IMP

Process View

Homo sapiens

3 genes annotated in human

replicative cell aging

The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "replicative cell aging"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "replicative cell aging" (in gray)

Name	Description	Probability	Func Analog Organism
PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.766
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.514
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.452	Yeast
APLF	aprataxin and PNKP like factor	0.430
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	0.340
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.265
H2AFX	H2A histone family, member X	0.255
RAD52	RAD52 homolog (S. cerevisiae)	0.206
RALBP1	ralA binding protein 1	0.167
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.136
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.119
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.115
BLM	Bloom syndrome, RecQ helicase-like	0.112
PGAM1	phosphoglycerate mutase 1 (brain)	0.108
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.108
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.107
PPP6R2	protein phosphatase 6, regulatory subunit 2	0.106
TMBIM6	transmembrane BAX inhibitor motif containing 6	0.102
TOP3A	topoisomerase (DNA) III alpha	0.096
WRN	Werner syndrome, RecQ helicase-like	0.092	Mouse
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.092	Yeast
STK4	serine/threonine kinase 4	0.086
TERF2	telomeric repeat binding factor 2	0.085	Human
MUS81	MUS81 endonuclease homolog (S. cerevisiae)	0.080
SATB2	SATB homeobox 2	0.075
XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	0.072
CABLES1	Cdk5 and Abl enzyme substrate 1	0.069
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.065
KRT5	keratin 5	0.063
ENO2	enolase 2 (gamma, neuronal)	0.057
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.056
PARP1	poly (ADP-ribose) polymerase 1	0.055
NBN	nibrin	0.054
TXN	thioredoxin	0.049
PGK1	phosphoglycerate kinase 1	0.048
DCLRE1B	DNA cross-link repair 1B	0.048
NEK6	NIMA (never in mitosis gene a)-related kinase 6	0.046
RALGDS	ral guanine nucleotide dissociation stimulator	0.040
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.039
HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B	0.037
PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	0.036	Yeast
APTX	aprataxin	0.035
SLC39A1	solute carrier family 39 (zinc transporter), member 1	0.035
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.034
ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	0.033
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.032
PRKAA2	protein kinase, AMP-activated, alpha 2 catalytic subunit	0.030	Yeast
SNX18	sorting nexin 18	0.030
ANKRD28	ankyrin repeat domain 28	0.029
RAP1A	RAP1A, member of RAS oncogene family	0.028
RIN1	Ras and Rab interactor 1	0.028
TSPAN4	tetraspanin 4	0.027
PAWR	PRKC, apoptosis, WT1, regulator	0.027
STARD7	StAR-related lipid transfer (START) domain containing 7	0.027
VDAC1	voltage-dependent anion channel 1	0.027
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.026
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.026
KRT6C	keratin 6C	0.026
UBQLN1	ubiquilin 1	0.025
MAP2K1	mitogen-activated protein kinase kinase 1	0.025
PEBP1	phosphatidylethanolamine binding protein 1	0.025
MRPL27	mitochondrial ribosomal protein L27	0.024
RASSF2	Ras association (RalGDS/AF-6) domain family member 2	0.023
PPP6R3	protein phosphatase 6, regulatory subunit 3	0.023
EME1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.023
PEBP4	phosphatidylethanolamine-binding protein 4	0.022
MRPL53	mitochondrial ribosomal protein L53	0.022
GMFB	glia maturation factor, beta	0.022
TUBA4A	tubulin, alpha 4a	0.021
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.020
NHEJ1	nonhomologous end-joining factor 1	0.020
CD151	CD151 molecule (Raph blood group)	0.020
GCKR	glucokinase (hexokinase 4) regulator	0.020
CDV3	CDV3 homolog (mouse)	0.020
S1PR5	sphingosine-1-phosphate receptor 5	0.020
NMNAT1	nicotinamide nucleotide adenylyltransferase 1	0.020
PPIA	peptidylprolyl isomerase A (cyclophilin A)	0.020
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.020
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.019
PSEN2	presenilin 2 (Alzheimer disease 4)	0.018
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.018	Yeast
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.018
PDE4DIP	phosphodiesterase 4D interacting protein	0.018
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.017
TP73	tumor protein p73	0.017
CHUK	conserved helix-loop-helix ubiquitous kinase	0.017
IGSF21	immunoglobin superfamily, member 21	0.017
TPI1	triosephosphate isomerase 1	0.017
SRI	sorcin	0.017
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.016
POLR2L	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	0.016
ATM	ataxia telangiectasia mutated	0.016
TAF2	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	0.016
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.016
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.016
FBXO4	F-box protein 4	0.016
ALDOA	aldolase A, fructose-bisphosphate	0.015
SIRT1	sirtuin 1	0.015
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.015
SNX9	sorting nexin 9	0.015
NIPSNAP3A	nipsnap homolog 3A (C. elegans)	0.015
DAXX	death-domain associated protein	0.015
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.015
MAP4	microtubule-associated protein 4	0.015
RIF1	RAP1 interacting factor homolog (yeast)	0.015
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.015
RIC8A	resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)	0.015
PLCE1	phospholipase C, epsilon 1	0.015
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.015
LGALS1	lectin, galactoside-binding, soluble, 1	0.015
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.014
RECQL	RecQ protein-like (DNA helicase Q1-like)	0.014
RHEB	Ras homolog enriched in brain	0.014
S100A11	S100 calcium binding protein A11	0.014
RPA2	replication protein A2, 32kDa	0.014
NSMAF	neutral sphingomyelinase (N-SMase) activation associated factor	0.014
CORO1C	coronin, actin binding protein, 1C	0.014
PEX26	peroxisomal biogenesis factor 26	0.014
E2F3	E2F transcription factor 3	0.014
PAFAH1B2	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)	0.014
DTX1	deltex homolog 1 (Drosophila)	0.014
PRDX6	peroxiredoxin 6	0.014
HNRNPCL1	heterogeneous nuclear ribonucleoprotein C-like 1	0.014
MYO10	myosin X	0.014
DR1	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	0.014
ELOVL1	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1	0.014
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.014
ANKRD44	ankyrin repeat domain 44	0.014
ATR	ataxia telangiectasia and Rad3 related	0.014
TWF1	twinfilin, actin-binding protein, homolog 1 (Drosophila)	0.013
GSTP1	glutathione S-transferase pi 1	0.013
CRY1	cryptochrome 1 (photolyase-like)	0.013
CLTB	clathrin, light chain B	0.013
RRAS2	related RAS viral (r-ras) oncogene homolog 2	0.013	Yeast
SOS1	son of sevenless homolog 1 (Drosophila)	0.013
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.013
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.013
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.013
MARCO	macrophage receptor with collagenous structure	0.013
LOC100131801	hypothetical protein LOC100131801	0.013
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.013
SFN	stratifin	0.013
IGBP1	immunoglobulin (CD79A) binding protein 1	0.013
KCNE3	potassium voltage-gated channel, Isk-related family, member 3	0.013
BZW1	basic leucine zipper and W2 domains 1	0.013
TMSB10	thymosin beta 10	0.013
SLX1B	SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)	0.013
EMP3	epithelial membrane protein 3	0.013
STK38L	serine/threonine kinase 38 like	0.012
FNIP1	folliculin interacting protein 1	0.012
ASGR1	asialoglycoprotein receptor 1	0.012
PKM2	pyruvate kinase, muscle	0.012
DGKZ	diacylglycerol kinase, zeta	0.012
SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	0.012
SHFM1	split hand/foot malformation (ectrodactyly) type 1	0.012
IL3RA	interleukin 3 receptor, alpha (low affinity)	0.012
EXOC2	exocyst complex component 2	0.012
RHOC	ras homolog gene family, member C	0.012
C6orf129	chromosome 6 open reading frame 129	0.012
GCLM	glutamate-cysteine ligase, modifier subunit	0.012
USP50	ubiquitin specific peptidase 50	0.012
ZNF676	zinc finger protein 676	0.012
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.012
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.012
PEX6	peroxisomal biogenesis factor 6	0.012	Yeast
S100A2	S100 calcium binding protein A2	0.011
ATMIN	ATM interactor	0.011
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.011
CYB5R4	cytochrome b5 reductase 4	0.011
TP53BP1	tumor protein p53 binding protein 1	0.011
KLF4	Kruppel-like factor 4 (gut)	0.011
ARL5B	ADP-ribosylation factor-like 5B	0.011
TUBA1C	tubulin, alpha 1c	0.011
AGFG1	ArfGAP with FG repeats 1	0.011
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.011
TKT	transketolase	0.011
RAD51L3	RAD51-like 3 (S. cerevisiae)	0.011
TALDO1	transaldolase 1	0.011
MRPL52	mitochondrial ribosomal protein L52	0.011
ENO1	enolase 1, (alpha)	0.011
CREB1	cAMP responsive element binding protein 1	0.011
CAMKK2	calcium/calmodulin-dependent protein kinase kinase 2, beta	0.011
SEC61G	Sec61 gamma subunit	0.011
UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	0.011
TIPRL	TIP41, TOR signaling pathway regulator-like (S. cerevisiae)	0.011
CD300A	CD300a molecule	0.011
BTRC	beta-transducin repeat containing	0.011
CRLF3	cytokine receptor-like factor 3	0.011
CCDC85B	coiled-coil domain containing 85B	0.011
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.011
ACY3	aspartoacylase (aminocyclase) 3	0.010
TRAPPC5	trafficking protein particle complex 5	0.010
CSNK1G3	casein kinase 1, gamma 3	0.010
NDUFA11	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa	0.010
ADIPOR1	adiponectin receptor 1	0.010
ATP13A3	ATPase type 13A3	0.010
ACLY	ATP citrate lyase	0.010
LSMD1	LSM domain containing 1	0.010
PTEN	phosphatase and tensin homolog	0.010
C12orf62	chromosome 12 open reading frame 62	0.010
MTR	5-methyltetrahydrofolate-homocysteine methyltransferase	0.010
ITIH4	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)	0.010
CD99	CD99 molecule	0.010
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.010
FHL1	four and a half LIM domains 1	0.010
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.010
KCTD9	potassium channel tetramerisation domain containing 9	0.010
HPX	hemopexin	0.010
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	0.010
PNP	purine nucleoside phosphorylase	0.010
HUS1	HUS1 checkpoint homolog (S. pombe)	0.010
SFXN3	sideroflexin 3	0.010
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.010
KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.010	Yeast