The network for 'regulation of tumor necrosis factor superfamily cytokine production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of tumor necrosis factor superfamily cytokine production

Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production.

Mus musculus
Name Description Probability Func Analog Organism
Myd88 myeloid differentiation primary response gene 88 0.999
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.945
Cd44 CD44 antigen 0.919
Tlr4 toll-like receptor 4 0.913
Lyz2 lysozyme 2 0.899
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.893
Ccl2 chemokine (C-C motif) ligand 2 0.882
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.860
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.816
Ccr2 chemokine (C-C motif) receptor 2 0.795
Tlr2 toll-like receptor 2 0.783
Otx2 orthodenticle homolog 2 (Drosophila) 0.781
Pax6 paired box gene 6 0.777
Clec4d C-type lectin domain family 4, member d 0.776
Gnrh1 gonadotropin releasing hormone 1 0.774
Neurod1 neurogenic differentiation 1 0.770
C3ar1 complement component 3a receptor 1 0.767
Ccr1 chemokine (C-C motif) receptor 1 0.747
Ccl3 chemokine (C-C motif) ligand 3 0.724
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.722
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.692
Ikzf1 IKAROS family zinc finger 1 0.669
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.663
Tnf tumor necrosis factor 0.624
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.596
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.570
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.555
Traf6 TNF receptor-associated factor 6 0.550
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.547
AF251705 cDNA sequence AF251705 0.546
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.522
Axl AXL receptor tyrosine kinase 0.504
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.504
Socs1 suppressor of cytokine signaling 1 0.503
Ccl4 chemokine (C-C motif) ligand 4 0.485
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.473
Cd300ld CD300 molecule-like family member d 0.459
Neurog2 neurogenin 2 0.448
Blk B lymphoid kinase 0.436
Fasl Fas ligand (TNF superfamily, member 6) 0.428
Stat3 signal transducer and activator of transcription 3 0.410
Gzma granzyme A 0.401
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.386
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.376
Cd180 CD180 antigen 0.356
Cd7 CD7 antigen 0.344
Gcet2 germinal center expressed transcript 2 0.344
Tnip1 TNFAIP3 interacting protein 1 0.323
Xcl1 chemokine (C motif) ligand 1 0.313
Clec4n C-type lectin domain family 4, member n 0.310
Itgax integrin alpha X 0.286
Snai1 snail homolog 1 (Drosophila) 0.279
Il2rg interleukin 2 receptor, gamma chain 0.279
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.278
Ptprc protein tyrosine phosphatase, receptor type, C 0.274
Ccr7 chemokine (C-C motif) receptor 7 0.273
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.272
Ifngr1 interferon gamma receptor 1 0.268
Lhx9 LIM homeobox protein 9 0.266
Ccr5 chemokine (C-C motif) receptor 5 0.265
Ggt5 gamma-glutamyltransferase 5 0.263
Pax2 paired box gene 2 0.261
Ccr6 chemokine (C-C motif) receptor 6 0.261
Gab1 growth factor receptor bound protein 2-associated protein 1 0.247
Il2rb interleukin 2 receptor, beta chain 0.246
Cybb cytochrome b-245, beta polypeptide 0.234
Ncr1 natural cytotoxicity triggering receptor 1 0.228
Emx2 empty spiracles homolog 2 (Drosophila) 0.227
Pou4f2 POU domain, class 4, transcription factor 2 0.226
Klra2 killer cell lectin-like receptor, subfamily A, member 2 0.225
Il12b interleukin 12b 0.224
Gzmk granzyme K 0.209
Il1rn interleukin 1 receptor antagonist 0.207
Pyhin1 pyrin and HIN domain family, member 1 0.202
Lhx3 LIM homeobox protein 3 0.199
Flt3 FMS-like tyrosine kinase 3 0.198
Fcrla Fc receptor-like A 0.198
Pou2f2 POU domain, class 2, transcription factor 2 0.196
Klrb1c killer cell lectin-like receptor subfamily B member 1C 0.193
Cxcr3 chemokine (C-X-C motif) receptor 3 0.192
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.190
Socs3 suppressor of cytokine signaling 3 0.190
Prf1 perforin 1 (pore forming protein) 0.190
Cyld cylindromatosis (turban tumor syndrome) 0.181
Ntf3 neurotrophin 3 0.179
Casp8 caspase 8 0.177
Ear2 eosinophil-associated, ribonuclease A family, member 2 0.170
Gzmb granzyme B 0.169
Tcra T-cell receptor alpha chain 0.168
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.163
Folr2 folate receptor 2 (fetal) 0.162
Neurod4 neurogenic differentiation 4 0.160
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.158
Kiss1 KiSS-1 metastasis-suppressor 0.157
Il7r interleukin 7 receptor 0.156
Lair1 leukocyte-associated Ig-like receptor 1 0.156
Ccl9 chemokine (C-C motif) ligand 9 0.155
Hcst hematopoietic cell signal transducer 0.153
Slamf8 SLAM family member 8 0.153
Mmp12 matrix metallopeptidase 12 0.153
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
IRAK2 interleukin-1 receptor-associated kinase 2 1.000
MYD88 myeloid differentiation primary response gene (88) 1.000
C1QA complement component 1, q subcomponent, A chain 0.999
CCR1 chemokine (C-C motif) receptor 1 0.977
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.975
BIRC3 baculoviral IAP repeat containing 3 0.938
IRAK1 interleukin-1 receptor-associated kinase 1 0.933
IRAK3 interleukin-1 receptor-associated kinase 3 0.924
TLR2 toll-like receptor 2 0.918
CXCL9 chemokine (C-X-C motif) ligand 9 0.904
CD163 CD163 molecule 0.896
RXRA retinoid X receptor, alpha 0.889
IL10RA interleukin 10 receptor, alpha 0.849
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.827
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.824
CXCL10 chemokine (C-X-C motif) ligand 10 0.812
AXL AXL receptor tyrosine kinase 0.812
SYK spleen tyrosine kinase 0.749
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.710
CD14 CD14 molecule 0.670
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.664
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) 0.647
CCL8 chemokine (C-C motif) ligand 8 0.606
CYBB cytochrome b-245, beta polypeptide 0.588
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.554
GAS6 growth arrest-specific 6 0.550
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.542
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.527
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.520
C1QB complement component 1, q subcomponent, B chain 0.456
RUNX1 runt-related transcription factor 1 0.450
HSF1 heat shock transcription factor 1 0.439
CREBBP CREB binding protein 0.427
CD86 CD86 molecule 0.424
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.418
CXCL11 chemokine (C-X-C motif) ligand 11 0.415
CCL4 chemokine (C-C motif) ligand 4 0.408
NLRC4 NLR family, CARD domain containing 4 0.407
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.403
TNF tumor necrosis factor 0.399
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.395
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.388
SETD8 SET domain containing (lysine methyltransferase) 8 0.386
MSR1 macrophage scavenger receptor 1 0.372
S100A9 S100 calcium binding protein A9 0.358
CCR2 chemokine (C-C motif) receptor 2 0.345
CCL5 chemokine (C-C motif) ligand 5 0.332
CCR5 chemokine (C-C motif) receptor 5 0.326
TRADD TNFRSF1A-associated via death domain 0.326
TRAF5 TNF receptor-associated factor 5 0.310
CCL2 chemokine (C-C motif) ligand 2 0.305
IGSF6 immunoglobulin superfamily, member 6 0.299
MARCO macrophage receptor with collagenous structure 0.298
S100A12 S100 calcium binding protein A12 0.296
FAS Fas (TNF receptor superfamily, member 6) 0.291
TLR4 toll-like receptor 4 0.287
CXCL3 chemokine (C-X-C motif) ligand 3 0.284
PML promyelocytic leukemia 0.280
CXCL2 chemokine (C-X-C motif) ligand 2 0.276
CD48 CD48 molecule 0.274
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.274
VSIG4 V-set and immunoglobulin domain containing 4 0.273
TRAF6 TNF receptor-associated factor 6 0.267
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.259
TFEC transcription factor EC 0.257
FADD Fas (TNFRSF6)-associated via death domain 0.257
MED15 mediator complex subunit 15 0.248
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.240
MED25 mediator complex subunit 25 0.238
SLAMF8 SLAM family member 8 0.238
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.237
CD33 CD33 molecule 0.237
NCOA1 nuclear receptor coactivator 1 0.228
TRIM34 tripartite motif containing 34 0.225
PLEK pleckstrin 0.225
IDE insulin-degrading enzyme 0.224
HK3 hexokinase 3 (white cell) 0.223
APOE apolipoprotein E 0.222
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 0.218
MPEG1 macrophage expressed 1 0.216
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.214
F13A1 coagulation factor XIII, A1 polypeptide 0.211
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.207
PILRA paired immunoglobin-like type 2 receptor alpha 0.202
LY86 lymphocyte antigen 86 0.198
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.196
MS4A4A membrane-spanning 4-domains, subfamily A, member 4 0.188
SOCS3 suppressor of cytokine signaling 3 0.185
TYMP thymidine phosphorylase 0.184
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.184
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.183
CXCL5 chemokine (C-X-C motif) ligand 5 0.178
SIGLEC7 sialic acid binding Ig-like lectin 7 0.177
FPR3 formyl peptide receptor 3 0.174
CMKLR1 chemokine-like receptor 1 0.174
ESR1 estrogen receptor 1 0.172
CLEC7A C-type lectin domain family 7, member A 0.172
RARA retinoic acid receptor, alpha 0.170
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.164
SH3BP2 SH3-domain binding protein 2 0.163
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ccl7 chemokine (C-C motif) ligand 7 0.336
Ccl2 chemokine (C-C motif) ligand 2 0.320
Cd14 CD14 molecule 0.193
Cxcl2 chemokine (C-X-C motif) ligand 2 0.129
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.120
Icam1 intercellular adhesion molecule 1 0.119
Il1b interleukin 1 beta 0.097
Stat3 signal transducer and activator of transcription 3 0.066
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.062
Myd88 myeloid differentiation primary response gene 88 0.061
C5ar1 complement component 5a receptor 1 0.059
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.058
Ccl3 chemokine (C-C motif) ligand 3 0.048
Hpgds hematopoietic prostaglandin D synthase 0.046
Plau plasminogen activator, urokinase 0.045
Junb jun B proto-oncogene 0.041
Aldh3a1 aldehyde dehydrogenase 3 family, member A1 0.039
Arl11 ADP-ribosylation factor-like 11 0.039
Rgs1 regulator of G-protein signaling 1 0.038
Il6 interleukin 6 0.038
Cebpd CCAAT/enhancer binding protein (C/EBP), delta 0.037
Igsf6 immunoglobulin superfamily, member 6 0.036
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.036
Cxcl10 chemokine (C-X-C motif) ligand 10 0.035
Ccl4 chemokine (C-C motif) ligand 4 0.035
Il2rb interleukin 2 receptor, beta 0.034
Mmp12 matrix metallopeptidase 12 0.033
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.033
Adrb2 adrenergic, beta-2-, receptor, surface 0.032
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.028
Musk muscle, skeletal, receptor tyrosine kinase 0.028
Nradd neurotrophin receptor associated death domain 0.028
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.028
Xdh xanthine dehydrogenase 0.026
Reg3b regenerating islet-derived 3 beta 0.025
Tmem88 transmembrane protein 88 0.025
Itgam integrin, alpha M 0.025
Ltbr lymphotoxin beta receptor (TNFR superfamily, member 3) 0.025
Igsf7 immunoglobulin superfamily, member 7 0.024
Clec9a C-type lectin domain family 9, member a 0.024
Tbxas1 thromboxane A synthase 1, platelet 0.024
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.024
Gzmk granzyme K 0.023
Tspan4 tetraspanin 4 0.023
Lpl lipoprotein lipase 0.022
Ccr1 chemokine (C-C motif) receptor 1 0.022
Ccr2 chemokine (C-C motif) receptor 2 0.022
Tlr2 toll-like receptor 2 0.022
Il1r2 interleukin 1 receptor, type II 0.021
Selp selectin P 0.021
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.021
Cd44 Cd44 molecule 0.020
Hmox1 heme oxygenase (decycling) 1 0.020
Irak3 interleukin-1 receptor-associated kinase 3 0.019
Ier3 immediate early response 3 0.019
Cd8a CD8a molecule 0.019
Folr2 folate receptor 2 (fetal) 0.019
Plscr1 phospholipid scramblase 1 0.019
Krt14 keratin 14 0.019
Cybb cytochrome b-245, beta polypeptide 0.018
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.018
Bcl3 B-cell CLL/lymphoma 3 0.018
Cidea cell death-inducing DFFA-like effector a 0.018
Cfd complement factor D (adipsin) 0.017
Tbc1d2b TBC1 domain family, member 2B 0.017
Sell selectin L 0.016
Il1a interleukin 1 alpha 0.016
LOC100361007 rCG32064-like 0.016
Il8rb interleukin 8 receptor, beta 0.016
Cd2 Cd2 molecule 0.016
Lrg1 leucine-rich alpha-2-glycoprotein 1 0.016
Ch25h cholesterol 25-hydroxylase 0.016
Lgals3 lectin, galactoside-binding, soluble, 3 0.015
Rhoj ras homolog gene family, member J 0.015
LOC500300 similar to hypothetical protein MGC6835 0.015
Slpi secretory leukocyte peptidase inhibitor 0.015
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.015
Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.015
Alox5ap arachidonate 5-lipoxygenase activating protein 0.015
Rab32 RAB32, member RAS oncogene family 0.015
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.014
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.014
C1qc complement component 1, q subcomponent, C chain 0.014
Lamb2 laminin, beta 2 0.013
Calcb calcitonin-related polypeptide, beta 0.013
C3ar1 complement component 3a receptor 1 0.013
Litaf lipopolysaccharide-induced TNF factor 0.013
Ifi204 interferon activated gene 204 0.013
Nkg7 natural killer cell group 7 sequence 0.013
Fosl1 fos-like antigen 1 0.013
Lcn2 lipocalin 2 0.013
Il1rl1 interleukin 1 receptor-like 1 0.012
Cd40 CD40 molecule, TNF receptor superfamily member 5 0.012
Smad1 SMAD family member 1 0.012
Fabp4 fatty acid binding protein 4, adipocyte 0.012
Glt25d1 glycosyltransferase 25 domain containing 1 0.012
Pion pigeon homolog (Drosophila) 0.012
Caprin1 cell cycle associated protein 1 0.012
Steap1 six transmembrane epithelial antigen of the prostate 1 0.012
Il9r interleukin 9 receptor 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism