IMP

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Homo sapiens

3 genes annotated in human

autophagic cell death

A form of programmed cell death that is accompanied by macroautophagy, which is characterized by the sequestration of cytoplasmic material within autophagosomes for bulk degradation by lysosomes. Autophagic cell death is characterized by lack of chromatin condensation, massive vacuolization of the cytoplasm, and accumulation of (double-membraned) autophagic vacuoles, with little or no uptake by phagocytic cells.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "autophagic cell death"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "autophagic cell death" (in gray)

Name	Description	Probability	Func Analog Organism
SMN1	survival of motor neuron 1, telomeric	0.998
CCND3	cyclin D3	0.981
CCND1	cyclin D1	0.972
CDK6	cyclin-dependent kinase 6	0.949
ATG3	ATG3 autophagy related 3 homolog (S. cerevisiae)	0.945
CDK2	cyclin-dependent kinase 2	0.878
NLRC4	NLR family, CARD domain containing 4	0.870
BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	0.588
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.472
DBF4	DBF4 homolog (S. cerevisiae)	0.465
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.358	Human
CCNE1	cyclin E1	0.337
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.305
ANXA7	annexin A7	0.280
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.277
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.262
EIF1B	eukaryotic translation initiation factor 1B	0.253
ATG7	ATG7 autophagy related 7 homolog (S. cerevisiae)	0.233
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.178	Fly
LRDD	leucine-rich repeats and death domain containing	0.151
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.135	Fly
CCND2	cyclin D2	0.125
CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.118
ELF4	E74-like factor 4 (ets domain transcription factor)	0.108
SKP1	S-phase kinase-associated protein 1	0.103
CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.102	Human
RBL1	retinoblastoma-like 1 (p107)	0.100
SOX4	SRY (sex determining region Y)-box 4	0.098
RB1	retinoblastoma 1	0.098
IFI16	interferon, gamma-inducible protein 16	0.094
CCNE2	cyclin E2	0.084
RIPK2	receptor-interacting serine-threonine kinase 2	0.083
SKP2	S-phase kinase-associated protein 2 (p45)	0.070
EIF3H	eukaryotic translation initiation factor 3, subunit H	0.068
CDKN2D	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.066
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.066
GBP2	guanylate binding protein 2, interferon-inducible	0.066
EIF4A2	eukaryotic translation initiation factor 4A2	0.056
TK1	thymidine kinase 1, soluble	0.056
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.053
CCNB2	cyclin B2	0.051
TNS1	tensin 1	0.049
MTHFD1L	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	0.047
SH3KBP1	SH3-domain kinase binding protein 1	0.047
TBC1D17	TBC1 domain family, member 17	0.046
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.046
EIF3M	eukaryotic translation initiation factor 3, subunit M	0.045
CDK4	cyclin-dependent kinase 4	0.043
NMI	N-myc (and STAT) interactor	0.043
CARD16	caspase recruitment domain family, member 16	0.043
CTSS	cathepsin S	0.041
DNM2	dynamin 2	0.036
EIF4EBP3	eukaryotic translation initiation factor 4E binding protein 3	0.036
RBL2	retinoblastoma-like 2 (p130)	0.035
SIAH1	seven in absentia homolog 1 (Drosophila)	0.035
SP100	SP100 nuclear antigen	0.034
EIF3L	eukaryotic translation initiation factor 3, subunit L	0.034
CLEC2B	C-type lectin domain family 2, member B	0.034
SMC1A	structural maintenance of chromosomes 1A	0.034
CDT1	chromatin licensing and DNA replication factor 1	0.034
GBP1	guanylate binding protein 1, interferon-inducible	0.033
ATG10	ATG10 autophagy related 10 homolog (S. cerevisiae)	0.032
CDK11B	cyclin-dependent kinase 11B	0.032
CCNG2	cyclin G2	0.031
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.031
PLSCR1	phospholipid scramblase 1	0.031
NFE2L1	nuclear factor (erythroid-derived 2)-like 1	0.030
ZNF655	zinc finger protein 655	0.029
IL18	interleukin 18 (interferon-gamma-inducing factor)	0.029
MTA2	metastasis associated 1 family, member 2	0.026
KCTD15	potassium channel tetramerisation domain containing 15	0.026
BASP1	brain abundant, membrane attached signal protein 1	0.025
ZEB2	zinc finger E-box binding homeobox 2	0.024
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.024
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.024
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.024
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.023
PCDHA4	protocadherin alpha 4	0.023
WDFY3	WD repeat and FYVE domain containing 3	0.023
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.023
ATF2	activating transcription factor 2	0.023
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.023
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.022
CDK14	cyclin-dependent kinase 14	0.022
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.022
TRIM22	tripartite motif containing 22	0.021
LY96	lymphocyte antigen 96	0.021
S100A8	S100 calcium binding protein A8	0.021
VTA1	Vps20-associated 1 homolog (S. cerevisiae)	0.021
CSNK2A2	casein kinase 2, alpha prime polypeptide	0.021
FAM118B	family with sequence similarity 118, member B	0.021
EIF4ENIF1	eukaryotic translation initiation factor 4E nuclear import factor 1	0.021
BTN3A2	butyrophilin, subfamily 3, member A2	0.020
DHX36	DEAH (Asp-Glu-Ala-His) box polypeptide 36	0.019
FOXM1	forkhead box M1	0.019
NR2C2	nuclear receptor subfamily 2, group C, member 2	0.019	Fly
TECPR1	tectonin beta-propeller repeat containing 1	0.019
EIF3A	eukaryotic translation initiation factor 3, subunit A	0.019
EIF3D	eukaryotic translation initiation factor 3, subunit D	0.018
TSC22D1	TSC22 domain family, member 1	0.018
NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.018
CCNA1	cyclin A1	0.018
LENG1	leukocyte receptor cluster (LRC) member 1	0.018
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.017
RNF115	ring finger protein 115	0.017
RPTOR	regulatory associated protein of MTOR, complex 1	0.017
EIF4EBP2	eukaryotic translation initiation factor 4E binding protein 2	0.017
SDCBP	syndecan binding protein (syntenin)	0.017
IER5	immediate early response 5	0.017
HNRNPL	heterogeneous nuclear ribonucleoprotein L	0.017
MYST2	MYST histone acetyltransferase 2	0.017
BTN3A3	butyrophilin, subfamily 3, member A3	0.017
UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.017
GRB7	growth factor receptor-bound protein 7	0.016
CASP2	caspase 2, apoptosis-related cysteine peptidase	0.016	Fly
NOD1	nucleotide-binding oligomerization domain containing 1	0.016
RB1CC1	RB1-inducible coiled-coil 1	0.016
SOD2	superoxide dismutase 2, mitochondrial	0.015
SPRY2	sprouty homolog 2 (Drosophila)	0.015
AHR	aryl hydrocarbon receptor	0.015
CCNA2	cyclin A2	0.015
EEA1	early endosome antigen 1	0.015
SS18	synovial sarcoma translocation, chromosome 18	0.015
RAB5A	RAB5A, member RAS oncogene family	0.015
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.015
PTP4A1	protein tyrosine phosphatase type IVA, member 1	0.015
SENP1	SUMO1/sentrin specific peptidase 1	0.015
PHF12	PHD finger protein 12	0.015
IL15	interleukin 15	0.015
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.015
HOXD8	homeobox D8	0.015
NOD2	nucleotide-binding oligomerization domain containing 2	0.015
GLRX	glutaredoxin (thioltransferase)	0.015
PLA2G10	phospholipase A2, group X	0.015
SH3GLB1	SH3-domain GRB2-like endophilin B1	0.015
OSGEP	O-sialoglycoprotein endopeptidase	0.015
GBP3	guanylate binding protein 3	0.014
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.014
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.014
MNDA	myeloid cell nuclear differentiation antigen	0.014
TUBB2B	tubulin, beta 2B	0.014
TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	0.014
ATG9A	ATG9 autophagy related 9 homolog A (S. cerevisiae)	0.014
C5orf13	chromosome 5 open reading frame 13	0.014
CHSY1	chondroitin sulfate synthase 1	0.014
SRGN	serglycin	0.014
WDR1	WD repeat domain 1	0.014
TFG	TRK-fused gene	0.014
ZCCHC10	zinc finger, CCHC domain containing 10	0.013
FBXW7	F-box and WD repeat domain containing 7	0.013
RHEB	Ras homolog enriched in brain	0.013
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.013
LTF	lactotransferrin	0.013
MCM10	minichromosome maintenance complex component 10	0.013
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.013
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.013
BIRC3	baculoviral IAP repeat containing 3	0.013
ORC1	origin recognition complex, subunit 1	0.013
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.013
GIMAP2	GTPase, IMAP family member 2	0.013
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.013
VIM	vimentin	0.013
GTF2F2	general transcription factor IIF, polypeptide 2, 30kDa	0.013
NFYA	nuclear transcription factor Y, alpha	0.013
KYNU	kynureninase	0.013
GORAB	golgin, RAB6-interacting	0.013
ORMDL3	ORM1-like 3 (S. cerevisiae)	0.013
RBM17	RNA binding motif protein 17	0.012
ALOX5AP	arachidonate 5-lipoxygenase-activating protein	0.012
FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	0.012
FAS	Fas (TNF receptor superfamily, member 6)	0.012
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.012
KCTD12	potassium channel tetramerisation domain containing 12	0.012
EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.012
EVI2A	ecotropic viral integration site 2A	0.012
CNN3	calponin 3, acidic	0.012
ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.012
CCR9	chemokine (C-C motif) receptor 9	0.012
RNF6	ring finger protein (C3H2C3 type) 6	0.012
PDCD10	programmed cell death 10	0.012
PLAC8	placenta-specific 8	0.012
MEF2A	myocyte enhancer factor 2A	0.012
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.012
FABP4	fatty acid binding protein 4, adipocyte	0.012
DDX39A	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A	0.012
DDX39B	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	0.012
MYL4	myosin, light chain 4, alkali; atrial, embryonic	0.012
SIK1	salt-inducible kinase 1	0.012
GPR15	G protein-coupled receptor 15	0.012
RAB6A	RAB6A, member RAS oncogene family	0.012
DIS3L2	DIS3 mitotic control homolog (S. cerevisiae)-like 2	0.012
CDK2AP1	cyclin-dependent kinase 2 associated protein 1	0.012
MLKL	mixed lineage kinase domain-like	0.012
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.012
SF3B14	splicing factor 3B, 14 kDa subunit	0.012
FAM100B	family with sequence similarity 100, member B	0.011
ZNF101	zinc finger protein 101	0.011
SH3GL2	SH3-domain GRB2-like 2	0.011
KLF11	Kruppel-like factor 11	0.011	Fly
GLE1	GLE1 RNA export mediator homolog (yeast)	0.011
DBN1	drebrin 1	0.011
TRIM38	tripartite motif containing 38	0.011
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.011
NECAP2	NECAP endocytosis associated 2	0.011
PIGR	polymeric immunoglobulin receptor	0.011
APAF1	apoptotic peptidase activating factor 1	0.011	Fly
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	0.011
CCNDBP1	cyclin D-type binding-protein 1	0.011
CDKAL1	CDK5 regulatory subunit associated protein 1-like 1	0.011
MKNK2	MAP kinase interacting serine/threonine kinase 2	0.011
CARD6	caspase recruitment domain family, member 6	0.011
APOL6	apolipoprotein L, 6	0.011
PGD	phosphogluconate dehydrogenase	0.011
C12orf65	chromosome 12 open reading frame 65	0.011
EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	0.011
RILP	Rab interacting lysosomal protein	0.011
KIAA0174	KIAA0174	0.011
PIK3IP1	phosphoinositide-3-kinase interacting protein 1	0.011
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.011
NPAT	nuclear protein, ataxia-telangiectasia locus	0.011
OBFC2A	oligonucleotide/oligosaccharide-binding fold containing 2A	0.011
WDR33	WD repeat domain 33	0.011
MLLT3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	0.011
USP2	ubiquitin specific peptidase 2	0.011
DCTN2	dynactin 2 (p50)	0.011
WTAP	Wilms tumor 1 associated protein	0.011
KEAP1	kelch-like ECH-associated protein 1	0.011
GLIPR1	GLI pathogenesis-related 1	0.011
XK	X-linked Kx blood group (McLeod syndrome)	0.011
PLXNC1	plexin C1	0.011
TTR	transthyretin	0.011
CSNK1G1	casein kinase 1, gamma 1	0.011
TLR1	toll-like receptor 1	0.011
RAB22A	RAB22A, member RAS oncogene family	0.011
WIPI2	WD repeat domain, phosphoinositide interacting 2	0.011
STK17B	serine/threonine kinase 17b	0.011
GSN	gelsolin	0.011
CCDC109B	coiled-coil domain containing 109B	0.011
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.010
VEZT	vezatin, adherens junctions transmembrane protein	0.010
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.010
DDIT3	DNA-damage-inducible transcript 3	0.010
SAMD9	sterile alpha motif domain containing 9	0.010
GOPC	golgi-associated PDZ and coiled-coil motif containing	0.010
TRAP1	TNF receptor-associated protein 1	0.010
MKRN1	makorin ring finger protein 1	0.010
FRG1	FSHD region gene 1	0.010
MOCS3	molybdenum cofactor synthesis 3	0.010
MXI1	MAX interactor 1	0.010
NOTCH3	notch 3	0.010
OCRL	oculocerebrorenal syndrome of Lowe	0.010
EIF2S3	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	0.010
WDR76	WD repeat domain 76	0.010
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.010