IMP

Process View

Mus musculus

15 genes annotated in mouse

Multi-species View

spongiotrophoblast layer development

GO:0060712

The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "spongiotrophoblast layer development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "spongiotrophoblast layer development" (in gray)

Name	Description	Probability	Func Analog Organism
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.940
Scn5a	sodium channel, voltage-gated, type V, alpha	0.582
Lepr	leptin receptor	0.567
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.531
Ldb3	LIM domain binding 3	0.422
Tgfb2	transforming growth factor, beta 2	0.380
Tcfap2a	transcription factor AP-2, alpha	0.246
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.223
Junb	Jun-B oncogene	0.215
Vhl	von Hippel-Lindau tumor suppressor	0.202
Akt1	thymoma viral proto-oncogene 1	0.190
Jak2	Janus kinase 2	0.181
Tbx5	T-box 5	0.166
Ptgs2	prostaglandin-endoperoxide synthase 2	0.155
Ryr2	ryanodine receptor 2, cardiac	0.121
Pitx2	paired-like homeodomain transcription factor 2	0.116
Socs2	suppressor of cytokine signaling 2	0.104	Mouse
Vegfa	vascular endothelial growth factor A	0.101
Cd28	CD28 antigen	0.101
Kel	Kell blood group	0.099
Fos	FBJ osteosarcoma oncogene	0.098
Gata6	GATA binding protein 6	0.097
Fgf4	fibroblast growth factor 4	0.097
Mcl1	myeloid cell leukemia sequence 1	0.094
Rhox6	reproductive homeobox 6	0.092
Mgrn1	mahogunin, ring finger 1	0.092
Dusp1	dual specificity phosphatase 1	0.083
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.081
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.079
Tjp1	tight junction protein 1	0.079
Gjb6	gap junction protein, beta 6	0.077	Mouse
Cish	cytokine inducible SH2-containing protein	0.071	Mouse
Gjb2	gap junction protein, beta 2	0.071	Mouse
Nppc	natriuretic peptide type C	0.065
Klf6	Kruppel-like factor 6	0.064
Tbx3	T-box 3	0.064
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.063
Notch2	Notch gene homolog 2 (Drosophila)	0.061
Wnt6	wingless-related MMTV integration site 6	0.061
Tcf15	transcription factor 15	0.057
Stat3	signal transducer and activator of transcription 3	0.056
Zfp36	zinc finger protein 36	0.055	Mouse
Btbd17	BTB (POZ) domain containing 17	0.054
Cd44	CD44 antigen	0.053
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.050
Il6st	interleukin 6 signal transducer	0.050
Rnf41	ring finger protein 41	0.050
Btg1	B-cell translocation gene 1, anti-proliferative	0.050
Jun	Jun oncogene	0.049
Bfsp1	beaded filament structural protein 1, in lens-CP94	0.049
Lmx1b	LIM homeobox transcription factor 1 beta	0.047
Spred1	sprouty protein with EVH-1 domain 1, related sequence	0.044
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.044
Cldn6	claudin 6	0.044
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.044
Ighmbp2	immunoglobulin mu binding protein 2	0.044
Mapkapk2	MAP kinase-activated protein kinase 2	0.043
Fas	Fas (TNF receptor superfamily member 6)	0.043
Egr1	early growth response 1	0.043
Phlda2	pleckstrin homology-like domain, family A, member 2	0.043
Cul5	cullin 5	0.042
Ltbp1	latent transforming growth factor beta binding protein 1	0.042
Pcdh12	protocadherin 12	0.042
Pard3	par-3 (partitioning defective 3) homolog (C. elegans)	0.041
Dppa2	developmental pluripotency associated 2	0.040
Inhbb	inhibin beta-B	0.040
Myh9	myosin, heavy polypeptide 9, non-muscle	0.040
Tulp2	tubby-like protein 2	0.039
Neurog2	neurogenin 2	0.039
Gata4	GATA binding protein 4	0.039
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.038
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.036
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.035
Pim1	proviral integration site 1	0.033
Uncx	UNC homeobox	0.033
Cyr61	cysteine rich protein 61	0.033
Prph2	peripherin 2	0.032
Fgf8	fibroblast growth factor 8	0.032
Akt2	thymoma viral proto-oncogene 2	0.032	Mouse
Hand2	heart and neural crest derivatives expressed transcript 2	0.032
Sult4a1	sulfotransferase family 4A, member 1	0.031
Adra1b	adrenergic receptor, alpha 1b	0.031
Smad3	MAD homolog 3 (Drosophila)	0.031
Ptk7	PTK7 protein tyrosine kinase 7	0.030
Bmp8b	bone morphogenetic protein 8b	0.030
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.030
Actn2	actinin alpha 2	0.030
Sall4	sal-like 4 (Drosophila)	0.029
Gpc3	glypican 3	0.029
Jag1	jagged 1	0.028
Gja5	gap junction protein, alpha 5	0.028	Mouse
Smad7	MAD homolog 7 (Drosophila)	0.028
Crabp2	cellular retinoic acid binding protein II	0.027
Fam83g	family with sequence similarity 83, member G	0.027
Midn	midnolin	0.027
Zfp36l1	zinc finger protein 36, C3H type-like 1	0.026
D19Wsu162e	DNA segment, Chr 19, Wayne State University 162, expressed	0.026
Actn4	actinin alpha 4	0.026
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.026
Foxo1	forkhead box O1	0.026
Sp1	trans-acting transcription factor 1	0.026
Msx2	homeobox, msh-like 2	0.026
Gdnf	glial cell line derived neurotrophic factor	0.025
Dact3	dapper homolog 3, antagonist of beta-catenin (xenopus)	0.025
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.025
Prkce	protein kinase C, epsilon	0.025
Ier2	immediate early response 2	0.025
Tcfap2c	transcription factor AP-2, gamma	0.025
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.025
Esx1	extraembryonic, spermatogenesis, homeobox 1	0.024
Bcl2	B-cell leukemia/lymphoma 2	0.024
Slc26a4	solute carrier family 26, member 4	0.024
Hcrt	hypocretin	0.024
Thrb	thyroid hormone receptor beta	0.024
Socs3	suppressor of cytokine signaling 3	0.024
Tead4	TEA domain family member 4	0.024
Il1r1	interleukin 1 receptor, type I	0.023
Nid1	nidogen 1	0.023
Plac1	placental specific protein 1	0.023
Egfr	epidermal growth factor receptor	0.022
Dmrt1	doublesex and mab-3 related transcription factor 1	0.022
Sox1	SRY-box containing gene 1	0.022
Plg	plasminogen	0.022
Rxra	retinoid X receptor alpha	0.022
Bmp10	bone morphogenetic protein 10	0.022
Npas1	neuronal PAS domain protein 1	0.021
Foxe3	forkhead box E3	0.021
Col13a1	collagen, type XIII, alpha 1	0.021
Vav3	vav 3 oncogene	0.021
Icam1	intercellular adhesion molecule 1	0.021
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.021
Atf3	activating transcription factor 3	0.021
Gjb5	gap junction protein, beta 5	0.021
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.021
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.021
Tgif1	TGFB-induced factor homeobox 1	0.021
Gem	GTP binding protein (gene overexpressed in skeletal muscle)	0.020
Epn3	epsin 3	0.020
Bach1	BTB and CNC homology 1	0.020
Foxc2	forkhead box C2	0.020
Nos2	nitric oxide synthase 2, inducible	0.019
Snai1	snail homolog 1 (Drosophila)	0.019
Phox2b	paired-like homeobox 2b	0.019
Krt36	keratin 36	0.019
Foxd3	forkhead box D3	0.019
Phox2a	paired-like homeobox 2a	0.018
Ptp4a2	protein tyrosine phosphatase 4a2	0.018
Tex19.1	testis expressed gene 19.1	0.018
Rnf44	ring finger protein 44	0.018
Dyrk1a	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	0.018
Zfp42	zinc finger protein 42	0.018
Scarb2	scavenger receptor class B, member 2	0.018
Irx3	Iroquois related homeobox 3 (Drosophila)	0.018
Pth2	parathyroid hormone 2	0.018
Kcne1l	potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene	0.018
Fut2	fucosyltransferase 2	0.018
Agrp	agouti related protein	0.018
Bcl3	B-cell leukemia/lymphoma 3	0.018
Edn2	endothelin 2	0.017
Pla2g4f	phospholipase A2, group IVF	0.017
Fmr1nb	fragile X mental retardation 1 neighbor	0.017
Nfil3	nuclear factor, interleukin 3, regulated	0.017
Atoh7	atonal homolog 7 (Drosophila)	0.017
Zyx	zyxin	0.017
Btg2	B-cell translocation gene 2, anti-proliferative	0.017
Glis1	GLIS family zinc finger 1	0.017
Vasp	vasodilator-stimulated phosphoprotein	0.017
Elf1	E74-like factor 1	0.017
Chd1	chromodomain helicase DNA binding protein 1	0.017
C1ql1	complement component 1, q subcomponent-like 1	0.017
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.017
Cdh3	cadherin 3	0.017
Sp3	trans-acting transcription factor 3	0.017
Ltbr	lymphotoxin B receptor	0.016
Fgf17	fibroblast growth factor 17	0.016
Dusp9	dual specificity phosphatase 9	0.016
Crabp1	cellular retinoic acid binding protein I	0.016
Hand1	heart and neural crest derivatives expressed transcript 1	0.016
Prl3b1	prolactin family 3, subfamily b, member 1	0.016
Krt17	keratin 17	0.016
Il6	interleukin 6	0.016
Git1	G protein-coupled receptor kinase-interactor 1	0.016
Bcl10	B-cell leukemia/lymphoma 10	0.016
Mdfi	MyoD family inhibitor	0.015
Skil	SKI-like	0.015
Errfi1	ERBB receptor feedback inhibitor 1	0.015
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.015
Pim3	proviral integration site 3	0.015
Fgf15	fibroblast growth factor 15	0.015
Tgif2	TGFB-induced factor homeobox 2	0.015
Mta2	metastasis-associated gene family, member 2	0.015
Calcrl	calcitonin receptor-like	0.015
Rapgef3	Rap guanine nucleotide exchange factor (GEF) 3	0.015
Slc39a7	solute carrier family 39 (zinc transporter), member 7	0.015
Crct1	cysteine-rich C-terminal 1	0.015
Zfpm2	zinc finger protein, multitype 2	0.015
Adra2b	adrenergic receptor, alpha 2b	0.015
Nptx2	neuronal pentraxin 2	0.015
Atp11c	ATPase, class VI, type 11C	0.015
Rbms1	RNA binding motif, single stranded interacting protein 1	0.015
Yap1	yes-associated protein 1	0.015
Pim2	proviral integration site 2	0.015
Pnoc	prepronociceptin	0.014
Sardh	sarcosine dehydrogenase	0.014
Smad1	MAD homolog 1 (Drosophila)	0.014
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.014
Stat5a	signal transducer and activator of transcription 5A	0.014
Mapk8	mitogen-activated protein kinase 8	0.014
Nrtn	neurturin	0.014
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.014
Krtap9-3	keratin associated protein 9-3	0.014
Tnf	tumor necrosis factor	0.014
Cdx2	caudal type homeobox 2	0.014
F12	coagulation factor XII (Hageman factor)	0.014
Sox15	SRY-box containing gene 15	0.014
Blnk	B-cell linker	0.014
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.014
Ret	ret proto-oncogene	0.014
Ncln	nicalin homolog (zebrafish)	0.014
Nrk	Nik related kinase	0.014
Nploc4	nuclear protein localization 4 homolog (S. cerevisiae)	0.014
Trim8	tripartite motif-containing 8	0.014
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.014
Crygd	crystallin, gamma D	0.014
Ghrh	growth hormone releasing hormone	0.014
Vav2	vav 2 oncogene	0.014
Podxl	podocalyxin-like	0.014
Foxn1	forkhead box N1	0.013
Cul7	cullin 7	0.013
Litaf	LPS-induced TN factor	0.013
Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	0.013
Homer1	homer homolog 1 (Drosophila)	0.013
Gli1	GLI-Kruppel family member GLI1	0.013
Actn1	actinin, alpha 1	0.013
Stat6	signal transducer and activator of transcription 6	0.013
Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.013
Dmkn	dermokine	0.013
Kctd20	potassium channel tetramerisation domain containing 20	0.013
Wfdc2	WAP four-disulfide core domain 2	0.013
Rhox9	reproductive homeobox 9	0.013
Peli1	pellino 1	0.013
Ppard	peroxisome proliferator activator receptor delta	0.013
Nphs2	nephrosis 2 homolog, podocin (human)	0.012
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.012
Hoxd4	homeobox D4	0.012
Obsl1	obscurin-like 1	0.012
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.012
Hivep2	human immunodeficiency virus type I enhancer binding protein 2	0.012
Arl4c	ADP-ribosylation factor-like 4C	0.012
Fbxo15	F-box protein 15	0.012
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.012
Gna13	guanine nucleotide binding protein, alpha 13	0.012
Traf6	TNF receptor-associated factor 6	0.012
Fgf18	fibroblast growth factor 18	0.012
Ppp2r2a	protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform	0.012
She	src homology 2 domain-containing transforming protein E	0.012
Ugcg	UDP-glucose ceramide glucosyltransferase	0.012
Gabrd	gamma-aminobutyric acid (GABA) A receptor, subunit delta	0.012
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.012
Hapln2	hyaluronan and proteoglycan link protein 2	0.012
Gabpb1	GA repeat binding protein, beta 1	0.012
Ski	ski sarcoma viral oncogene homolog (avian)	0.012
Csnk1g2	casein kinase 1, gamma 2	0.012
Pex5	peroxisomal biogenesis factor 5	0.012
Slc12a2	solute carrier family 12, member 2	0.012
Ctdnep1	CTD nuclear envelope phosphatase 1	0.012
Gdf15	growth differentiation factor 15	0.012
Fosl1	fos-like antigen 1	0.012
Bdkrb2	bradykinin receptor, beta 2	0.011
Fstl3	follistatin-like 3	0.011
Mib1	mindbomb homolog 1 (Drosophila)	0.011
Lcat	lecithin cholesterol acyltransferase	0.011
Lhx5	LIM homeobox protein 5	0.011
Lama5	laminin, alpha 5	0.011
Fosl2	fos-like antigen 2	0.011
Egr2	early growth response 2	0.011
Rhob	ras homolog gene family, member B	0.011
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.011
Sfrp5	secreted frizzled-related sequence protein 5	0.011
Clock	circadian locomotor output cycles kaput	0.011
Tbl1xr1	transducin (beta)-like 1X-linked receptor 1	0.011
Otx2	orthodenticle homolog 2 (Drosophila)	0.011
Phlda1	pleckstrin homology-like domain, family A, member 1	0.011
B4galt1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	0.011
Egln3	EGL nine homolog 3 (C. elegans)	0.011
Arid5b	AT rich interactive domain 5B (MRF1-like)	0.011
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.011
Lmna	lamin A	0.011
Rell1	RELT-like 1	0.011
Nefm	neurofilament, medium polypeptide	0.011
Vax1	ventral anterior homeobox containing gene 1	0.011
Creb1	cAMP responsive element binding protein 1	0.011
Rod1	ROD1 regulator of differentiation 1 (S. pombe)	0.011
Lrrc58	leucine rich repeat containing 58	0.011
Rasip1	Ras interacting protein 1	0.011
F2	coagulation factor II	0.011
Hes1	hairy and enhancer of split 1 (Drosophila)	0.011
Wt1	Wilms tumor 1 homolog	0.011
Map3k1	mitogen-activated protein kinase kinase kinase 1	0.011
Hmx1	H6 homeobox 1	0.011
Apoa5	apolipoprotein A-V	0.011
Dazl	deleted in azoospermia-like	0.011
Sox3	SRY-box containing gene 3	0.011
Alms1	Alstrom syndrome 1 homolog (human)	0.011
Gsc	goosecoid homeobox	0.011
Etv2	ets variant gene 2	0.011
Mark4	MAP/microtubule affinity-regulating kinase 4	0.011
Gp9	glycoprotein 9 (platelet)	0.011
Dusp6	dual specificity phosphatase 6	0.011
Sall1	sal-like 1 (Drosophila)	0.011
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.010
Hes3	hairy and enhancer of split 3 (Drosophila)	0.010
Hopx	HOP homeobox	0.010
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.010
Dsc1	desmocollin 1	0.010
Gatad2a	GATA zinc finger domain containing 2A	0.010
Tpbg	trophoblast glycoprotein	0.010
Prkca	protein kinase C, alpha	0.010
Parg	poly (ADP-ribose) glycohydrolase	0.010
Mobp	myelin-associated oligodendrocytic basic protein	0.010
Sycn	syncollin	0.010
Wnt9a	wingless-type MMTV integration site 9A	0.010
Ier3	immediate early response 3	0.010
Myl7	myosin, light polypeptide 7, regulatory	0.010
Iqgap1	IQ motif containing GTPase activating protein 1	0.010
Pam	peptidylglycine alpha-amidating monooxygenase	0.010
Itga1	integrin alpha 1	0.010
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.010
Socs1	suppressor of cytokine signaling 1	0.010	Mouse