IMP

Process View

Homo sapiens

23 genes annotated in human

limb development

The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "limb development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "limb development" (in gray)

Name	Description	Probability	Func Analog Organism
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.991	Human
FHL2	four and a half LIM domains 2	0.970
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.555
ZNF43	zinc finger protein 43	0.542
JAG1	jagged 1	0.535
FN1	fibronectin 1	0.507
PAX3	paired box 3	0.437
SMAD3	SMAD family member 3	0.434
ZFYVE9	zinc finger, FYVE domain containing 9	0.380
TGFB1	transforming growth factor, beta 1	0.361
ZNF253	zinc finger protein 253	0.336
APP	amyloid beta (A4) precursor protein	0.315
ENG	endoglin	0.258
ZNF273	zinc finger protein 273	0.215	Human
COL1A1	collagen, type I, alpha 1	0.207
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.196	Human Mouse
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.192
BMP2	bone morphogenetic protein 2	0.178
MEIS1	Meis homeobox 1	0.136
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.134	Human
ZNF675	zinc finger protein 675	0.132	Human
SUFU	suppressor of fused homolog (Drosophila)	0.130
FLNB	filamin B, beta	0.123
FKBP1A	FK506 binding protein 1A, 12kDa	0.114
SMO	smoothened homolog (Drosophila)	0.111
PML	promyelocytic leukemia	0.102
CHD7	chromodomain helicase DNA binding protein 7	0.098
ELL2	elongation factor, RNA polymerase II, 2	0.096
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.095
HOXA10	homeobox A10	0.093
SMAD2	SMAD family member 2	0.086
ARRB1	arrestin, beta 1	0.080
THBS1	thrombospondin 1	0.077	Human
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.076
COL2A1	collagen, type II, alpha 1	0.065	Mouse
SETD8	SET domain containing (lysine methyltransferase) 8	0.064
SKIL	SKI-like oncogene	0.057
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.057
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.054
ZNF430	zinc finger protein 430	0.052	Human
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.052
FBLN1	fibulin 1	0.052
MLLT1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	0.052
BMPR1A	bone morphogenetic protein receptor, type IA	0.052	Human Mouse
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.049	Human
SOX2	SRY (sex determining region Y)-box 2	0.048
HOXD13	homeobox D13	0.048	Mouse
ZNF254	zinc finger protein 254	0.048	Human
FSTL1	follistatin-like 1	0.047
GATA4	GATA binding protein 4	0.047
HTT	huntingtin	0.046
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.046
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.045
TLN1	talin 1	0.044
TJP1	tight junction protein 1 (zona occludens 1)	0.044
MDFI	MyoD family inhibitor	0.044
YY1	YY1 transcription factor	0.044
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.042
ZNF117	zinc finger protein 117	0.042	Human
FGF1	fibroblast growth factor 1 (acidic)	0.041
MEIS2	Meis homeobox 2	0.040
BAK1	BCL2-antagonist/killer 1	0.039
ZNF708	zinc finger protein 708	0.038	Human
SMAD4	SMAD family member 4	0.038
FGF18	fibroblast growth factor 18	0.038
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.038
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.037
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.036
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.036
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.035
HOXC8	homeobox C8	0.035
FOXF2	forkhead box F2	0.033
FOXC1	forkhead box C1	0.033
PSEN1	presenilin 1	0.032	Mouse
BMP4	bone morphogenetic protein 4	0.032	Mouse
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.032
PDZD11	PDZ domain containing 11	0.032
TGFB3	transforming growth factor, beta 3	0.031
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.031
DLX4	distal-less homeobox 4	0.030
HDAC1	histone deacetylase 1	0.030	Mouse
ACAN	aggrecan	0.029
ZNF93	zinc finger protein 93	0.029
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.029	Mouse
HOXD9	homeobox D9	0.029	Mouse
SFRP1	secreted frizzled-related protein 1	0.029
COL17A1	collagen, type XVII, alpha 1	0.028
HOXD11	homeobox D11	0.028	Mouse
MSX2	msh homeobox 2	0.027	Human Mouse
NRP1	neuropilin 1	0.027
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.027
ITGB4	integrin, beta 4	0.027
ZNF680	zinc finger protein 680	0.027	Human
LRP6	low density lipoprotein receptor-related protein 6	0.026	Human Mouse
FLNA	filamin A, alpha	0.026
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.026
HOXC6	homeobox C6	0.026
COL1A2	collagen, type I, alpha 2	0.026
RARG	retinoic acid receptor, gamma	0.026	Mouse
COL11A1	collagen, type XI, alpha 1	0.025
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.025
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.025	Mouse
LBX1	ladybird homeobox 1	0.025
MSX1	msh homeobox 1	0.025
DLX5	distal-less homeobox 5	0.025	Mouse
WNT1	wingless-type MMTV integration site family, member 1	0.024	Human
FGF10	fibroblast growth factor 10	0.024
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.024
ATN1	atrophin 1	0.023
PPARA	peroxisome proliferator-activated receptor alpha	0.023
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.023
CTCF	CCCTC-binding factor (zinc finger protein)	0.023
HOXC11	homeobox C11	0.023	Mouse
ZNF92	zinc finger protein 92	0.023	Human
CHD8	chromodomain helicase DNA binding protein 8	0.023	Human
ZNF85	zinc finger protein 85	0.023	Human
ITGB5	integrin, beta 5	0.022	Human
TGFBR1	transforming growth factor, beta receptor 1	0.022	Human
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.022
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.022
HOXB9	homeobox B9	0.022
STK36	serine/threonine kinase 36	0.021
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.021
ZNF91	zinc finger protein 91	0.021
SMAD7	SMAD family member 7	0.021
PAX2	paired box 2	0.020
BARX1	BARX homeobox 1	0.020
BAX	BCL2-associated X protein	0.020	Mouse
HOXC13	homeobox C13	0.020	Mouse
NGFR	nerve growth factor receptor	0.020
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.020
RBBP4	retinoblastoma binding protein 4	0.020
PRKG1	protein kinase, cGMP-dependent, type I	0.020
WNT11	wingless-type MMTV integration site family, member 11	0.020	Human
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.020
EPS8	epidermal growth factor receptor pathway substrate 8	0.020
GLI3	GLI family zinc finger 3	0.020
COL6A1	collagen, type VI, alpha 1	0.019
MYO10	myosin X	0.019
ZNF682	zinc finger protein 682	0.019	Human
TNRC6A	trinucleotide repeat containing 6A	0.019
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.018
CRLF1	cytokine receptor-like factor 1	0.018
LAMB1	laminin, beta 1	0.018
BIK	BCL2-interacting killer (apoptosis-inducing)	0.018
GATA2	GATA binding protein 2	0.018
SATB2	SATB homeobox 2	0.018
BAD	BCL2-associated agonist of cell death	0.018
HMGA2	high mobility group AT-hook 2	0.018
BMP7	bone morphogenetic protein 7	0.017	Mouse
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.017
WISP1	WNT1 inducible signaling pathway protein 1	0.017
AQP5	aquaporin 5	0.017
HOXB5	homeobox B5	0.016
CDX2	caudal type homeobox 2	0.016
GATA5	GATA binding protein 5	0.016
TBX2	T-box 2	0.016	Human
CTGF	connective tissue growth factor	0.016
GLI1	GLI family zinc finger 1	0.016	Human
NRP2	neuropilin 2	0.016
GDF6	growth differentiation factor 6	0.016
FZD1	frizzled homolog 1 (Drosophila)	0.016
FZD7	frizzled homolog 7 (Drosophila)	0.016
HOXD12	homeobox D12	0.016	Mouse
HSPG2	heparan sulfate proteoglycan 2	0.016
AGTR1	angiotensin II receptor, type 1	0.016
SFRP4	secreted frizzled-related protein 4	0.016
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.016
FNDC3B	fibronectin type III domain containing 3B	0.015
ACVR1	activin A receptor, type I	0.015	Human
RBBP5	retinoblastoma binding protein 5	0.015
FKBP8	FK506 binding protein 8, 38kDa	0.015
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.015
JAG2	jagged 2	0.015
FGF3	fibroblast growth factor 3	0.015
ZNF107	zinc finger protein 107	0.015
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.015	Human
HOXD10	homeobox D10	0.015	Mouse
HES2	hairy and enhancer of split 2 (Drosophila)	0.015
NOTCH3	notch 3	0.015
CDK19	cyclin-dependent kinase 19	0.015
BECN1	beclin 1, autophagy related	0.015
FGF8	fibroblast growth factor 8 (androgen-induced)	0.015
TAL1	T-cell acute lymphocytic leukemia 1	0.015
RNR2	l-rRNA	0.014
CCNT1	cyclin T1	0.014
ITGA6	integrin, alpha 6	0.014
TBX5	T-box 5	0.014
RXRA	retinoid X receptor, alpha	0.014
WNT3	wingless-type MMTV integration site family, member 3	0.014
NKX3-2	NK3 homeobox 2	0.014
SPECC1L	sperm antigen with calponin homology and coiled-coil domains 1-like	0.014
SHOX2	short stature homeobox 2	0.014	Mouse
CDK8	cyclin-dependent kinase 8	0.014
TGFB2	transforming growth factor, beta 2	0.014
FGF7	fibroblast growth factor 7	0.014
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.014
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.014	Mouse
IRX4	iroquois homeobox 4	0.014
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.014	Mouse
HOXB13	homeobox B13	0.014
COL10A1	collagen, type X, alpha 1	0.014
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.014	Mouse
CELF1	CUGBP, Elav-like family member 1	0.014
CABLES1	Cdk5 and Abl enzyme substrate 1	0.013
MAPK8	mitogen-activated protein kinase 8	0.013
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.013
SRI	sorcin	0.013
FEV	FEV (ETS oncogene family)	0.013
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.013
HOXA3	homeobox A3	0.013
KRT5	keratin 5	0.013
PBRM1	polybromo 1	0.013
EN1	engrailed homeobox 1	0.013	Mouse
PPP1R12A	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.013
COL4A1	collagen, type IV, alpha 1	0.013
PRRX2	paired related homeobox 2	0.013	Mouse
NPAS1	neuronal PAS domain protein 1	0.013
TRIP6	thyroid hormone receptor interactor 6	0.013
DOCK7	dedicator of cytokinesis 7	0.013
CRABP2	cellular retinoic acid binding protein 2	0.013	Mouse
PDX1	pancreatic and duodenal homeobox 1	0.013
PDIA3	protein disulfide isomerase family A, member 3	0.013
THBS2	thrombospondin 2	0.013	Human
OTP	orthopedia homeobox	0.013
TBX1	T-box 1	0.012	Human
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.012	Human
SIX2	SIX homeobox 2	0.012
PXN	paxillin	0.012
RXRB	retinoid X receptor, beta	0.012
HOXA11	homeobox A11	0.012	Mouse
EFNB3	ephrin-B3	0.012
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.012
PRRX1	paired related homeobox 1	0.012	Mouse
C7orf64	chromosome 7 open reading frame 64	0.012
SIX6	SIX homeobox 6	0.012
TERF2	telomeric repeat binding factor 2	0.012
GLI2	GLI family zinc finger 2	0.012	Human Mouse
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.012
DIO3	deiodinase, iodothyronine, type III	0.012
CAPRIN2	caprin family member 2	0.012
MED13L	mediator complex subunit 13-like	0.012
WT1	Wilms tumor 1	0.011
MED29	mediator complex subunit 29	0.011
PRPH	peripherin	0.011
EDNRA	endothelin receptor type A	0.011
COMP	cartilage oligomeric matrix protein	0.011
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.011	Human
FGF4	fibroblast growth factor 4	0.011	Mouse
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.011
ROR2	receptor tyrosine kinase-like orphan receptor 2	0.011
SOX11	SRY (sex determining region Y)-box 11	0.011	Mouse
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.011
LOXL2	lysyl oxidase-like 2	0.011
TMSB4X	thymosin beta 4, X-linked	0.011
CD9	CD9 molecule	0.011
DLL1	delta-like 1 (Drosophila)	0.011
AFF1	AF4/FMR2 family, member 1	0.011
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.011
POU4F2	POU class 4 homeobox 2	0.011
KRT6C	keratin 6C	0.011
INHBB	inhibin, beta B	0.011
THY1	Thy-1 cell surface antigen	0.011
WNT3A	wingless-type MMTV integration site family, member 3A	0.011
WIF1	WNT inhibitory factor 1	0.011
CRABP1	cellular retinoic acid binding protein 1	0.011
MYOD1	myogenic differentiation 1	0.011
NRIP1	nuclear receptor interacting protein 1	0.011
GCSH	glycine cleavage system protein H (aminomethyl carrier)	0.011
CEP350	centrosomal protein 350kDa	0.011
HUWE1	HECT, UBA and WWE domain containing 1	0.011
KCTD1	potassium channel tetramerisation domain containing 1	0.011
LUM	lumican	0.010
COL4A2	collagen, type IV, alpha 2	0.010
BCL2L1	BCL2-like 1	0.010
RBPMS	RNA binding protein with multiple splicing	0.010
TNRC6B	trinucleotide repeat containing 6B	0.010
EPHB3	EPH receptor B3	0.010
SOX9	SRY (sex determining region Y)-box 9	0.010	Mouse
GAS1	growth arrest-specific 1	0.010	Mouse
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.010
WNT2	wingless-type MMTV integration site family member 2	0.010	Human