IMP

Process View

Mus musculus

13 genes annotated in mouse

positive regulation of epithelial to mesenchymal transition

Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of epithelial to mesenchymal transition"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of epithelial to mesenchymal transition" (in gray)

Name	Description	Probability	Func Analog Organism
Ctnnb1	catenin (cadherin associated protein), beta 1	0.998	Human
Shh	sonic hedgehog	0.998
Bmp4	bone morphogenetic protein 4	0.965	Mouse
Notch1	Notch gene homolog 1 (Drosophila)	0.916
Neurod1	neurogenic differentiation 1	0.915	Mouse
Tgfb2	transforming growth factor, beta 2	0.899	Human Mouse
Pax3	paired box gene 3	0.881
Msx1	homeobox, msh-like 1	0.868
Otx2	orthodenticle homolog 2 (Drosophila)	0.862
Gli3	GLI-Kruppel family member GLI3	0.848
Smad3	MAD homolog 3 (Drosophila)	0.845	Human Mouse
Runx2	runt related transcription factor 2	0.834
Pten	phosphatase and tensin homolog	0.794
Ptf1a	pancreas specific transcription factor, 1a	0.792	Mouse
Smad4	MAD homolog 4 (Drosophila)	0.775
Foxc1	forkhead box C1	0.718
Snai1	snail homolog 1 (Drosophila)	0.694
Hand1	heart and neural crest derivatives expressed transcript 1	0.687	Mouse
Gli2	GLI-Kruppel family member GLI2	0.651
Apc	adenomatosis polyposis coli	0.638
Axin1	axin 1	0.624
Smad1	MAD homolog 1 (Drosophila)	0.608	Mouse
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.587
Pax6	paired box gene 6	0.539
Ptch1	patched homolog 1	0.527
Hes1	hairy and enhancer of split 1 (Drosophila)	0.522
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.510
Prph2	peripherin 2	0.508
Fgfr2	fibroblast growth factor receptor 2	0.471
Msx2	homeobox, msh-like 2	0.458
Gja1	gap junction protein, alpha 1	0.434
Emx1	empty spiracles homolog 1 (Drosophila)	0.395
Psen1	presenilin 1	0.386
Hand2	heart and neural crest derivatives expressed transcript 2	0.370	Mouse
Fgfr1	fibroblast growth factor receptor 1	0.362
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.360
Yap1	yes-associated protein 1	0.360
Hic1	hypermethylated in cancer 1	0.359
Prrx1	paired related homeobox 1	0.358
Lef1	lymphoid enhancer binding factor 1	0.343	Human
Bmp7	bone morphogenetic protein 7	0.314
Smad7	MAD homolog 7 (Drosophila)	0.296	Mouse
Smad6	MAD homolog 6 (Drosophila)	0.283	Mouse
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.278
Sox9	SRY-box containing gene 9	0.269
Pbx1	pre B-cell leukemia transcription factor 1	0.255
Neurod4	neurogenic differentiation 4	0.249	Mouse
Smo	smoothened homolog (Drosophila)	0.211
Tbx3	T-box 3	0.176
Col1a1	collagen, type I, alpha 1	0.172	Human
Gsk3b	glycogen synthase kinase 3 beta	0.164
Gata4	GATA binding protein 4	0.157
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.155
En1	engrailed 1	0.153
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.151
Neurog2	neurogenin 2	0.150	Mouse
Fst	follistatin	0.150
Thbs1	thrombospondin 1	0.149
Sox2	SRY-box containing gene 2	0.149
Gnrhr	gonadotropin releasing hormone receptor	0.146
Csf1	colony stimulating factor 1 (macrophage)	0.144
Gsc	goosecoid homeobox	0.143
Nhlh1	nescient helix loop helix 1	0.138	Mouse
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.136
Bmp2	bone morphogenetic protein 2	0.136
Nodal	nodal	0.135
Atoh7	atonal homolog 7 (Drosophila)	0.128	Mouse
Prrx2	paired related homeobox 2	0.126
Crb2	crumbs homolog 2 (Drosophila)	0.122
Col2a1	collagen, type II, alpha 1	0.114
Hoxd13	homeobox D13	0.100
Gas1	growth arrest specific 1	0.097
Onecut1	one cut domain, family member 1	0.096
Efnb1	ephrin B1	0.095
Runx1	runt related transcription factor 1	0.090
Hoxb1	homeobox B1	0.090
Zic3	zinc finger protein of the cerebellum 3	0.085
Sox11	SRY-box containing gene 11	0.081
Trp53	transformation related protein 53	0.081
Gata6	GATA binding protein 6	0.080
Tcfap2a	transcription factor AP-2, alpha	0.077
Pax7	paired box gene 7	0.075
Meox2	mesenchyme homeobox 2	0.074
Acvr1	activin A receptor, type 1	0.074
Lhx5	LIM homeobox protein 5	0.072
Dll1	delta-like 1 (Drosophila)	0.072
Gdf3	growth differentiation factor 3	0.070	Mouse
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.068
Gpc3	glypican 3	0.068
Pax9	paired box gene 9	0.067
Pthlh	parathyroid hormone-like peptide	0.065
Pdx1	pancreatic and duodenal homeobox 1	0.064
Nes	nestin	0.062
Axin2	axin2	0.060	Human
Efna2	ephrin A2	0.060
Lrp6	low density lipoprotein receptor-related protein 6	0.059
Pitx2	paired-like homeodomain transcription factor 2	0.059
Kiss1	KiSS-1 metastasis-suppressor	0.059
Rb1	retinoblastoma 1	0.059
Lep	leptin	0.057
Neurog3	neurogenin 3	0.056	Mouse
Wfikkn2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.056
Tlx3	T-cell leukemia, homeobox 3	0.056
Gata2	GATA binding protein 2	0.056
Mecom	MDS1 and EVI1 complex locus	0.056
Nkx3-2	NK3 homeobox 2	0.055
Rnf111	ring finger 111	0.055
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.054
Hoxa10	homeobox A10	0.053
Esr1	estrogen receptor 1 (alpha)	0.053
Foxc2	forkhead box C2	0.052
Foxd2	forkhead box D2	0.050
Col8a1	collagen, type VIII, alpha 1	0.050
Fgf8	fibroblast growth factor 8	0.050
Braf	Braf transforming gene	0.049
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.049
Insm1	insulinoma-associated 1	0.049
Mmp24	matrix metallopeptidase 24	0.048
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.047
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.047
Hmx1	H6 homeobox 1	0.047
Bdnf	brain derived neurotrophic factor	0.047
Socs1	suppressor of cytokine signaling 1	0.047
Tcf15	transcription factor 15	0.046	Mouse
Hoxa13	homeobox A13	0.044
Zeb1	zinc finger E-box binding homeobox 1	0.043
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.043
Foxg1	forkhead box G1	0.043
Foxa2	forkhead box A2	0.042
Kitl	kit ligand	0.042
Hoxd11	homeobox D11	0.042
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.042
Hoxa1	homeobox A1	0.042
Tcf7	transcription factor 7, T-cell specific	0.041
Sim2	single-minded homolog 2 (Drosophila)	0.041
Mn1	meningioma 1	0.041
Smad2	MAD homolog 2 (Drosophila)	0.040
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.039
Foxd3	forkhead box D3	0.039
Foxf2	forkhead box F2	0.039
Pkd1	polycystic kidney disease 1 homolog	0.038
Dlx5	distal-less homeobox 5	0.038
Sox13	SRY-box containing gene 13	0.037
Tbx2	T-box 2	0.037
Hoxb4	homeobox B4	0.037
Tgfbr2	transforming growth factor, beta receptor II	0.037
Zfhx3	zinc finger homeobox 3	0.037
Chrd	chordin	0.037
Gata1	GATA binding protein 1	0.037
Jag1	jagged 1	0.036
Notch3	Notch gene homolog 3 (Drosophila)	0.035	Mouse
Nog	noggin	0.035
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.034
Alx4	aristaless-like homeobox 4	0.034
Wfikkn1	WAP, FS, Ig, KU, and NTR-containing protein 1	0.034
Irs2	insulin receptor substrate 2	0.033
T	brachyury	0.033
Foxf1a	forkhead box F1a	0.033
Nkd1	naked cuticle 1 homolog (Drosophila)	0.033
Psen2	presenilin 2	0.032
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.032
Zic1	zinc finger protein of the cerebellum 1	0.032
Gdnf	glial cell line derived neurotrophic factor	0.032
Amotl2	angiomotin-like 2	0.031
Tead4	TEA domain family member 4	0.031
Npc1	Niemann Pick type C1	0.031
Bnc1	basonuclin 1	0.031
Fgf15	fibroblast growth factor 15	0.031
Lrp5	low density lipoprotein receptor-related protein 5	0.031
Tagln	transgelin	0.031
Pou3f3	POU domain, class 3, transcription factor 3	0.031
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.030
Wnt11	wingless-related MMTV integration site 11	0.030
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.029
Tbx1	T-box 1	0.029
Sox7	SRY-box containing gene 7	0.029
Ptgs2	prostaglandin-endoperoxide synthase 2	0.029
Tead3	TEA domain family member 3	0.028
Amhr2	anti-Mullerian hormone type 2 receptor	0.028
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.028
Nynrin	NYN domain and retroviral integrase containing	0.028
Hmga2	high mobility group AT-hook 2	0.027
Fbn1	fibrillin 1	0.027
Tead1	TEA domain family member 1	0.027
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.027
Jun	Jun oncogene	0.026
Nkx6-1	NK6 homeobox 1	0.026
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.026
Cyr61	cysteine rich protein 61	0.026
Adam17	a disintegrin and metallopeptidase domain 17	0.026
Ccnd1	cyclin D1	0.026
Inhba	inhibin beta-A	0.025
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.025
Wnt6	wingless-related MMTV integration site 6	0.025
Numb	numb gene homolog (Drosophila)	0.025
Eomes	eomesodermin homolog (Xenopus laevis)	0.025
Zfp703	zinc finger protein 703	0.024
Pou4f2	POU domain, class 4, transcription factor 2	0.024
Zfp503	zinc finger protein 503	0.024
Has2	hyaluronan synthase 2	0.024
Fzd2	frizzled homolog 2 (Drosophila)	0.024
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.023
Il6st	interleukin 6 signal transducer	0.023
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.023
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.023
Ahr	aryl-hydrocarbon receptor	0.023
Dlx2	distal-less homeobox 2	0.022
Pitx3	paired-like homeodomain transcription factor 3	0.022
Alx3	aristaless-like homeobox 3	0.022
Tead2	TEA domain family member 2	0.022
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.022
Ntf3	neurotrophin 3	0.022
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.022
Gdf11	growth differentiation factor 11	0.022	Mouse
Klf4	Kruppel-like factor 4 (gut)	0.022
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.022
Irx1	Iroquois related homeobox 1 (Drosophila)	0.021
Fzd8	frizzled homolog 8 (Drosophila)	0.021
Lmx1b	LIM homeobox transcription factor 1 beta	0.021
Pitx1	paired-like homeodomain transcription factor 1	0.021
Fgf17	fibroblast growth factor 17	0.021
Aplnr	apelin receptor	0.021
Zic2	zinc finger protein of the cerebellum 2	0.021
Hoxb6	homeobox B6	0.020
Efnb2	ephrin B2	0.020
Reg3a	regenerating islet-derived 3 alpha	0.020
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.020
Hoxa4	homeobox A4	0.020
Hoxd1	homeobox D1	0.020
Prx	periaxin	0.020
Col5a1	collagen, type V, alpha 1	0.020
Atoh8	atonal homolog 8 (Drosophila)	0.020
Hes5	hairy and enhancer of split 5 (Drosophila)	0.020
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.020
Tbx6	T-box 6	0.019
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.019
Hoxa2	homeobox A2	0.019
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.019
Fgf18	fibroblast growth factor 18	0.019
Arx	aristaless related homeobox	0.019
Efna5	ephrin A5	0.019
Irx3	Iroquois related homeobox 3 (Drosophila)	0.019
Foxe3	forkhead box E3	0.019
Pkdcc	protein kinase domain containing, cytoplasmic	0.018
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.018
Matn3	matrilin 3	0.018
Gpr50	G-protein-coupled receptor 50	0.018
Vdr	vitamin D receptor	0.018
Emid2	EMI domain containing 2	0.018
Isl1	ISL1 transcription factor, LIM/homeodomain	0.018
Efs	embryonal Fyn-associated substrate	0.018
Nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.018
Dab1	disabled homolog 1 (Drosophila)	0.018	Mouse
Msi1	Musashi homolog 1(Drosophila)	0.018
She	src homology 2 domain-containing transforming protein E	0.017
Kctd10	potassium channel tetramerisation domain containing 10	0.017
Mmp11	matrix metallopeptidase 11	0.017
Tcf3	transcription factor 3	0.017
Hoxc8	homeobox C8	0.017
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.017
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.017
Hoxd10	homeobox D10	0.017
Irx5	Iroquois related homeobox 5 (Drosophila)	0.017
Wnt4	wingless-related MMTV integration site 4	0.017
Lpar1	lysophosphatidic acid receptor 1	0.017
Cdh1	cadherin 1	0.017
Tcf21	transcription factor 21	0.017
Tcfap2b	transcription factor AP-2 beta	0.017
Acvr2b	activin receptor IIB	0.017
Shox2	short stature homeobox 2	0.016
Fhl3	four and a half LIM domains 3	0.016
Alx1	ALX homeobox 1	0.016
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.016
Crb1	crumbs homolog 1 (Drosophila)	0.016	Mouse
Ptk7	PTK7 protein tyrosine kinase 7	0.016
Igfbp5	insulin-like growth factor binding protein 5	0.016
Evx2	even skipped homeotic gene 2 homolog	0.016
Fzd7	frizzled homolog 7 (Drosophila)	0.016
Rim4	recombination induced mutation 4	0.016
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.016
Apcdd1	adenomatosis polyposis coli down-regulated 1	0.016
Ebf2	early B-cell factor 2	0.016
Il11	interleukin 11	0.016
Uncx	UNC homeobox	0.015
Lrp2	low density lipoprotein receptor-related protein 2	0.015
Hes2	hairy and enhancer of split 2 (Drosophila)	0.015
App	amyloid beta (A4) precursor protein	0.015
Cnn1	calponin 1	0.015
Nfe2	nuclear factor, erythroid derived 2	0.015
Cbfb	core binding factor beta	0.015
Fgfr3	fibroblast growth factor receptor 3	0.015
Hhex	hematopoietically expressed homeobox	0.015
Dlx6	distal-less homeobox 6	0.015
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.015
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.015
Rhag	Rhesus blood group-associated A glycoprotein	0.015
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.014
Ctnnd1	catenin (cadherin associated protein), delta 1	0.014
Cdx2	caudal type homeobox 2	0.014
Sall3	sal-like 3 (Drosophila)	0.014
Plin1	perilipin 1	0.014
Slc25a29	solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29	0.014
Nos3	nitric oxide synthase 3, endothelial cell	0.014
Gata3	GATA binding protein 3	0.014
Rho	rhodopsin	0.014
Wnt3a	wingless-related MMTV integration site 3A	0.014
Hoxa7	homeobox A7	0.014
Isl2	insulin related protein 2 (islet 2)	0.014
Fkbp10	FK506 binding protein 10	0.013
Creb3l1	cAMP responsive element binding protein 3-like 1	0.013
Wiz	widely-interspaced zinc finger motifs	0.013
Angptl2	angiopoietin-like 2	0.013
Tgif2	TGFB-induced factor homeobox 2	0.013
Dag1	dystroglycan 1	0.013
Apon	apolipoprotein N	0.013
Sox4	SRY-box containing gene 4	0.013
Id3	inhibitor of DNA binding 3	0.013
Pou3f2	POU domain, class 3, transcription factor 2	0.013
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.013
Foxb1	forkhead box B1	0.013
Hoxb5	homeobox B5	0.013
Foxd4	forkhead box D4	0.013
Erbb2ip	Erbb2 interacting protein	0.013
Hoxa11	homeobox A11	0.013
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.013
Jarid2	jumonji, AT rich interactive domain 2	0.013
Hoxa5	homeobox A5	0.013
Sox1	SRY-box containing gene 1	0.013
Sall4	sal-like 4 (Drosophila)	0.013
Wnt5a	wingless-related MMTV integration site 5A	0.013
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.013
Foxh1	forkhead box H1	0.012
Cbl	Casitas B-lineage lymphoma	0.012
Fgf4	fibroblast growth factor 4	0.012
Lhx1	LIM homeobox protein 1	0.012
Sox21	SRY-box containing gene 21	0.012
Hoxb9	homeobox B9	0.012
Hdac7	histone deacetylase 7	0.012
F2r	coagulation factor II (thrombin) receptor	0.012
Marveld1	MARVEL (membrane-associating) domain containing 1	0.012
Wwtr1	WW domain containing transcription regulator 1	0.012	Human
Bcl2	B-cell leukemia/lymphoma 2	0.012
Inhbb	inhibin beta-B	0.012
Gdf1	growth differentiation factor 1	0.012	Mouse
Pdgfa	platelet derived growth factor, alpha	0.012
Hoxc6	homeobox C6	0.012
Glra1	glycine receptor, alpha 1 subunit	0.012
Tbx5	T-box 5	0.012
Atoh1	atonal homolog 1 (Drosophila)	0.012	Mouse
Foxp1	forkhead box P1	0.012
Trim10	tripartite motif-containing 10	0.012
Tal1	T-cell acute lymphocytic leukemia 1	0.012	Mouse
Nostrin	nitric oxide synthase trafficker	0.012
Ntn3	netrin 3	0.012
Tcfap2c	transcription factor AP-2, gamma	0.012
Tdgf1	teratocarcinoma-derived growth factor 1	0.012
Dll4	delta-like 4 (Drosophila)	0.012
Hbegf	heparin-binding EGF-like growth factor	0.012
Lhx6	LIM homeobox protein 6	0.012
Cer1	cerberus 1 homolog (Xenopus laevis)	0.011
Egr1	early growth response 1	0.011
Ddr2	discoidin domain receptor family, member 2	0.011
Hoxd3	homeobox D3	0.011
Myod1	myogenic differentiation 1	0.011
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.011
BC057022	cDNA sequence BC057022	0.011
Whrn	whirlin	0.011
Col4a1	collagen, type IV, alpha 1	0.011
Mnx1	motor neuron and pancreas homeobox 1	0.011
Kit	kit oncogene	0.011
Sh3rf1	SH3 domain containing ring finger 1	0.011
Tal2	T-cell acute lymphocytic leukemia 2	0.011	Mouse
Fbln2	fibulin 2	0.011
Myf5	myogenic factor 5	0.011
Tcf4	transcription factor 4	0.011
Ctgf	connective tissue growth factor	0.011
Adra2a	adrenergic receptor, alpha 2a	0.011
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.011
Twist1	twist homolog 1 (Drosophila)	0.011
Cux2	cut-like homeobox 2	0.011
Col9a1	collagen, type IX, alpha 1	0.011
Epha2	Eph receptor A2	0.011
Lgr5	leucine rich repeat containing G protein coupled receptor 5	0.011
Hlx	H2.0-like homeobox	0.010
Sh3pxd2a	SH3 and PX domains 2A	0.010
Dkk2	dickkopf homolog 2 (Xenopus laevis)	0.010
Ankrd33	ankyrin repeat domain 33	0.010
Slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.010
Srrm4	serine/arginine repetitive matrix 4	0.010
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.010
Hnf4a	hepatic nuclear factor 4, alpha	0.010