IMP

Process View

Mus musculus

10 genes annotated in mouse

epithelial to mesenchymal transition involved in endocardial cushion formation

A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "epithelial to mesenchymal transition involved in endocardial cushion formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "epithelial to mesenchymal transition involved in endocardial cushion formation" (in gray)

Name	Description	Probability	Func Analog Organism
Ctnnb1	catenin (cadherin associated protein), beta 1	1.000
Smad4	MAD homolog 4 (Drosophila)	1.000
Notch1	Notch gene homolog 1 (Drosophila)	1.000
Jag1	jagged 1	1.000
Hand2	heart and neural crest derivatives expressed transcript 2	0.999
Foxc1	forkhead box C1	0.999
Gata4	GATA binding protein 4	0.999
Msx1	homeobox, msh-like 1	0.992
Shh	sonic hedgehog	0.991
Fgf8	fibroblast growth factor 8	0.990
Fgfr1	fibroblast growth factor receptor 1	0.986
Bmp4	bone morphogenetic protein 4	0.982
Efnb2	ephrin B2	0.982
Tgfb2	transforming growth factor, beta 2	0.979
Smad6	MAD homolog 6 (Drosophila)	0.978	Mouse
Pitx2	paired-like homeodomain transcription factor 2	0.972
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.966
Tbx1	T-box 1	0.966
Fgfr2	fibroblast growth factor receptor 2	0.950
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.942
Gli3	GLI-Kruppel family member GLI3	0.938
Smad3	MAD homolog 3 (Drosophila)	0.934	Mouse
Foxc2	forkhead box C2	0.926
Hand1	heart and neural crest derivatives expressed transcript 1	0.906
Hes1	hairy and enhancer of split 1 (Drosophila)	0.906
Axin1	axin 1	0.878
Dll1	delta-like 1 (Drosophila)	0.873
Psen1	presenilin 1	0.852
Notch2	Notch gene homolog 2 (Drosophila)	0.801	Mouse
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.800
Tbx3	T-box 3	0.795
Otx2	orthodenticle homolog 2 (Drosophila)	0.792
Smad1	MAD homolog 1 (Drosophila)	0.791	Mouse
Pax3	paired box gene 3	0.784
Prrx1	paired related homeobox 1	0.782
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.737
Prrx2	paired related homeobox 2	0.725
Ednra	endothelin receptor type A	0.721
Smo	smoothened homolog (Drosophila)	0.720
Gsc	goosecoid homeobox	0.665
Apc	adenomatosis polyposis coli	0.660
Eya1	eyes absent 1 homolog (Drosophila)	0.643
Lmx1b	LIM homeobox transcription factor 1 beta	0.640
Gata6	GATA binding protein 6	0.630
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.603	Mouse
Acvr1	activin A receptor, type 1	0.571
Hoxa2	homeobox A2	0.568
Lef1	lymphoid enhancer binding factor 1	0.564
Tbx2	T-box 2	0.557
Dll4	delta-like 4 (Drosophila)	0.549
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.503
Msx2	homeobox, msh-like 2	0.499
Pax2	paired box gene 2	0.480
Bmp7	bone morphogenetic protein 7	0.464
Hoxa1	homeobox A1	0.442
Sox9	SRY-box containing gene 9	0.437
She	src homology 2 domain-containing transforming protein E	0.430
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.427
Nodal	nodal	0.388
Dlx5	distal-less homeobox 5	0.366
Gli2	GLI-Kruppel family member GLI2	0.364
Ntf3	neurotrophin 3	0.344
Nos3	nitric oxide synthase 3, endothelial cell	0.342
Pten	phosphatase and tensin homolog	0.341
Chd7	chromodomain helicase DNA binding protein 7	0.337
En1	engrailed 1	0.331
Tcfap2a	transcription factor AP-2, alpha	0.316
Smad2	MAD homolog 2 (Drosophila)	0.296	Mouse
Rxra	retinoid X receptor alpha	0.273
Snai1	snail homolog 1 (Drosophila)	0.254
Foxf1a	forkhead box F1a	0.248
Efnb1	ephrin B1	0.245
Alx4	aristaless-like homeobox 4	0.239
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.229
Erbb2ip	Erbb2 interacting protein	0.215
Sox18	SRY-box containing gene 18	0.204
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.202
Pthlh	parathyroid hormone-like peptide	0.199
Notch3	Notch gene homolog 3 (Drosophila)	0.191	Mouse
Sox7	SRY-box containing gene 7	0.185
Rarg	retinoic acid receptor, gamma	0.177
Zfpm2	zinc finger protein, multitype 2	0.173
Lrp6	low density lipoprotein receptor-related protein 6	0.171
Vegfa	vascular endothelial growth factor A	0.162
Pcdh12	protocadherin 12	0.152
Pbx1	pre B-cell leukemia transcription factor 1	0.152
Wnt3a	wingless-related MMTV integration site 3A	0.148
Foxg1	forkhead box G1	0.133
Gata2	GATA binding protein 2	0.128
Gbx2	gastrulation brain homeobox 2	0.124
Gsk3b	glycogen synthase kinase 3 beta	0.121
Wnt11	wingless-related MMTV integration site 11	0.120
Sox17	SRY-box containing gene 17	0.119
Tcf15	transcription factor 15	0.115
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.114
Mesp1	mesoderm posterior 1	0.113
Ptch1	patched homolog 1	0.099
Fgfr3	fibroblast growth factor receptor 3	0.099
Egfl7	EGF-like domain 7	0.098
Pitx1	paired-like homeodomain transcription factor 1	0.097
Tgfbr2	transforming growth factor, beta receptor II	0.097
Smad7	MAD homolog 7 (Drosophila)	0.096	Mouse
Sox2	SRY-box containing gene 2	0.094
Gja1	gap junction protein, alpha 1	0.092
Meox2	mesenchyme homeobox 2	0.092
Otx1	orthodenticle homolog 1 (Drosophila)	0.090
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.086
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.086
Foxh1	forkhead box H1	0.085
Klf3	Kruppel-like factor 3 (basic)	0.080
Kitl	kit ligand	0.077
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.076
Hr	hairless	0.074
Rnf111	ring finger 111	0.070
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.068
Ptf1a	pancreas specific transcription factor, 1a	0.068
Gata3	GATA binding protein 3	0.067
Bmp2	bone morphogenetic protein 2	0.067
Tbx4	T-box 4	0.066
Heyl	hairy/enhancer-of-split related with YRPW motif-like	0.065
Emx1	empty spiracles homolog 1 (Drosophila)	0.063
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.062
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.058
Axin2	axin2	0.058
Fzd2	frizzled homolog 2 (Drosophila)	0.057
Hoxa3	homeobox A3	0.055
Col13a1	collagen, type XIII, alpha 1	0.055
Dlx2	distal-less homeobox 2	0.054
Aplnr	apelin receptor	0.053
Gli1	GLI-Kruppel family member GLI1	0.053
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.052
Wnt6	wingless-related MMTV integration site 6	0.052
Alx3	aristaless-like homeobox 3	0.052
Bnc1	basonuclin 1	0.051
Tcf21	transcription factor 21	0.050
Ptk7	PTK7 protein tyrosine kinase 7	0.050
Sox13	SRY-box containing gene 13	0.048
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.048
Kdr	kinase insert domain protein receptor	0.048
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.047
Hif1a	hypoxia inducible factor 1, alpha subunit	0.047
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.047
Ager	advanced glycosylation end product-specific receptor	0.046
Amhr2	anti-Mullerian hormone type 2 receptor	0.046
Pax6	paired box gene 6	0.044
Gas1	growth arrest specific 1	0.044
Braf	Braf transforming gene	0.043
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.043
Adcy4	adenylate cyclase 4	0.042
Nkd1	naked cuticle 1 homolog (Drosophila)	0.041
Atoh8	atonal homolog 8 (Drosophila)	0.038
Fgf15	fibroblast growth factor 15	0.038
Trp53	transformation related protein 53	0.038
Tbx5	T-box 5	0.038
Ece1	endothelin converting enzyme 1	0.035
Chrd	chordin	0.033
Zeb1	zinc finger E-box binding homeobox 1	0.033
Hmx1	H6 homeobox 1	0.033
Sp6	trans-acting transcription factor 6	0.032
BC020535	cDNA sequence BC020535	0.032
Tead2	TEA domain family member 2	0.031
Psen2	presenilin 2	0.031
Yap1	yes-associated protein 1	0.030
Hes5	hairy and enhancer of split 5 (Drosophila)	0.030
Mrc2	mannose receptor, C type 2	0.029
Foxd3	forkhead box D3	0.028
Lhx1	LIM homeobox protein 1	0.028
Pax9	paired box gene 9	0.028
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.028
Cdh5	cadherin 5	0.027
Foxo1	forkhead box O1	0.027
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.026
Emid2	EMI domain containing 2	0.025
Pou3f3	POU domain, class 3, transcription factor 3	0.025
Pitx3	paired-like homeodomain transcription factor 3	0.025
Col4a1	collagen, type IV, alpha 1	0.025
Zfp362	zinc finger protein 362	0.025
Bcl6b	B-cell CLL/lymphoma 6, member B	0.025
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.025
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.025
Hoxb4	homeobox B4	0.025
Gpc3	glypican 3	0.025
Lrp5	low density lipoprotein receptor-related protein 5	0.024
Obsl1	obscurin-like 1	0.024
Nes	nestin	0.023
Efna4	ephrin A4	0.023
Runx2	runt related transcription factor 2	0.023
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.022
Hoxd13	homeobox D13	0.022
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.022
Hoxb6	homeobox B6	0.022
Smurf1	SMAD specific E3 ubiquitin protein ligase 1	0.021
Gja4	gap junction protein, alpha 4	0.021
Zfp503	zinc finger protein 503	0.021
Wwtr1	WW domain containing transcription regulator 1	0.021
Hoxa13	homeobox A13	0.021
Neurog1	neurogenin 1	0.021
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.021
Hic1	hypermethylated in cancer 1	0.020
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.020
Sall4	sal-like 4 (Drosophila)	0.020
Gata5	GATA binding protein 5	0.020
En2	engrailed 2	0.020
Hoxa4	homeobox A4	0.020
Vax1	ventral anterior homeobox containing gene 1	0.020
Hmx3	H6 homeobox 3	0.019
Esr2	estrogen receptor 2 (beta)	0.019
Irx4	Iroquois related homeobox 4 (Drosophila)	0.019
Flt4	FMS-like tyrosine kinase 4	0.019
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.019
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.019
Tlx3	T-cell leukemia, homeobox 3	0.019
Vangl2	vang-like 2 (van gogh, Drosophila)	0.018
Lmx1a	LIM homeobox transcription factor 1 alpha	0.018
Foxn1	forkhead box N1	0.018
Jun	Jun oncogene	0.018
Nog	noggin	0.018
Tcfap2c	transcription factor AP-2, gamma	0.018
Prdm1	PR domain containing 1, with ZNF domain	0.017
Hes3	hairy and enhancer of split 3 (Drosophila)	0.017
Foxa2	forkhead box A2	0.017
Hoxb3	homeobox B3	0.017
Pou4f3	POU domain, class 4, transcription factor 3	0.017
Efna2	ephrin A2	0.017
Col4a2	collagen, type IV, alpha 2	0.017
Amotl2	angiomotin-like 2	0.017
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.016
Twist2	twist homolog 2 (Drosophila)	0.016
Gdnf	glial cell line derived neurotrophic factor	0.016
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.016
Pdgfb	platelet derived growth factor, B polypeptide	0.016
Lama5	laminin, alpha 5	0.015
Pou5f1	POU domain, class 5, transcription factor 1	0.015
Bcl2	B-cell leukemia/lymphoma 2	0.015
Wnt4	wingless-related MMTV integration site 4	0.015
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.015
Rspo1	R-spondin homolog (Xenopus laevis)	0.015
Rb1	retinoblastoma 1	0.015
Col22a1	collagen, type XXII, alpha 1	0.015
Mdfi	MyoD family inhibitor	0.014
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.014
Gja5	gap junction protein, alpha 5	0.014
Robo4	roundabout homolog 4 (Drosophila)	0.014
Edn3	endothelin 3	0.014
Scn5a	sodium channel, voltage-gated, type V, alpha	0.013
Adam17	a disintegrin and metallopeptidase domain 17	0.013
Rarb	retinoic acid receptor, beta	0.013
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.013
Podxl	podocalyxin-like	0.013
Wnt5b	wingless-related MMTV integration site 5B	0.013
Hoxb5	homeobox B5	0.012
Cldn5	claudin 5	0.012
Prx	periaxin	0.012
Thbs1	thrombospondin 1	0.012
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.012
Hoxa7	homeobox A7	0.012
Tead4	TEA domain family member 4	0.012
Ushbp1	Usher syndrome 1C binding protein 1	0.012
Mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.012
Tgif2	TGFB-induced factor homeobox 2	0.012
Foxf2	forkhead box F2	0.012
Pknox1	Pbx/knotted 1 homeobox	0.012
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.012
Dlx6	distal-less homeobox 6	0.011
Fgd5	FYVE, RhoGEF and PH domain containing 5	0.011
Wnt9a	wingless-type MMTV integration site 9A	0.011
Cox4i2	cytochrome c oxidase subunit IV isoform 2	0.011
Jag2	jagged 2	0.011
Tlx2	T-cell leukemia, homeobox 2	0.011
Hoxd12	homeobox D12	0.011
Wnt10b	wingless related MMTV integration site 10b	0.011
Tshz1	teashirt zinc finger family member 1	0.011
Foxd2	forkhead box D2	0.011
Grb10	growth factor receptor bound protein 10	0.011
Ephb4	Eph receptor B4	0.010
Ski	ski sarcoma viral oncogene homolog (avian)	0.010
Cxcr4	chemokine (C-X-C motif) receptor 4	0.010
Zfhx3	zinc finger homeobox 3	0.010
Fgf3	fibroblast growth factor 3	0.010
Prkg1	protein kinase, cGMP-dependent, type I	0.010
Tssk1	testis-specific serine kinase 1	0.010
Ptprb	protein tyrosine phosphatase, receptor type, B	0.010
Efna1	ephrin A1	0.010