IMP

Process View

Homo sapiens

23 genes annotated in human

er nucleus signaling pathway

Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "er nucleus signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "er nucleus signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.999	Mouse Worm
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.998	Fly
PDIA3	protein disulfide isomerase family A, member 3	0.996
P4HB	prolyl 4-hydroxylase, beta polypeptide	0.993	Worm
DERL1	Der1-like domain family, member 1	0.970
HSP90B1	heat shock protein 90kDa beta (Grp94), member 1	0.969
VCP	valosin containing protein	0.941	Worm
BCL2L1	BCL2-like 1	0.835	Human
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.757
CANX	calnexin	0.755	Worm
SELS	selenoprotein S	0.715
DNAJB11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.653
BAX	BCL2-associated X protein	0.649
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.637	Human
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.631
BAD	BCL2-associated agonist of cell death	0.601
HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.570	Mouse
BCL2	B-cell CLL/lymphoma 2	0.555	Human
GHR	growth hormone receptor	0.549
STON2	stonin 2	0.478
PPIB	peptidylprolyl isomerase B (cyclophilin B)	0.459
DNAJB9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.374
PDIA4	protein disulfide isomerase family A, member 4	0.307	Worm
TP53	tumor protein p53	0.238
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.221
TMED10	transmembrane emp24-like trafficking protein 10 (yeast)	0.202
HYOU1	hypoxia up-regulated 1	0.198
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.172
TP53BP2	tumor protein p53 binding protein, 2	0.170
UBE2J1	ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)	0.162
PDIA6	protein disulfide isomerase family A, member 6	0.159	Worm
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.155
BAK1	BCL2-antagonist/killer 1	0.140
AMFR	autocrine motility factor receptor	0.132
SEC61A1	Sec61 alpha 1 subunit (S. cerevisiae)	0.124
WWOX	WW domain containing oxidoreductase	0.119
CUL1	cullin 1	0.115
SOS1	son of sevenless homolog 1 (Drosophila)	0.093
TOM1L1	target of myb1 (chicken)-like 1	0.093
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.091
CCND3	cyclin D3	0.083
HSPA9	heat shock 70kDa protein 9 (mortalin)	0.081	Worm
DNAJC3	DnaJ (Hsp40) homolog, subfamily C, member 3	0.079
ERO1L	ERO1-like (S. cerevisiae)	0.075	Mouse
CDK6	cyclin-dependent kinase 6	0.075
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.071
AXIN1	axin 1	0.068
CABLES1	Cdk5 and Abl enzyme substrate 1	0.065
ERN1	endoplasmic reticulum to nucleus signaling 1	0.055
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.054
CALU	calumenin	0.053
BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	0.052
KRT5	keratin 5	0.052
ATXN3	ataxin 3	0.052
VDAC1	voltage-dependent anion channel 1	0.051
SSR1	signal sequence receptor, alpha	0.050
FYN	FYN oncogene related to SRC, FGR, YES	0.049
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.049
MANF	mesencephalic astrocyte-derived neurotrophic factor	0.049
GRB10	growth factor receptor-bound protein 10	0.049
C4orf14	chromosome 4 open reading frame 14	0.048
RABAC1	Rab acceptor 1 (prenylated)	0.046
BAG1	BCL2-associated athanogene	0.046
KEAP1	kelch-like ECH-associated protein 1	0.045
GANAB	glucosidase, alpha; neutral AB	0.041
SLC33A1	solute carrier family 33 (acetyl-CoA transporter), member 1	0.041
CCNE1	cyclin E1	0.040
KDELR2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	0.039
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.038
FAF2	Fas associated factor family member 2	0.038
ATP5B	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	0.037
TMED2	transmembrane emp24 domain trafficking protein 2	0.037
SATB2	SATB homeobox 2	0.036
EMD	emerin	0.034
FBXO33	F-box protein 33	0.034
EIF1	eukaryotic translation initiation factor 1	0.034
PLCG1	phospholipase C, gamma 1	0.034
ASNS	asparagine synthetase (glutamine-hydrolyzing)	0.034
BBC3	BCL2 binding component 3	0.033
RNF144B	ring finger protein 144B	0.033
ARHGEF40	Rho guanine nucleotide exchange factor (GEF) 40	0.033
PPP1R13B	protein phosphatase 1, regulatory (inhibitor) subunit 13B	0.032
HSPH1	heat shock 105kDa/110kDa protein 1	0.032
SURF4	surfeit 4	0.031
HM13	histocompatibility (minor) 13	0.031
KRT6C	keratin 6C	0.030
NCL	nucleolin	0.030
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.029
STT3A	STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)	0.029
ATF3	activating transcription factor 3	0.029
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.029
OXA1L	oxidase (cytochrome c) assembly 1-like	0.028
HSPD1	heat shock 60kDa protein 1 (chaperonin)	0.028	Worm
OSBPL9	oxysterol binding protein-like 9	0.028
CALR	calreticulin	0.027	Worm
EIF3CL	eukaryotic translation initiation factor 3, subunit C-like	0.027
SLC3A2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	0.027
HUWE1	HECT, UBA and WWE domain containing 1	0.026
NSFL1C	NSFL1 (p97) cofactor (p47)	0.025
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.025
MARS	methionyl-tRNA synthetase	0.025
RPN2	ribophorin II	0.025
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.025
HNRNPCL1	heterogeneous nuclear ribonucleoprotein C-like 1	0.025
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.024
BID	BH3 interacting domain death agonist	0.024
SARS	seryl-tRNA synthetase	0.024
NUCB2	nucleobindin 2	0.024
TUFM	Tu translation elongation factor, mitochondrial	0.023
AKAP1	A kinase (PRKA) anchor protein 1	0.023
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.023
ATF2	activating transcription factor 2	0.023
FKBP4	FK506 binding protein 4, 59kDa	0.023
CCDC6	coiled-coil domain containing 6	0.023
STX8	syntaxin 8	0.023
VEGFA	vascular endothelial growth factor A	0.023
LDLR	low density lipoprotein receptor	0.022
JUN	jun proto-oncogene	0.022
KLHL24	kelch-like 24 (Drosophila)	0.022
C19orf10	chromosome 19 open reading frame 10	0.022
VAPA	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	0.021	Human
UBE3A	ubiquitin protein ligase E3A	0.021
RPN1	ribophorin I	0.021
MTDH	metadherin	0.021
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.020
TRIB3	tribbles homolog 3 (Drosophila)	0.020
RNR2	l-rRNA	0.019
GFPT1	glutamine--fructose-6-phosphate transaminase 1	0.019
SFN	stratifin	0.018
TP53BP1	tumor protein p53 binding protein 1	0.018
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.018
SERP1	stress-associated endoplasmic reticulum protein 1	0.018	Mouse
TRAM1	translocation associated membrane protein 1	0.018
VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	0.018
UBXN2A	UBX domain protein 2A	0.017
GARS	glycyl-tRNA synthetase	0.017
DERL2	Der1-like domain family, member 2	0.017
TRAP1	TNF receptor-associated protein 1	0.017	Worm
ERO1LB	ERO1-like beta (S. cerevisiae)	0.017
IMPDH2	IMP (inosine 5'-monophosphate) dehydrogenase 2	0.017
ITGA1	integrin, alpha 1	0.017
USP46	ubiquitin specific peptidase 46	0.017
HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	0.017
MAX	MYC associated factor X	0.016
CRELD2	cysteine-rich with EGF-like domains 2	0.016
ARF4	ADP-ribosylation factor 4	0.016
RSL1D1	ribosomal L1 domain containing 1	0.015
LMTK2	lemur tyrosine kinase 2	0.015
SSR3	signal sequence receptor, gamma (translocon-associated protein gamma)	0.014
DNAJA3	DnaJ (Hsp40) homolog, subfamily A, member 3	0.014
BIK	BCL2-interacting killer (apoptosis-inducing)	0.014
MMS19	MMS19 nucleotide excision repair homolog (S. cerevisiae)	0.014
KAT2A	K(lysine) acetyltransferase 2A	0.014
CNBP	CCHC-type zinc finger, nucleic acid binding protein	0.014
BCAR1	breast cancer anti-estrogen resistance 1	0.014
FCHSD2	FCH and double SH3 domains 2	0.013
TRIP10	thyroid hormone receptor interactor 10	0.013
UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)	0.013
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.013
DUSP5	dual specificity phosphatase 5	0.013
ALOX12	arachidonate 12-lipoxygenase	0.013
FNIP1	folliculin interacting protein 1	0.013
DNAJC10	DnaJ (Hsp40) homolog, subfamily C, member 10	0.013
CSRNP1	cysteine-serine-rich nuclear protein 1	0.013
CLTC	clathrin, heavy chain (Hc)	0.013
AHNAK	AHNAK nucleoprotein	0.013
GTF2I	general transcription factor IIi	0.012
UBXN1	UBX domain protein 1	0.012
SH2B1	SH2B adaptor protein 1	0.012
FLNB	filamin B, beta	0.012
PSEN2	presenilin 2 (Alzheimer disease 4)	0.012
PDIA5	protein disulfide isomerase family A, member 5	0.012
MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)	0.012
MAPK8	mitogen-activated protein kinase 8	0.012
FASN	fatty acid synthase	0.012
SNX9	sorting nexin 9	0.012
SREBF2	sterol regulatory element binding transcription factor 2	0.012
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.012
SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	0.012
HSPA8	heat shock 70kDa protein 8	0.012
POLR2C	polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	0.011
HSPB1	heat shock 27kDa protein 1	0.011
YAP1	Yes-associated protein 1	0.011
SLC25A6	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	0.011
PSAT1	phosphoserine aminotransferase 1	0.011
XBP1	X-box binding protein 1	0.011
TAGLN2	transgelin 2	0.011
PJA2	praja ring finger 2	0.011
NUS1	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)	0.011
PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	0.011
VCPIP1	valosin containing protein (p97)/p47 complex interacting protein 1	0.011
ZFYVE9	zinc finger, FYVE domain containing 9	0.011
TCTEX1D4	Tctex1 domain containing 4	0.011
CARS	cysteinyl-tRNA synthetase	0.010
SLU7	SLU7 splicing factor homolog (S. cerevisiae)	0.010
CCND2	cyclin D2	0.010
BCL2L2	BCL2-like 2	0.010	Human
PTN	pleiotrophin	0.010
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.010