The network for 'regulation of osteoblast differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of osteoblast differentiation

Any process that modulates the frequency, rate or extent of osteoblast differentiation.

Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.998
Pax3 paired box gene 3 0.994
Fgfr1 fibroblast growth factor receptor 1 0.990
Shh sonic hedgehog 0.986
Ctnnb1 catenin (cadherin associated protein), beta 1 0.983
Bmp4 bone morphogenetic protein 4 0.978
Notch1 Notch gene homolog 1 (Drosophila) 0.978
Pten phosphatase and tensin homolog 0.976
Otx2 orthodenticle homolog 2 (Drosophila) 0.974
Foxc1 forkhead box C1 0.969
Trp53 transformation related protein 53 0.965
Smad4 MAD homolog 4 (Drosophila) 0.959
Nodal nodal 0.950
Fgf8 fibroblast growth factor 8 0.943
Tgfb2 transforming growth factor, beta 2 0.942
Smad3 MAD homolog 3 (Drosophila) 0.939
Runx2 runt related transcription factor 2 0.929
Sox9 SRY-box containing gene 9 0.912
Gata4 GATA binding protein 4 0.901
Vegfa vascular endothelial growth factor A 0.889
Nog noggin 0.879
Hand2 heart and neural crest derivatives expressed transcript 2 0.866
Hes1 hairy and enhancer of split 1 (Drosophila) 0.862
Pthlh parathyroid hormone-like peptide 0.857
Bmp7 bone morphogenetic protein 7 0.851
Prrx1 paired related homeobox 1 0.841
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.836
Gli3 GLI-Kruppel family member GLI3 0.828
Mdm2 transformed mouse 3T3 cell double minute 2 0.828
Msx1 homeobox, msh-like 1 0.826
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.819
Smad6 MAD homolog 6 (Drosophila) 0.819
Ptf1a pancreas specific transcription factor, 1a 0.818
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.818
Csf1 colony stimulating factor 1 (macrophage) 0.801
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.796
Fgfr3 fibroblast growth factor receptor 3 0.788
Neurod1 neurogenic differentiation 1 0.778
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.774
Smo smoothened homolog (Drosophila) 0.772
Dlx5 distal-less homeobox 5 0.770
Rarg retinoic acid receptor, gamma 0.755
Acvr1 activin A receptor, type 1 0.741
Hand1 heart and neural crest derivatives expressed transcript 1 0.731
Prrx2 paired related homeobox 2 0.703
Bmpr1a bone morphogenetic protein receptor, type 1A 0.692
Mef2d myocyte enhancer factor 2D 0.679
Apc adenomatosis polyposis coli 0.677
Ltb lymphotoxin B 0.675
Pax2 paired box gene 2 0.655
Ntf3 neurotrophin 3 0.654
Gpc3 glypican 3 0.648
Msx2 homeobox, msh-like 2 0.640
Pax8 paired box gene 8 0.619
Gli2 GLI-Kruppel family member GLI2 0.613
Nos3 nitric oxide synthase 3, endothelial cell 0.602
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.598
Tnf tumor necrosis factor 0.586
Pax6 paired box gene 6 0.586
Jag1 jagged 1 0.577
Gata3 GATA binding protein 3 0.576
Pitx2 paired-like homeodomain transcription factor 2 0.575
Lepr leptin receptor 0.575
Fgf18 fibroblast growth factor 18 0.566
Zic3 zinc finger protein of the cerebellum 3 0.564
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.551
Smad2 MAD homolog 2 (Drosophila) 0.551
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.550
Wnt4 wingless-related MMTV integration site 4 0.541
Eya1 eyes absent 1 homolog (Drosophila) 0.531
Id3 inhibitor of DNA binding 3 0.528
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.519
Alx4 aristaless-like homeobox 4 0.510
Id1 inhibitor of DNA binding 1 0.508
Ncoa3 nuclear receptor coactivator 3 0.506
Adra2a adrenergic receptor, alpha 2a 0.493
Foxc2 forkhead box C2 0.488
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.486
Tbx3 T-box 3 0.471
Hoxd13 homeobox D13 0.468
Ptgs2 prostaglandin-endoperoxide synthase 2 0.461
Rarb retinoic acid receptor, beta 0.461
Snai1 snail homolog 1 (Drosophila) 0.459
Twist2 twist homolog 2 (Drosophila) 0.448
Lhx1 LIM homeobox protein 1 0.436
Dll1 delta-like 1 (Drosophila) 0.432
Twist1 twist homolog 1 (Drosophila) 0.431
Thra thyroid hormone receptor alpha 0.424
Hoxa2 homeobox A2 0.424
Mndal myeloid nuclear differentiation antigen like 0.424
Zfpm2 zinc finger protein, multitype 2 0.420
Adam17 a disintegrin and metallopeptidase domain 17 0.419
Tgfb1 transforming growth factor, beta 1 0.417
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.415
Hey1 hairy/enhancer-of-split related with YRPW motif 1 0.411
Tcfap2a transcription factor AP-2, alpha 0.411
Vdr vitamin D receptor 0.408
En1 engrailed 1 0.408
Gsc goosecoid homeobox 0.405
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.403
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SMAD4 SMAD family member 4 0.998
SMAD2 SMAD family member 2 0.997
SMAD7 SMAD family member 7 0.996
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.995
CREBBP CREB binding protein 0.995
SMAD3 SMAD family member 3 0.992
SKIL SKI-like oncogene 0.985
FBLN1 fibulin 1 0.953
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.908
CAV1 caveolin 1, caveolae protein, 22kDa 0.857
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.814
SMAD1 SMAD family member 1 0.791
PAX3 paired box 3 0.730
YAP1 Yes-associated protein 1 0.717
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.685
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.627
SNX9 sorting nexin 9 0.604
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.602
SP1 Sp1 transcription factor 0.598
JAG1 jagged 1 0.593
ATF3 activating transcription factor 3 0.566
JUN jun proto-oncogene 0.554
NOTCH3 notch 3 0.550
HIPK2 homeodomain interacting protein kinase 2 0.531
FKBP1A FK506 binding protein 1A, 12kDa 0.529
ENG endoglin 0.523
FGFR1 fibroblast growth factor receptor 1 0.511
SKI v-ski sarcoma viral oncogene homolog (avian) 0.490
POU3F2 POU class 3 homeobox 2 0.457
HLA-B major histocompatibility complex, class I, B 0.442
BMP2 bone morphogenetic protein 2 0.429
BMPR1A bone morphogenetic protein receptor, type IA 0.401
NCK2 NCK adaptor protein 2 0.394
FSTL1 follistatin-like 1 0.387
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.384
JUP junction plakoglobin 0.375
NOTCH1 notch 1 0.363
BMPR1B bone morphogenetic protein receptor, type IB 0.353
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.353
FGFR2 fibroblast growth factor receptor 2 0.349
SMAD5 SMAD family member 5 0.343
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.338
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.335
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.310
NCOR1 nuclear receptor corepressor 1 0.308
CXXC5 CXXC finger protein 5 0.286
BMP7 bone morphogenetic protein 7 0.279
AXIN1 axin 1 0.273
TGFB1 transforming growth factor, beta 1 0.262
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.259
GDF5 growth differentiation factor 5 0.258
CCND1 cyclin D1 0.257
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.256
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.242
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.232
SOCS3 suppressor of cytokine signaling 3 0.222
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.219
BCAR1 breast cancer anti-estrogen resistance 1 0.214
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.206
JUB jub, ajuba homolog (Xenopus laevis) 0.203
FGF1 fibroblast growth factor 1 (acidic) 0.196
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.185
S100A4 S100 calcium binding protein A4 0.178
WWOX WW domain containing oxidoreductase 0.178
ESR1 estrogen receptor 1 0.170
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.166
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.162
ADAM15 ADAM metallopeptidase domain 15 0.161
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.160
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.159
AR androgen receptor 0.158
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.155
SMO smoothened homolog (Drosophila) 0.152
FN1 fibronectin 1 0.149
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.149
BMP4 bone morphogenetic protein 4 0.147
IFITM3 interferon induced transmembrane protein 3 (1-8U) 0.144
SETD7 SET domain containing (lysine methyltransferase) 7 0.139
SFRP1 secreted frizzled-related protein 1 0.139
NRP1 neuropilin 1 0.134
EP300 E1A binding protein p300 0.132
WNT3A wingless-type MMTV integration site family, member 3A 0.131
BMP1 bone morphogenetic protein 1 0.126
TM4SF1 transmembrane 4 L six family member 1 0.125
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.122
AMOTL2 angiomotin like 2 0.122
DCN decorin 0.116
TGFB3 transforming growth factor, beta 3 0.114
SMAD6 SMAD family member 6 0.114
NOG noggin 0.113
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.113
RUNX2 runt-related transcription factor 2 0.112
EGR1 early growth response 1 0.111
TGFBR1 transforming growth factor, beta receptor 1 0.108
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.102
IGF2R insulin-like growth factor 2 receptor 0.101
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.097
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.097
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.096
SQSTM1 sequestosome 1 0.094
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Rattus norvegicus
Name Description Probability Func Analog Organism
Timp3 TIMP metallopeptidase inhibitor 3 0.550
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.539
Id3 inhibitor of DNA binding 3 0.267
Fgfr2 fibroblast growth factor receptor 2 0.200
Nradd neurotrophin receptor associated death domain 0.179
Id1 inhibitor of DNA binding 1 0.160
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.156
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.155
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.112
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.108
Col12a1 collagen, type XII, alpha 1 0.088
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.086
Cald1 caldesmon 1 0.074
Bmp3 bone morphogenetic protein 3 0.069
Cpd carboxypeptidase D 0.064
Foxe3 forkhead box E3 0.064
Acvr1 activin A receptor, type I 0.063
Sod3 superoxide dismutase 3, extracellular 0.063
Fgfr1 Fibroblast growth factor receptor 1 0.060
Cpxm2 carboxypeptidase X (M14 family), member 2 0.058
Wnt5a wingless-type MMTV integration site family, member 5A 0.057
Bcl2 B-cell CLL/lymphoma 2 0.056
Actc1 actin, alpha, cardiac muscle 1 0.052
Grm5 glutamate receptor, metabotropic 5 0.051
Znf503 zinc finger protein 503 0.050
Arhgap28 Rho GTPase activating protein 28 0.049
Igfbp5 insulin-like growth factor binding protein 5 0.049
Jub jub, ajuba homolog (Xenopus laevis) 0.046
Ednrb endothelin receptor type B 0.044
Mmp23 matrix metallopeptidase 23 0.044
Ppic peptidylprolyl isomerase C 0.043
Twist2 twist homolog 2 (Drosophila) 0.042
Sox4 SRY (sex determining region Y)-box 4 0.040
Slit3 slit homolog 3 (Drosophila) 0.040
Nfia nuclear factor I/A 0.039
Bmp4 bone morphogenetic protein 4 0.039
Sc65 synaptonemal complex protein SC65 0.037
Sox13 SRY (sex determining region Y)-box 13 0.036
Agtr1a angiotensin II receptor, type 1a 0.034
Crtap cartilage associated protein 0.034
Emp1 epithelial membrane protein 1 0.034
Tcf12 transcription factor 12 0.034
Errfi1 ERBB receptor feedback inhibitor 1 0.033
Hapln1 hyaluronan and proteoglycan link protein 1 0.031
Lepr leptin receptor 0.031
Vcan versican 0.030
Tead3 TEA domain family member 3 0.030
Smad7 SMAD family member 7 0.029
Chrng cholinergic receptor, nicotinic, gamma 0.028
Madcam1 mucosal vascular addressin cell adhesion molecule 1 0.027
Smo smoothened homolog (Drosophila) 0.027
Ptpn1 protein tyrosine phosphatase, non-receptor type 1 0.026
Igfbp2 insulin-like growth factor binding protein 2 0.025
Glg1 golgi apparatus protein 1 0.025
App amyloid beta (A4) precursor protein 0.024
Olfml2a olfactomedin-like 2A 0.024
Adrb1 adrenergic, beta-1-, receptor 0.024
Lamc1 laminin, gamma 1 0.024
Epha2 Eph receptor A2 0.024
Rbpms RNA binding protein with multiple splicing 0.024
Efemp2 EGF-containing fibulin-like extracellular matrix protein 2 0.023
Gdf11 growth differentiation factor 11 0.022
Fcgrt Fc fragment of IgG, receptor, transporter, alpha 0.022
Mid1 midline 1 0.022
Notch2 Notch homolog 2 (Drosophila) 0.022
Jak1 Janus kinase 1 0.022
Col6a3 procollagen, type VI, alpha 3 0.021
Svep1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 0.021
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.021
Fgf10 fibroblast growth factor 10 0.021
Calcrl calcitonin receptor-like 0.021
Pawr PRKC, apoptosis, WT1, regulator 0.021
Tnmd tenomodulin 0.020
Irs1 insulin receptor substrate 1 0.020
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.020
Hes1 hairy and enhancer of split 1 (Drosophila) 0.019
Bhlhe40 basic helix-loop-helix family, member e40 0.019
Cxcl12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) 0.019
Myoc myocilin 0.019
Ppap2b phosphatidic acid phosphatase type 2B 0.019
Mcam melanoma cell adhesion molecule 0.018
Fstl3 follistatin-like 3 (secreted glycoprotein) 0.018
Efemp1 EGF-containing fibulin-like extracellular matrix protein 1 0.018
Sgce sarcoglycan, epsilon 0.018
Col4a5 collagen, type IV, alpha 5 0.018
Tgfb3 transforming growth factor, beta 3 0.018
Asph aspartate-beta-hydroxylase 0.018
Vom2r44 vomeronasal 2 receptor 44 0.017
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.017
Cav1 caveolin 1, caveolae protein 0.017
Tcf3 transcription factor 3 0.017
Nfib nuclear factor I/B 0.017
Foxd1 forkhead box D1 0.016
Spta1 spectrin, alpha, erythrocytic 1 (elliptocytosis 2) 0.016
Six1 SIX homeobox 1 0.016
Agtr2 angiotensin II receptor, type 2 0.016
Cd9 CD9 molecule 0.016
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.016
Meox2 mesenchyme homeobox 2 0.016
Ltb4r leukotriene B4 receptor 0.016
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism