IMP

Process View

Mus musculus

13 genes annotated in mouse

endocardial cushion formation

The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endocardial cushion formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "endocardial cushion formation" (in gray)

Name	Description	Probability	Func Analog Organism
Foxc1	forkhead box C1	1.000
Hand2	heart and neural crest derivatives expressed transcript 2	1.000
Shh	sonic hedgehog	1.000
Fgfr2	fibroblast growth factor receptor 2	0.999
Tgfbr2	transforming growth factor, beta receptor II	0.999	Mouse
Foxc2	forkhead box C2	0.999
Jag1	jagged 1	0.999
Pitx2	paired-like homeodomain transcription factor 2	0.998
Bmp4	bone morphogenetic protein 4	0.998
Prrx1	paired related homeobox 1	0.998
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.997
Fgf8	fibroblast growth factor 8	0.997
Tgfb2	transforming growth factor, beta 2	0.997
Hoxa1	homeobox A1	0.994
Pax3	paired box gene 3	0.994
Ctnnb1	catenin (cadherin associated protein), beta 1	0.993
Eya1	eyes absent 1 homolog (Drosophila)	0.989
Tbx1	T-box 1	0.989	Mouse
Notch1	Notch gene homolog 1 (Drosophila)	0.988
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.988
Gata4	GATA binding protein 4	0.986
Pax2	paired box gene 2	0.972
Acvr1	activin A receptor, type 1	0.970	Mouse
Smad3	MAD homolog 3 (Drosophila)	0.959	Mouse
Fgfr1	fibroblast growth factor receptor 1	0.958
Hand1	heart and neural crest derivatives expressed transcript 1	0.957
Smad4	MAD homolog 4 (Drosophila)	0.954
Efnb2	ephrin B2	0.951
Sox9	SRY-box containing gene 9	0.948
Msx1	homeobox, msh-like 1	0.947
Nos3	nitric oxide synthase 3, endothelial cell	0.933
Vegfa	vascular endothelial growth factor A	0.925
Gli3	GLI-Kruppel family member GLI3	0.922
Dll4	delta-like 4 (Drosophila)	0.914
Ednra	endothelin receptor type A	0.912
Tcfap2a	transcription factor AP-2, alpha	0.910
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.864
Nodal	nodal	0.858
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.855
Pitx1	paired-like homeodomain transcription factor 1	0.834
Tbx3	T-box 3	0.825	Mouse
Apc	adenomatosis polyposis coli	0.800
Otx2	orthodenticle homolog 2 (Drosophila)	0.770
Rarg	retinoic acid receptor, gamma	0.745
Dlx5	distal-less homeobox 5	0.707
Gsc	goosecoid homeobox	0.692
Smad6	MAD homolog 6 (Drosophila)	0.671	Mouse
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.662
Meox2	mesenchyme homeobox 2	0.647
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.647	Mouse
Foxg1	forkhead box G1	0.629
Hoxa3	homeobox A3	0.605
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.589
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.589
Prrx2	paired related homeobox 2	0.585
Smad1	MAD homolog 1 (Drosophila)	0.568	Mouse
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.536
Sall4	sal-like 4 (Drosophila)	0.531
Smo	smoothened homolog (Drosophila)	0.528
Gata6	GATA binding protein 6	0.507
Zic3	zinc finger protein of the cerebellum 3	0.484
Gli2	GLI-Kruppel family member GLI2	0.480
Zeb1	zinc finger E-box binding homeobox 1	0.478
Acvrl1	activin A receptor, type II-like 1	0.475	Mouse
Chrd	chordin	0.471
Lrp6	low density lipoprotein receptor-related protein 6	0.464
Notch2	Notch gene homolog 2 (Drosophila)	0.459	Mouse
Ece1	endothelin converting enzyme 1	0.454
Hoxa2	homeobox A2	0.398
Pten	phosphatase and tensin homolog	0.386
Runx2	runt related transcription factor 2	0.379
Rxra	retinoid X receptor alpha	0.367
Vangl2	vang-like 2 (van gogh, Drosophila)	0.359
Chd7	chromodomain helicase DNA binding protein 7	0.349
Bmp7	bone morphogenetic protein 7	0.339
Pbx1	pre B-cell leukemia transcription factor 1	0.329
Foxf1a	forkhead box F1a	0.302
Axin1	axin 1	0.296
Eng	endoglin	0.291
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.279
Lef1	lymphoid enhancer binding factor 1	0.268
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.265
She	src homology 2 domain-containing transforming protein E	0.247
Gbx2	gastrulation brain homeobox 2	0.239
Fgfr3	fibroblast growth factor receptor 3	0.228
Snai1	snail homolog 1 (Drosophila)	0.228
Cdh5	cadherin 5	0.222
Tbx5	T-box 5	0.219	Mouse
Kiss1	KiSS-1 metastasis-suppressor	0.218
Sox2	SRY-box containing gene 2	0.214
Wt1	Wilms tumor 1 homolog	0.207
Pou5f1	POU domain, class 5, transcription factor 1	0.207
Foxd3	forkhead box D3	0.205
Psen1	presenilin 1	0.205
Smad5	MAD homolog 5 (Drosophila)	0.204	Mouse
Hes1	hairy and enhancer of split 1 (Drosophila)	0.186
Sox7	SRY-box containing gene 7	0.184
Ntf3	neurotrophin 3	0.183
Nog	noggin	0.178
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.178
Rarb	retinoic acid receptor, beta	0.178
Braf	Braf transforming gene	0.177
Tlx3	T-cell leukemia, homeobox 3	0.174
Wnt3a	wingless-related MMTV integration site 3A	0.174
Tcf15	transcription factor 15	0.169
Hoxa13	homeobox A13	0.167
Fgf10	fibroblast growth factor 10	0.163
Pax9	paired box gene 9	0.159
Tcf21	transcription factor 21	0.142
Dll1	delta-like 1 (Drosophila)	0.142
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.137
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.135
Msx2	homeobox, msh-like 2	0.125
Tbx4	T-box 4	0.122	Mouse
Prkg1	protein kinase, cGMP-dependent, type I	0.117
Mesp1	mesoderm posterior 1	0.115
Bmp2	bone morphogenetic protein 2	0.112
Zfpm2	zinc finger protein, multitype 2	0.109
Nkx3-2	NK3 homeobox 2	0.107
Sox18	SRY-box containing gene 18	0.105
Dlx2	distal-less homeobox 2	0.101
Isl1	ISL1 transcription factor, LIM/homeodomain	0.099
Hoxb4	homeobox B4	0.097
Lmx1b	LIM homeobox transcription factor 1 beta	0.096
Tgfbr1	transforming growth factor, beta receptor I	0.094	Mouse
Gata2	GATA binding protein 2	0.093
Tbx2	T-box 2	0.090	Mouse
Alx1	ALX homeobox 1	0.089
Sox17	SRY-box containing gene 17	0.088
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.076
Meox1	mesenchyme homeobox 1	0.076
Hoxa10	homeobox A10	0.074
Trp63	transformation related protein 63	0.074
Twist2	twist homolog 2 (Drosophila)	0.072
Mecom	MDS1 and EVI1 complex locus	0.071
Bmp5	bone morphogenetic protein 5	0.070
Ptf1a	pancreas specific transcription factor, 1a	0.070
Aplnr	apelin receptor	0.068
Pcdh12	protocadherin 12	0.067
Gja1	gap junction protein, alpha 1	0.065
Hoxd13	homeobox D13	0.062
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.062
Wnt11	wingless-related MMTV integration site 11	0.062
Erbb2ip	Erbb2 interacting protein	0.060
Axin2	axin2	0.059
Gata3	GATA binding protein 3	0.058
Hoxb3	homeobox B3	0.058
Hoxd3	homeobox D3	0.057
Ighmbp2	immunoglobulin mu binding protein 2	0.057
Scn5a	sodium channel, voltage-gated, type V, alpha	0.057
Cox4i2	cytochrome c oxidase subunit IV isoform 2	0.057
T	brachyury	0.055	Mouse
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.055
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.054
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.053
Ptch1	patched homolog 1	0.052
Prdm1	PR domain containing 1, with ZNF domain	0.050
Esr1	estrogen receptor 1 (alpha)	0.049
Smad7	MAD homolog 7 (Drosophila)	0.049	Mouse
Gdnf	glial cell line derived neurotrophic factor	0.047
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.047
En1	engrailed 1	0.047
Kitl	kit ligand	0.046
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.046
Rara	retinoic acid receptor, alpha	0.045
Hic1	hypermethylated in cancer 1	0.045
Gata5	GATA binding protein 5	0.044
Foxf2	forkhead box F2	0.044
Hif1a	hypoxia inducible factor 1, alpha subunit	0.044
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.043
Col13a1	collagen, type XIII, alpha 1	0.042
Pitx3	paired-like homeodomain transcription factor 3	0.041
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.041
Esr2	estrogen receptor 2 (beta)	0.041
Foxa2	forkhead box A2	0.040
Tgfbr3	transforming growth factor, beta receptor III	0.039	Mouse
Wnt5a	wingless-related MMTV integration site 5A	0.039
Rnf2	ring finger protein 2	0.038
Gpc3	glypican 3	0.038
Oprm1	opioid receptor, mu 1	0.037
Foxh1	forkhead box H1	0.036
Kdr	kinase insert domain protein receptor	0.036
Fgf15	fibroblast growth factor 15	0.036
Eda	ectodysplasin-A	0.036
Zfp503	zinc finger protein 503	0.035
Adcy4	adenylate cyclase 4	0.035
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.034	Mouse
Sox11	SRY-box containing gene 11	0.034
Alx4	aristaless-like homeobox 4	0.033
Gli1	GLI-Kruppel family member GLI1	0.032
Pou4f3	POU domain, class 4, transcription factor 3	0.032
Hoxb6	homeobox B6	0.031
Efna4	ephrin A4	0.030
Dlx6	distal-less homeobox 6	0.027
Hoxb5	homeobox B5	0.027
Hoxa11	homeobox A11	0.026
Neurog1	neurogenin 1	0.026
Uncx	UNC homeobox	0.025
Bnc1	basonuclin 1	0.025
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.024
Atoh8	atonal homolog 8 (Drosophila)	0.024
Bcl2	B-cell leukemia/lymphoma 2	0.024
Shox2	short stature homeobox 2	0.024
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.024
Hoxd10	homeobox D10	0.023
Bptf	bromodomain PHD finger transcription factor	0.023
Efnb1	ephrin B1	0.023
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.022
Rnf111	ring finger 111	0.022
Pou3f3	POU domain, class 3, transcription factor 3	0.022
En2	engrailed 2	0.021
Ptk7	PTK7 protein tyrosine kinase 7	0.021
Npr3	natriuretic peptide receptor 3	0.020
Rybp	RING1 and YY1 binding protein	0.020
Hoxa5	homeobox A5	0.020
Rem1	rad and gem related GTP binding protein 1	0.020
Hoxd9	homeobox D9	0.020
Flt4	FMS-like tyrosine kinase 4	0.019
Sox13	SRY-box containing gene 13	0.019
Tbx18	T-box18	0.019	Mouse
Col22a1	collagen, type XXII, alpha 1	0.019
Nkx2-1	NK2 homeobox 1	0.019
Wnt7a	wingless-related MMTV integration site 7A	0.019
Podxl	podocalyxin-like	0.019
Egfl7	EGF-like domain 7	0.019
Nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.018
Irx3	Iroquois related homeobox 3 (Drosophila)	0.018
Gdf3	growth differentiation factor 3	0.018
Bdnf	brain derived neurotrophic factor	0.017
BC020535	cDNA sequence BC020535	0.017
Adam17	a disintegrin and metallopeptidase domain 17	0.017
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.017
Ager	advanced glycosylation end product-specific receptor	0.017
Wnt6	wingless-related MMTV integration site 6	0.017
Mrc2	mannose receptor, C type 2	0.017
Klf3	Kruppel-like factor 3 (basic)	0.016
Htt	huntingtin	0.016
Itga8	integrin alpha 8	0.016
Pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.016
Flt1	FMS-like tyrosine kinase 1	0.016
Upk3b	uroplakin 3B	0.016
Gsk3b	glycogen synthase kinase 3 beta	0.015
Myl7	myosin, light polypeptide 7, regulatory	0.015
Olig3	oligodendrocyte transcription factor 3	0.015
Heyl	hairy/enhancer-of-split related with YRPW motif-like	0.015
Angpt1	angiopoietin 1	0.015
Itgb3	integrin beta 3	0.015
Bcl6b	B-cell CLL/lymphoma 6, member B	0.015
Ptprb	protein tyrosine phosphatase, receptor type, B	0.015
Grb10	growth factor receptor bound protein 10	0.015
Tal1	T-cell acute lymphocytic leukemia 1	0.014
Dhh	desert hedgehog	0.014
Pofut1	protein O-fucosyltransferase 1	0.014
Rspo1	R-spondin homolog (Xenopus laevis)	0.014
Sall1	sal-like 1 (Drosophila)	0.014
Ptgfr	prostaglandin F receptor	0.014
Pax7	paired box gene 7	0.014
Lrp5	low density lipoprotein receptor-related protein 5	0.014
Cdx2	caudal type homeobox 2	0.013
Hes5	hairy and enhancer of split 5 (Drosophila)	0.013
Fzd1	frizzled homolog 1 (Drosophila)	0.013
BC024139	cDNA sequence BC024139	0.013
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.013
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.013
Hoxa7	homeobox A7	0.013
Irx4	Iroquois related homeobox 4 (Drosophila)	0.013
Nfia	nuclear factor I/A	0.013
Foxe3	forkhead box E3	0.012
Itk	IL2-inducible T-cell kinase	0.012
Mn1	meningioma 1	0.012
Btbd17	BTB (POZ) domain containing 17	0.012
Hoxd1	homeobox D1	0.012
Pthlh	parathyroid hormone-like peptide	0.012
Hoxa4	homeobox A4	0.012
Thsd1	thrombospondin, type I, domain 1	0.012
Efs	embryonal Fyn-associated substrate	0.012
Btbd3	BTB (POZ) domain containing 3	0.012
Socs1	suppressor of cytokine signaling 1	0.012
Gja4	gap junction protein, alpha 4	0.012
Arhgap29	Rho GTPase activating protein 29	0.012
Nkd1	naked cuticle 1 homolog (Drosophila)	0.012
Acvr2a	activin receptor IIA	0.012
Tbx6	T-box 6	0.012	Mouse
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.012
Hdac7	histone deacetylase 7	0.012
Hoxd4	homeobox D4	0.011
Myf5	myogenic factor 5	0.011
Emx1	empty spiracles homolog 1 (Drosophila)	0.011
Prdm6	PR domain containing 6	0.011
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.011
Efna1	ephrin A1	0.011
Nanog	Nanog homeobox	0.011
Npr1	natriuretic peptide receptor 1	0.011
Pax6	paired box gene 6	0.011
Smad2	MAD homolog 2 (Drosophila)	0.011	Mouse
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.011
Sos1	son of sevenless homolog 1 (Drosophila)	0.011
Gja5	gap junction protein, alpha 5	0.011
Rdh10	retinol dehydrogenase 10 (all-trans)	0.011
Fgf7	fibroblast growth factor 7	0.011
Kcnk3	potassium channel, subfamily K, member 3	0.011
Fgf18	fibroblast growth factor 18	0.010	Mouse
Lmx1a	LIM homeobox transcription factor 1 alpha	0.010
Nsd1	nuclear receptor-binding SET-domain protein 1	0.010
Epas1	endothelial PAS domain protein 1	0.010
Hoxa9	homeobox A9	0.010
Mfng	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.010
Tcl1	T-cell lymphoma breakpoint 1	0.010
Ebf2	early B-cell factor 2	0.010