IMP
Process View
negative regulation of i kappab kinase nf kappab signaling
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of i kappab kinase nf kappab signaling"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.867 | Human | |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.722 | ||
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 0.628 | Human | |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.628 | ||
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.613 | ||
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.607 | ||
| IKBKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 0.589 | ||
| BIRC2 | baculoviral IAP repeat containing 2 | 0.556 | ||
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.545 | ||
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.489 | ||
| C1QA | complement component 1, q subcomponent, A chain | 0.449 | Human | |
| XIAP | X-linked inhibitor of apoptosis | 0.446 | ||
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.440 | ||
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.394 | ||
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.242 | Human | |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.239 | ||
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.213 | ||
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.195 | Human | |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.178 | Human | |
| TNIP2 | TNFAIP3 interacting protein 2 | 0.160 | ||
| REL | v-rel reticuloendotheliosis viral oncogene homolog (avian) | 0.156 | ||
| NLRC4 | NLR family, CARD domain containing 4 | 0.154 | ||
| TRAF1 | TNF receptor-associated factor 1 | 0.149 | ||
| NFKBIB | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 0.141 | Human Rat | |
| IL4R | interleukin 4 receptor | 0.127 | ||
| RELB | v-rel reticuloendotheliosis viral oncogene homolog B | 0.114 | ||
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.114 | ||
| MAP3K8 | mitogen-activated protein kinase kinase kinase 8 | 0.103 | ||
| HIPK3 | homeodomain interacting protein kinase 3 | 0.102 | ||
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.096 | ||
| FAS | Fas (TNF receptor superfamily, member 6) | 0.090 | ||
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | 0.089 | ||
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 0.079 | Human | |
| NR0B1 | nuclear receptor subfamily 0, group B, member 1 | 0.079 | ||
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.064 | ||
| GFM1 | G elongation factor, mitochondrial 1 | 0.058 | ||
| C1QC | complement component 1, q subcomponent, C chain | 0.055 | Human | |
| CUL1 | cullin 1 | 0.050 | ||
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.050 | ||
| TNIP1 | TNFAIP3 interacting protein 1 | 0.049 | ||
| APAF1 | apoptotic peptidase activating factor 1 | 0.047 | ||
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.047 | Human | |
| TRAF6 | TNF receptor-associated factor 6 | 0.046 | ||
| EP300 | E1A binding protein p300 | 0.044 | ||
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 0.044 | ||
| TRAF3 | TNF receptor-associated factor 3 | 0.042 | ||
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.041 | Human | |
| BBS10 | Bardet-Biedl syndrome 10 | 0.041 | ||
| LATS2 | LATS, large tumor suppressor, homolog 2 (Drosophila) | 0.039 | ||
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.036 | ||
| IRF1 | interferon regulatory factor 1 | 0.034 | ||
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | 0.034 | ||
| JAK1 | Janus kinase 1 | 0.034 | ||
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.034 | ||
| IRF9 | interferon regulatory factor 9 | 0.029 | ||
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.029 | ||
| IL2RB | interleukin 2 receptor, beta | 0.028 | ||
| MYH9 | myosin, heavy chain 9, non-muscle | 0.027 | ||
| MAP3K3 | mitogen-activated protein kinase kinase kinase 3 | 0.027 | ||
| ZNF84 | zinc finger protein 84 | 0.024 | ||
| IFNAR2 | interferon (alpha, beta and omega) receptor 2 | 0.023 | ||
| RANBP3 | RAN binding protein 3 | 0.023 | ||
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.023 | ||
| C1QB | complement component 1, q subcomponent, B chain | 0.023 | Human | |
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.023 | ||
| ZNF260 | zinc finger protein 260 | 0.022 | ||
| OPTN | optineurin | 0.022 | ||
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.022 | ||
| TRAF5 | TNF receptor-associated factor 5 | 0.021 | ||
| CSNK1E | casein kinase 1, epsilon | 0.021 | ||
| IL12RB2 | interleukin 12 receptor, beta 2 | 0.020 | ||
| ZNF585A | zinc finger protein 585A | 0.020 | ||
| NMI | N-myc (and STAT) interactor | 0.020 | ||
| SNAI1 | snail homolog 1 (Drosophila) | 0.019 | ||
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.019 | ||
| ZNF432 | zinc finger protein 432 | 0.018 | ||
| DIABLO | diablo, IAP-binding mitochondrial protein | 0.018 | ||
| PSMD6 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 0.018 | ||
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.017 | ||
| ACTN1 | actinin, alpha 1 | 0.017 | ||
| KAT2B | K(lysine) acetyltransferase 2B | 0.017 | ||
| GIT2 | G protein-coupled receptor kinase interacting ArfGAP 2 | 0.017 | ||
| TRIM63 | tripartite motif containing 63 | 0.017 | Human | |
| FLNA | filamin A, alpha | 0.016 | ||
| CCDC90B | coiled-coil domain containing 90B | 0.016 | ||
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.016 | ||
| PFN1 | profilin 1 | 0.016 | ||
| HOXA9 | homeobox A9 | 0.016 | ||
| PYDC2 | pyrin domain containing 2 | 0.016 | ||
| USP15 | ubiquitin specific peptidase 15 | 0.016 | ||
| FLNB | filamin B, beta | 0.015 | ||
| RIPK3 | receptor-interacting serine-threonine kinase 3 | 0.015 | Human | |
| STAT5A | signal transducer and activator of transcription 5A | 0.015 | Human | |
| MEFV | Mediterranean fever | 0.015 | ||
| PXN | paxillin | 0.014 | ||
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 0.014 | Human | |
| ZNF189 | zinc finger protein 189 | 0.014 | ||
| ZNF180 | zinc finger protein 180 | 0.014 | ||
| ARL4D | ADP-ribosylation factor-like 4D | 0.013 | ||
| ZNF569 | zinc finger protein 569 | 0.013 | ||
| ITK | IL2-inducible T-cell kinase | 0.013 | ||
| ZNF623 | zinc finger protein 623 | 0.013 | ||
| LEF1 | lymphoid enhancer-binding factor 1 | 0.013 | ||
| STAP2 | signal transducing adaptor family member 2 | 0.013 | ||
| CREBBP | CREB binding protein | 0.013 | ||
| LASP1 | LIM and SH3 protein 1 | 0.013 | ||
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.013 | ||
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.013 | ||
| PPP5C | protein phosphatase 5, catalytic subunit | 0.013 | ||
| NOD1 | nucleotide-binding oligomerization domain containing 1 | 0.012 | ||
| NOTCH1 | notch 1 | 0.012 | ||
| MTA2 | metastasis associated 1 family, member 2 | 0.012 | ||
| FBXW11 | F-box and WD repeat domain containing 11 | 0.012 | Mouse Fly | |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.012 | ||
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.012 | ||
| NCF1 | neutrophil cytosolic factor 1 | 0.012 | ||
| JAK2 | Janus kinase 2 | 0.012 | ||
| ACTN4 | actinin, alpha 4 | 0.012 | ||
| ZNF571 | zinc finger protein 571 | 0.012 | ||
| MTA3 | metastasis associated 1 family, member 3 | 0.012 | ||
| ZNF567 | zinc finger protein 567 | 0.012 | ||
| ZNF559 | zinc finger protein 559 | 0.012 | ||
| PPARG | peroxisome proliferator-activated receptor gamma | 0.012 | ||
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.012 | ||
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | 0.012 | ||
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.011 | ||
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | 0.011 | Human | |
| UBE2D1 | ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) | 0.011 | ||
| RXRA | retinoid X receptor, alpha | 0.011 | ||
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.011 | ||
| CLPX | ClpX caseinolytic peptidase X homolog (E. coli) | 0.011 | ||
| ZNF304 | zinc finger protein 304 | 0.011 | ||
| C5orf41 | chromosome 5 open reading frame 41 | 0.010 | ||
| NOG | noggin | 0.010 | ||
| LATS1 | LATS, large tumor suppressor, homolog 1 (Drosophila) | 0.010 | ||
| SPRR2A | small proline-rich protein 2A | 0.010 | ||
| ZNF529 | zinc finger protein 529 | 0.010 | ||
| TRAF2 | TNF receptor-associated factor 2 | 0.010 | ||
| TBK1 | TANK-binding kinase 1 | 0.010 | ||
| TUBA1A | tubulin, alpha 1a | 0.010 | ||
| VCL | vinculin | 0.010 | ||
| ITCH | itchy E3 ubiquitin protein ligase homolog (mouse) | 0.010 | ||
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.010 |