptor 4	0.014
Spn	sialophorin	0.014
Ebi3	Epstein-Barr virus induced gene 3	0.014
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.013
Tnf	tumor necrosis factor	0.013
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.013
Prf1	perforin 1 (pore forming protein)	0.013
Slc25a45	solute carrier family 25, member 45	0.013
Adamdec1	ADAM-like, decysin 1	0.013
Shc1	src homology 2 domain-containing transforming protein C1	0.013
Clec5a	C-type lectin domain family 5, member a	0.013
Il1rn	interleukin 1 receptor antagonist	0.013
Gpr97	G protein-coupled receptor 97	0.013
Psap	prosaposin	0.013
Pla2g2d	phospholipase A2, group IID	0.013
BC013712	cDNA sequence BC013712	0.013
Ccr8	chemokine (C-C motif) receptor 8	0.012	Mouse
Itgal	integrin alpha L	0.012
Lcn4	lipocalin 4	0.012
Il6	interleukin 6	0.012
Ctsb	cathepsin B	0.012
Ccl8	chemokine (C-C motif) ligand 8	0.012
Pdcd1lg2	programmed cell death 1 ligand 2	0.012
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.012
Cd86	CD86 antigen	0.012
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.012
Ear5	eosinophil-associated, ribonuclease A family, member 5	0.012
Mcpt1	mast cell protease 1	0.012
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.012
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.012
Hk3	hexokinase 3	0.012
Il10	interleukin 10	0.012
Gab1	growth factor receptor bound protein 2-associated protein 1	0.011	Mouse
Cysltr1	cysteinyl leukotriene receptor 1	0.011
Il3ra	interleukin 3 receptor, alpha chain	0.011	Mouse
Slfn4	schlafen 4	0.011
Sftpb	surfactant associated protein B	0.011
Il4ra	interleukin 4 receptor, alpha	0.011
Rel	reticuloendotheliosis oncogene	0.011
Il17a	interleukin 17A	0.011
Clec4a2	C-type lectin domain family 4, member a2	0.011
Il2ra	interleukin 2 receptor, alpha chain	0.011
Pdgfb	platelet derived growth factor, B polypeptide	0.011
P2ry13	purinergic receptor P2Y, G-protein coupled 13	0.011
Bdkrb1	bradykinin receptor, beta 1	0.011
P2ry6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.011
Mpeg1	macrophage expressed gene 1	0.011
Grem1	gremlin 1	0.011
Il1f9	interleukin 1 family, member 9	0.011
Cd5	CD5 antigen	0.011
Tifab	TRAF-interacting protein with forkhead-associated domain, family member B	0.011
Klra9	killer cell lectin-like receptor subfamily A, member 9	0.011
Cyp1a1	cytochrome P450, family 1, subfamily a, polypeptide 1	0.011
Mmp19	matrix metallopeptidase 19	0.011
Hmha1	histocompatibility (minor) HA-1	0.011
Mmp12	matrix metallopeptidase 12	0.010
Ccr3	chemokine (C-C motif) receptor 3	0.010	Mouse
Cd207	CD207 antigen	0.010
Sdc3	syndecan 3	0.010
Bmx	BMX non-receptor tyrosine kinase	0.010
Sh3bp2	SH3-domain binding protein 2	0.010
Vpreb3	pre-B lymphocyte gene 3	0.010
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.010
Trem1	triggering receptor expressed on myeloid cells 1	0.010