The network for 'negative regulation of cell cycle g1 s phase transition' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell cycle g1 s phase transition

Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G1/S phase transition.

Homo sapiens
Name Description Probability Func Analog Organism
RB1 retinoblastoma 1 1.000
RBL2 retinoblastoma-like 2 (p130) 0.982
TP53 tumor protein p53 0.949
CCND1 cyclin D1 0.913
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.877
CDK6 cyclin-dependent kinase 6 0.864
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.810
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.800
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.672
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.663
CDK2 cyclin-dependent kinase 2 0.618
RBL1 retinoblastoma-like 1 (p107) 0.581
EGFR epidermal growth factor receptor 0.562
CCND3 cyclin D3 0.506
XIAP X-linked inhibitor of apoptosis 0.498
SMAD1 SMAD family member 1 0.449
ARID1A AT rich interactive domain 1A (SWI-like) 0.422
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.411
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.389
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.349
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.340
ARID1B AT rich interactive domain 1B (SWI1-like) 0.312
CFLAR CASP8 and FADD-like apoptosis regulator 0.306
APAF1 apoptotic peptidase activating factor 1 0.293
FAS Fas (TNF receptor superfamily, member 6) 0.275
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.266
NCOA1 nuclear receptor coactivator 1 0.253
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.243
SMAD7 SMAD family member 7 0.242
E2F8 E2F transcription factor 8 0.240
IRAK2 interleukin-1 receptor-associated kinase 2 0.239
SMAD5 SMAD family member 5 0.234
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.233
PAX3 paired box 3 0.233
RBBP8 retinoblastoma binding protein 8 0.230
HBP1 HMG-box transcription factor 1 0.210
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.207
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.205
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.195
E2F1 E2F transcription factor 1 0.191
BTRC beta-transducin repeat containing 0.189
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.169
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.154
RIPK2 receptor-interacting serine-threonine kinase 2 0.151
POU3F2 POU class 3 homeobox 2 0.138
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.133
SOS1 son of sevenless homolog 1 (Drosophila) 0.132
WWOX WW domain containing oxidoreductase 0.131
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.118
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.117
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.116
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.116
E2F3 E2F transcription factor 3 0.113
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.110
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.110
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.109
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.108
AR androgen receptor 0.100
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.098
POU5F1 POU class 5 homeobox 1 0.095
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.095
RBBP4 retinoblastoma binding protein 4 0.093
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.084
E2F2 E2F transcription factor 2 0.082
UBE3A ubiquitin protein ligase E3A 0.080
NLRC4 NLR family, CARD domain containing 4 0.078
YAP1 Yes-associated protein 1 0.076
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.076
LIN54 lin-54 homolog (C. elegans) 0.070
SPRR2A small proline-rich protein 2A 0.063
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 0.060
IFI16 interferon, gamma-inducible protein 16 0.060
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.057
BCL2 B-cell CLL/lymphoma 2 0.056
ABI1 abl-interactor 1 0.056
SMAD3 SMAD family member 3 0.055
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.054
TFDP1 transcription factor Dp-1 0.053
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.052
BRD3 bromodomain containing 3 0.052
LRDD leucine-rich repeats and death domain containing 0.051
NCOR1 nuclear receptor corepressor 1 0.050
PTCH1 patched 1 0.050
CABLES1 Cdk5 and Abl enzyme substrate 1 0.049
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.049
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.049
E2F4 E2F transcription factor 4, p107/p130-binding 0.047
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.047
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.045
RAD18 RAD18 homolog (S. cerevisiae) 0.044
CTR9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.044
CUX1 cut-like homeobox 1 0.044
FASLG Fas ligand (TNF superfamily, member 6) 0.044
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like 0.044
PLCG1 phospholipase C, gamma 1 0.043
TXNIP thioredoxin interacting protein 0.043
PDE4DIP phosphodiesterase 4D interacting protein 0.041
SATB2 SATB homeobox 2 0.040
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.039
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.039
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rbf Retinoblastoma-family protein 0.853
Ras85D Ras oncogene at 85D 0.630
Akt1 CG4006 gene product from transcript CG4006-RA 0.471
babo baboon 0.417
Dp DP transcription factor 0.369
brm brahma 0.299
yki yorkie 0.258
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.242
dap dacapo 0.242
rl rolled 0.196
p53 CG33336 gene product from transcript CG33336-RB 0.156
cdc2c CG10498 gene product from transcript CG10498-RC 0.140
Tsc1 CG6147 gene product from transcript CG6147-RA 0.123
Cdk4 Cyclin-dependent kinase 4 0.122
Myd88 CG2078 gene product from transcript CG2078-RA 0.115
RASSF8 CG5053 gene product from transcript CG5053-RA 0.099
wts warts 0.098
CycD Cyclin D 0.075
Atg1 Autophagy-specific gene 1 0.071
imd immune deficiency 0.070
Ubqn Ubiquilin 0.067
Rel Relish 0.065
Cbl CG7037 gene product from transcript CG7037-RB 0.062
Dcr-1 Dicer-1 0.061
Dap160 Dynamin associated protein 160 0.060
mus205 mutagen-sensitive 205 0.059
CG13373 CG13373 gene product from transcript CG13373-RB 0.055
pie pineapple eye 0.053
CycH Cyclin H 0.052
CycG Cyclin G 0.050
Trf2 TATA box binding protein-related factor 2 0.050
nej nejire 0.046
CycE Cyclin E 0.045
osa CG7467 gene product from transcript CG7467-RD 0.044
CG9772 CG9772 gene product from transcript CG9772-RB 0.043
smo smoothened 0.041
CycA Cyclin A 0.040
exd extradenticle 0.040
ush u-shaped 0.034
mip120 Myb-interacting protein 120 0.032
Su(H) Suppressor of Hairless 0.031
sd scalloped 0.029
heph hephaestus 0.028
E2f E2F transcription factor 0.028
Smr Smrter 0.028
RpS16 Ribosomal protein S16 0.027
gro groucho 0.026
Fak56D Focal Adhesion Kinase 0.025
feo fascetto 0.025
e(y)3 enhancer of yellow 3 0.025
spn-A spindle A 0.025
rap retina aberrant in pattern 0.025
MED19 Mediator complex subunit 19 0.024
CG8455 CG8455 gene product from transcript CG8455-RA 0.024
BG4 CG12297 gene product from transcript CG12297-RA 0.022
eIF-1A Eukaryotic initiation factor 1A 0.022
jub Ajuba LIM protein 0.022
pasha partner of drosha 0.022
sax saxophone 0.022
grp grapes 0.022
Caf1-180 CG12109 gene product from transcript CG12109-RB 0.022
CycJ Cyclin J 0.021
Caf1 Chromatin assembly factor 1 subunit 0.021
CG9339 CG9339 gene product from transcript CG9339-RG 0.020
tefu telomere fusion 0.020
Dcp-1 Death caspase-1 0.018
ik2 IkappaB kinase-like 2 0.018
Eps-15 Epidermal growth factor receptor pathway substrate clone 15 0.018
HipHop HP1-HOAP-interacting protein 0.017
rev7 CG2948 gene product from transcript CG2948-RA 0.017
MED17 Mediator complex subunit 17 0.017
RnrL Ribonucleoside diphosphate reductase large subunit 0.017
CkIalpha Casein kinase Ialpha 0.017
RpS17 Ribosomal protein S17 0.016
Mad Mothers against dpp 0.016
Tis11 Tis11 homolog 0.016
CG14074 CG14074 gene product from transcript CG14074-RA 0.015
Bre1 CG10542 gene product from transcript CG10542-RA 0.015
swm second mitotic wave missing 0.015
nct nicastrin 0.014
emc extra macrochaetae 0.014
Cip4 CG15015 gene product from transcript CG15015-RA 0.014
simj simjang 0.014
gig gigas 0.014
RpL21 Ribosomal protein L21 0.013
east enhanced adult sensory threshold 0.013
ci cubitus interruptus 0.013
drosha CG8730 gene product from transcript CG8730-RA 0.013
gbb glass bottom boat 0.013
Traf6 TNF-receptor-associated factor 6 0.012
Nf-YA Nuclear factor Y-box A 0.012
RpL10Ab Ribosomal protein L10Ab 0.012
Caf1-105 CG12892 gene product from transcript CG12892-RA 0.012
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.012
CG18754 CG18754 gene product from transcript CG18754-RB 0.012
SAK Sak kinase 0.012
Atg7 Autophagy-specific gene 7 0.011
plu plutonium 0.011
JhI-1 Juvenile hormone-inducible protein 1 0.011
Tao-1 CG14217 gene product from transcript CG14217-RF 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.986
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.842
Rb1 retinoblastoma 1 0.813
Arid1b AT rich interactive domain 1B (SWI-like) 0.273
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.213
E2f1 E2F transcription factor 1 0.176
Arid1a AT rich interactive domain 1A (SWI-like) 0.158
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.130
Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.125
Mdm4 transformed mouse 3T3 cell double minute 4 0.121
Brca1 breast cancer 1 0.111
Pdcd1 programmed cell death 1 0.092
Cdk4 cyclin-dependent kinase 4 0.084
Bax BCL2-associated X protein 0.084
Mdm2 transformed mouse 3T3 cell double minute 2 0.076
Pten phosphatase and tensin homolog 0.076
Cd80 CD80 antigen 0.075
Vhl von Hippel-Lindau tumor suppressor 0.067
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.062
Bak1 BCL2-antagonist/killer 1 0.061
Rbl1 retinoblastoma-like 1 (p107) 0.059
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.058
Tcf3 transcription factor 3 0.057
Msh2 mutS homolog 2 (E. coli) 0.053
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.052
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.051
Nbn nibrin 0.051
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.049
Rbl2 retinoblastoma-like 2 0.048
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.046
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.046
Nf1 neurofibromatosis 1 0.045
Kit kit oncogene 0.036
Mtf2 metal response element binding transcription factor 2 0.033
Zfp830 zinc finger protein 830 0.031
Ntf3 neurotrophin 3 0.029
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.029
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.029
Meox2 mesenchyme homeobox 2 0.029
Atm ataxia telangiectasia mutated homolog (human) 0.028
Hif1a hypoxia inducible factor 1, alpha subunit 0.028
Trp73 transformation related protein 73 0.024
Ret ret proto-oncogene 0.023
Aebp2 AE binding protein 2 0.022
Fgfr2 fibroblast growth factor receptor 2 0.021
Pkd1 polycystic kidney disease 1 homolog 0.021
Igh immunoglobulin heavy chain complex 0.019
Apc adenomatosis polyposis coli 0.019
Nrg1 neuregulin 1 0.019
Ctnnb1 catenin (cadherin associated protein), beta 1 0.018
Tgfb2 transforming growth factor, beta 2 0.018
Cdk2 cyclin-dependent kinase 2 0.018
Trp63 transformation related protein 63 0.018
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.018
Rara retinoic acid receptor, alpha 0.017
Psen1 presenilin 1 0.016
Fgfr1 fibroblast growth factor receptor 1 0.016
Ptch1 patched homolog 1 0.016
A930001N09Rik RIKEN cDNA A930001N09 gene 0.015
Nacc1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.015
Chd7 chromodomain helicase DNA binding protein 7 0.014
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.014
Cdk6 cyclin-dependent kinase 6 0.014
Brca2 breast cancer 2 0.014
Foxc1 forkhead box C1 0.014
Tfdp2 transcription factor Dp 2 0.014
Daxx Fas death domain-associated protein 0.013
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.013
Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.012
Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 0.012
Stk38 serine/threonine kinase 38 0.012
Osbpl11 oxysterol binding protein-like 11 0.012
Notch1 Notch gene homolog 1 (Drosophila) 0.012
Gli2 GLI-Kruppel family member GLI2 0.012
Lrrc58 leucine rich repeat containing 58 0.012
Bmpr1a bone morphogenetic protein receptor, type 1A 0.012
Bcl2l1 BCL2-like 1 0.012
Crkl v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.011
Tcf7l1 transcription factor 7-like 1 (T-cell specific, HMG box) 0.011
Adam17 a disintegrin and metallopeptidase domain 17 0.011
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.011
Pkdcc protein kinase domain containing, cytoplasmic 0.011
Tmem123 transmembrane protein 123 0.011
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.011
Bicc1 bicaudal C homolog 1 (Drosophila) 0.011
Socs1 suppressor of cytokine signaling 1 0.011
Numa1 nuclear mitotic apparatus protein 1 0.011
Braf Braf transforming gene 0.010
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.010
Skil SKI-like 0.010
Bcl2 B-cell leukemia/lymphoma 2 0.010
Bach1 BTB and CNC homology 1 0.010
Hes1 hairy and enhancer of split 1 (Drosophila) 0.010
Kif16b kinesin family member 16B 0.010
Nfic nuclear factor I/C 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Arhgef1 Rho guanine nucleotide exchange factor (GEF) 1 0.111
Mbtps1 membrane-bound transcription factor peptidase, site 1 0.042
Rara retinoic acid receptor, alpha 0.030
Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.028
Stxbp3 syntaxin binding protein 3 0.026
Igf2r insulin-like growth factor 2 receptor 0.024
Whsc2 Wolf-Hirschhorn syndrome candidate 2 (human) 0.023
Ptbp1 polypyrimidine tract binding protein 1 0.020
Inppl1 inositol polyphosphate phosphatase-like 1 0.020
Hfe hemochromatosis 0.019
Cdk2 cyclin dependent kinase 2 0.018
Pcnxl3 pecanex-like 3 (Drosophila) 0.018
Lzts2 leucine zipper, putative tumor suppressor 2 0.018
Tgfbr2 transforming growth factor, beta receptor II 0.018
Tcfe2a transcription factor E2a 0.018
Slc29a3 solute carrier family 29 (nucleoside transporters), member 3 0.017
Cdk4 cyclin-dependent kinase 4 0.017
Prkd3 protein kinase D3 0.016
S1pr2 sphingosine-1-phosphate receptor 2 0.016
Creb1 cAMP responsive element binding protein 1 0.015
March8 membrane-associated ring finger (C3HC4) 8 0.015
Pdgfb platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.015
Slc4a2 solute carrier family 4 (anion exchanger), member 2 0.015
Casp7 caspase 7 0.015
Smad3 SMAD family member 3 0.015
Shc1 SHC (Src homology 2 domain containing) transforming protein 1 0.014
Slfn2 schlafen 2 0.014
Nos2 nitric oxide synthase 2, inducible 0.014
Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.013
Rgl2 ral guanine nucleotide dissociation stimulator-like 2 0.013
Txnrd2 thioredoxin reductase 2 0.013
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.013
Myo1e myosin IE 0.013
Apba3 amyloid beta (A4) precursor protein-binding, family A, member 3 0.013
Ahr aryl hydrocarbon receptor 0.013
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.013
Chd4 chromodomain helicase DNA binding protein 4 0.013
Npepl1 aminopeptidase-like 1 0.013
Tmem150a transmembrane protein 150A 0.013
Parp1 poly (ADP-ribose) polymerase 1 0.013
Stat2 signal transducer and activator of transcription 2 0.012
Csk c-src tyrosine kinase 0.012
Snd1 staphylococcal nuclease and tudor domain containing 1 0.012
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.011
Ccnd3 cyclin D3 0.011
Cabin1 calcineurin binding protein 1 0.011
Ubtf upstream binding transcription factor, RNA polymerase I 0.011
Dgkz diacylglycerol kinase zeta 0.011
Sardh sarcosine dehydrogenase 0.011
Lmnb1 lamin B1 0.011
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.011
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.011
Scamp2 secretory carrier membrane protein 2 0.011
Sidt2 SID1 transmembrane family, member 2 0.011
Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.011
Arih1 ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila) 0.011
Tcp11l2 t-complex 11 (mouse) like 2 0.011
Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 0.011
Rfc1 replication factor C (activator 1) 1 0.010
Colq collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.010
Gtf2i general transcription factor II I 0.010
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.010
Fzr1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.010
Zfyve26 zinc finger, FYVE domain containing 26 0.010
Zfand6 zinc finger, AN1-type domain 6 0.010
Igfbp5 insulin-like growth factor binding protein 5 0.010
Cdc7 cell division cycle 7 homolog (S. cerevisiae) 0.010
Cd44 Cd44 molecule 0.010
Traf4 Tnf receptor associated factor 4 0.010
Uap1l1 UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism