The network for 'negative regulation of cell adhesion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell adhesion

Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.

Mus musculus
Name Description Probability Func Analog Organism
Ctnnb1 catenin (cadherin associated protein), beta 1 0.964
Trp53 transformation related protein 53 0.922
Dlg1 discs, large homolog 1 (Drosophila) 0.704
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.703
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.685
Thbs1 thrombospondin 1 0.668
Nos3 nitric oxide synthase 3, endothelial cell 0.654
Col1a1 collagen, type I, alpha 1 0.579
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.568
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.555
Snai1 snail homolog 1 (Drosophila) 0.519
Nid1 nidogen 1 0.517
Ptk2 PTK2 protein tyrosine kinase 2 0.508
Bgn biglycan 0.482
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.468
Col5a1 collagen, type V, alpha 1 0.467
Col3a1 collagen, type III, alpha 1 0.440
Pten phosphatase and tensin homolog 0.423
Mmp2 matrix metallopeptidase 2 0.369
Tgfb2 transforming growth factor, beta 2 0.355
Fbn1 fibrillin 1 0.338
Wnt5a wingless-related MMTV integration site 5A 0.336
Thbs2 thrombospondin 2 0.335
Postn periostin, osteoblast specific factor 0.313
Col8a1 collagen, type VIII, alpha 1 0.302
Col5a2 collagen, type V, alpha 2 0.296
Tnc tenascin C 0.275
Gli3 GLI-Kruppel family member GLI3 0.274
Flt4 FMS-like tyrosine kinase 4 0.272
Col4a4 collagen, type IV, alpha 4 0.259
Col6a3 collagen, type VI, alpha 3 0.257
Tgfbr2 transforming growth factor, beta receptor II 0.247
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.235
Smad4 MAD homolog 4 (Drosophila) 0.224
Col6a1 collagen, type VI, alpha 1 0.223
Ddr2 discoidin domain receptor family, member 2 0.223
Acvr1 activin A receptor, type 1 0.222
Mrc2 mannose receptor, C type 2 0.210
Fstl1 follistatin-like 1 0.209
Nf1 neurofibromatosis 1 0.208
Nos1 nitric oxide synthase 1, neuronal 0.201
Wisp1 WNT1 inducible signaling pathway protein 1 0.191
Twsg1 twisted gastrulation homolog 1 (Drosophila) 0.182
Efnb2 ephrin B2 0.181
Fzd8 frizzled homolog 8 (Drosophila) 0.180
Col6a2 collagen, type VI, alpha 2 0.171
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.171
Lama4 laminin, alpha 4 0.170
Gopc golgi associated PDZ and coiled-coil motif containing 0.169
Pcolce procollagen C-endopeptidase enhancer protein 0.162
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.154
Nphs2 nephrosis 2 homolog, podocin (human) 0.148
Fyn Fyn proto-oncogene 0.144
Prrx2 paired related homeobox 2 0.139
Fbln2 fibulin 2 0.138
Csf1 colony stimulating factor 1 (macrophage) 0.137
Col12a1 collagen, type XII, alpha 1 0.136
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.132
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.130
Eln elastin 0.127
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.126
Hif1a hypoxia inducible factor 1, alpha subunit 0.125
Col1a2 collagen, type I, alpha 2 0.118
Ctsk cathepsin K 0.117
Lama5 laminin, alpha 5 0.117
Eng endoglin 0.116
Creb3l1 cAMP responsive element binding protein 3-like 1 0.116
Sox9 SRY-box containing gene 9 0.115
Smad1 MAD homolog 1 (Drosophila) 0.114
Arhgef12 Rho guanine nucleotide exchange factor (GEF) 12 0.114
Hes1 hairy and enhancer of split 1 (Drosophila) 0.112
Apc adenomatosis polyposis coli 0.111
Lhx1 LIM homeobox protein 1 0.111
Col4a5 collagen, type IV, alpha 5 0.110
Gsk3b glycogen synthase kinase 3 beta 0.109
Thbd thrombomodulin 0.106
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.105
Lox lysyl oxidase 0.103
Zfhx3 zinc finger homeobox 3 0.101
Ntf3 neurotrophin 3 0.097
Col11a1 collagen, type XI, alpha 1 0.093
Rarg retinoic acid receptor, gamma 0.091
Fgf7 fibroblast growth factor 7 0.091
Twist1 twist homolog 1 (Drosophila) 0.090
Bmp4 bone morphogenetic protein 4 0.089
Angptl2 angiopoietin-like 2 0.088
Aebp1 AE binding protein 1 0.087
Notch2 Notch gene homolog 2 (Drosophila) 0.087
Fndc1 fibronectin type III domain containing 1 0.086
Smad3 MAD homolog 3 (Drosophila) 0.085
Loxl1 lysyl oxidase-like 1 0.084
Foxf1a forkhead box F1a 0.084
Sox4 SRY-box containing gene 4 0.082
Ceacam16 carcinoembryonic antigen-related cell adhesion molecule 16 0.082
Kitl kit ligand 0.081
Phldb2 pleckstrin homology-like domain, family B, member 2 0.081
Emp2 epithelial membrane protein 2 0.081
Fkbp10 FK506 binding protein 10 0.080
Pdgfb platelet derived growth factor, B polypeptide 0.080
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.080
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cdh1 cadherin 1, epithelial 0.590
gna13a guanine nucleotide binding protein (G protein), alpha 13a 0.539
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.382
gna13b guanine nucleotide binding protein (G protein), alpha 13b 0.309
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.260
bmp4 bone morphogenetic protein 4 0.240
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.210
nf1a neurofibromin 1a 0.149
spry4 sprouty (Drosophila) homolog 4 0.143
plxnd1 plexin D1 0.142
gna11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.122
bmpr2b bone morphogenetic protein receptor, type II b (serine/threonine kinase) 0.118
kdrl kinase insert domain receptor like 0.114
wnt5b wingless-type MMTV integration site family, member 5b 0.104
hlxb9lb homeo box HB9 like b 0.100
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.087
gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.086
spns2 spinster homolog 2 (Drosophila) 0.084
fetub fetuin B 0.082
msxc muscle segment homeobox C 0.076
col5a1 procollagen, type V, alpha 1 0.075
sox10 SRY-box containing gene 10 0.073
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.072
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.070
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.067
nrp1a neuropilin 1a 0.065
lmo4a LIM domain only 4a 0.063
grhl1 grainyhead-like 1 (Drosophila) 0.061
bmp2b bone morphogenetic protein 2b 0.060
fga fibrinogen alpha chain 0.054
epas1b endothelial PAS domain protein 1b 0.053
fbn2b fibrillin 2b 0.050
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.049
col12a1 collagen, type XII, alpha 1 0.047
ippk inositol 1,3,4,5,6-pentakisphosphate 2-kinase 0.047
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.041
snai1a snail homolog 1a (Drosophila) 0.038
tac1 tachykinin 1 0.037
axin1 axin 1 0.037
fzd7b frizzled homolog 7b 0.036
plce1 phospholipase C, epsilon 1 0.036
emp2 epithelial membrane protein 2 0.035
zgc:101761 zgc:101761 0.033
ambpl alpha-1-microglobulin/bikunin precursor, like 0.033
zgc:123178 zgc:123178 0.032
fras1 Fraser syndrome 1 0.029
uox urate oxidase 0.028
rarab retinoic acid receptor, alpha b 0.028
cnn2 calponin 2 0.028
kirrel3l kin of IRRE like 3 like 0.027
nrarpa notch-regulated ankyrin repeat protein a 0.027
wtip Wilms tumor 1 interacting protein 0.027
rarga retinoic acid receptor gamma a 0.027
ccm2 cerebral cavernous malformation 2 0.027
zgc:85866 zgc:85866 0.027
tie1 endothelium-specific receptor tyrosine kinase 1 0.027
gnas GNAS complex locus 0.026
vegfc vascular endothelial growth factor c 0.026
irx3a iroquois homeobox protein 3a 0.025
chd chordin 0.024
col1a2 collagen, type I, alpha 2 0.024
sept6 septin 6 0.023
llgl2 lethal giant larvae homolog 2 (Drosophila) 0.022
bnc2 basonuclin 2 0.022
gnai3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.020
hsp47 heat shock protein 47 0.020
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.020
apom apolipoprotein M 0.019
rasl11b RAS-like, family 11, member B 0.019
itih2 inter-alpha (globulin) inhibitor H2 0.019
scn8aa sodium channel, voltage-gated, type VIII, alpha a 0.019
slc25a22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 0.018
nsa2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 0.018
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.017
postn periostin, osteoblast specific factor 0.017
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.017
ptpra protein tyrosine phosphatase, receptor type, A 0.017
egr1 early growth response 1 0.017
tp63 tumor protein p63 0.017
itga2b integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) 0.017
zgc:193613 zgc:193613 0.016
gnaia guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a 0.016
mapk1 mitogen-activated protein kinase 1 0.016
si:dkey-261h17.1 si:dkey-261h17.1 0.016
c9 complement component 9 0.016
wls wntless homolog (Drosophila) 0.016
psen1 presenilin 1 0.015
zgc:100942 zgc:100942 0.015
xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 0.015
ppp3cb protein phosphatase 3, catalytic subunit, beta isozyme 0.015
styk1 serine/threonine/tyrosine kinase 1 0.015
osr1 odd-skipped related 1 (Drosophila) 0.014
qk quaking 0.014
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.014
bmp3 bone morphogenetic protein 3 0.014
nf1b neurofibromin 1b 0.014
dab1b disabled homolog 1b (Drosophila) 0.014
f11r F11 receptor 0.014
si:dkey-204a24.2 si:dkey-204a24.2 0.014
her1 hairy-related 1 0.013
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.195
pan pangolin 0.115
usp ultraspiracle 0.103
l(2)gl lethal (2) giant larvae 0.095
Ras85D Ras oncogene at 85D 0.094
LIMK1 LIM-kinase1 0.090
wg wingless 0.089
EcR Ecdysone receptor 0.056
Mcr Macroglobulin complement-related 0.054
rho rhomboid 0.052
wun wunen 0.044
Akt1 CG4006 gene product from transcript CG4006-RA 0.042
drk downstream of receptor kinase 0.040
babo baboon 0.038
shg shotgun 0.037
dpp decapentaplegic 0.036
Egfr Epidermal growth factor receptor 0.036
ed echinoid 0.034
Cbl CG7037 gene product from transcript CG7037-RB 0.034
stai stathmin 0.032
shi shibire 0.030
tai taiman 0.029
ttk tramtrack 0.029
pck pickel 0.028
par-1 CG8201 gene product from transcript CG8201-RA 0.028
hh hedgehog 0.027
pnt pointed 0.027
plexA plexin A 0.027
mav maverick 0.026
myoglianin CG1838 gene product from transcript CG1838-RD 0.025
N Notch 0.024
Src64B Src oncogene at 64B 0.020
spi spitz 0.019
Stat92E Signal-transducer and activator of transcription protein at 92E 0.018
Src42A Src oncogene at 42A 0.017
Mmp1 Matrix metalloproteinase 1 0.016
gt giant 0.015
ftz-f1 ftz transcription factor 1 0.015
CaMKII Calcium/calmodulin-dependent protein kinase II 0.015
crb crumbs 0.014
chico CG5686 gene product from transcript CG5686-RB 0.014
wit wishful thinking 0.014
CG1021 CG1021 gene product from transcript CG1021-RE 0.013
gcm glial cells missing 0.013
CG3797 CG3797 gene product from transcript CG3797-RA 0.012
rst roughest 0.012
argos CG4531 gene product from transcript CG4531-RA 0.011
sei seizure 0.011
L Lobe 0.011
CG32810 CG32810 gene product from transcript CG32810-RB 0.011
NFAT NFAT homolog 0.011
G-oalpha47A G protein oalpha 47A 0.011
eas easily shocked 0.011
Tl Toll 0.011
drl derailed 0.010
Cont Contactin 0.010
Fhos CG42610 gene product from transcript CG42610-RC 0.010
Nrx-IV Neurexin IV 0.010
Tao-1 CG14217 gene product from transcript CG14217-RF 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
BCAR1 breast cancer anti-estrogen resistance 1 0.999
EGFR epidermal growth factor receptor 0.986
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.975
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.973
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.966
JAG1 jagged 1 0.956
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.943
TEK TEK tyrosine kinase, endothelial 0.942
IL1R1 interleukin 1 receptor, type I 0.922
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.903
NRP1 neuropilin 1 0.903
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.834
TGFB1 transforming growth factor, beta 1 0.808
C1QA complement component 1, q subcomponent, A chain 0.805
BMPR1A bone morphogenetic protein receptor, type IA 0.790
FN1 fibronectin 1 0.768
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.745
PTK2 PTK2 protein tyrosine kinase 2 0.738
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.724
BMP2 bone morphogenetic protein 2 0.721
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.713
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.673
ENG endoglin 0.653
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.641
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.604
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.599
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.594
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.573
IGFBP3 insulin-like growth factor binding protein 3 0.556
EZR ezrin 0.553
MET met proto-oncogene (hepatocyte growth factor receptor) 0.526
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.517
FSTL1 follistatin-like 1 0.496
PLAT plasminogen activator, tissue 0.485
CD44 CD44 molecule (Indian blood group) 0.471
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.460
SOCS3 suppressor of cytokine signaling 3 0.459
FHL2 four and a half LIM domains 2 0.454
CD63 CD63 molecule 0.434
COL5A1 collagen, type V, alpha 1 0.421
FKBP1A FK506 binding protein 1A, 12kDa 0.410
INADL InaD-like (Drosophila) 0.397
PLAUR plasminogen activator, urokinase receptor 0.395
THBS1 thrombospondin 1 0.388
SMAD7 SMAD family member 7 0.369
FZD1 frizzled homolog 1 (Drosophila) 0.366
C1QC complement component 1, q subcomponent, C chain 0.364
FGA fibrinogen alpha chain 0.355
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.350
LCK lymphocyte-specific protein tyrosine kinase 0.344
AR androgen receptor 0.337
NCOA1 nuclear receptor coactivator 1 0.300
APP amyloid beta (A4) precursor protein 0.284
HOXB5 homeobox B5 0.275
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.262
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.249
ABI2 abl-interactor 2 0.244
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.239
RXRA retinoid X receptor, alpha 0.236
PTPRJ protein tyrosine phosphatase, receptor type, J 0.233
GRB2 growth factor receptor-bound protein 2 0.227
BBS10 Bardet-Biedl syndrome 10 0.226
TNC tenascin C 0.218
FNDC3B fibronectin type III domain containing 3B 0.218
HDAC6 histone deacetylase 6 0.217
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.213
TIMP2 TIMP metallopeptidase inhibitor 2 0.212
HOXA10 homeobox A10 0.210
COL4A1 collagen, type IV, alpha 1 0.209
GAB1 GRB2-associated binding protein 1 0.209
NOTCH1 notch 1 0.208
DSG2 desmoglein 2 0.203
PLXND1 plexin D1 0.200
TGFB3 transforming growth factor, beta 3 0.197
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.191
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 0.187
C1QB complement component 1, q subcomponent, B chain 0.183
A2M alpha-2-macroglobulin 0.183
COL4A2 collagen, type IV, alpha 2 0.181
SDC2 syndecan 2 0.180
COL1A1 collagen, type I, alpha 1 0.176
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.173
SFRP1 secreted frizzled-related protein 1 0.168
ILK integrin-linked kinase 0.166
MUC1 mucin 1, cell surface associated 0.161
THBS2 thrombospondin 2 0.159
COL1A2 collagen, type I, alpha 2 0.159
PLAU plasminogen activator, urokinase 0.158
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.154
MAPK1 mitogen-activated protein kinase 1 0.154
DSP desmoplakin 0.152
IGFBP5 insulin-like growth factor binding protein 5 0.148
ESR1 estrogen receptor 1 0.147
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.146
CDCP1 CUB domain containing protein 1 0.144
WNT5A wingless-type MMTV integration site family, member 5A 0.143
COL7A1 collagen, type VII, alpha 1 0.142
DLG1 discs, large homolog 1 (Drosophila) 0.142
LPXN leupaxin 0.142
HOXA5 homeobox A5 0.141
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism