The network for 'regulation of mitochondrial membrane permeability' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of mitochondrial membrane permeability

Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.

Mus musculus
Name Description Probability Func Analog Organism
Bax BCL2-associated X protein 0.998
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.988
Bcl2 B-cell leukemia/lymphoma 2 0.857
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.805
Apc adenomatosis polyposis coli 0.732
Mcl1 myeloid cell leukemia sequence 1 0.611
Trp53 transformation related protein 53 0.557
Pdcd6ip programmed cell death 6 interacting protein 0.498
Pten phosphatase and tensin homolog 0.473
Bcl2l1 BCL2-like 1 0.439
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.434
Kit kit oncogene 0.295
Dlg4 discs, large homolog 4 (Drosophila) 0.283
Smad3 MAD homolog 3 (Drosophila) 0.271
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.257
Axin1 axin 1 0.252
Ctnnb1 catenin (cadherin associated protein), beta 1 0.210
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.174
Dnm1 dynamin 1 0.174
Sharpin SHANK-associated RH domain interacting protein 0.162
Vhl von Hippel-Lindau tumor suppressor 0.159
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.153
Bak1 BCL2-antagonist/killer 1 0.144
Mtap2 microtubule-associated protein 2 0.109
Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 0.105
Btrc beta-transducin repeat containing protein 0.098
Mta1 metastasis associated 1 0.094
Dctpp1 dCTP pyrophosphatase 1 0.093
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.088
Atxn2 ataxin 2 0.066
Mapk1 mitogen-activated protein kinase 1 0.065
Mlf2 myeloid leukemia factor 2 0.063
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.061
Mapk8 mitogen-activated protein kinase 8 0.060
Arc activity regulated cytoskeletal-associated protein 0.058
Akt1 thymoma viral proto-oncogene 1 0.053
Homer1 homer homolog 1 (Drosophila) 0.053
Rock2 Rho-associated coiled-coil containing protein kinase 2 0.051
Actn2 actinin alpha 2 0.049
Btbd2 BTB (POZ) domain containing 2 0.045
Rab1b RAB1B, member RAS oncogene family 0.045
Stim2 stromal interaction molecule 2 0.041
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.039
Camk2b calcium/calmodulin-dependent protein kinase II, beta 0.037
Ccnd1 cyclin D1 0.035
Igh immunoglobulin heavy chain complex 0.033
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.032
Bbc3 BCL2 binding component 3 0.031
Bhlhe40 basic helix-loop-helix family, member e40 0.031
Prkci protein kinase C, iota 0.030
Casp3 caspase 3 0.030
Grm1 glutamate receptor, metabotropic 1 0.030
Rbck1 RanBP-type and C3HC4-type zinc finger containing 1 0.029
Foxp3 forkhead box P3 0.028
Dlg2 discs, large homolog 2 (Drosophila) 0.028
Emx1 empty spiracles homolog 1 (Drosophila) 0.027
Skil SKI-like 0.027
Drap1 Dr1 associated protein 1 (negative cofactor 2 alpha) 0.027
Mdm2 transformed mouse 3T3 cell double minute 2 0.027
Gstz1 glutathione transferase zeta 1 (maleylacetoacetate isomerase) 0.026
Mapk14 mitogen-activated protein kinase 14 0.026
Snap25 synaptosomal-associated protein 25 0.025
Acd adrenocortical dysplasia 0.025
Rara retinoic acid receptor, alpha 0.025
Prkaca protein kinase, cAMP dependent, catalytic, alpha 0.024
Mfn2 mitofusin 2 0.024
Flii flightless I homolog (Drosophila) 0.024
Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.023
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.022
Rfc2 replication factor C (activator 1) 2 0.022
Lef1 lymphoid enhancer binding factor 1 0.021
Pik3r2 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) 0.021
Syn1 synapsin I 0.021
Ptgs2 prostaglandin-endoperoxide synthase 2 0.019
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.019
Ikzf1 IKAROS family zinc finger 1 0.019
Socs3 suppressor of cytokine signaling 3 0.018
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.018
Sox2 SRY-box containing gene 2 0.018
Nf2 neurofibromatosis 2 0.017
Epn1 epsin 1 0.016
Pmm1 phosphomannomutase 1 0.016
Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit 1 0.016
Mta2 metastasis-associated gene family, member 2 0.016
Six2 sine oculis-related homeobox 2 homolog (Drosophila) 0.015
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.015
Ar androgen receptor 0.015
Ilk integrin linked kinase 0.015
Emx2 empty spiracles homolog 2 (Drosophila) 0.015
Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) 0.015
Daxx Fas death domain-associated protein 0.015
Esr1 estrogen receptor 1 (alpha) 0.015
Acadm acyl-Coenzyme A dehydrogenase, medium chain 0.015
2700094K13Rik RIKEN cDNA 2700094K13 gene 0.015
Pgam1 phosphoglycerate mutase 1 0.014
Dsg1a desmoglein 1 alpha 0.014
Cdk4 cyclin-dependent kinase 4 0.014
Mapk3 mitogen-activated protein kinase 3 0.014
Psen1 presenilin 1 0.014
Ncoa3 nuclear receptor coactivator 3 0.014
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
BCL2 B-cell CLL/lymphoma 2 1.000
BCL2L1 BCL2-like 1 0.998
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.989
BAX BCL2-associated X protein 0.932
JUN jun proto-oncogene 0.874
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.865
BAD BCL2-associated agonist of cell death 0.814
BAK1 BCL2-antagonist/killer 1 0.726
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.681
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.601
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 0.431
ATF3 activating transcription factor 3 0.421
BID BH3 interacting domain death agonist 0.373
FOS FBJ murine osteosarcoma viral oncogene homolog 0.354
VDAC1 voltage-dependent anion channel 1 0.270
PXMP2 peroxisomal membrane protein 2, 22kDa 0.250
GADD45A growth arrest and DNA-damage-inducible, alpha 0.249
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.248
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.191
BIK BCL2-interacting killer (apoptosis-inducing) 0.166
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.144
TP53BP2 tumor protein p53 binding protein, 2 0.143
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.131
IER2 immediate early response 2 0.112
BBC3 BCL2 binding component 3 0.106
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.100
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.099
HUWE1 HECT, UBA and WWE domain containing 1 0.082
EEF2 eukaryotic translation elongation factor 2 0.075
JUNB jun B proto-oncogene 0.071
BECN1 beclin 1, autophagy related 0.066
FKBP8 FK506 binding protein 8, 38kDa 0.063
DTNBP1 dystrobrevin binding protein 1 0.056
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 0.055
BHLHE40 basic helix-loop-helix family, member e40 0.048
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.047
ACAT1 acetyl-CoA acetyltransferase 1 0.047
ZHX1 zinc fingers and homeoboxes 1 0.045
JDP2 Jun dimerization protein 2 0.044
HDAC6 histone deacetylase 6 0.042
C4orf14 chromosome 4 open reading frame 14 0.040
NBR1 neighbor of BRCA1 gene 1 0.039
RANGAP1 Ran GTPase activating protein 1 0.039
AMBRA1 autophagy/beclin-1 regulator 1 0.039
OCIAD1 OCIA domain containing 1 0.037
VDAC2 voltage-dependent anion channel 2 0.034
MAPK8 mitogen-activated protein kinase 8 0.033
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.032
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.032
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.032
MUTED muted homolog (mouse) 0.031
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 0.028
SNAPIN SNAP-associated protein 0.027
TP53 tumor protein p53 0.025
HRK harakiri, BCL2 interacting protein (contains only BH3 domain) 0.025
PGK1 phosphoglycerate kinase 1 0.025
TMEM11 transmembrane protein 11 0.023
RNF144B ring finger protein 144B 0.023
HMOX2 heme oxygenase (decycling) 2 0.023
PSEN2 presenilin 2 (Alzheimer disease 4) 0.022
MAGEH1 melanoma antigen family H, 1 0.022
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.022
OXA1L oxidase (cytochrome c) assembly 1-like 0.022
DEAF1 deformed epidermal autoregulatory factor 1 (Drosophila) 0.021
ZFYVE1 zinc finger, FYVE domain containing 1 0.020
BCL2L2 BCL2-like 2 0.020
MRPS12 mitochondrial ribosomal protein S12 0.019
PDCD6 programmed cell death 6 0.019
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.018
IMMT inner membrane protein, mitochondrial 0.018
GNB5 guanine nucleotide binding protein (G protein), beta 5 0.018
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.018
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.018
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.018
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.017
PLDN pallidin homolog (mouse) 0.017
DUSP1 dual specificity phosphatase 1 0.017
RHOA ras homolog gene family, member A 0.016
CLU clusterin 0.015
CDK10 cyclin-dependent kinase 10 0.015
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0.015
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.014
GRIA4 glutamate receptor, ionotrophic, AMPA 4 0.014
IRF2BP1 interferon regulatory factor 2 binding protein 1 0.014
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 0.014
QARS glutaminyl-tRNA synthetase 0.014
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.014
ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 0.014
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 0.014
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.014
JUND jun D proto-oncogene 0.014
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.013
C11orf2 chromosome 11 open reading frame 2 0.013
SMAD4 SMAD family member 4 0.013
PGAM1 phosphoglycerate mutase 1 (brain) 0.013
MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 0.013
EGR1 early growth response 1 0.013
AHCY adenosylhomocysteinase 0.012
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.012
ELK1 ELK1, member of ETS oncogene family 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.038
Rnf213 ring finger protein 213 0.031
Ppia peptidylprolyl isomerase A (cyclophilin A) 0.028
Hspd1 heat shock protein 1 (chaperonin) 0.027
LOC100365106 rCG32755-like 0.027
Pgam1 phosphoglycerate mutase 1 (brain) 0.022
Eif2c2 eukaryotic translation initiation factor 2C, 2 0.021
Sp110 SP110 nuclear body protein 0.019
LOC100362108 poly (ADP-ribose) polymerase family, member 10 0.016
Tp53 tumor protein p53 0.014
Prdx1 peroxiredoxin 1 0.013
Chp2 calcineurin B homologous protein 2 0.013
Capn1 calpain 1 0.011
Mdh1 malate dehydrogenase 1, NAD (soluble) 0.011
Flt1 FMS-related tyrosine kinase 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism