IMP

Process View

Homo sapiens

22 genes annotated in human

Multi-species View

signal transduction in absence of ligand

GO:0038034

A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "signal transduction in absence of ligand"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "signal transduction in absence of ligand" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2	B-cell CLL/lymphoma 2	0.999
BCL2L1	BCL2-like 1	0.995	Human Mouse
PML	promyelocytic leukemia	0.950
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.883	Mouse
BAX	BCL2-associated X protein	0.881	Human Mouse
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.829
TAL1	T-cell acute lymphocytic leukemia 1	0.792
BID	BH3 interacting domain death agonist	0.779
HSPA1A	heat shock 70kDa protein 1A	0.695
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.682	Human
BAD	BCL2-associated agonist of cell death	0.679
FAS	Fas (TNF receptor superfamily, member 6)	0.666	Mouse
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.611
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.594	Human
HSPA1B	heat shock 70kDa protein 1B	0.556
IL8	interleukin 8	0.508
EGFR	epidermal growth factor receptor	0.468	Human
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.416
CXCL2	chemokine (C-X-C motif) ligand 2	0.325
CXCL5	chemokine (C-X-C motif) ligand 5	0.312	Human
IL1R1	interleukin 1 receptor, type I	0.273
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.247
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.243
HSPB1	heat shock 27kDa protein 1	0.220
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.213
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.205
MAPK14	mitogen-activated protein kinase 14	0.197
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.196
BCL2A1	BCL2-related protein A1	0.186	Human
PLCG1	phospholipase C, gamma 1	0.182
CCL20	chemokine (C-C motif) ligand 20	0.161
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.153
TRADD	TNFRSF1A-associated via death domain	0.153
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.142
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.136
MAP2K5	mitogen-activated protein kinase kinase 5	0.130	Rat
CXCL3	chemokine (C-X-C motif) ligand 3	0.106	Human
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.094	Human
IL1B	interleukin 1, beta	0.090
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.083
DAXX	death-domain associated protein	0.081
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.081
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.080
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.078
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.076
BAG1	BCL2-associated athanogene	0.075
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.066
BAK1	BCL2-antagonist/killer 1	0.065	Human
CCL4	chemokine (C-C motif) ligand 4	0.061
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.058
IL1R2	interleukin 1 receptor, type II	0.058
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.057
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.056
APP	amyloid beta (A4) precursor protein	0.055
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.054
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.053
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.051
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.051
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.048
CXCL10	chemokine (C-X-C motif) ligand 10	0.046	Human
IL6	interleukin 6 (interferon, beta 2)	0.044
CXCL9	chemokine (C-X-C motif) ligand 9	0.044	Human
RIPK3	receptor-interacting serine-threonine kinase 3	0.044
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.043
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.043
CCL8	chemokine (C-C motif) ligand 8	0.043
HSPH1	heat shock 105kDa/110kDa protein 1	0.042
IL4R	interleukin 4 receptor	0.042
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.037
MAPK7	mitogen-activated protein kinase 7	0.037
ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	0.037
JUP	junction plakoglobin	0.036
TP53	tumor protein p53	0.036
BCL2L2	BCL2-like 2	0.036	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.034	Human
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.034
DIABLO	diablo, IAP-binding mitochondrial protein	0.033
RIPK2	receptor-interacting serine-threonine kinase 2	0.033
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.032	Mouse
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.031
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.030
XIAP	X-linked inhibitor of apoptosis	0.030
BIRC2	baculoviral IAP repeat containing 2	0.030
GRB7	growth factor receptor-bound protein 7	0.030
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.030
TRAF1	TNF receptor-associated factor 1	0.030
IFI27	interferon, alpha-inducible protein 27	0.029	Human
FGF1	fibroblast growth factor 1 (acidic)	0.029
RNF144B	ring finger protein 144B	0.029
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.028
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.028	Human Mouse
AXIN1	axin 1	0.028
CCL2	chemokine (C-C motif) ligand 2	0.028
BIRC3	baculoviral IAP repeat containing 3	0.027
INSR	insulin receptor	0.027
PI3	peptidase inhibitor 3, skin-derived	0.026
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.025
VDAC1	voltage-dependent anion channel 1	0.024
STK11	serine/threonine kinase 11	0.024
UBD	ubiquitin D	0.024
SMG6	Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)	0.023
GSK3B	glycogen synthase kinase 3 beta	0.023	Mouse
FASLG	Fas ligand (TNF superfamily, member 6)	0.022
TNF	tumor necrosis factor	0.022
IFNG	interferon, gamma	0.022
PPP5C	protein phosphatase 5, catalytic subunit	0.021
CCL7	chemokine (C-C motif) ligand 7	0.021
TRO	trophinin	0.020
IFI44L	interferon-induced protein 44-like	0.020
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.020
PTK6	PTK6 protein tyrosine kinase 6	0.020
CD83	CD83 molecule	0.020
IL1A	interleukin 1, alpha	0.020	Human Mouse
BBC3	BCL2 binding component 3	0.019
S100A12	S100 calcium binding protein A12	0.019
HSPB8	heat shock 22kDa protein 8	0.019
BAG3	BCL2-associated athanogene 3	0.019	Mouse
IGFBP3	insulin-like growth factor binding protein 3	0.019
CD320	CD320 molecule	0.019
STIP1	stress-induced-phosphoprotein 1	0.019
CFLAR	CASP8 and FADD-like apoptosis regulator	0.018
FADD	Fas (TNFRSF6)-associated via death domain	0.018	Mouse
LAPTM4A	lysosomal protein transmembrane 4 alpha	0.018
PF4V1	platelet factor 4 variant 1	0.018	Human
INHBA	inhibin, beta A	0.018
TREM1	triggering receptor expressed on myeloid cells 1	0.017
CXCL13	chemokine (C-X-C motif) ligand 13	0.017
PF4	platelet factor 4	0.017
KLF13	Kruppel-like factor 13	0.017
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.016
HBG2	hemoglobin, gamma G	0.016
APC	adenomatous polyposis coli	0.016
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.016
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.016
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.015
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.015
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.015
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.015
MAPK3	mitogen-activated protein kinase 3	0.015
FST	follistatin	0.015
FRS2	fibroblast growth factor receptor substrate 2	0.015
TP73	tumor protein p73	0.015
IL11	interleukin 11	0.015
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.015
ASRGL1	asparaginase like 1	0.014
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.014
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.014
RNR2	l-rRNA	0.014
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.014
ATM	ataxia telangiectasia mutated	0.014
NRG1	neuregulin 1	0.013
MAGEH1	melanoma antigen family H, 1	0.013
GPR109B	G protein-coupled receptor 109B	0.013
CSF3	colony stimulating factor 3 (granulocyte)	0.013
VAV3	vav 3 guanine nucleotide exchange factor	0.013
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.013
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.013
CXCR3	chemokine (C-X-C motif) receptor 3	0.013
NPTN	neuroplastin	0.013
IDO1	indoleamine 2,3-dioxygenase 1	0.013
DLG2	discs, large homolog 2 (Drosophila)	0.013
IFI6	interferon, alpha-inducible protein 6	0.013
IL7R	interleukin 7 receptor	0.013
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.013
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.012
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.012
DPP4	dipeptidyl-peptidase 4	0.012
ECSIT	ECSIT homolog (Drosophila)	0.012
IL1RN	interleukin 1 receptor antagonist	0.012	Human
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.012
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.012
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.012
EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	0.012
SP1	Sp1 transcription factor	0.012
DUSP9	dual specificity phosphatase 9	0.011
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.011
SOS1	son of sevenless homolog 1 (Drosophila)	0.011
CCL22	chemokine (C-C motif) ligand 22	0.011
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.011
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.011
EFNA1	ephrin-A1	0.011
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.011
ISG15	ISG15 ubiquitin-like modifier	0.011
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.011
AQP9	aquaporin 9	0.011
SFN	stratifin	0.011
FGF2	fibroblast growth factor 2 (basic)	0.010
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.010
VCL	vinculin	0.010
RGS1	regulator of G-protein signaling 1	0.010
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.010
RAI1	retinoic acid induced 1	0.010
BIK	BCL2-interacting killer (apoptosis-inducing)	0.010