IMP

Process View

Danio rerio

14 genes annotated in zebrafish

forebrain neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in zebrafish Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "forebrain neuron differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "forebrain neuron differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
lhx2b	LIM homeobox 2b	0.935
dla	deltaA	0.856
dlx2a	distal-less homeobox gene 2a	0.802
tbx1	T-box 1	0.746
lef1	lymphocyte enhancer binding factor 1	0.707
wnt1	wingless-type MMTV integration site family, member 1	0.608	Zebrafish
barhl2	BarH-like 2	0.597
wnt8b	wingless-type MMTV integration site family, member 8b	0.554
gli1	GLI-Kruppel family member 1	0.552
lhx5	LIM homeobox 5	0.531	Mouse
foxp2	forkhead box P2	0.522
dbx1a	developing brain homeobox 1a	0.499
dld	deltaD	0.493
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.482
pitx3	paired-like homeodomain transcription factor 3	0.444
otx2	orthodenticle homolog 2	0.418
eya1	eyes absent homolog 1	0.418
fgf3	fibroblast growth factor 3	0.401
otpb	orthopedia homolog b	0.399
sfrp1a	secreted frizzled-related protein 1a	0.362
fezf2	FEZ family zinc finger 2	0.343
rx3	retinal homeobox gene 3	0.342
otx1b	orthodenticle homolog 1b	0.336
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.322
oprd1b	opioid receptor, delta 1b	0.307
sim1a	single-minded homolog 1a (Drosophila)	0.297
arx	aristaless related homeobox	0.281	Mouse
shha	sonic hedgehog a	0.276
zic1	zic family member 1 (odd-paired homolog, Drosophila)	0.274
ephb4b	eph receptor B4b	0.264
notch2	notch homolog 2	0.258
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.256	Zebrafish
wnt7ba	wingless-type MMTV integration site family, member 7Ba	0.253	Zebrafish
dlx1a	distal-less homeobox gene 1a	0.252	Mouse
notch1a	notch homolog 1a	0.250
robo3	roundabout homolog 3	0.231
gbx2	gastrulation brain homeo box 2	0.220	Mouse
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.219
wnt3	wingless-type MMTV integration site family, member 3	0.217	Zebrafish
olig2	oligodendrocyte lineage transcription factor 2	0.212
pax6a	paired box gene 6a	0.211	Mouse
gli2a	GLI-Kruppel family member GLI2a	0.209
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.204	Human Mouse
fgfr3	fibroblast growth factor receptor 3	0.198
wnt3a	wingless-type MMTV integration site family, member 3A	0.188	Zebrafish
wnt4a	wingless-type MMTV integration site family, member 4a	0.183	Zebrafish
met	met proto-oncogene (hepatocyte growth factor receptor)	0.178
nrp2b	neuropilin 2b	0.166	Mouse
nkx2.1a	NK2 homeobox 1a	0.163
foxg1a	forkhead box G1a	0.159	Mouse
six2a	sine oculis-related homeobox 2a	0.152
myf5	myogenic factor 5	0.152
lhx1a	LIM homeobox 1a	0.142
zic3	zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)	0.142
sema3aa	semaphorin 3aa	0.139	Mouse
mib	mind bomb	0.135
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.133
smad1	MAD homolog 1 (Drosophila)	0.131
eomesa	eomesodermin homolog a	0.129
sox1a	SRY-box containing gene 1a	0.122
pcdh10b	protocadherin 10b	0.121
atoh1b	atonal homolog 1b	0.119	Zebrafish
rest	RE1-silencing transcription factor	0.107
nkx2.1b	NK2 homeobox 1b	0.101	Mouse
dlx2b	distal-less homeobox gene 2b	0.096	Mouse
ndr2	nodal-related 2	0.095
sox2	SRY-box containing gene 2	0.090	Mouse
hmx4	H6 family homeobox 4	0.089
isl1	islet1	0.088
dlx6a	distal-less homeobox gene 6a	0.088
hmgcrb	3-hydroxy-3-methylglutaryl-Coenzyme A reductase b	0.086
robo2	roundabout homolog 2	0.086	Mouse
elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.085
jag2	jagged 2	0.084
ephb3a	eph receptor B3a	0.083
notch3	notch homolog 3	0.082
fgfr4	fibroblast growth factor receptor 4	0.082
foxc1a	forkhead box C1a	0.082
cdh2	cadherin 2, neuronal	0.078
wnt5b	wingless-type MMTV integration site family, member 5b	0.076	Zebrafish Mouse
pou3f1	POU class 3 homeobox 1	0.076
six3a	sine oculis homeobox homolog 3a	0.075
gro1	groucho 1	0.074
eng2a	engrailed 2a	0.073
sox21b	SRY-box containing gene 21 b	0.073
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.072
shhb	sonic hedgehog b	0.069
sst1.1	somatostatin 1, tandem duplicate 1	0.069
spry2	sprouty homolog 2	0.068
wnt2	wingless-type MMTV integration site family member 2	0.068	Zebrafish
epha4a	eph receptor A4a	0.067
tal1	T-cell acute lymphocytic leukemia 1	0.067	Zebrafish
nkx2.2a	NK2 transcription factor related 2a	0.066
znf503	zinc finger protein 503	0.065
spry4	sprouty (Drosophila) homolog 4	0.065
fgfr2	fibroblast growth factor receptor 2	0.064	Mouse
boc	brother of CDO	0.064
fzd7a	frizzled homolog 7a	0.063
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.063
wif1	wnt inhibitory factor 1	0.062
fgf19	fibroblast growth factor 19	0.061
sox3	SRY-box containing gene 3	0.060
foxd3	forkhead box D3	0.060
ntn1a	netrin 1a	0.060
her15.1	hairy and enhancer of split-related 15.1	0.060	Rat
foxn4	forkhead box N4	0.059
her1	hairy-related 1	0.058
neo1	neogenin 1	0.058
tgfb2	transforming growth factor, beta 2	0.058
fgf10a	fibroblast growth factor 10a	0.057
eng2b	engrailed 2b	0.057
chrna6	cholinergic receptor, nicotinic, alpha 6	0.057
sox10	SRY-box containing gene 10	0.057
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.056	Zebrafish
fgf8b	fibroblast growth factor 8 b	0.054
coe2	coe2	0.054
tbr1b	T-box, brain, 1b	0.053	Mouse
disp1	dispatched homolog 1 (Drosophila)	0.053
fgf17	fibroblast growth factor 17	0.053
hhip	hedgehog interacting protein	0.051
gli2b	GLI-Kruppel family member GLI2b	0.051
gfra1a	gdnf family receptor alpha 1a	0.051
irx1a	iroquois homeobox protein 1, a	0.050
hoxd4a	homeo box D4a	0.049
her12	hairy-related 12	0.049	Rat
nr4a2b	nuclear receptor subfamily 4, group A, member 2b	0.048
wnt9b	wingless-type MMTV integration site family, member 9B	0.048	Zebrafish
bhlhe22	basic helix-loop-helix family, member e22	0.047
osr2	odd-skipped related 2 (Drosophila)	0.046
pcdh19	protocadherin 19	0.046
wu:fv91b12	wu:fv91b12	0.046
six3b	sine oculis homeobox homolog 3b	0.046
irx1b	iroquois homeobox protein 1, b	0.044
ntn1b	netrin 1b	0.042
atoh1a	atonal homolog 1a	0.042	Zebrafish
vsx1	visual system homeobox 1 homolog, chx10-like	0.042
pax6b	paired box gene 6b	0.041	Mouse
wnt7aa	wingless-type MMTV integration site family, member 7Aa	0.041	Zebrafish
gli3	GLI-Kruppel family member GLI3	0.041
pvrl1b	poliovirus receptor-related 1b	0.040
gata1a	GATA binding protein 1a	0.039
notum3	notum 3	0.038
slit3	slit (Drosophila) homolog 3	0.037
igfbp3	insulin-like growth factor binding protein 3	0.037
tbx2b	T-box 2b	0.037
nrp1b	neuropilin 1b	0.036	Mouse
emx1	empty spiracles homeobox 1	0.036	Zebrafish
fzd8b	frizzled homolog 8b	0.035	Zebrafish
hnf1ba	HNF1 homeobox Ba	0.035
frzb	frizzled-related protein	0.034	Zebrafish
klf4	Kruppel-like factor 4	0.033
jag1b	jagged 1b	0.033
epb4.1l4	erythrocyte protein band 4.1-like 4	0.033
zbtb4	zinc finger and BTB domain containing 4	0.032
emx3	empty spiracles homeobox 3	0.032
emx2	empty spiracles homeobox 2	0.032	Zebrafish
rx2	retinal homeobox gene 2	0.032
six4b	sine oculis homeobox homolog 4b	0.031
cnr1	cannabinoid receptor 1	0.031
axin2	axin 2 (conductin, axil)	0.031	Zebrafish
irx4a	iroquois homeobox protein 4a	0.031
dmbx1a	diencephalon/mesencephalon homeobox 1a	0.031
map2k4a	mitogen-activated protein kinase kinase 4a	0.030
nrp2a	neuropilin 2a	0.030	Mouse
drd3	dopamine receptor D3	0.029
pbx4	pre-B-cell leukemia transcription factor 4	0.029
wnt9a	wingless-type MMTV integration site family, member 9A	0.029	Zebrafish
fzd9b	frizzled homolog 9b	0.028	Zebrafish
robo1	roundabout homolog 1	0.028	Human Mouse
wnt10a	wingless-type MMTV integration site family, member 10a	0.027	Zebrafish
lfng	lunatic fringe homolog	0.027
hoxa13b	homeo box A13b	0.027
nr2f2	nuclear receptor subfamily 2, group F, member 2	0.027
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.027
six4a	sine oculis homeobox homolog 4a	0.027
hnf1bb	HNF1 homeobox Bb	0.027
pkd2	polycystic kidney disease 2	0.027
gbx1	gastrulation brain homeobox 1	0.026
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.026
id2a	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a	0.026
twist1a	twist1a	0.026	Zebrafish
per2	period homolog 2 (Drosophila)	0.026
itgav	integrin, alpha V	0.026
dharma	dharma	0.026
tmem2	transmembrane protein 2	0.026
nxph1	neurexophilin 1	0.025
bactin2	bactin2	0.025
ptprsa	protein tyrosine phosphatase, receptor type, s, a	0.025
barhl1.2	BarH-like 1.2	0.025
pcdh17	protocadherin 17	0.025
traf4a	tnf receptor-associated factor 4a	0.025
gata3	GATA-binding protein 3	0.025
dzip1	DAZ interacting protein 1	0.024
msxc	muscle segment homeobox C	0.024
fzd10	frizzled homolog 10	0.024	Zebrafish
axin1	axin 1	0.023
zic2a	zic family member 2 (odd-paired homolog, Drosophila), a	0.023
rarga	retinoic acid receptor gamma a	0.023
flh	floating head	0.023
grhl2b	grainyhead-like 2b (Drosophila)	0.023
fzd8a	frizzled homolog 8a	0.023
foxa1	forkhead box A1	0.023
irx5a	iroquois homeobox protein 5a	0.022
wls	wntless homolog (Drosophila)	0.022
zic6	zic family member 6	0.022
fzd5	frizzled homolog 5	0.022	Zebrafish
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.021
hmx3	homeo box (H6 family) 3	0.021
bmper	BMP binding endothelial regulator	0.021
cenph	centromere protein H	0.020
prtga	protogenin homolog a (Gallus gallus)	0.020
lzts2a	leucine zipper, putative tumor suppressor 2a	0.020
insm1b	insulinoma-associated 1b	0.020
dlb	deltaB	0.020
bmp3	bone morphogenetic protein 3	0.020
tnc	tenascin C	0.020
ptenb	phosphatase and tensin homolog B (mutated in multiple advanced cancers 1)	0.020
lhx6	LIM homeobox 6	0.020	Mouse
olfm2	olfactomedin 2	0.020
hoxa3a	homeo box A3a	0.019
olig3	oligodendrocyte transcription factor 3	0.019
smad3b	MAD, mothers against decapentaplegic homolog 3b (Drosophila)	0.019
inka1a	induced in neural crest by AP2, 1a	0.019
dlx5a	distal-less homeobox gene 5a	0.019
neurod4	neurogenic differentiation 4	0.019	Zebrafish
gnrh3	gonadotropin-releasing hormone 3	0.019
zic5	zic family member 5 (odd-paired homolog, Drosophila)	0.019
lmo3	LIM domain only 3	0.019
foxa2	forkhead box A2	0.018
irx4b	iroquois homeobox protein 4b	0.018
ek1	eph-like kinase 1	0.018
kdrl	kinase insert domain receptor like	0.018
otx5	orthodenticle homolog 5	0.017
rgma	RGM domain family, member A	0.017
snai1b	snail homolog 1b (Drosophila)	0.017
wnt11r	wingless-type MMTV integration site family, member 11, related	0.017	Zebrafish
loxl2b	lysyl oxidase-like 2b	0.016
otpa	orthopedia homolog a	0.016
nr4a3	nuclear receptor subfamily 4, group A, member 3	0.016	Zebrafish
mef2bnb	mef2b neighbor	0.016
tnfsf10l3	tumor necrosis factor (ligand) superfamily, member 10 like 3	0.016
glcea	glucuronyl C5-epimerase a	0.016
lhx1b	LIM homeobox 1b	0.016
meis2.2	myeloid ecotropic viral integration site 2.2	0.016
mll	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.016
zic4	zic family member 4	0.016
ptch1	patched 1	0.016
ascl1b	achaete-scute complex-like 1b (Drosophila)	0.016
wu:fi18a01	wu:fi18a01	0.016
apc	adenomatosis polyposis coli	0.016
lmo4a	LIM domain only 4a	0.016
rela	v-rel reticuloendotheliosis viral oncogene homolog A	0.015
wnt16	wingless-type MMTV integration site family, member 16	0.015
csf1ra	colony stimulating factor 1 receptor, a	0.015
prl	prolactin	0.015
mesp2	mesoderm posterior 2 homolog (mouse)	0.015
cdx4	caudal type homeo box transcription factor 4	0.015
phox2a	paired-like homeobox 2a	0.015
hoxa13a	homeo box A13a	0.015
dusp6	dual specificity phosphatase 6	0.015
fzd7b	frizzled homolog 7b	0.015	Zebrafish
hoxa9a	homeo box A9a	0.015
sox19a	SRY-box containing gene 19a	0.015
gdf6b	growth differentiation factor 6b	0.015
twist1b	twist1b	0.015
neurod6b	neurogenic differentiation 6b	0.015	Zebrafish
olig4	oligodendrocyte transcription factor 4	0.014
ebf3	early B-cell factor 3	0.014
hoxb2a	homeo box B2a	0.014
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.014
neurog1	neurogenin 1	0.014
tbx5a	T-box 5a	0.014
nrp1a	neuropilin 1a	0.014	Mouse
sesn1	sestrin 1	0.014
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.014
adarb1	adenosine deaminase, RNA-specific, B1	0.014
adcyap1r1	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	0.014
gro2	groucho 2	0.014
dbx1b	developing brain homeobox 1b	0.014
slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.014
lama1	laminin, alpha 1	0.014
lhx9	LIM homeobox 9	0.014
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.013
nog1	noggin 1	0.013
sp5l	Sp5 transcription factor-like	0.013
sfrp5	secreted frizzled-related protein 5	0.013
sox17	SRY-box containing gene 17	0.013
pitx2	paired-like homeodomain transcription factor 2	0.013
nrxn2a	neurexin 2a	0.013
dlx4b	distal-less homeobox gene 4b	0.013
tgfbi	transforming growth factor, beta-induced	0.012
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.012
szl	sizzled	0.012
tfec	transcription factor EC	0.012
sim2	single-minded homolog 2 (Drosophila)	0.012
dmrt2a	doublesex and mab-3 related transcription factor 2a	0.012
oprk1	opioid receptor, kappa 1	0.012
nkd1	naked cuticle homolog 1 (Drosophila)	0.012
tcf7l1a	transcription factor 7-like 1a (T-cell specific, HMG-box)	0.012	Zebrafish
tfap2b	transcription factor AP-2 beta	0.012
ddc	dopa decarboxylase	0.012
pcdh18b	protocadherin 18b	0.012
pax7a	paired box gene 7a	0.012
egr2b	early growth response 2b	0.012
tbx22	T-box 22	0.012
pmp22a	peripheral myelin protein 22a	0.012
pcdh10a	protocadherin 10a	0.012
hapln1a	hyaluronan and proteoglycan link protein 1a	0.012
LOC100002342	carboxypeptidase A6-like	0.011
znfl2a	zinc finger-like gene 2a	0.011
her4.2	hairy-related 4.2	0.011	Rat
meis2.1	myeloid ecotropic viral integration site 2.1	0.011
efnb1	ephrin B1	0.011
wnt5a	wingless-type MMTV integration site family, member 5a	0.011	Zebrafish
mab21l2	mab-21-like 2	0.011
dkk3	dickkopf homolog 3 (Xenopus laevis)	0.011
tcf4	transcription factor 4	0.011
ier2	immediate early response 2	0.011
gsc	goosecoid	0.011
eya2	eyes absent homolog 2 (Drosophila)	0.011
dpysl2b	dihydropyrimidinase-like 2b	0.011
pou3f3b	POU class 3 homeobox 3b	0.011
zfyve26	zinc finger, FYVE domain containing 26	0.011
stmn4	stathmin-like 4	0.011
lmx1b.2	LIM homeobox transcription factor 1, beta 2	0.011
pea3	ETS-domain transcription factor pea3	0.011
neurod6a	neurogenic differentiation 6a	0.011
meis3	myeloid ecotropic viral integration site 3	0.011
fech	ferrochelatase	0.011
gsx1	GS homeobox 1	0.010
ndel1a	nudE nuclear distribution gene E homolog like 1 (A. nidulans) A	0.010
dlc	deltaC	0.010
map2k7	mitogen-activated protein kinase kinase 7	0.010
supt6h	suppressor of Ty 6 homolog	0.010
bmp2a	bone morphogenetic protein 2a	0.010
irx7	iroquois homeobox protein 7	0.010
vangl2	vang-like 2 (van gogh, Drosophila)	0.010
nrg2a	neuregulin 2a	0.010
ppp1r12a	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.010
grem2	gremlin 2, cysteine knot superfamily	0.010
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.010