IMP

Process View

Homo sapiens

22 genes annotated in human

positive regulation of tumor necrosis factor superfamily cytokine production

GO:1903557

Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of tumor necrosis factor superfamily cytokine production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of tumor necrosis factor superfamily cytokine production" (in gray)

Name	Description	Probability	Func Analog Organism
BIRC3	baculoviral IAP repeat containing 3	1.000
TRAF1	TNF receptor-associated factor 1	0.999
RIPK2	receptor-interacting serine-threonine kinase 2	0.999	Human Mouse
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.998
TRAF2	TNF receptor-associated factor 2	0.995
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.985
BIRC2	baculoviral IAP repeat containing 2	0.966
TRAF3	TNF receptor-associated factor 3	0.959
TRADD	TNFRSF1A-associated via death domain	0.932
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.918
MYD88	myeloid differentiation primary response gene (88)	0.901	Mouse
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.831
TLR2	toll-like receptor 2	0.810
CXCL10	chemokine (C-X-C motif) ligand 10	0.795	Human
SYK	spleen tyrosine kinase	0.794
CCL5	chemokine (C-C motif) ligand 5	0.750
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.673
TLR4	toll-like receptor 4	0.655
IL8	interleukin 8	0.609
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.604
CXCL2	chemokine (C-X-C motif) ligand 2	0.575
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.559	Human
CXCL3	chemokine (C-X-C motif) ligand 3	0.488	Human
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.478
CXCL11	chemokine (C-X-C motif) ligand 11	0.476	Human
TNF	tumor necrosis factor	0.447
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.439
ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	0.429
CXCL9	chemokine (C-X-C motif) ligand 9	0.414	Human
NLRC4	NLR family, CARD domain containing 4	0.402
IRAK3	interleukin-1 receptor-associated kinase 3	0.391
TRAF5	TNF receptor-associated factor 5	0.384
IDE	insulin-degrading enzyme	0.353
IL23A	interleukin 23, alpha subunit p19	0.290
TICAM2	toll-like receptor adaptor molecule 2	0.281
FAS	Fas (TNF receptor superfamily, member 6)	0.276
ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	0.275	Human
CCL4	chemokine (C-C motif) ligand 4	0.252	Rat
IRAK2	interleukin-1 receptor-associated kinase 2	0.213
CCL8	chemokine (C-C motif) ligand 8	0.213
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.207
CCR1	chemokine (C-C motif) receptor 1	0.203
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.198
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.179	Human
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.150
IL1B	interleukin 1, beta	0.146
CXCL5	chemokine (C-X-C motif) ligand 5	0.145	Human
FASLG	Fas ligand (TNF superfamily, member 6)	0.144
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.135
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.135
MEFV	Mediterranean fever	0.130
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.102
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	0.101
CCL20	chemokine (C-C motif) ligand 20	0.096
SETD8	SET domain containing (lysine methyltransferase) 8	0.092
PLEK	pleckstrin	0.087
CFLAR	CASP8 and FADD-like apoptosis regulator	0.082
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.082
CCR7	chemokine (C-C motif) receptor 7	0.081
IRAK1	interleukin-1 receptor-associated kinase 1	0.080
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.077	Rat
CD33	CD33 molecule	0.076
CYBB	cytochrome b-245, beta polypeptide	0.073
CCR2	chemokine (C-C motif) receptor 2	0.066	Mouse Rat
CCL2	chemokine (C-C motif) ligand 2	0.065
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.064	Mouse
MARK2	MAP/microtubule affinity-regulating kinase 2	0.063
CD48	CD48 molecule	0.059
PF4	platelet factor 4	0.055
SLA	Src-like-adaptor	0.053
PYDC2	pyrin domain containing 2	0.052
CXCR3	chemokine (C-X-C motif) receptor 3	0.052
CD163	CD163 molecule	0.052
RIPK3	receptor-interacting serine-threonine kinase 3	0.048	Human
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.048
SOD2	superoxide dismutase 2, mitochondrial	0.047
S100A12	S100 calcium binding protein A12	0.047
IRAK4	interleukin-1 receptor-associated kinase 4	0.046
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.046
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.046
EPOR	erythropoietin receptor	0.046
SOCS1	suppressor of cytokine signaling 1	0.045
NOD2	nucleotide-binding oligomerization domain containing 2	0.044
DPP4	dipeptidyl-peptidase 4	0.042
TLR1	toll-like receptor 1	0.041	Human Mouse
BLNK	B-cell linker	0.040
CXCR6	chemokine (C-X-C motif) receptor 6	0.040
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.040
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.040
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.038
UBD	ubiquitin D	0.037
GATA2	GATA binding protein 2	0.037
FYB	FYN binding protein	0.037
S100A9	S100 calcium binding protein A9	0.035
CLEC7A	C-type lectin domain family 7, member A	0.035	Mouse
PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.035	Human
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.034
TFEC	transcription factor EC	0.034
S100A8	S100 calcium binding protein A8	0.034
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.033
CCL13	chemokine (C-C motif) ligand 13	0.033
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.032
CSF1R	colony stimulating factor 1 receptor	0.032
CD14	CD14 molecule	0.032
TGFB1	transforming growth factor, beta 1	0.031
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.031
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.031
LY86	lymphocyte antigen 86	0.030
AIM2	absent in melanoma 2	0.030
IFIH1	interferon induced with helicase C domain 1	0.030
A2M	alpha-2-macroglobulin	0.030
LCK	lymphocyte-specific protein tyrosine kinase	0.030
CXCR4	chemokine (C-X-C motif) receptor 4	0.029
STAT5A	signal transducer and activator of transcription 5A	0.029
TMEM173	transmembrane protein 173	0.028
CD40	CD40 molecule, TNF receptor superfamily member 5	0.027
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.027
IGSF6	immunoglobulin superfamily, member 6	0.027
RUNX1	runt-related transcription factor 1	0.027
MPO	myeloperoxidase	0.026
FADD	Fas (TNFRSF6)-associated via death domain	0.026
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.025
IL6	interleukin 6 (interferon, beta 2)	0.025
SLAMF8	SLAM family member 8	0.025
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.025
CXCL13	chemokine (C-X-C motif) ligand 13	0.024
BST1	bone marrow stromal cell antigen 1	0.024
CD86	CD86 molecule	0.024
FGL2	fibrinogen-like 2	0.024
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.024
HSPB8	heat shock 22kDa protein 8	0.023
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.023
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.022
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.021
HBG2	hemoglobin, gamma G	0.021
LTF	lactotransferrin	0.021
BCL2A1	BCL2-related protein A1	0.021
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.020
CLEC4A	C-type lectin domain family 4, member A	0.020
C3AR1	complement component 3a receptor 1	0.020
NLRP3	NLR family, pyrin domain containing 3	0.020	Human
AZU1	azurocidin 1	0.020
DEFA4	defensin, alpha 4, corticostatin	0.020
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.020	Mouse
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.020
TRIM38	tripartite motif containing 38	0.019
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.019	Mouse
IDO1	indoleamine 2,3-dioxygenase 1	0.019
NOD1	nucleotide-binding oligomerization domain containing 1	0.019	Mouse
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.019
TYROBP	TYRO protein tyrosine kinase binding protein	0.018
CCL7	chemokine (C-C motif) ligand 7	0.018
TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	0.018
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.018
CCL3	chemokine (C-C motif) ligand 3	0.018	Mouse
RNASE6	ribonuclease, RNase A family, k6	0.018
CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	0.017
CYTIP	cytohesin 1 interacting protein	0.017
C3	complement component 3	0.017
LMO2	LIM domain only 2 (rhombotin-like 1)	0.016
IL10	interleukin 10	0.016
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.016
HP	haptoglobin	0.016
BAG3	BCL2-associated athanogene 3	0.016
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.016
SAMHD1	SAM domain and HD domain 1	0.015
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.015
PF4V1	platelet factor 4 variant 1	0.015	Human
IFNGR1	interferon gamma receptor 1	0.015
CRYAB	crystallin, alpha B	0.015
INSR	insulin receptor	0.015
ELANE	elastase, neutrophil expressed	0.015	Human
HK3	hexokinase 3 (white cell)	0.014
HSPA6	heat shock 70kDa protein 6 (HSP70B')	0.014
HLA-DMB	major histocompatibility complex, class II, DM beta	0.014
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.014
C5AR1	complement component 5a receptor 1	0.014
SLAMF7	SLAM family member 7	0.014
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.013
IL10RA	interleukin 10 receptor, alpha	0.013
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.013
CAMP	cathelicidin antimicrobial peptide	0.013
MSR1	macrophage scavenger receptor 1	0.013
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.013
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.013
IFNG	interferon, gamma	0.013
FSTL1	follistatin-like 1	0.013
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.013
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.013
NFE2	nuclear factor (erythroid-derived 2), 45kDa	0.013
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.012
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.012
CXCR2	chemokine (C-X-C motif) receptor 2	0.012
BIN2	bridging integrator 2	0.012
FPR3	formyl peptide receptor 3	0.012
PTAFR	platelet-activating factor receptor	0.012
ZBTB48	zinc finger and BTB domain containing 48	0.012
SPOP	speckle-type POZ protein	0.012
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.012
RNASE3	ribonuclease, RNase A family, 3	0.012
PRTN3	proteinase 3	0.012	Human
CD93	CD93 molecule	0.012
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.011
CD28	CD28 molecule	0.011
MTA2	metastasis associated 1 family, member 2	0.011
ZMYND11	zinc finger, MYND-type containing 11	0.011
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.011
TIFA	TRAF-interacting protein with forkhead-associated domain	0.011
TYMP	thymidine phosphorylase	0.011
TLR5	toll-like receptor 5	0.011	Human
PYCARD	PYD and CARD domain containing	0.011
LAMP3	lysosomal-associated membrane protein 3	0.011
CMKLR1	chemokine-like receptor 1	0.011
TANK	TRAF family member-associated NFKB activator	0.011
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.011
AOAH	acyloxyacyl hydrolase (neutrophil)	0.011
LY96	lymphocyte antigen 96	0.011
CD53	CD53 molecule	0.011
HSPA1L	heat shock 70kDa protein 1-like	0.011
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.011
CTSG	cathepsin G	0.011
SIGLEC7	sialic acid binding Ig-like lectin 7	0.010
HBD	hemoglobin, delta	0.010
RARRES1	retinoic acid receptor responder (tazarotene induced) 1	0.010
CD1D	CD1d molecule	0.010