IMP

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Mus musculus

19 genes annotated in mouse

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endochondral bone growth

GO:0003416

The increase in size or mass of an endochondral bone that contributes to the shaping of the bone.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endochondral bone growth"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "endochondral bone growth" (in gray)

Name	Description	Probability	Func Analog Organism
Tgfbr2	transforming growth factor, beta receptor II	0.986
Rarg	retinoic acid receptor, gamma	0.941
Fgfr2	fibroblast growth factor receptor 2	0.938
Prrx1	paired related homeobox 1	0.833
Prrx2	paired related homeobox 2	0.815
Rara	retinoic acid receptor, alpha	0.804
Foxc1	forkhead box C1	0.785
Shh	sonic hedgehog	0.762
Fgfr1	fibroblast growth factor receptor 1	0.744
Fbn1	fibrillin 1	0.693
Lox	lysyl oxidase	0.665
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.644	Mouse
Gli2	GLI-Kruppel family member GLI2	0.635
Bmp4	bone morphogenetic protein 4	0.592
Twist2	twist homolog 2 (Drosophila)	0.586
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.531
Hoxa3	homeobox A3	0.494
Gli3	GLI-Kruppel family member GLI3	0.482
Fgfr3	fibroblast growth factor receptor 3	0.460
Smo	smoothened homolog (Drosophila)	0.417
Eya1	eyes absent 1 homolog (Drosophila)	0.408
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.400
Foxc2	forkhead box C2	0.399
Tgfb2	transforming growth factor, beta 2	0.387
Fgf8	fibroblast growth factor 8	0.382
Pax3	paired box gene 3	0.356
Acvr1	activin A receptor, type 1	0.331	Mouse
Wt1	Wilms tumor 1 homolog	0.325
Apc	adenomatosis polyposis coli	0.315
Tcfap2a	transcription factor AP-2, alpha	0.315
Sox9	SRY-box containing gene 9	0.283
Tgfbr1	transforming growth factor, beta receptor I	0.254	Mouse
Smad3	MAD homolog 3 (Drosophila)	0.253
Isl1	ISL1 transcription factor, LIM/homeodomain	0.230
Chrd	chordin	0.222
Evc2	Ellis van Creveld syndrome 2 homolog (human)	0.217
Ece1	endothelin converting enzyme 1	0.200
Nodal	nodal	0.195
Pten	phosphatase and tensin homolog	0.193
Pitx2	paired-like homeodomain transcription factor 2	0.177
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.174
Hand1	heart and neural crest derivatives expressed transcript 1	0.166
Rarb	retinoic acid receptor, beta	0.157
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.150
Otx2	orthodenticle homolog 2 (Drosophila)	0.149
Egfr	epidermal growth factor receptor	0.142
Pax8	paired box gene 8	0.141
Thbs2	thrombospondin 2	0.139	Mouse
Hoxa2	homeobox A2	0.132
Smad4	MAD homolog 4 (Drosophila)	0.127
Snai1	snail homolog 1 (Drosophila)	0.123
Ednra	endothelin receptor type A	0.119
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.110
Hoxb3	homeobox B3	0.104
Vegfa	vascular endothelial growth factor A	0.104
Ctnnb1	catenin (cadherin associated protein), beta 1	0.101
Hand2	heart and neural crest derivatives expressed transcript 2	0.099
Inhba	inhibin beta-A	0.092
En1	engrailed 1	0.091
Tgfbr3	transforming growth factor, beta receptor III	0.086
Tbx1	T-box 1	0.085
Thra	thyroid hormone receptor alpha	0.085	Mouse
Col11a1	collagen, type XI, alpha 1	0.084
Pax2	paired box gene 2	0.084
Ltbp2	latent transforming growth factor beta binding protein 2	0.083
Col1a1	collagen, type I, alpha 1	0.077
Fgf7	fibroblast growth factor 7	0.076
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.074
Col16a1	collagen, type XVI, alpha 1	0.071
Hoxa1	homeobox A1	0.068
Sox4	SRY-box containing gene 4	0.068
Aebp1	AE binding protein 1	0.068
Dlx2	distal-less homeobox 2	0.067
Rxra	retinoid X receptor alpha	0.066
Cyp1b1	cytochrome P450, family 1, subfamily b, polypeptide 1	0.065
Hoxa5	homeobox A5	0.063
Msx2	homeobox, msh-like 2	0.063
Nos3	nitric oxide synthase 3, endothelial cell	0.061
Ltbp3	latent transforming growth factor beta binding protein 3	0.060
Fbln1	fibulin 1	0.058
C1qtnf1	C1q and tumor necrosis factor related protein 1	0.057
Fst	follistatin	0.054
Hoxd11	homeobox D11	0.054
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.053
Tecta	tectorin alpha	0.053
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.052
Meox2	mesenchyme homeobox 2	0.052
Col8a1	collagen, type VIII, alpha 1	0.052
Alx3	aristaless-like homeobox 3	0.050
Jag1	jagged 1	0.050
Twist1	twist homolog 1 (Drosophila)	0.048
Gfpt2	glutamine fructose-6-phosphate transaminase 2	0.048
Fshr	follicle stimulating hormone receptor	0.048
Esr1	estrogen receptor 1 (alpha)	0.047
Dlx5	distal-less homeobox 5	0.047
Pax9	paired box gene 9	0.047
Pkd1	polycystic kidney disease 1 homolog	0.046
Wisp1	WNT1 inducible signaling pathway protein 1	0.046
Lhx1	LIM homeobox protein 1	0.046
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.045
Thbs1	thrombospondin 1	0.044
Mdm2	transformed mouse 3T3 cell double minute 2	0.044
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.043
Ctsk	cathepsin K	0.042
Il1rn	interleukin 1 receptor antagonist	0.042
Slc10a6	solute carrier family 10 (sodium/bile acid cotransporter family), member 6	0.041
Rbl2	retinoblastoma-like 2	0.040
Gdnf	glial cell line derived neurotrophic factor	0.040
Htra3	HtrA serine peptidase 3	0.040
Col12a1	collagen, type XII, alpha 1	0.039
Crlf1	cytokine receptor-like factor 1	0.039
Dbp	D site albumin promoter binding protein	0.039
Hoxd3	homeobox D3	0.039
Acvrl1	activin A receptor, type II-like 1	0.039	Mouse
Mfap5	microfibrillar associated protein 5	0.038
Eln	elastin	0.038
Tshr	thyroid stimulating hormone receptor	0.037
Runx2	runt related transcription factor 2	0.037
Bmper	BMP-binding endothelial regulator	0.037
Creb3l1	cAMP responsive element binding protein 3-like 1	0.037
Bmp7	bone morphogenetic protein 7	0.036
Ptx3	pentraxin related gene	0.036
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.036
Gab2	growth factor receptor bound protein 2-associated protein 2	0.035
Fgfrl1	fibroblast growth factor receptor-like 1	0.034
Srpx	sushi-repeat-containing protein	0.034
Trp53	transformation related protein 53	0.033
Mmp2	matrix metallopeptidase 2	0.033	Mouse
Col6a3	collagen, type VI, alpha 3	0.033
C5ar1	complement component 5a receptor 1	0.032
Fzd1	frizzled homolog 1 (Drosophila)	0.031
Col6a2	collagen, type VI, alpha 2	0.031
Loxl1	lysyl oxidase-like 1	0.031
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.031
Duox2	dual oxidase 2	0.030
Mgp	matrix Gla protein	0.030
Smoc2	SPARC related modular calcium binding 2	0.030
Hic1	hypermethylated in cancer 1	0.030
Nog	noggin	0.029
Foxd1	forkhead box D1	0.029
Hoxa11	homeobox A11	0.029
Wnt4	wingless-related MMTV integration site 4	0.029
Fbn2	fibrillin 2	0.029
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.028
Fgf9	fibroblast growth factor 9	0.028
Ptch1	patched homolog 1	0.028
Ltbp1	latent transforming growth factor beta binding protein 1	0.028
Gpc3	glypican 3	0.027
Fgf18	fibroblast growth factor 18	0.027
Grem1	gremlin 1	0.027	Mouse
Clec4d	C-type lectin domain family 4, member d	0.027
Svep1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	0.026
Tll1	tolloid-like	0.026
Tbx15	T-box 15	0.026
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.026
Fgf2	fibroblast growth factor 2	0.026
Igfbp6	insulin-like growth factor binding protein 6	0.026
Fzd2	frizzled homolog 2 (Drosophila)	0.026
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.025
Zfp503	zinc finger protein 503	0.025
Bmp5	bone morphogenetic protein 5	0.025
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.025
Ch25h	cholesterol 25-hydroxylase	0.025
Inhbb	inhibin beta-B	0.024
Ret	ret proto-oncogene	0.024
Matn4	matrilin 4	0.024	Mouse
Col11a2	collagen, type XI, alpha 2	0.024
Dpt	dermatopontin	0.023
Apoe	apolipoprotein E	0.023
Adamts2	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2	0.023
Prkg1	protein kinase, cGMP-dependent, type I	0.023
Mfap4	microfibrillar-associated protein 4	0.023
Gja1	gap junction protein, alpha 1	0.023
Mrc2	mannose receptor, C type 2	0.022
Fbln2	fibulin 2	0.022
Idua	iduronidase, alpha-L-	0.022
Plat	plasminogen activator, tissue	0.022
Nanog	Nanog homeobox	0.022
Hes1	hairy and enhancer of split 1 (Drosophila)	0.022
Ngp	neutrophilic granule protein	0.022
Tef	thyrotroph embryonic factor	0.022
Csf1	colony stimulating factor 1 (macrophage)	0.022
Cd44	CD44 antigen	0.021
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.021
Figf	c-fos induced growth factor	0.021
Npc1	Niemann Pick type C1	0.021
Zic3	zinc finger protein of the cerebellum 3	0.021
Tead3	TEA domain family member 3	0.021
Thbs3	thrombospondin 3	0.020
Arhgef25	Rho guanine nucleotide exchange factor (GEF) 25	0.020
Npr2	natriuretic peptide receptor 2	0.020
Mia1	melanoma inhibitory activity 1	0.020
Htr2b	5-hydroxytryptamine (serotonin) receptor 2B	0.020
Disp1	dispatched homolog 1 (Drosophila)	0.020
Prss12	protease, serine, 12 neurotrypsin (motopsin)	0.019
Col2a1	collagen, type II, alpha 1	0.019
Col5a1	collagen, type V, alpha 1	0.019
Ptk7	PTK7 protein tyrosine kinase 7	0.019
C3ar1	complement component 3a receptor 1	0.019
S100a8	S100 calcium binding protein A8 (calgranulin A)	0.018
Hoxd9	homeobox D9	0.018
Wnt9b	wingless-type MMTV integration site 9B	0.018
Apod	apolipoprotein D	0.018
Adam8	a disintegrin and metallopeptidase domain 8	0.018
Hoxd10	homeobox D10	0.018
Calca	calcitonin/calcitonin-related polypeptide, alpha	0.018
S100a9	S100 calcium binding protein A9 (calgranulin B)	0.018
Shox2	short stature homeobox 2	0.018
Scara3	scavenger receptor class A, member 3	0.018
Lef1	lymphoid enhancer binding factor 1	0.018
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.018
Emx2	empty spiracles homolog 2 (Drosophila)	0.018
Nf1	neurofibromatosis 1	0.018
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.018
Bptf	bromodomain PHD finger transcription factor	0.018
Ncoa2	nuclear receptor coactivator 2	0.018
Fibin	fin bud initiation factor homolog (zebrafish)	0.017
Ccl7	chemokine (C-C motif) ligand 7	0.017
Dlk1	delta-like 1 homolog (Drosophila)	0.017
Smad6	MAD homolog 6 (Drosophila)	0.017
Serpinb2	serine (or cysteine) peptidase inhibitor, clade B, member 2	0.017
Tgfb3	transforming growth factor, beta 3	0.017
Col9a2	collagen, type IX, alpha 2	0.016
Gata4	GATA binding protein 4	0.016
Sfrp2	secreted frizzled-related protein 2	0.016
Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	0.016
Angptl2	angiopoietin-like 2	0.016
Slit3	slit homolog 3 (Drosophila)	0.016
Has1	hyaluronan synthase1	0.016
Dio2	deiodinase, iodothyronine, type II	0.016
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.016
Osr1	odd-skipped related 1 (Drosophila)	0.016
Wnt11	wingless-related MMTV integration site 11	0.015
Usp9x	ubiquitin specific peptidase 9, X chromosome	0.015
Pthlh	parathyroid hormone-like peptide	0.015
Shc1	src homology 2 domain-containing transforming protein C1	0.015
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.015
Epha3	Eph receptor A3	0.015
Yap1	yes-associated protein 1	0.015
Sphk1	sphingosine kinase 1	0.015
Bmpr1b	bone morphogenetic protein receptor, type 1B	0.015	Mouse
Mmp3	matrix metallopeptidase 3	0.015	Mouse
Il6	interleukin 6	0.015
Trim47	tripartite motif-containing 47	0.015
Bmp2	bone morphogenetic protein 2	0.015
Foxf1a	forkhead box F1a	0.015
Krtap3-3	keratin associated protein 3-3	0.015
Mst1r	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	0.015
Tpbg	trophoblast glycoprotein	0.014
Wisp2	WNT1 inducible signaling pathway protein 2	0.014
Pkp1	plakophilin 1	0.014
Tmem119	transmembrane protein 119	0.014
Smad7	MAD homolog 7 (Drosophila)	0.014
Adora2b	adenosine A2b receptor	0.014
Sox2	SRY-box containing gene 2	0.014
Gsc	goosecoid homeobox	0.014
Sntb2	syntrophin, basic 2	0.014
Otx1	orthodenticle homolog 1 (Drosophila)	0.014
Actg2	actin, gamma 2, smooth muscle, enteric	0.014
Sorbs3	sorbin and SH3 domain containing 3	0.013
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.013
Hipk3	homeodomain interacting protein kinase 3	0.013
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.013
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.013
Lpar1	lysophosphatidic acid receptor 1	0.013
Homer3	homer homolog 3 (Drosophila)	0.013
Itgb3	integrin beta 3	0.013
Hoxa7	homeobox A7	0.013
Boc	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	0.013
Itgbl1	integrin, beta-like 1	0.013
Gas1	growth arrest specific 1	0.013
Nkx3-2	NK3 homeobox 2	0.013
Vangl2	vang-like 2 (van gogh, Drosophila)	0.013
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.013
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.013
Rtkn	rhotekin	0.013
Ubap2	ubiquitin-associated protein 2	0.013
Kcne4	potassium voltage-gated channel, Isk-related subfamily, gene 4	0.013
Agtr2	angiotensin II receptor, type 2	0.012
Leprel2	leprecan-like 2	0.012
Mkl2	MKL/myocardin-like 2	0.012
Map3k6	mitogen-activated protein kinase kinase kinase 6	0.012
Foxg1	forkhead box G1	0.012
Mmp10	matrix metallopeptidase 10	0.012	Mouse
Itga8	integrin alpha 8	0.012
Spsb1	splA/ryanodine receptor domain and SOCS box containing 1	0.012
Fzd7	frizzled homolog 7 (Drosophila)	0.012
Hoxc5	homeobox C5	0.012
Lefty1	left right determination factor 1	0.012
Emilin3	elastin microfibril interfacer 3	0.012
Lhx8	LIM homeobox protein 8	0.012
Col6a1	collagen, type VI, alpha 1	0.012
C1qtnf3	C1q and tumor necrosis factor related protein 3	0.012
Bcl2l10	Bcl2-like 10	0.012
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.012
Fmn1	formin 1	0.012
Nrk	Nik related kinase	0.012
Pitx1	paired-like homeodomain transcription factor 1	0.012
Tpo	thyroid peroxidase	0.012
Mfap2	microfibrillar-associated protein 2	0.012
Msr1	macrophage scavenger receptor 1	0.012
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.012
Fmod	fibromodulin	0.012
Npr3	natriuretic peptide receptor 3	0.012
Marveld1	MARVEL (membrane-associating) domain containing 1	0.012
Plcd1	phospholipase C, delta 1	0.012
Nynrin	NYN domain and retroviral integrase containing	0.012
Musk	muscle, skeletal, receptor tyrosine kinase	0.012
Mmp16	matrix metallopeptidase 16	0.012
Tppp3	tubulin polymerization-promoting protein family member 3	0.011
Chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)	0.011	Zebrafish
Plagl1	pleiomorphic adenoma gene-like 1	0.011
Pld1	phospholipase D1	0.011
Pappa	pregnancy-associated plasma protein A	0.011
Zfp362	zinc finger protein 362	0.011
Hr	hairless	0.011
Prkg2	protein kinase, cGMP-dependent, type II	0.011
Itgb4	integrin beta 4	0.011
Ext1	exostoses (multiple) 1	0.011
Gm22	predicted gene 22	0.011
Mrgprf	MAS-related GPR, member F	0.011
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.011
Tnfaip6	tumor necrosis factor alpha induced protein 6	0.011
Smad5	MAD homolog 5 (Drosophila)	0.011
Col19a1	collagen, type XIX, alpha 1	0.011
Runx1	runt related transcription factor 1	0.011
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.011
Ntn1	netrin 1	0.011
Robo3	roundabout homolog 3 (Drosophila)	0.011
1500015O10Rik	RIKEN cDNA 1500015O10 gene	0.011
Tenc1	tensin like C1 domain-containing phosphatase	0.011
Il6st	interleukin 6 signal transducer	0.011
Prdm16	PR domain containing 16	0.011
Has2	hyaluronan synthase 2	0.011
Slc7a11	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	0.011
Lamc2	laminin, gamma 2	0.011
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.011
Col10a1	collagen, type X, alpha 1	0.011
Gpr133	G protein-coupled receptor 133	0.011
Gbx2	gastrulation brain homeobox 2	0.011
Pbx1	pre B-cell leukemia transcription factor 1	0.011
Ccl2	chemokine (C-C motif) ligand 2	0.011
Timp3	tissue inhibitor of metalloproteinase 3	0.011
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.011
Acan	aggrecan	0.011
Adam33	a disintegrin and metallopeptidase domain 33	0.011
Artn	artemin	0.010
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.010
Klhl24	kelch-like 24 (Drosophila)	0.010
Hoxb4	homeobox B4	0.010
Krt19	keratin 19	0.010
Ncoa1	nuclear receptor coactivator 1	0.010
Tnmd	tenomodulin	0.010
Fgf17	fibroblast growth factor 17	0.010
Dsg4	desmoglein 4	0.010
Fstl3	follistatin-like 3	0.010
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.010
Alx4	aristaless-like homeobox 4	0.010
Il12b	interleukin 12b	0.010
Hoxb6	homeobox B6	0.010
Timp1	tissue inhibitor of metalloproteinase 1	0.010
Ar	androgen receptor	0.010
Fgf5	fibroblast growth factor 5	0.010
Apln	apelin	0.010
Chi3l3	chitinase 3-like 3	0.010
Col17a1	collagen, type XVII, alpha 1	0.010
Cry2	cryptochrome 2 (photolyase-like)	0.010
Clec4e	C-type lectin domain family 4, member e	0.010
Rspo1	R-spondin homolog (Xenopus laevis)	0.010
Itga10	integrin, alpha 10	0.010