IMP

Process View

Homo sapiens

34 genes annotated in human

cellular response to light stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular response to light stimulus"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular response to light stimulus" (in gray)

Name	Description	Probability	Func Analog Organism
TP53	tumor protein p53	0.721	Mouse
BCL2	B-cell CLL/lymphoma 2	0.667
DDB1	damage-specific DNA binding protein 1, 127kDa	0.533
TEK	TEK tyrosine kinase, endothelial	0.527
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.428	Human Yeast
HIST2H2BE	histone cluster 2, H2be	0.399
CUL4A	cullin 4A	0.394	Human
INO80	INO80 homolog (S. cerevisiae)	0.384
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.331
YY1	YY1 transcription factor	0.219
BAX	BCL2-associated X protein	0.210	Human Mouse
HIST1H2BG	histone cluster 1, H2bg	0.197
RUVBL1	RuvB-like 1 (E. coli)	0.184
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.168
CFLAR	CASP8 and FADD-like apoptosis regulator	0.152
APAF1	apoptotic peptidase activating factor 1	0.148
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.121
SMAD4	SMAD family member 4	0.100
BAD	BCL2-associated agonist of cell death	0.099
CUL1	cullin 1	0.081
NLRC4	NLR family, CARD domain containing 4	0.076
HIST1H2AI	histone cluster 1, H2ai	0.076	Human
BAK1	BCL2-antagonist/killer 1	0.075
KIAA1377	KIAA1377	0.070
RIPK2	receptor-interacting serine-threonine kinase 2	0.066
HIST1H2AJ	histone cluster 1, H2aj	0.066	Human
IRAK2	interleukin-1 receptor-associated kinase 2	0.064
USP15	ubiquitin specific peptidase 15	0.060
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.060	Human
CAND1	cullin-associated and neddylation-dissociated 1	0.059
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.059
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.051	Human
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.050	Human
MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.048
RAD50	RAD50 homolog (S. cerevisiae)	0.048
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.047	Human
TRIM37	tripartite motif containing 37	0.046
VPRBP	Vpr (HIV-1) binding protein	0.045
FBXW11	F-box and WD repeat domain containing 11	0.044
HIST1H3A	histone cluster 1, H3a	0.043
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.043
GUCY1B3	guanylate cyclase 1, soluble, beta 3	0.042
FGG	fibrinogen gamma chain	0.041
ZFYVE9	zinc finger, FYVE domain containing 9	0.039
ADRBK1	adrenergic, beta, receptor kinase 1	0.038	Human
NCF1	neutrophil cytosolic factor 1	0.038
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.036
ACTR5	ARP5 actin-related protein 5 homolog (yeast)	0.036
CLSPN	claspin	0.036
WRN	Werner syndrome, RecQ helicase-like	0.035
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.035	Human
CCDC6	coiled-coil domain containing 6	0.034
RICTOR	RPTOR independent companion of MTOR, complex 2	0.033
FOXM1	forkhead box M1	0.033
FAS	Fas (TNF receptor superfamily, member 6)	0.032
ITPR2	inositol 1,4,5-trisphosphate receptor, type 2	0.032
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.032
HIST1H2BM	histone cluster 1, H2bm	0.031
HIST1H2AG	histone cluster 1, H2ag	0.030	Human
HIST1H3D	histone cluster 1, H3d	0.029	Human
FGA	fibrinogen alpha chain	0.029
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.029
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.029	Human Yeast
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.029
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.029
FANCD2	Fanconi anemia, complementation group D2	0.028
BLOC1S2	biogenesis of lysosomal organelles complex-1, subunit 2	0.027
KCTD17	potassium channel tetramerisation domain containing 17	0.027
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.026
HUWE1	HECT, UBA and WWE domain containing 1	0.026
INO80E	INO80 complex subunit E	0.026
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.026
AP1M1	adaptor-related protein complex 1, mu 1 subunit	0.026
CCNE1	cyclin E1	0.025
MAX	MYC associated factor X	0.025
HIST1H1C	histone cluster 1, H1c	0.025
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.025
SKIL	SKI-like oncogene	0.025
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.025
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.025
HIST1H2BJ	histone cluster 1, H2bj	0.024
FBXL15	F-box and leucine-rich repeat protein 15	0.024
ERCC6	excision repair cross-complementing rodent repair deficiency, complementation group 6	0.023
HIST1H2AM	histone cluster 1, H2am	0.023
RB1	retinoblastoma 1	0.023
NBN	nibrin	0.022
PRKCA	protein kinase C, alpha	0.022	Fly
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.022
TRIM9	tripartite motif containing 9	0.022
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.022
ACTB	actin, beta	0.021
RFWD2	ring finger and WD repeat domain 2	0.021
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.020	Human
ANGPT2	angiopoietin 2	0.020	Human
ADAMTSL4	ADAMTS-like 4	0.020
PLCG1	phospholipase C, gamma 1	0.020
DDB2	damage-specific DNA binding protein 2, 48kDa	0.020
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.019
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.019
E2F1	E2F transcription factor 1	0.019
XPC	xeroderma pigmentosum, complementation group C	0.019
HIST1H2BB	histone cluster 1, H2bb	0.019
HIST1H4H	histone cluster 1, H4h	0.019
RYBP	RING1 and YY1 binding protein	0.019
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.019
RIOK3	RIO kinase 3 (yeast)	0.019
ANKRD13A	ankyrin repeat domain 13A	0.018
BRD7	bromodomain containing 7	0.018
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.018	Human Yeast
XIAP	X-linked inhibitor of apoptosis	0.018
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.018
BTRC	beta-transducin repeat containing	0.018
MYOD1	myogenic differentiation 1	0.018
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.018
ANGPT1	angiopoietin 1	0.017	Human
TTI1	Tel2 interacting protein 1 homolog (S. pombe)	0.017
PRKCD	protein kinase C, delta	0.017
HIST1H4D	histone cluster 1, H4d	0.017
CAV1	caveolin 1, caveolae protein, 22kDa	0.016
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.016
BID	BH3 interacting domain death agonist	0.016
RNR2	l-rRNA	0.016
FASLG	Fas ligand (TNF superfamily, member 6)	0.016
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.016	Human Yeast
HIST1H2AL	histone cluster 1, H2al	0.016	Human
HIST2H2AA3	histone cluster 2, H2aa3	0.016	Human
HDAC6	histone deacetylase 6	0.016
MAP2K4	mitogen-activated protein kinase kinase 4	0.016
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.015
HIST1H4I	histone cluster 1, H4i	0.015
HIST1H2AB	histone cluster 1, H2ab	0.015	Human
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.015
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.015
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.015
HTT	huntingtin	0.015
HIST1H3H	histone cluster 1, H3h	0.015
KAT2B	K(lysine) acetyltransferase 2B	0.015
FBN1	fibrillin 1	0.015
UIMC1	ubiquitin interaction motif containing 1	0.015
DDIT4	DNA-damage-inducible transcript 4	0.015
COPS6	COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)	0.014
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.014
HIST1H4E	histone cluster 1, H4e	0.014
HIST1H2AE	histone cluster 1, H2ae	0.014	Human
DIABLO	diablo, IAP-binding mitochondrial protein	0.014
HIST1H4B	histone cluster 1, H4b	0.014
USP28	ubiquitin specific peptidase 28	0.014
RNF144B	ring finger protein 144B	0.014
UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.014
PIAS4	protein inhibitor of activated STAT, 4	0.013
WNK1	WNK lysine deficient protein kinase 1	0.013
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.013
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.013	Human Yeast
TIMELESS	timeless homolog (Drosophila)	0.013
CXXC5	CXXC finger protein 5	0.013
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.013
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.013
XPO7	exportin 7	0.013
EPS15	epidermal growth factor receptor pathway substrate 15	0.013
HIST1H2AK	histone cluster 1, H2ak	0.013	Human
EPAS1	endothelial PAS domain protein 1	0.013
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.013
CARD16	caspase recruitment domain family, member 16	0.012
MAGEB18	melanoma antigen family B, 18	0.012
DBN1	drebrin 1	0.012
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.012
HIST1H3B	histone cluster 1, H3b	0.012
CUL2	cullin 2	0.012
SFN	stratifin	0.012
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.012
EGLN1	egl nine homolog 1 (C. elegans)	0.012
SNX33	sorting nexin 33	0.012
GET4	golgi to ER traffic protein 4 homolog (S. cerevisiae)	0.012
CUL5	cullin 5	0.012
MYO6	myosin VI	0.012
ZNF420	zinc finger protein 420	0.012
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.012
HIST1H2BE	histone cluster 1, H2be	0.012
SAT1	spermidine/spermine N1-acetyltransferase 1	0.011
HIST1H2BC	histone cluster 1, H2bc	0.011
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.011
C4orf14	chromosome 4 open reading frame 14	0.011
EGR1	early growth response 1	0.011
FKBP4	FK506 binding protein 4, 59kDa	0.011
USP25	ubiquitin specific peptidase 25	0.011	Human
CYBA	cytochrome b-245, alpha polypeptide	0.011
ELN	elastin	0.011
IFI16	interferon, gamma-inducible protein 16	0.011
BIRC3	baculoviral IAP repeat containing 3	0.011
SHPRH	SNF2 histone linker PHD RING helicase	0.011
HIST1H3G	histone cluster 1, H3g	0.011
C15orf63	chromosome 15 open reading frame 63	0.011
HSPH1	heat shock 105kDa/110kDa protein 1	0.011
MMS22L	MMS22-like, DNA repair protein	0.011
FDXR	ferredoxin reductase	0.010
KIAA1712	KIAA1712	0.010
JUN	jun proto-oncogene	0.010
FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	0.010
IRS1	insulin receptor substrate 1	0.010
HIST2H4A	histone cluster 2, H4a	0.010
VDAC1	voltage-dependent anion channel 1	0.010
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.010	Human Yeast
UNC119	unc-119 homolog (C. elegans)	0.010
PYCARD	PYD and CARD domain containing	0.010
BIRC5	baculoviral IAP repeat containing 5	0.010
FXR2	fragile X mental retardation, autosomal homolog 2	0.010
CD34	CD34 molecule	0.010