The network for 'negative regulation of protein localization to nucleus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of protein localization to nucleus

Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.

Homo sapiens
Name Description Probability Func Analog Organism
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.807
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.695
BTRC beta-transducin repeat containing 0.460
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.435
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.432
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.327
CREBBP CREB binding protein 0.315
DTX3L deltex 3-like (Drosophila) 0.276
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.270
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.264
ZNF420 zinc finger protein 420 0.240
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.233
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.223
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.191
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 0.187
GSK3B glycogen synthase kinase 3 beta 0.175
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.174
AXIN1 axin 1 0.172
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.166
RB1 retinoblastoma 1 0.139
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.129
SLMAP sarcolemma associated protein 0.113
CHUK conserved helix-loop-helix ubiquitous kinase 0.112
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.110
ZNF529 zinc finger protein 529 0.107
DCAF7 DDB1 and CUL4 associated factor 7 0.105
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.101
GCC1 GRIP and coiled-coil domain containing 1 0.099
RARA retinoic acid receptor, alpha 0.096
APC adenomatous polyposis coli 0.085
FBXW11 F-box and WD repeat domain containing 11 0.081
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.075
SKP1 S-phase kinase-associated protein 1 0.075
ERBB2IP erbb2 interacting protein 0.071
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.069
STRN3 striatin, calmodulin binding protein 3 0.066
RANBP3 RAN binding protein 3 0.066
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.064
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.063
LZTS2 leucine zipper, putative tumor suppressor 2 0.062
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.061
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.058
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.055
PML promyelocytic leukemia 0.055
LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila) 0.054
HIPK3 homeodomain interacting protein kinase 3 0.052
CKAP5 cytoskeleton associated protein 5 0.050
TEK TEK tyrosine kinase, endothelial 0.050
ZNF432 zinc finger protein 432 0.047
ZNF84 zinc finger protein 84 0.046
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.041
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.041
AXL AXL receptor tyrosine kinase 0.040
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.039
FAS Fas (TNF receptor superfamily, member 6) 0.039
ZNF260 zinc finger protein 260 0.036
NCF1 neutrophil cytosolic factor 1 0.036
IFIH1 interferon induced with helicase C domain 1 0.035
JUB jub, ajuba homolog (Xenopus laevis) 0.035
MOBKL1A MOB1, Mps One Binder kinase activator-like 1A (yeast) 0.035
EFCAB4B EF-hand calcium binding domain 4B 0.034
HIPK2 homeodomain interacting protein kinase 2 0.033
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.033
CDK9 cyclin-dependent kinase 9 0.033
BBS10 Bardet-Biedl syndrome 10 0.032
TJP2 tight junction protein 2 (zona occludens 2) 0.031
LMO4 LIM domain only 4 0.031
INSR insulin receptor 0.030
HDAC2 histone deacetylase 2 0.029
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.029
YAP1 Yes-associated protein 1 0.029
PSEN2 presenilin 2 (Alzheimer disease 4) 0.029
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 0.028
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 0.027
SREBF2 sterol regulatory element binding transcription factor 2 0.026
PROX1 prospero homeobox 1 0.026
TNIP1 TNFAIP3 interacting protein 1 0.026
CFLAR CASP8 and FADD-like apoptosis regulator 0.026
ZNF585A zinc finger protein 585A 0.026
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.025
GLI1 GLI family zinc finger 1 0.025
IRS1 insulin receptor substrate 1 0.025
ACTN1 actinin, alpha 1 0.025
IRS2 insulin receptor substrate 2 0.025
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.025
SNAI1 snail homolog 1 (Drosophila) 0.025
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.025
AMOTL1 angiomotin like 1 0.024
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.023
IGF1R insulin-like growth factor 1 receptor 0.023
PEX26 peroxisomal biogenesis factor 26 0.023
MAP2K5 mitogen-activated protein kinase kinase 5 0.023
ZNF571 zinc finger protein 571 0.023
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.023
MED24 mediator complex subunit 24 0.022
ZNF140 zinc finger protein 140 0.021
HCFC1 host cell factor C1 (VP16-accessory protein) 0.021
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.021
FLNB filamin B, beta 0.021
SMAD3 SMAD family member 3 0.021
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
nf1a neurofibromin 1a 0.654
plk1 polo-like kinase 1 (Drosophila) 0.489
cdc20 cell division cycle 20 homolog 0.446
igf1rb insulin-like growth factor 1b receptor 0.435
gdf6a growth differentiation factor 6a 0.310
cdh1 cadherin 1, epithelial 0.213
mapk3 mitogen-activated protein kinase 3 0.183
mad2l1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.180
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.176
kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.154
vdra vitamin D receptor a 0.150
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.141
kif11 kinesin family member 11 0.138
thraa thyroid hormone receptor alpha a 0.133
nf1b neurofibromin 1b 0.132
LOC100535549 cytoplasmic polyadenylation element-binding protein 4-like 0.129
prc1b protein regulator of cytokinesis 1b 0.124
zgc:73328 zgc:73328 0.120
scn1lab sodium channel, voltage-gated, type I like, alpha b 0.114
wls wntless homolog (Drosophila) 0.112
sox21a SRY-box containing gene 21a 0.109
aurkb aurora kinase B 0.108
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.107
szl sizzled 0.106
zgc:101761 zgc:101761 0.103
jag2 jagged 2 0.095
zgc:92027 zgc:92027 0.094
sox11b SRY-box containing gene 11b 0.092
birc5a baculoviral IAP repeat-containing 5a 0.089
ip6k2 inositol hexaphosphate kinase 2 0.088
kif23 kinesin family member 23 0.088
si:ch211-69g19.2 si:ch211-69g19.2 0.086
sc:d0144 sc:d0144 0.083
atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0.079
zgc:172136 zgc:172136 0.078
rarga retinoic acid receptor gamma a 0.078
akt2 v-akt murine thymoma viral oncogene homolog 2 0.078
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.076
gro2 groucho 2 0.075
s100v2 S100 calcium binding protein V2 0.075
jazf1b JAZF zinc finger 1b 0.074
capns1a calpain, small subunit 1 a 0.073
ddx3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 0.073
kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 0.073
nuf2 NUF2, NDC80 kinetochore complex component, homolog 0.072
smad9 MAD homolog 9 (Drosophila) 0.071
tbx1 T-box 1 0.071
pnx posterior neuron-specific homeobox 0.071
ccnb1 cyclin B1 0.070
zgc:110340 zgc:110340 0.068
xiap X-linked inhibitor of apoptosis 0.068
vgll4l vestigial like 4 like 0.067
nrg1 neuregulin 1 0.066
LOC100536090 targeting protein for Xklp2-B-like 0.066
LOC100005232 Gig2-like protein DreD 0.066
cdca8 cell division cycle associated 8 0.065
sec24c SEC24 family, member C (S. cerevisiae) 0.065
tp53bp2 tumor protein p53 binding protein, 2 0.064
atp6v1c1b ATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1b 0.064
mcl1a myeloid cell leukemia sequence 1a 0.063
acot11a acyl-CoA thioesterase 11a 0.062
pppde1 PPPDE peptidase domain containing 1 0.061
pea3 ETS-domain transcription factor pea3 0.061
fzd7a frizzled homolog 7a 0.060
LOC100332245 cordon-bleu protein-like 1-like 0.059
serpinb1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.059
zgc:86764 zgc:86764 0.058
ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 0.058
tmem161b transmembrane protein 161B 0.055
col27a1a collagen, type XXVII, alpha 1a 0.054
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.053
g2e3 G2/M-phase specific E3 ubiquitin ligase 0.053
spred1 sprouty-related, EVH1 domain containing 1 0.053
rnf128a ring finger protein 128a 0.051
akap9 A kinase (PRKA) anchor protein (yotiao) 9 0.051
gins2 GINS complex subunit 2 0.051
litaf lipopolysaccharide-induced TNF factor 0.050
zgc:162965 zgc:162965 0.050
atp6v1d ATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D 0.049
LOC100150924 DNA polymerase subunit gamma-1-like 0.049
insrb insulin receptor b 0.049
thrab thyroid hormone receptor alpha b 0.048
mapk6 mitogen-activated protein kinase 6 0.047
fzd5 frizzled homolog 5 0.046
cflar CASP8 and FADD-like apoptosis regulator 0.046
ptena phosphatase and tensin homolog A 0.046
zgc:110847 zgc:110847 0.046
pdlim3a PDZ and LIM domain 3a 0.046
wars tryptophanyl-tRNA synthetase 0.045
id:ibd5045 id:ibd5045 0.044
fbxo45 F-box protein 45 0.044
f2rl1.2 coagulation factor II (thrombin) receptor-like 1.2 0.044
nr5a1b nuclear receptor subfamily 5, group A, member 1b 0.044
cd63 Cd63 antigen 0.043
mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.043
lpp LIM domain containing preferred translocation partner in lipoma 0.043
anxa13 annexin A13 0.042
cyp1a cytochrome P450, family 1, subfamily A 0.042
irgq1 immunity-related GTPase family, q1 0.042
shmt2 serine hydroxymethyltransferase 2 (mitochondrial) 0.042
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Yap1 yes-associated protein 1 0.808
Ctnnb1 catenin (cadherin associated protein), beta 1 0.771
Trp53 transformation related protein 53 0.602
Apc adenomatosis polyposis coli 0.598
Rarg retinoic acid receptor, gamma 0.584
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.452
Casp1 caspase 1 0.372
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.295
Grb10 growth factor receptor bound protein 10 0.287
Gli3 GLI-Kruppel family member GLI3 0.281
Thra thyroid hormone receptor alpha 0.256
Trp63 transformation related protein 63 0.240
Ncoa3 nuclear receptor coactivator 3 0.237
Axin1 axin 1 0.226
Rara retinoic acid receptor, alpha 0.211
Pycard PYD and CARD domain containing 0.186
Rxra retinoid X receptor alpha 0.171
Gopc golgi associated PDZ and coiled-coil motif containing 0.134
Iigp1 interferon inducible GTPase 1 0.116
Aim2 absent in melanoma 2 0.109
Fgfr1 fibroblast growth factor receptor 1 0.100
Gbp2 guanylate binding protein 2 0.094
Rnf115 ring finger protein 115 0.088
Smad3 MAD homolog 3 (Drosophila) 0.087
Kitl kit ligand 0.072
Fzd8 frizzled homolog 8 (Drosophila) 0.072
Dlg2 discs, large homolog 2 (Drosophila) 0.067
Bcl2 B-cell leukemia/lymphoma 2 0.065
Ikbkg inhibitor of kappaB kinase gamma 0.064
Bicc1 bicaudal C homolog 1 (Drosophila) 0.060
Il6st interleukin 6 signal transducer 0.058
Smad6 MAD homolog 6 (Drosophila) 0.057
Slc12a6 solute carrier family 12, member 6 0.057
Rras Harvey rat sarcoma oncogene, subgroup R 0.054
Smo smoothened homolog (Drosophila) 0.054
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.053
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.052
Notch2 Notch gene homolog 2 (Drosophila) 0.051
Htt huntingtin 0.050
Casp12 caspase 12 0.049
Mapkap1 mitogen-activated protein kinase associated protein 1 0.047
Pax8 paired box gene 8 0.046
Pax2 paired box gene 2 0.045
Mdm2 transformed mouse 3T3 cell double minute 2 0.044
Pten phosphatase and tensin homolog 0.043
Dlg1 discs, large homolog 1 (Drosophila) 0.042
Nmi N-myc (and STAT) interactor 0.040
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.039
Bcl3 B-cell leukemia/lymphoma 3 0.039
Sox4 SRY-box containing gene 4 0.039
Pbx1 pre B-cell leukemia transcription factor 1 0.039
Wnt9b wingless-type MMTV integration site 9B 0.038
Hes1 hairy and enhancer of split 1 (Drosophila) 0.037
Tcf7l1 transcription factor 7-like 1 (T-cell specific, HMG box) 0.037
Meox2 mesenchyme homeobox 2 0.035
Twist2 twist homolog 2 (Drosophila) 0.035
Fzd1 frizzled homolog 1 (Drosophila) 0.034
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.032
Fzd2 frizzled homolog 2 (Drosophila) 0.032
Flot1 flotillin 1 0.030
Lef1 lymphoid enhancer binding factor 1 0.030
Sap18 Sin3-associated polypeptide 18 0.029
Tbx3 T-box 3 0.028
Duox2 dual oxidase 2 0.028
Arhgef25 Rho guanine nucleotide exchange factor (GEF) 25 0.028
Rptor regulatory associated protein of MTOR, complex 1 0.028
Efnb1 ephrin B1 0.028
Dlg4 discs, large homolog 4 (Drosophila) 0.028
Marveld1 MARVEL (membrane-associating) domain containing 1 0.028
Sorbs3 sorbin and SH3 domain containing 3 0.027
Fgfr2 fibroblast growth factor receptor 2 0.027
Rhbdf1 rhomboid family 1 (Drosophila) 0.026
Megf8 multiple EGF-like-domains 8 0.026
Ncor1 nuclear receptor co-repressor 1 0.026
Cuedc1 CUE domain containing 1 0.026
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.026
Wnt5a wingless-related MMTV integration site 5A 0.026
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.026
Rab34 RAB34, member of RAS oncogene family 0.026
Gli2 GLI-Kruppel family member GLI2 0.025
Cstb cystatin B 0.025
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.025
Smtn smoothelin 0.025
Emx2 empty spiracles homolog 2 (Drosophila) 0.025
Osr1 odd-skipped related 1 (Drosophila) 0.024
Srgn serglycin 0.024
Ikbkb inhibitor of kappaB kinase beta 0.024
Lrp5 low density lipoprotein receptor-related protein 5 0.024
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.024
Mlst8 MTOR associated protein, LST8 homolog (S. cerevisiae) 0.024
Zfp358 zinc finger protein 358 0.024
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.023
Pdgfb platelet derived growth factor, B polypeptide 0.023
Rnh1 ribonuclease/angiogenin inhibitor 1 0.023
Thrb thyroid hormone receptor beta 0.023
F2r coagulation factor II (thrombin) receptor 0.023
Vegfa vascular endothelial growth factor A 0.022
Ptpn21 protein tyrosine phosphatase, non-receptor type 21 0.022
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.022
Rictor RPTOR independent companion of MTOR, complex 2 0.022
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism