IMP

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Homo sapiens

21 genes annotated in human

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t cell receptor signaling pathway

GO:0050852

A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "t cell receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "t cell receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
LCK	lymphocyte-specific protein tyrosine kinase	1.000	Human Mouse
LAT	linker for activation of T cells	0.996
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.996	Mouse
SYK	spleen tyrosine kinase	0.995
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.995
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.992
GRB2	growth factor receptor-bound protein 2	0.984
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.983	Mouse
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.975
FYN	FYN oncogene related to SRC, FGR, YES	0.903
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.878
CD80	CD80 molecule	0.869
VAV1	vav 1 guanine nucleotide exchange factor	0.869
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.811
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.802
BTN3A2	butyrophilin, subfamily 3, member A2	0.759	Human
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.650
BLNK	B-cell linker	0.645
BTN3A3	butyrophilin, subfamily 3, member A3	0.625	Human
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.625
TRAF3	TNF receptor-associated factor 3	0.604	Human
TRAF6	TNF receptor-associated factor 6	0.564
CD247	CD247 molecule	0.503	Mouse
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.473	Human
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.432	Mouse
FYB	FYN binding protein	0.416
GHR	growth hormone receptor	0.402
BTN3A1	butyrophilin, subfamily 3, member A1	0.399
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.389
TFF1	trefoil factor 1	0.385
PLCG1	phospholipase C, gamma 1	0.384	Mouse
BIRC3	baculoviral IAP repeat containing 3	0.378
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.339
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.316
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.293
CARD11	caspase recruitment domain family, member 11	0.291
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.290
SH2D1A	SH2 domain containing 1A	0.282
CD40	CD40 molecule, TNF receptor superfamily member 5	0.281
MAPK1	mitogen-activated protein kinase 1	0.279	Mouse
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.272
SPRR2A	small proline-rich protein 2A	0.255
APP	amyloid beta (A4) precursor protein	0.252
SH3BP2	SH3-domain binding protein 2	0.232
RNF31	ring finger protein 31	0.207
PRKCQ	protein kinase C, theta	0.174
ADAM15	ADAM metallopeptidase domain 15	0.159
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.154
TRAF1	TNF receptor-associated factor 1	0.136	Human
MAPK3	mitogen-activated protein kinase 3	0.113
SOS1	son of sevenless homolog 1 (Drosophila)	0.109
C9orf89	chromosome 9 open reading frame 89	0.109
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.106
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.104
PSEN1	presenilin 1	0.096	Mouse
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.094
NUMBL	numb homolog (Drosophila)-like	0.093
RIPK2	receptor-interacting serine-threonine kinase 2	0.092	Mouse
BTN2A2	butyrophilin, subfamily 2, member A2	0.091	Human Mouse
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.090
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.088
SH3KBP1	SH3-domain kinase binding protein 1	0.082
PHYHIPL	phytanoyl-CoA 2-hydroxylase interacting protein-like	0.081
CD2	CD2 molecule	0.075
MED28	mediator complex subunit 28	0.073
STRADA	STE20-related kinase adaptor alpha	0.071
BIRC2	baculoviral IAP repeat containing 2	0.071
SNAP23	synaptosomal-associated protein, 23kDa	0.071
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.069
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.068
HDAC7	histone deacetylase 7	0.067
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.066
TRIM32	tripartite motif containing 32	0.061
EGFR	epidermal growth factor receptor	0.060
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.056
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.056
SQSTM1	sequestosome 1	0.051
SLA	Src-like-adaptor	0.049
TRAF5	TNF receptor-associated factor 5	0.049	Human
GRAP2	GRB2-related adaptor protein 2	0.045
HCK	hemopoietic cell kinase	0.045	Human
IBTK	inhibitor of Bruton agammaglobulinemia tyrosine kinase	0.043
PDCD6IP	programmed cell death 6 interacting protein	0.041
TANK	TRAF family member-associated NFKB activator	0.041
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.039
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.039
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.039
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.039
PSEN2	presenilin 2 (Alzheimer disease 4)	0.037	Mouse
UBASH3B	ubiquitin associated and SH3 domain containing B	0.037
MICA	MHC class I polypeptide-related sequence A	0.036
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.036
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.035
PILRA	paired immunoglobin-like type 2 receptor alpha	0.034
BTK	Bruton agammaglobulinemia tyrosine kinase	0.033	Human
MAP2K1	mitogen-activated protein kinase kinase 1	0.033
PTK2	PTK2 protein tyrosine kinase 2	0.033
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.032
NCK1	NCK adaptor protein 1	0.031
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.030
SH2D2A	SH2 domain containing 2A	0.029
TRAT1	T cell receptor associated transmembrane adaptor 1	0.028
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.027
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.027
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.027	Human
DPYSL4	dihydropyrimidinase-like 4	0.026
VAV2	vav 2 guanine nucleotide exchange factor	0.026
PEA15	phosphoprotein enriched in astrocytes 15	0.026
PTPRB	protein tyrosine phosphatase, receptor type, B	0.026	Human
MAPK14	mitogen-activated protein kinase 14	0.025
NOD2	nucleotide-binding oligomerization domain containing 2	0.025
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.025
PTPRC	protein tyrosine phosphatase, receptor type, C	0.024
WIPF1	WAS/WASL interacting protein family, member 1	0.024
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.023
BTN2A1	butyrophilin, subfamily 2, member A1	0.022	Human Mouse
STRADB	STE20-related kinase adaptor beta	0.021
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.021
THAP2	THAP domain containing, apoptosis associated protein 2	0.021
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.021
SP1	Sp1 transcription factor	0.020
PLK3	polo-like kinase 3	0.020
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.020
ZMYND11	zinc finger, MYND-type containing 11	0.019
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.019
FLNB	filamin B, beta	0.019
ITK	IL2-inducible T-cell kinase	0.018	Mouse
DUSP7	dual specificity phosphatase 7	0.018
VAV3	vav 3 guanine nucleotide exchange factor	0.017
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.017
CD22	CD22 molecule	0.017
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.017
CD69	CD69 molecule	0.017
DUSP3	dual specificity phosphatase 3	0.017
TNF	tumor necrosis factor	0.017
SHARPIN	SHANK-associated RH domain interactor	0.016	Human
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.016
DNM1	dynamin 1	0.016
HCP5	HLA complex P5	0.016
SMAD1	SMAD family member 1	0.016
SLAMF1	signaling lymphocytic activation molecule family member 1	0.016
PTPRR	protein tyrosine phosphatase, receptor type, R	0.015
IFI16	interferon, gamma-inducible protein 16	0.015
CD2AP	CD2-associated protein	0.015
TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	0.015
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.015
CD28	CD28 molecule	0.014	Mouse
ALOX5	arachidonate 5-lipoxygenase	0.014
GAB1	GRB2-associated binding protein 1	0.014
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.014
ZNF512B	zinc finger protein 512B	0.014
CD83	CD83 molecule	0.014
DLG4	discs, large homolog 4 (Drosophila)	0.014
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.014
DUSP6	dual specificity phosphatase 6	0.014
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.014
CD274	CD274 molecule	0.014	Human
TIFA	TRAF-interacting protein with forkhead-associated domain	0.014
P2RY10	purinergic receptor P2Y, G-protein coupled, 10	0.013
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.013
MUC1	mucin 1, cell surface associated	0.013
GRB10	growth factor receptor-bound protein 10	0.013
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.013
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.013
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.013
GPS1	G protein pathway suppressor 1	0.013
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.012
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.012
SOS2	son of sevenless homolog 2 (Drosophila)	0.012
PRKCB	protein kinase C, beta	0.012
RRAS2	related RAS viral (r-ras) oncogene homolog 2	0.012
ZNF267	zinc finger protein 267	0.011
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.011
HDAC9	histone deacetylase 9	0.011
PLEK	pleckstrin	0.011
DPPA4	developmental pluripotency associated 4	0.011
SMAD5	SMAD family member 5	0.011
CSK	c-src tyrosine kinase	0.011
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.011
AXL	AXL receptor tyrosine kinase	0.011
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.011
IL2RB	interleukin 2 receptor, beta	0.011
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.011
CCR1	chemokine (C-C motif) receptor 1	0.011
CTNND1	catenin (cadherin-associated protein), delta 1	0.010
NCSTN	nicastrin	0.010
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.010
SH3BP5	SH3-domain binding protein 5 (BTK-associated)	0.010
SMAD3	SMAD family member 3	0.010
IL2RA	interleukin 2 receptor, alpha	0.010
SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	0.010
CD44	CD44 molecule (Indian blood group)	0.010
TRAF3IP2	TRAF3 interacting protein 2	0.010